iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ppa-095431

Ensembl Protein ID

PP1S55_148V6.1

UniProt Accession

A9S846; A9S846_PHYPA

Genbank Protein ID

EDQ72607.1

Protein Name

Presenilin

Genbank Nucleotide ID

DS544944

Gene Name

PHYPADRAFT_182224

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PP1S55_148V6	PP1S55_148V6.1	PP1S55_148V6.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	30.29	2.00e-43	173.00	IUUC-Cel-018553
UBD/Alpha-Helix/CUE	31.78	2.00e-26	118.00	IUUC-Hsa-046455

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Physcomitrella patens

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MEKGILDVVG GEIVGIVTPV SICMFLVVTL VHILDPRGED APVSNIAMMV YNEQASDSFS 60
EKLGGALLNA IVFVVIVTLV TFMLVALFYY RCTRCLRVYM GISAFTVLAW MGGIVAVQII 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTCTCGG ATAACAATTT CGCTGCGAAT ATCTCACGTC CGATTGCTTG CTTCGCCTTG 60
CTTGCTTGCT GCCCCCAGTG ACGCATTCGA TTTGATACTG TGAACTTCAC AGTGGCAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0005634--C:nucleus
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

KEGG

ppp:PHYPADRAFT_182224

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	43.97	6.00e-68	251.00
IUUC-Aml-001648	Ailuropoda melanoleuca	31.03	3.00e-31	128.00
IUUC-Atr-003039	Amborella trichopoda	46.15	1.00e-98	352.00
IUUC-Apl-003959	Anas platyrhynchos	30.28	2.00e-25	109.00
IUUC-Aca-005160	Anolis carolinensis	30.22	2.00e-28	119.00
IUUC-Aly-005455	Arabidopsis lyrata	54.63	1.00e-53	202.00
IUUC-Ath-006730	Arabidopsis thaliana	46.47	2.00e-89	322.00
IUUC-Ame-010686	Astyanax mexicanus	33.80	7.00e-29	120.00
IUUC-Bta-013097	Bos taurus	31.40	7.00e-30	124.00
IUUC-Bdi-014196	Brachypodium distachyon	44.47	2.00e-76	279.00
IUUC-Bol-015841	Brassica oleracea	54.50	3.00e-45	175.00
IUUC-Bra-017580	Brassica rapa	55.24	4.00e-38	151.00
IUUC-Cel-018553	Caenorhabditis elegans	30.29	1.00e-43	170.00
IUUC-Cja-018824	Callithrix jacchus	31.25	1.00e-29	124.00
IUUC-Cfa-020253	Canis familiaris	31.40	1.00e-29	123.00
IUUC-Cpo-021401	Cavia porcellus	31.40	7.00e-30	124.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	46.72	2.00e-53	203.00
IUUC-Csa-023369	Chlorocebus sabaeus	31.78	2.00e-30	125.00
IUUC-Cho-024735	Choloepus hoffmanni	46.30	5.00e-21	95.10
IUUC-Cin-025780	Ciona intestinalis	29.00	1.00e-36	146.00
IUUC-Csv-025967	Ciona savignyi	30.09	9.00e-27	113.00
IUUC-Dre-028526	Danio rerio	33.63	2.00e-28	119.00
IUUC-Dno-029758	Dasypus novemcinctus	32.41	3.00e-23	102.00
IUUC-Dor-031127	Dipodomys ordii	32.17	1.00e-27	116.00
IUUC-Dme-031929	Drosophila melanogaster	34.51	3.00e-30	125.00
IUUC-Ete-033081	Echinops telfairi	36.49	7.00e-09	54.70
IUUC-Eca-034387	Equus caballus	31.40	2.00e-29	122.00
IUUC-Eeu-035134	Erinaceus europaeus	34.81	7.00e-22	97.10
IUUC-Fca-035396	Felis catus	31.40	9.00e-30	124.00
IUUC-Fal-037457	Ficedula albicollis	32.93	2.00e-26	112.00
IUUC-Gmo-038550	Gadus morhua	34.07	7.00e-28	117.00
IUUC-Gga-040706	Gallus gallus	29.54	7.00e-31	127.00
IUUC-Gac-042511	Gasterosteus aculeatus	31.97	2.00e-25	109.00
IUUC-Gma-043822	Glycine max	52.81	8.00e-35	140.00
IUUC-Ggo-045338	Gorilla gorilla	31.78	2.00e-30	125.00
IUUC-Hsa-046455	Homo sapiens	31.78	2.00e-30	125.00
IUUC-Hvu-047141	Hordeum vulgare	43.98	9.00e-72	263.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	31.40	5.00e-30	124.00
IUUC-Lch-049638	Latimeria chalumnae	32.87	8.00e-29	120.00
IUUC-Lpe-051132	Leersia perrieri	43.53	1.00e-70	259.00
IUUC-Loc-052469	Lepisosteus oculatus	30.54	3.00e-38	152.00
IUUC-Laf-053758	Loxodonta africana	29.86	3.00e-30	125.00
IUUC-Mcc-054755	Macaca mulatta	31.78	3.00e-30	125.00
IUUC-Meu-056004	Macropus eugenii	30.09	2.00e-22	99.00
IUUC-Mtr-058392	Medicago truncatula	44.47	3.00e-80	291.00
IUUC-Mga-059466	Meleagris gallopavo	29.50	3.00e-24	105.00
IUUC-Mmr-060890	Microcebus murinus	32.17	4.00e-31	128.00
IUUC-Mdo-062197	Monodelphis domestica	33.33	2.00e-28	119.00
IUUC-Mmu-063823	Mus musculus	31.78	2.00e-30	126.00
IUUC-Mac-064858	Musa acuminata	53.85	2.00e-34	138.00
IUUC-Mpu-066181	Mustela putorius furo	31.40	9.00e-30	124.00
IUUC-Mlu-067079	Myotis lucifugus	30.58	4.00e-30	125.00
IUUC-Nle-069596	Nomascus leucogenys	31.78	2.00e-30	125.00
IUUC-Opr-070344	Ochotona princeps	31.08	1.00e-27	117.00
IUUC-Ont-071846	Oreochromis niloticus	32.11	4.00e-24	105.00
IUUC-Oan-073378	Ornithorhynchus anatinus	33.33	3.00e-28	118.00
IUUC-Ocu-074652	Oryctolagus cuniculus	31.47	1.00e-29	124.00
IUUC-Oba-075256	Oryza barthii	42.22	6.00e-67	247.00
IUUC-Obr-076302	Oryza brachyantha	53.89	6.00e-38	151.00
IUUC-Ogl-077097	Oryza glaberrima	42.32	1.00e-72	266.00
IUUC-Ogu-078570	Oryza glumaepatula	42.56	3.00e-71	261.00
IUUC-Oin-079244	Oryza indica	42.53	4.00e-73	268.00
IUUC-Olo-080484	Oryza longistaminata	43.22	1.00e-51	196.00
IUUC-Ome-081814	Oryza meridionalis	43.22	1.00e-73	269.00
IUUC-Oni-082057	Oryza nivara	42.82	1.00e-71	263.00
IUUC-Opu-084176	Oryza punctata	44.36	3.00e-71	261.00
IUUC-Oru-084618	Oryza rufipogon	42.82	2.00e-71	262.00
IUUC-Osa-085602	Oryza sativa	44.06	2.00e-71	262.00
IUUC-Ola-086707	Oryzias latipes	33.33	4.00e-29	120.00
IUUC-Olu-087811	Ostreococcus lucimarinus	46.54	2.00e-47	182.00
IUUC-Oga-088560	Otolemur garnettii	32.43	3.00e-31	128.00
IUUC-Oar-089200	Ovis aries	31.40	8.00e-30	124.00
IUUC-Ptr-090569	Pan troglodytes	31.78	2.00e-30	126.00
IUUC-Pan-091742	Papio anubis	31.78	2.00e-30	125.00
IUUC-Psi-093297	Pelodiscus sinensis	31.85	1.00e-26	113.00
IUUC-Pma-094612	Petromyzon marinus	31.94	1.00e-21	97.10
IUUC-Pfo-097396	Poecilia formosa	31.65	2.00e-24	105.00
IUUC-Pab-098531	Pongo abelii	31.78	2.00e-30	125.00
IUUC-Pop-099661	Populus trichocarpa	60.96	3.00e-65	241.00
IUUC-Pca-101029	Procavia capensis	40.58	5.00e-20	91.70
IUUC-Ppe-101495	Prunus persica	45.60	5.00e-95	340.00
IUUC-Pva-102934	Pteropus vampyrus	30.23	1.00e-29	123.00
IUUC-Rno-106052	Rattus norvegicus	31.78	2.00e-30	125.00
IUUC-Sha-106876	Sarcophilus harrisii	29.59	7.00e-28	117.00
IUUC-Smo-109325	Selaginella moellendorffii	55.41	4.00e-51	194.00
IUUC-Sit-110624	Setaria italica	43.10	2.00e-70	259.00
IUUC-Sly-110865	Solanum lycopersicum	77.14	5.00e-27	111.00
IUUC-Stu-112433	Solanum tuberosum	43.92	1.00e-81	295.00
IUUC-Sar-113169	Sorex araneus	36.14	9.00e-21	94.00
IUUC-Sbi-114305	Sorghum bicolor	43.78	4.00e-72	265.00
IUUC-Ssc-115380	Sus scrofa	31.40	1.00e-31	129.00
IUUC-Tgu-117280	Taeniopygia guttata	32.93	2.00e-26	112.00
IUUC-Tru-117732	Takifugu rubripes	27.85	8.00e-25	107.00
IUUC-Tsy-119624	Tarsius syrichta	30.09	2.00e-22	99.80
IUUC-Tni-119852	Tetraodon nigroviridis	31.19	1.00e-23	103.00
IUUC-Tca-121865	Theobroma cacao	46.65	2.00e-86	311.00
IUUC-Tae-125925	Triticum aestivum	46.01	1.00e-75	276.00
IUUC-Tur-126237	Triticum urartu	45.04	4.00e-65	241.00
IUUC-Tbe-127632	Tupaia belangeri	31.78	3.00e-30	125.00
IUUC-Ttr-129008	Tursiops truncatus	30.62	8.00e-28	117.00
IUUC-Vpa-130625	Vicugna pacos	46.23	2.00e-20	93.20
IUUC-Vvi-131312	Vitis vinifera	58.10	7.00e-48	184.00
IUUC-Xtr-132756	Xenopus tropicalis	30.21	1.00e-29	123.00
IUUC-Xma-133377	Xiphophorus maculatus	31.65	4.00e-24	105.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence