iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008762

Ensembl Protein ID

CADAFUAP00008748

UniProt Accession

Q4WJV7; Q4WJV7_ASPFU

Genbank Protein ID

EAL88175.1

Protein Name

Ubiquitin-protein ligase (Hul4), putative

Genbank Nucleotide ID

AAHF01000007

Gene Name

AFUA_1G04640

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00008748	CADAFUAT00008748	CADAFUAP00008748

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-75	253.1	856	1200

Active Site

Position(s)	Description	Evidence
1169	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           ++++kk l++efvgEeg+d+gG+ +e++ ll++e+++p  glfly+e+++   + np  +    e  + F ++G+llg+a++++ +ld+ l
   Q: 856  QEEIKKGLRIEFVGEEGVDAGGLRKEWFLLLVREIFDPHHGLFLYDEDSR-FCYFNPYCF----ESSEQFFLVGVLLGLAIYNSTILDIAL 941
           67899****************************************99655.557799888....5678888******************** PP
   S: 93   sksfyklllgk................klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtn 167
           +++ +k+ll                  +++l+dl+e  p l+k l  ++e  + d+ ++ ++  f ++ + +ge+ ++ L+pgGe+ pVtn
   Q: 942  PPFAFKKLLAAapqtsgpqpssarsnyRCTLDDLAEYRPALAKGLRALLEF-DGDVADT-FCYDFVAHVDRYGEAVAVPLCPGGETRPVTN 1030
           ********98877777777777777667*********************99.7899997.******************************* PP
   S: 168  eNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketky...kggytedspaiqwFwevle 254
           +N++e+v+l+v+y l + +++q+e f++Gf +v+  + lslF++ee+ell+ G+ e +dv +l++ ++y    +   e+ p+++wFwe++e
   Q: 1031 ANRREFVDLYVHYMLDTAVTRQFEPFKRGFFTVCGGNALSLFRPEEIELLVRGSdEALDVASLRAVATYdnwSHPRPENIPVVRWFWEFFE 1121
           ******************************************************999**********9944445555677888******** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           + + + ++++L F+Tgs+r+P+ G  +l  rl ++ +  + +r+P + TCfn+L L +Y++ e+l+++L  A+ +++gF+l
   Q: 1122 NTDPQAQRKILSFITGSDRIPAMGATSLTIRLACLGD--DASRYPIARTCFNTLGLYRYPTREKLERMLWEAVGNSEGFGL 1200
           *****************************99999999..779*************************************98 PP

Organism

Aspergillus fumigatus

Protein Sequence
(Fasta)

MPSRSAYNQP LPPTLNSSTV YPNAALLSSS AERSAQRHIH HDVPILPTMT GNPATSPPHH 60
RGHSRSISHP FPSSFGGRRR NPNPGFIDSD SDDDDIEVTH LPDVLSSSPR KGSSRPLPGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGTCGC GGTCCGCGTA TAACCAGCCT CTTCCCCCGA CTCTGAACTC CTCAACTGTC 60
TATCCCAACG CCGCCCTTCT CTCTTCTTCA GCAGAGAGGA GTGCACAGCG CCACATCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

afm:AFUA_1G04640

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	34.42	2.00e-95	342.00
IUUC-Atr-003144	Amborella trichopoda	37.40	3.00e-84	303.00
IUUC-Apl-003589	Anas platyrhynchos	33.33	8.00e-88	316.00
IUUC-Aca-004350	Anolis carolinensis	39.51	3.00e-91	327.00
IUUC-Ago-007908	Ashbya gossypii	31.42	7.00e-103	366.00
IUUC-Acl-008288	Aspergillus clavatus	76.88	0.00e+00	1793.00
IUUC-Afl-008402	Aspergillus flavus	78.62	0.00e+00	1088.00
IUUC-Ani-009176	Aspergillus nidulans	74.51	0.00e+00	921.00
IUUC-Ang-009791	Aspergillus niger	68.11	0.00e+00	1372.00
IUUC-Aor-009921	Aspergillus oryzae	80.03	0.00e+00	994.00
IUUC-Ate-010295	Aspergillus terreus	67.93	0.00e+00	1478.00
IUUC-Ame-011166	Astyanax mexicanus	37.69	8.00e-82	296.00
IUUC-Bgr-011981	Blumeria graminis	46.86	0.00e+00	997.00
IUUC-Bta-012945	Bos taurus	39.29	8.00e-93	333.00
IUUC-Bci-013697	Botrytis cinerea	55.53	0.00e+00	881.00
IUUC-Cel-018150	Caenorhabditis elegans	30.98	5.00e-52	197.00
IUUC-Cja-019263	Callithrix jacchus	38.41	1.00e-89	322.00
IUUC-Cfa-020486	Canis familiaris	34.32	1.00e-95	342.00
IUUC-Cpo-021755	Cavia porcellus	34.86	3.00e-97	347.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	42.48	4.00e-60	223.00
IUUC-Csa-023814	Chlorocebus sabaeus	38.42	5.00e-80	290.00
IUUC-Cho-025059	Choloepus hoffmanni	34.96	5.00e-68	251.00
IUUC-Cin-025643	Ciona intestinalis	31.00	3.00e-66	245.00
IUUC-Csv-026282	Ciona savignyi	35.88	9.00e-60	223.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	52.50	0.00e+00	849.00
IUUC-Cme-027151	Cyanidioschyzon merolae	36.84	3.00e-76	278.00
IUUC-Dre-028551	Danio rerio	38.80	3.00e-90	324.00
IUUC-Dno-029497	Dasypus novemcinctus	39.07	3.00e-92	331.00
IUUC-Dor-030158	Dipodomys ordii	33.88	2.00e-67	249.00
IUUC-Dse-031239	Dothistroma septosporum	50.94	0.00e+00	863.00
IUUC-Dme-032103	Drosophila melanogaster	34.27	6.00e-68	251.00
IUUC-Ete-032902	Echinops telfairi	32.02	1.00e-86	312.00
IUUC-Eca-033678	Equus caballus	34.48	1.00e-96	345.00
IUUC-Eeu-035109	Erinaceus europaeus	36.36	7.00e-70	256.00
IUUC-Fca-035590	Felis catus	34.81	4.00e-98	350.00
IUUC-Fal-036747	Ficedula albicollis	37.92	2.00e-79	288.00
IUUC-Fox-037941	Fusarium oxysporum	44.92	0.00e+00	941.00
IUUC-Fso-038388	Fusarium solani	45.37	0.00e+00	918.00
IUUC-Gmo-039553	Gadus morhua	38.58	5.00e-80	290.00
IUUC-Ggr-040110	Gaeumannomyces graminis	50.28	0.00e+00	824.00
IUUC-Gga-040406	Gallus gallus	33.50	8.00e-92	329.00
IUUC-Gac-042141	Gasterosteus aculeatus	32.84	3.00e-87	314.00
IUUC-Ggo-045504	Gorilla gorilla	38.41	6.00e-90	323.00
IUUC-Hsa-045786	Homo sapiens	38.41	4.00e-90	324.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	38.48	5.00e-75	274.00
IUUC-Kpa-049152	Komagataella pastoris	35.44	4.00e-99	354.00
IUUC-Lch-049824	Latimeria chalumnae	39.51	2.00e-78	285.00
IUUC-Loc-052173	Lepisosteus oculatus	34.65	2.00e-98	352.00
IUUC-Laf-054017	Loxodonta africana	39.07	2.00e-92	331.00
IUUC-Mcc-055713	Macaca mulatta	38.41	1.00e-89	322.00
IUUC-Meu-056061	Macropus eugenii	37.25	9.00e-76	276.00
IUUC-Mor-057045	Magnaporthe oryzae	45.56	0.00e+00	909.00
IUUC-Mla-059187	Melampsora laricipopulina	42.28	9.00e-94	335.00
IUUC-Mga-059884	Meleagris gallopavo	39.01	5.00e-84	303.00
IUUC-Mmr-061344	Microcebus murinus	34.32	1.00e-96	345.00
IUUC-Mdo-062653	Monodelphis domestica	39.96	5.00e-93	333.00
IUUC-Mmu-063775	Mus musculus	39.87	4.00e-94	337.00
IUUC-Mpu-066069	Mustela putorius furo	34.48	2.00e-96	344.00
IUUC-Mlu-067925	Myotis lucifugus	39.51	8.00e-94	336.00
IUUC-Nfi-068439	Neosartorya fischeri	92.09	0.00e+00	2130.00
IUUC-Ncr-068903	Neurospora crassa	45.03	0.00e+00	844.00
IUUC-Nle-070046	Nomascus leucogenys	33.61	1.00e-92	332.00
IUUC-Opr-070891	Ochotona princeps	34.43	4.00e-57	215.00
IUUC-Ont-072126	Oreochromis niloticus	34.32	9.00e-95	339.00
IUUC-Oan-072933	Ornithorhynchus anatinus	38.50	1.00e-89	322.00
IUUC-Ocu-073800	Oryctolagus cuniculus	38.63	7.00e-90	323.00
IUUC-Ola-086988	Oryzias latipes	33.61	5.00e-91	327.00
IUUC-Oga-088117	Otolemur garnettii	39.07	5.00e-91	326.00
IUUC-Oar-089371	Ovis aries	39.29	1.00e-92	332.00
IUUC-Ptr-090551	Pan troglodytes	38.41	5.00e-90	323.00
IUUC-Pan-092067	Papio anubis	38.41	1.00e-89	322.00
IUUC-Psi-092963	Pelodiscus sinensis	39.07	4.00e-90	324.00
IUUC-Pma-094643	Petromyzon marinus	33.84	9.00e-82	296.00
IUUC-Ppa-095354	Physcomitrella patens	38.46	7.00e-85	307.00
IUUC-Pfo-096562	Poecilia formosa	33.33	2.00e-92	331.00
IUUC-Pab-098680	Pongo abelii	38.19	1.00e-89	322.00
IUUC-Pca-100869	Procavia capensis	36.59	2.00e-76	278.00
IUUC-Pva-102219	Pteropus vampyrus	37.02	4.00e-74	271.00
IUUC-Pgr-103315	Puccinia graminis	36.63	5.00e-102	363.00
IUUC-Ptt-103736	Puccinia triticina	41.53	1.00e-100	358.00
IUUC-Rno-105270	Rattus norvegicus	39.96	7.00e-95	340.00
IUUC-Sce-106306	Saccharomyces cerevisiae	32.48	1.00e-85	309.00
IUUC-Sha-106819	Sarcophilus harrisii	35.08	2.00e-98	351.00
IUUC-Sja-107974	Schizosaccharomyces japonicus	35.73	1.00e-59	222.00
IUUC-Spo-108271	Schizosaccharomyces pombe	35.89	3.00e-111	394.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	55.43	0.00e+00	905.00
IUUC-Smo-108858	Selaginella moellendorffii	39.91	5.00e-86	310.00
IUUC-Sar-113134	Sorex araneus	35.33	6.00e-76	276.00
IUUC-Ssc-115441	Sus scrofa	39.21	1.00e-92	332.00
IUUC-Tgu-117166	Taeniopygia guttata	33.50	3.00e-87	314.00
IUUC-Tru-118368	Takifugu rubripes	36.81	7.00e-79	286.00
IUUC-Tsy-118898	Tarsius syrichta	35.15	4.00e-73	267.00
IUUC-Tni-120143	Tetraodon nigroviridis	37.03	4.00e-79	287.00
IUUC-Tre-122108	Trichoderma reesei	45.33	0.00e+00	887.00
IUUC-Tvi-122644	Trichoderma virens	45.67	0.00e+00	894.00
IUUC-Tme-127004	Tuber melanosporum	49.12	0.00e+00	814.00
IUUC-Tbe-127640	Tupaia belangeri	36.56	5.00e-64	237.00
IUUC-Ttr-128352	Tursiops truncatus	36.87	4.00e-83	300.00
IUUC-Vda-129969	Verticillium dahliae	44.59	0.00e+00	867.00
IUUC-Vpa-130448	Vicugna pacos	34.51	3.00e-68	251.00
IUUC-Xtr-132594	Xenopus tropicalis	38.07	5.00e-80	290.00
IUUC-Xma-134157	Xiphophorus maculatus	33.27	3.00e-83	301.00
IUUC-Yli-134470	Yarrowia lipolytica	34.74	5.00e-107	380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence