iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.50e-51	171.4	247	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           + ++ly ++a +++eL ++ Gd+++++   + + gWl+g   l+gk G+fP+ Fv+
   Q: 247  YGIALYRFQALESNELDFEVGDKIRIL--GTLEDGWLEG--RLKGKTGIFPHRFVK 298
           6789***********************..88899*****..9************98 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MEPGSVVRAI FDFCPSVSEE LPLFVGDVIE VLTVVDEFWL LGKKEDVTGQ FPSSFVEIVT 60
IPSLKEGERL FVCTCDFISR EPNSLSLHRG DLVIIDGTPT AGWLQGRSSL GARGFFPSSC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGACCGCGG CCGGGCTGGG CCACCAGTGG CCGTGCGCGG AGGGAACGCC GAGCGCAGAG 60
AGCAGGTCGG TGCGGGGCCG GGCTCTGGCG GGGTGGCGGG GTGGCGGGGT GGCGGGGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS00741--DH_1
PS50010--DH_2
PS50002--SH3

Pfam

PF03114--BAR
PF00621--RhoGEF
PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9

SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

KEGG

rno:309362

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002128	Ailuropoda melanoleuca	73.34	0.00e+00	2055.00
IUUC-Apl-003934	Anas platyrhynchos	76.40	0.00e+00	994.00
IUUC-Aca-005005	Anolis carolinensis	63.44	0.00e+00	1130.00
IUUC-Ame-011361	Astyanax mexicanus	56.50	0.00e+00	927.00
IUUC-Bta-013210	Bos taurus	73.66	0.00e+00	2060.00
IUUC-Cel-018396	Caenorhabditis elegans	25.18	2.00e-29	125.00
IUUC-Cja-019104	Callithrix jacchus	74.37	0.00e+00	2030.00
IUUC-Cfa-020960	Canis familiaris	72.64	0.00e+00	2019.00
IUUC-Cpo-022440	Cavia porcellus	73.56	0.00e+00	2091.00
IUUC-Csa-023391	Chlorocebus sabaeus	75.20	0.00e+00	2106.00
IUUC-Cho-024795	Choloepus hoffmanni	64.48	0.00e+00	1642.00
IUUC-Cin-025137	Ciona intestinalis	33.16	4.00e-29	120.00
IUUC-Dre-027932	Danio rerio	60.72	0.00e+00	821.00
IUUC-Dno-029750	Dasypus novemcinctus	72.35	0.00e+00	2060.00
IUUC-Dor-031109	Dipodomys ordii	73.02	0.00e+00	1977.00
IUUC-Ete-032660	Echinops telfairi	67.86	0.00e+00	1576.00
IUUC-Eca-033433	Equus caballus	74.54	0.00e+00	2029.00
IUUC-Eeu-034929	Erinaceus europaeus	67.18	0.00e+00	1161.00
IUUC-Fca-035859	Felis catus	73.87	0.00e+00	2069.00
IUUC-Fal-036653	Ficedula albicollis	63.61	0.00e+00	1119.00
IUUC-Gmo-038948	Gadus morhua	60.80	0.00e+00	747.00
IUUC-Gga-040279	Gallus gallus	66.70	0.00e+00	1085.00
IUUC-Gac-041641	Gasterosteus aculeatus	59.48	0.00e+00	798.00
IUUC-Hsa-046063	Homo sapiens	75.16	0.00e+00	2102.00
IUUC-Itr-049071	Ictidomys tridecemlineatus	75.05	0.00e+00	2144.00
IUUC-Lch-049865	Latimeria chalumnae	48.34	0.00e+00	1098.00
IUUC-Loc-051754	Lepisosteus oculatus	58.11	0.00e+00	996.00
IUUC-Laf-054037	Loxodonta africana	72.11	0.00e+00	2052.00
IUUC-Mcc-055002	Macaca mulatta	75.33	0.00e+00	2107.00
IUUC-Meu-056420	Macropus eugenii	57.94	0.00e+00	1192.00
IUUC-Mga-059868	Meleagris gallopavo	67.68	0.00e+00	1100.00
IUUC-Mmr-060767	Microcebus murinus	75.22	0.00e+00	2137.00
IUUC-Mdo-061939	Monodelphis domestica	64.00	0.00e+00	1757.00
IUUC-Mmu-063980	Mus musculus	86.59	0.00e+00	2580.00
IUUC-Mpu-065913	Mustela putorius furo	72.22	0.00e+00	2070.00
IUUC-Mlu-067340	Myotis lucifugus	72.35	0.00e+00	1952.00
IUUC-Nle-069343	Nomascus leucogenys	74.91	0.00e+00	2074.00
IUUC-Opr-070694	Ochotona princeps	69.42	0.00e+00	1939.00
IUUC-Ont-071844	Oreochromis niloticus	62.83	0.00e+00	795.00
IUUC-Oan-073605	Ornithorhynchus anatinus	38.63	4.00e-46	179.00
IUUC-Ocu-074406	Oryctolagus cuniculus	72.64	0.00e+00	2011.00
IUUC-Oba-075707	Oryza barthii	56.52	2.90e-02	33.50
IUUC-Ogu-078055	Oryza glumaepatula	52.17	3.70e-02	33.10
IUUC-Oni-082309	Oryza nivara	56.52	2.90e-02	33.50
IUUC-Opu-083196	Oryza punctata	56.52	2.90e-02	33.50
IUUC-Oru-085213	Oryza rufipogon	56.52	2.90e-02	33.50
IUUC-Ola-087343	Oryzias latipes	57.97	0.00e+00	671.00
IUUC-Oga-088847	Otolemur garnettii	73.74	0.00e+00	2061.00
IUUC-Oar-089817	Ovis aries	72.06	0.00e+00	2023.00
IUUC-Pan-092104	Papio anubis	74.95	0.00e+00	2095.00
IUUC-Psi-094045	Pelodiscus sinensis	64.24	7.00e-91	328.00
IUUC-Pma-094663	Petromyzon marinus	40.90	4.00e-151	529.00
IUUC-Pfo-096714	Poecilia formosa	52.78	0.00e+00	866.00
IUUC-Pab-097918	Pongo abelii	75.33	0.00e+00	2108.00
IUUC-Pca-101096	Procavia capensis	66.14	0.00e+00	1027.00
IUUC-Pva-102490	Pteropus vampyrus	72.28	0.00e+00	2053.00
IUUC-Sha-107509	Sarcophilus harrisii	63.14	0.00e+00	1615.00
IUUC-Sbi-114441	Sorghum bicolor	50.00	2.50e-02	33.50
IUUC-Ssc-115250	Sus scrofa	73.82	0.00e+00	2016.00
IUUC-Tru-118279	Takifugu rubripes	47.61	0.00e+00	1261.00
IUUC-Tni-120459	Tetraodon nigroviridis	61.69	0.00e+00	724.00
IUUC-Tbe-127753	Tupaia belangeri	60.42	0.00e+00	874.00
IUUC-Ttr-129096	Tursiops truncatus	74.22	0.00e+00	1515.00
IUUC-Vpa-130643	Vicugna pacos	72.05	0.00e+00	1744.00
IUUC-Xtr-131979	Xenopus tropicalis	54.53	0.00e+00	1490.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence