iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033839

Ensembl Protein ID

ENSECAP00000009365.1

UniProt Accession

F6ZLY8; F6ZLY8_HORSE

Protein Name

Uncharacterized protein

Gene Name

NGEF

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000011222.1	ENSECAT00000011887.1	ENSECAP00000009332.1
ENSECAG00000011222.1	ENSECAT00000011924.1	ENSECAP00000009365.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.10e-11	42.1	495	550

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +vq  ++y aq+ deLtl+  d++ ++  e+++ gW+ g++   + rG fP+n +e++
   Q: 495  QVQCVHPYVAQQPDELTLELADILNIL--EKTEDGWIFGERLHDQERGWFPSNMTEEI 550
           6999***********************..9999*********************9987 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

SESSSTPGNG ATPEECPALA DSPTTLTEAL QMIRPIPADS WRNLIEQIGL LYQEYRDKST 60
LQEIETRRQQ DAQIHANVHG SPAGQETPEE EEEEEEEEEE EEEEEPASPP ERRALPQICL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCCTCCT TCTCTCTGGC AGCGAGTCGT CCTCCACCCC GGGAAATGGG GCCACGCCCG 60
AGGAGTGCCC GGCCCTCGCT GACAGCCCCA CCACGCTCAC CGAGGCCCTG CAGATGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00621--RhoGEF
PF14604--SH3_9

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005169	Anolis carolinensis	45.41	3.00e-99	355.00
IUUC-Bta-013108	Bos taurus	92.70	0.00e+00	1059.00
IUUC-Cin-025559	Ciona intestinalis	42.06	1.00e-27	114.00
IUUC-Lch-049409	Latimeria chalumnae	44.37	3.00e-96	345.00
IUUC-Mlu-067642	Myotis lucifugus	94.40	0.00e+00	1072.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence