iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.60e-10	38.8	318	363

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C++C+e+++    l+ C+ C   fH+ C  ++  +e+p++e+w Cp+C+
   Q: 318  EFCKICKETEN----LLLCDSCVCSFHAYCIDPP-LTEVPKEETWSCPRCE 363
           69*****9999....*******************.***************7 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development.

Protein Sequence
(Fasta)

MSTEEDPSLV DAEESMEEGS VTQDATEETE EEEEQEQGDE AGPSERKRSS RKKGGKGGKK 60
GSKKSAAAAS KVEIPDPYNS TSEEVCAAIG LTDVEFDYDE EEFQGISNLK TFSSIIKPQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATTGTATT TCTCCTGAGA ATTCAACAAT GTCAACTGAA GAAGATCCGT CTTTAGTGGA 60
CGCGGAAGAA TCAATGGAAG AGGGTTCTGT CACTCAAGAC GCAACTGAAG AAACAGAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR012957--CHD_C2
IPR012958--CHD_N
IPR000953--Chromo/chromo_shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR009462--DUF1086
IPR009463--DUF1087
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50013--CHROMO_2
PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF08074--CHDCT2
PF08073--CHDNT
PF00385--Chromo
PF06461--DUF1086
PF06465--DUF1087
PF00271--Helicase_C
PF00628--PHD
PF00176--SNF2_N

SMART

SM00298--CHROMO
SM00487--DEXDc
SM01146--DUF1086
SM01147--DUF1087
SM00490--HELICc
SM00249--PHD

Gene Ontology

GO:0016581--C:NuRD complex
GO:0090571--C:RNA polymerase II transcription repressor complex
GO:0005524--F:ATP binding
GO:0008026--F:ATP-dependent helicase activity
GO:0003677--F:DNA binding
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0040027--P:negative regulation of vulval development

KEGG

cel:CELE_F26F12.7

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004175	Anas platyrhynchos	58.19	0.00e+00	1303.00
IUUC-Aly-005645	Arabidopsis lyrata	41.21	3.00e-141	496.00
IUUC-Bta-013220	Bos taurus	57.96	0.00e+00	1300.00
IUUC-Bol-016073	Brassica oleracea	38.56	2.00e-146	513.00
IUUC-Cfa-020422	Canis familiaris	57.96	0.00e+00	1300.00
IUUC-Cpo-021704	Cavia porcellus	57.96	0.00e+00	1299.00
IUUC-Dno-029656	Dasypus novemcinctus	57.96	0.00e+00	1300.00
IUUC-Eca-034112	Equus caballus	57.96	0.00e+00	1300.00
IUUC-Fca-036056	Felis catus	57.96	0.00e+00	1300.00
IUUC-Fal-037282	Ficedula albicollis	51.36	0.00e+00	1473.00
IUUC-Gga-040216	Gallus gallus	58.19	0.00e+00	1300.00
IUUC-Itr-048002	Ictidomys tridecemlineatus	57.96	0.00e+00	1300.00
IUUC-Mga-059633	Meleagris gallopavo	58.27	0.00e+00	1305.00
IUUC-Mmu-063672	Mus musculus	57.96	0.00e+00	1298.00
IUUC-Mpu-066692	Mustela putorius furo	57.96	0.00e+00	1300.00
IUUC-Mlu-067785	Myotis lucifugus	57.92	0.00e+00	1297.00
IUUC-Oar-090422	Ovis aries	57.96	0.00e+00	1298.00
IUUC-Pab-097677	Pongo abelii	53.64	0.00e+00	1492.00
IUUC-Rno-105692	Rattus norvegicus	57.96	0.00e+00	1300.00
IUUC-Ssc-115295	Sus scrofa	57.96	0.00e+00	1299.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence