iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000011638.3	ENSXETT00000065293.1	ENSXETP00000063060.1
ENSXETG00000011638.3	ENSXETT00000025451.2	ENSXETP00000025451.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.60e-17	63.8	46	115
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.30e-09	35.3	149	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg....geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv l+v+    + ef ahkivLa+sS+vF+a+f+++l+e    ++v+i++v p+v++ ll+F Yt +++ 
   Q: 46   CDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECG-METVTIEGVHPKVMQRLLEFAYTASISV 115
           8******66679*****************************9.***********************98875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi +fA++ +c++L+++a+++i  +F
   Q: 149  PSNAIGIATFAEQIGCHELHQKAREYIYMQF 179
           89**************************999 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MYATECQAEV TPSHSNGNRQ FQYSLADHTN QAFQIMNELR LGQQLCDVKL KVKYNDVQDE 60
FVAHKIVLAS SSPVFRAMFT NGLRECGMET VTIEGVHPKV MQRLLEFAYT ASISVGEKCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACGCGA CAGAGTGCCA GGCGGAAGTG ACGCCCTCGC ACAGCAATGG CAACCGGCAG 60
TTTCAGTATA GCCTGGCCGA CCACACCAAC CAGGCCTTCC AGATTATGAA CGAGCTCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0008134--F:transcription factor binding
GO:0071379--P:cellular response to prostaglandin stimulus
GO:0071466--P:cellular response to xenobiotic stimulus
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	76.45	0.00e+00	953.00
IUUC-Aca-005389	Anolis carolinensis	76.24	0.00e+00	941.00
IUUC-Ame-010749	Astyanax mexicanus	73.64	0.00e+00	919.00
IUUC-Bta-013505	Bos taurus	75.94	0.00e+00	949.00
IUUC-Cja-018823	Callithrix jacchus	75.94	0.00e+00	946.00
IUUC-Cfa-021202	Canis familiaris	76.11	0.00e+00	951.00
IUUC-Cpo-021830	Cavia porcellus	74.50	0.00e+00	652.00
IUUC-Csa-023728	Chlorocebus sabaeus	76.11	0.00e+00	949.00
IUUC-Cin-025195	Ciona intestinalis	52.93	0.00e+00	646.00
IUUC-Csv-026155	Ciona savignyi	50.44	3.00e-170	591.00
IUUC-Dre-027388	Danio rerio	72.57	0.00e+00	899.00
IUUC-Dno-029066	Dasypus novemcinctus	68.77	0.00e+00	829.00
IUUC-Dor-030674	Dipodomys ordii	74.19	0.00e+00	647.00
IUUC-Dme-032165	Drosophila melanogaster	47.49	1.00e-150	526.00
IUUC-Ete-032255	Echinops telfairi	77.59	8.00e-78	283.00
IUUC-Eca-034381	Equus caballus	74.44	0.00e+00	930.00
IUUC-Eeu-034791	Erinaceus europaeus	74.14	0.00e+00	634.00
IUUC-Fca-036067	Felis catus	76.28	0.00e+00	952.00
IUUC-Gmo-039691	Gadus morhua	71.60	0.00e+00	885.00
IUUC-Gga-040266	Gallus gallus	72.06	0.00e+00	891.00
IUUC-Gac-041866	Gasterosteus aculeatus	71.77	0.00e+00	893.00
IUUC-Ggo-044719	Gorilla gorilla	76.28	0.00e+00	952.00
IUUC-Hsa-046255	Homo sapiens	76.28	0.00e+00	952.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	76.11	0.00e+00	951.00
IUUC-Lch-049646	Latimeria chalumnae	77.84	0.00e+00	975.00
IUUC-Laf-054579	Loxodonta africana	76.28	0.00e+00	953.00
IUUC-Mcc-055315	Macaca mulatta	76.11	0.00e+00	949.00
IUUC-Meu-056288	Macropus eugenii	72.50	0.00e+00	886.00
IUUC-Mmr-061639	Microcebus murinus	76.11	0.00e+00	949.00
IUUC-Mdo-062072	Monodelphis domestica	77.44	0.00e+00	966.00
IUUC-Mmu-063622	Mus musculus	75.26	0.00e+00	942.00
IUUC-Mpu-066737	Mustela putorius furo	76.09	0.00e+00	929.00
IUUC-Mlu-068173	Myotis lucifugus	76.28	0.00e+00	951.00
IUUC-Nle-069336	Nomascus leucogenys	48.22	7.00e-133	467.00
IUUC-Opr-070432	Ochotona princeps	76.62	0.00e+00	952.00
IUUC-Ont-072160	Oreochromis niloticus	71.26	0.00e+00	881.00
IUUC-Oan-072691	Ornithorhynchus anatinus	67.41	0.00e+00	818.00
IUUC-Ocu-073798	Oryctolagus cuniculus	76.33	0.00e+00	953.00
IUUC-Ola-086367	Oryzias latipes	72.18	0.00e+00	881.00
IUUC-Oga-088231	Otolemur garnettii	76.28	0.00e+00	947.00
IUUC-Oar-089227	Ovis aries	74.57	0.00e+00	926.00
IUUC-Ptr-091460	Pan troglodytes	76.28	0.00e+00	952.00
IUUC-Pan-092713	Papio anubis	76.11	0.00e+00	949.00
IUUC-Ppa-095249	Physcomitrella patens	33.77	2.00e-16	80.50
IUUC-Pfo-096468	Poecilia formosa	73.15	0.00e+00	887.00
IUUC-Pab-098357	Pongo abelii	76.28	0.00e+00	952.00
IUUC-Pca-100837	Procavia capensis	76.11	0.00e+00	945.00
IUUC-Pva-103249	Pteropus vampyrus	73.38	0.00e+00	890.00
IUUC-Rno-106086	Rattus norvegicus	74.57	0.00e+00	930.00
IUUC-Sha-107245	Sarcophilus harrisii	77.61	0.00e+00	966.00
IUUC-Sar-112985	Sorex araneus	76.16	0.00e+00	951.00
IUUC-Ssc-115756	Sus scrofa	76.28	0.00e+00	953.00
IUUC-Tgu-116838	Taeniopygia guttata	49.87	1.00e-103	369.00
IUUC-Tru-117644	Takifugu rubripes	72.29	0.00e+00	902.00
IUUC-Tni-120245	Tetraodon nigroviridis	68.98	0.00e+00	900.00
IUUC-Tbe-127472	Tupaia belangeri	81.43	4.00e-121	428.00
IUUC-Ttr-128953	Tursiops truncatus	71.95	3.00e-138	485.00
IUUC-Vpa-130683	Vicugna pacos	73.79	0.00e+00	843.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence