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Tag Content
iUUCD ID IUUC-Bta-013557
Ensembl Protein ID ENSBTAP00000020774.4
UniProt Accession Q29RQ3; DC1I1_BOVIN
Genbank Protein ID AAI14075.1
Protein Name Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic
Genbank Nucleotide ID BC114074
Gene Name DYNC1I1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000027134.3 ENSBTAT00000020774.4 ENSBTAP00000020774.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.30e-13 50.7 303 337
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tdsvtclaf....sdtllvsGsdDgtikvWDlrtgv 34
    ++sv +++f + +l+v G++ g+i +WD r+++
   Q: 303 QSSVMSVCFarfhP-NLVVGGTYSGQIVLWDNRSHR 337
    57899999999754.9999999*********98875 PP
   

Organism Bos taurus
Functional Description
(View)

Functional Description



     Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores (By similarity).
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores (By similarity).
Protein Sequence
(Fasta)
MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVPDDS DLDRKRRETE 60
ALLQSIGISP EPPLVPTPMS PSSKSVSTPS EAGSQDSGDL GPLTRRRLHK LGVSKITQVD 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Bta-013557|E3,WD_repeat|Bos taurus
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Nucleotide Sequence
(Fasta)
AGTGTCACGC TCGGGAGCGG GAGGAAGTGC CGGGTGCCCG AGGAGCGCGA GCCGAGGGCC 60
GGCGCAGCGT GAGACAGCAC ATCCTGCGCG CGCCCGGCCC GCCGCCCTCG GGAAACGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Bta-013557|E3,WD_repeat|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0243--Dynein
KW-0995--Kinetochore
KW-0493--Microtubule
KW-0505--Motor protein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR025956--DYNC1I1/DYNC1I2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF11540--Dynein_IC2
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005868--C:cytoplasmic dynein complex
GO:0036464--C:cytoplasmic ribonucleoprotein granule
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0055037--C:recycling endosome
GO:0000922--C:spindle pole
GO:0031982--C:vesicle
GO:0003774--F:motor activity
GO:0047496--P:vesicle transport along microtubule

KEGG bta:613724
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001500 Ailuropoda melanoleuca 91.94 0.00e+00 1134.00
IUUC-Aca-004659 Anolis carolinensis 91.40 0.00e+00 1093.00
IUUC-Afu-009032 Aspergillus fumigatus 40.04 7.00e-89 321.00
IUUC-Ame-010879 Astyanax mexicanus 80.92 0.00e+00 1008.00
IUUC-Bgr-011987 Blumeria graminis 39.17 5.00e-100 358.00
IUUC-Bci-013835 Botrytis cinerea 43.12 8.00e-98 351.00
IUUC-Cja-018913 Callithrix jacchus 92.11 0.00e+00 1137.00
IUUC-Cfa-020794 Canis familiaris 94.90 0.00e+00 1144.00
IUUC-Csa-023506 Chlorocebus sabaeus 95.06 0.00e+00 1146.00
IUUC-Cho-025102 Choloepus hoffmanni 81.71 0.00e+00 967.00
IUUC-Csv-025876 Ciona savignyi 48.14 8.00e-170 590.00
IUUC-Cgl-026617 Colletotrichum gloeosporioides 39.74 1.00e-87 317.00
IUUC-Dre-028093 Danio rerio 77.87 0.00e+00 939.00
IUUC-Dno-029846 Dasypus novemcinctus 97.60 0.00e+00 944.00
IUUC-Dor-030613 Dipodomys ordii 91.33 0.00e+00 1125.00
IUUC-Dme-032157 Drosophila melanogaster 62.86 1.00e-166 580.00
IUUC-Ete-032322 Echinops telfairi 86.46 0.00e+00 820.00
IUUC-Eca-033324 Equus caballus 91.80 0.00e+00 1134.00
IUUC-Fca-036050 Felis catus 97.89 0.00e+00 1117.00
IUUC-Fal-037664 Ficedula albicollis 93.47 0.00e+00 1132.00
IUUC-Gmo-038624 Gadus morhua 78.62 0.00e+00 887.00
IUUC-Ggr-039785 Gaeumannomyces graminis 38.59 5.00e-82 298.00
IUUC-Gga-040886 Gallus gallus 93.15 0.00e+00 1128.00
IUUC-Gac-042215 Gasterosteus aculeatus 81.91 0.00e+00 928.00
IUUC-Ggo-045363 Gorilla gorilla 91.95 0.00e+00 1136.00
IUUC-Hsa-046861 Homo sapiens 91.95 0.00e+00 1136.00
IUUC-Itr-048603 Ictidomys tridecemlineatus 98.48 0.00e+00 951.00
IUUC-Kpa-049295 Komagataella pastoris 25.11 3.00e-29 123.00
IUUC-Loc-052873 Lepisosteus oculatus 86.98 0.00e+00 1050.00
IUUC-Laf-053494 Loxodonta africana 90.87 0.00e+00 1125.00
IUUC-Mcc-055731 Macaca mulatta 91.95 0.00e+00 1136.00
IUUC-Mor-056924 Magnaporthe oryzae 42.40 5.00e-100 358.00
IUUC-Mpo-057521 Magnaporthe poae 38.17 1.00e-81 297.00
IUUC-Mla-058954 Melampsora laricipopulina 40.70 8.00e-104 370.00
IUUC-Mvi-060541 Microbotryum violaceum 42.65 4.00e-112 399.00
IUUC-Mmr-060828 Microcebus murinus 91.94 0.00e+00 1131.00
IUUC-Mmu-063862 Mus musculus 91.49 0.00e+00 1130.00
IUUC-Mpu-066835 Mustela putorius furo 94.90 0.00e+00 1146.00
IUUC-Mlu-067993 Myotis lucifugus 91.53 0.00e+00 1129.00
IUUC-Nfi-068441 Neosartorya fischeri 40.13 1.00e-89 324.00
IUUC-Nle-069711 Nomascus leucogenys 92.11 0.00e+00 1138.00
IUUC-Opr-070509 Ochotona princeps 89.84 0.00e+00 1075.00
IUUC-Ont-072346 Oreochromis niloticus 74.85 0.00e+00 915.00
IUUC-Ocu-074398 Oryctolagus cuniculus 94.11 0.00e+00 1135.00
IUUC-Ola-087168 Oryzias latipes 81.41 0.00e+00 966.00
IUUC-Oga-088138 Otolemur garnettii 97.18 0.00e+00 929.00
IUUC-Oar-090454 Ovis aries 95.86 0.00e+00 1156.00
IUUC-Ptr-090850 Pan troglodytes 91.95 0.00e+00 1136.00
IUUC-Pan-092449 Papio anubis 95.06 0.00e+00 1146.00
IUUC-Psi-093490 Pelodiscus sinensis 93.15 0.00e+00 1111.00
IUUC-Pma-094729 Petromyzon marinus 70.03 0.00e+00 834.00
IUUC-Pab-098252 Pongo abelii 91.95 0.00e+00 1135.00
IUUC-Pca-100827 Procavia capensis 98.03 0.00e+00 642.00
IUUC-Pva-102223 Pteropus vampyrus 94.19 0.00e+00 1036.00
IUUC-Pgr-103384 Puccinia graminis 40.75 3.00e-108 385.00
IUUC-Ptt-103792 Puccinia triticina 40.79 3.00e-109 389.00
IUUC-Rno-105683 Rattus norvegicus 91.49 0.00e+00 1125.00
IUUC-Sja-107798 Schizosaccharomyces japonicus 25.64 9.00e-30 125.00
IUUC-Ssl-108411 Sclerotinia sclerotiorum 42.89 2.00e-91 330.00
IUUC-Ssc-115238 Sus scrofa 94.07 0.00e+00 1037.00
IUUC-Tgu-117310 Taeniopygia guttata 88.08 0.00e+00 938.00
IUUC-Ttr-129188 Tursiops truncatus 92.87 0.00e+00 1142.00
IUUC-Xtr-132370 Xenopus tropicalis 81.38 0.00e+00 876.00
Created Date 25-Jun-2017

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