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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046472
Ensembl Protein ID ENSP00000419153.1
UniProt Accession Q9HC78; Q63HP6; Q8N6R5; Q9Y410; ZBT20_HUMAN
Genbank Protein ID AAG28340.2; CAB43377.1; CAH56190.1; EAW79598.1; AAH29041.1
Protein Name Zinc finger and BTB domain-containing protein 20; Dendritic-derived BTB/POZ zinc finger protein; Zinc finger protein 288
Genbank Nucleotide ID AF139460; AL050276; BX647778; CH471052; BC029041
Gene Name ZBTB20; DPZF; ZNF288
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000181722.16 ENST00000474710.5 ENSP00000419153.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRecordsRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.70e-07 32.1 104 165
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv++ + g+  +ah++vLaa S++F++ +l + ++       ei   v+ ++++ l++F+Y+g l+ 
   Q: 104  CDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDI------EIPSvVSVQSVQKLIDFMYSGVLRV 165
           8*****************************9888875......577557788************9976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
 May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
Protein Sequence
(Fasta)
MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA 60
HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046472|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGCGGGGG GAAGTTTAGG AGTTGAGGAA AGAAGATTAA AGAGCGCGAG GAGGTAATGC 60
CACAAACTCT AATTTGTTGT GGGACGGGCG GGAGAGAGGG AGGAGTGTGT GCGTGCCGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046472|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0032728--P:positive regulation of interferon-beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0006351--P:transcription, DNA-templated
KEGG hsa:26137
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002366 Ailuropoda melanoleuca 98.52 0.00e+00 1398.00
IUUC-Apl-003862 Anas platyrhynchos 89.44 0.00e+00 1310.00
IUUC-Aca-005090 Anolis carolinensis 86.04 0.00e+00 1265.00
IUUC-Ame-010940 Astyanax mexicanus 67.57 0.00e+00 726.00
IUUC-Bta-012346 Bos taurus 98.37 0.00e+00 1435.00
IUUC-Cja-019161 Callithrix jacchus 99.46 0.00e+00 1439.00
IUUC-Cfa-020769 Canis familiaris 99.19 0.00e+00 1409.00
IUUC-Cpo-021745 Cavia porcellus 96.90 0.00e+00 1369.00
IUUC-Csa-024179 Chlorocebus sabaeus 99.40 0.00e+00 1290.00
IUUC-Cho-024960 Choloepus hoffmanni 97.45 0.00e+00 924.00
IUUC-Dre-028517 Danio rerio 67.85 0.00e+00 717.00
IUUC-Dno-029085 Dasypus novemcinctus 98.25 0.00e+00 1407.00
IUUC-Dor-030803 Dipodomys ordii 98.25 0.00e+00 1421.00
IUUC-Ete-032886 Echinops telfairi 97.74 1.00e-153 537.00
IUUC-Eca-034022 Equus caballus 98.50 0.00e+00 1254.00
IUUC-Eeu-035184 Erinaceus europaeus 97.75 0.00e+00 1255.00
IUUC-Fca-035822 Felis catus 96.49 0.00e+00 1380.00
IUUC-Fal-036868 Ficedula albicollis 90.31 0.00e+00 1198.00
IUUC-Gmo-038534 Gadus morhua 87.01 2.00e-75 275.00
IUUC-Gga-040560 Gallus gallus 89.08 0.00e+00 1304.00
IUUC-Gac-042540 Gasterosteus aculeatus 63.62 0.00e+00 752.00
IUUC-Ggo-045443 Gorilla gorilla 99.87 0.00e+00 1442.00
IUUC-Itr-048471 Ictidomys tridecemlineatus 98.38 0.00e+00 1434.00
IUUC-Lch-050620 Latimeria chalumnae 77.81 0.00e+00 973.00
IUUC-Loc-051793 Lepisosteus oculatus 74.84 0.00e+00 881.00
IUUC-Laf-053382 Loxodonta africana 96.77 0.00e+00 1422.00
IUUC-Mcc-055395 Macaca mulatta 99.46 0.00e+00 1435.00
IUUC-Meu-056456 Macropus eugenii 93.71 0.00e+00 1292.00
IUUC-Mga-059977 Meleagris gallopavo 88.72 0.00e+00 1314.00
IUUC-Mmr-061361 Microcebus murinus 99.06 0.00e+00 1444.00
IUUC-Mdo-062760 Monodelphis domestica 92.44 0.00e+00 1216.00
IUUC-Mmu-063230 Mus musculus 97.71 0.00e+00 1417.00
IUUC-Mpu-066367 Mustela putorius furo 98.65 0.00e+00 1404.00
IUUC-Mlu-067638 Myotis lucifugus 97.17 0.00e+00 1394.00
IUUC-Nle-069275 Nomascus leucogenys 99.67 0.00e+00 1188.00
IUUC-Opr-070230 Ochotona princeps 94.76 0.00e+00 875.00
IUUC-Ont-071373 Oreochromis niloticus 63.04 0.00e+00 760.00
IUUC-Ocu-073942 Oryctolagus cuniculus 97.85 0.00e+00 1421.00
IUUC-Oga-088490 Otolemur garnettii 98.91 0.00e+00 1432.00
IUUC-Oar-090130 Ovis aries 76.64 0.00e+00 1028.00
IUUC-Ptr-090567 Pan troglodytes 100.00 0.00e+00 1293.00
IUUC-Pan-092221 Papio anubis 99.46 0.00e+00 1441.00
IUUC-Psi-093694 Pelodiscus sinensis 89.35 5.00e-86 311.00
IUUC-Pfo-096692 Poecilia formosa 62.38 0.00e+00 757.00
IUUC-Pab-098500 Pongo abelii 99.33 0.00e+00 1436.00
IUUC-Pca-100185 Procavia capensis 97.84 0.00e+00 736.00
IUUC-Pva-102151 Pteropus vampyrus 98.63 0.00e+00 866.00
IUUC-Rno-105171 Rattus norvegicus 97.46 0.00e+00 1276.00
IUUC-Sha-106646 Sarcophilus harrisii 92.25 0.00e+00 1342.00
IUUC-Sar-113486 Sorex araneus 96.86 0.00e+00 1216.00
IUUC-Ssc-116214 Sus scrofa 98.66 0.00e+00 1269.00
IUUC-Tgu-117045 Taeniopygia guttata 90.28 0.00e+00 1345.00
IUUC-Tru-118699 Takifugu rubripes 61.20 0.00e+00 746.00
IUUC-Tsy-119393 Tarsius syrichta 96.36 0.00e+00 1385.00
IUUC-Tni-119917 Tetraodon nigroviridis 61.86 0.00e+00 730.00
IUUC-Vpa-130539 Vicugna pacos 98.34 0.00e+00 1149.00
IUUC-Xtr-132883 Xenopus tropicalis 81.29 0.00e+00 1167.00
Created Date 25-Jun-2017

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