iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053686

Ensembl Protein ID

ENSLAFP00000020380.1

UniProt Accession

G3TXS2; G3TXS2_LOXAF

Protein Name

Histone acetyltransferase

Gene Name

KAT6A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000004860.3	ENSLAFT00000032943.1	ENSLAFP00000020380.1
ENSLAFG00000004860.3	ENSLAFT00000004861.3	ENSLAFP00000004071.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.80e-09	38.0	263	312

Active Site

Position(s)	Description	Evidence
679	Proton donor/acceptor	{ECO:0000256\|PIRSR:PIRSR602717-51}

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           k C  C+++g++ ++++ C+ C++ fH +C  ++  + +p+   wiC+ Cr 
   Q: 263  KTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPP-LTRMPKGM-WICQICRP 312
           68999******99*********************.9*****97.******85 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ LELSVKDGTI 60
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQNVDWN KLIKRAVEGL AESGGSTLKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAAAAC TCGCTAACCC GCTGTACACG GAGTGGATTT TAGAGGCCAT CAAAAAAGTG 60
AAGAAGCAGA AACAGCGTCC TTCAGAGGAA AGGATATGCA ATGCAGTATC TTCATCCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR002717--HAT_MYST-type
IPR005818--Histone_H1/H5_H15
IPR031280--KAT6A
IPR011991--WHTH_DNA-bd_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51504--H15
PS51726--MYST_HAT
PS50016--ZF_PHD_2

Pfam

PF01853--MOZ_SAS
PF00628--PHD

SMART

SM00526--H15
SM00249--PHD

Gene Ontology

GO:0005829--C:cytosol
GO:0070776--C:MOZ/MORF histone acetyltransferase complex
GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0000786--C:nucleosome
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0090398--P:cellular senescence
GO:0043966--P:histone H3 acetylation
GO:0030099--P:myeloid cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006334--P:nucleosome assembly
GO:0045893--P:positive regulation of transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001219	Ailuropoda melanoleuca	93.28	0.00e+00	2503.00
IUUC-Aca-004549	Anolis carolinensis	78.23	0.00e+00	1586.00
IUUC-Ame-010711	Astyanax mexicanus	69.92	0.00e+00	629.00
IUUC-Bta-013426	Bos taurus	87.21	0.00e+00	2244.00
IUUC-Cja-019124	Callithrix jacchus	94.20	0.00e+00	2048.00
IUUC-Cfa-021165	Canis familiaris	94.61	0.00e+00	2484.00
IUUC-Cpo-022332	Cavia porcellus	84.01	0.00e+00	1970.00
IUUC-Cne-026801	Cryptococcus neoformans	63.59	1.00e-73	271.00
IUUC-Dre-028624	Danio rerio	79.90	0.00e+00	676.00
IUUC-Dno-029878	Dasypus novemcinctus	87.83	0.00e+00	1947.00
IUUC-Ete-032342	Echinops telfairi	95.19	0.00e+00	1862.00
IUUC-Eca-033925	Equus caballus	94.30	0.00e+00	2458.00
IUUC-Fca-035985	Felis catus	94.79	0.00e+00	2495.00
IUUC-Gmo-039182	Gadus morhua	74.87	0.00e+00	1197.00
IUUC-Gga-041028	Gallus gallus	82.54	0.00e+00	1803.00
IUUC-Gac-042131	Gasterosteus aculeatus	73.15	0.00e+00	1189.00
IUUC-Gma-044341	Glycine max	42.37	4.00e-10	60.10
IUUC-Ggo-044664	Gorilla gorilla	94.12	0.00e+00	2018.00
IUUC-Hsa-046832	Homo sapiens	94.04	0.00e+00	2020.00
IUUC-Loc-052537	Lepisosteus oculatus	76.90	0.00e+00	1250.00
IUUC-Mcc-055429	Macaca mulatta	94.62	0.00e+00	2035.00
IUUC-Mvi-060531	Microbotryum violaceum	54.91	6.00e-72	266.00
IUUC-Mmr-061249	Microcebus murinus	91.00	0.00e+00	2388.00
IUUC-Mdo-062826	Monodelphis domestica	93.96	0.00e+00	689.00
IUUC-Mmu-063474	Mus musculus	88.31	0.00e+00	2028.00
IUUC-Mpu-066585	Mustela putorius furo	94.54	0.00e+00	2482.00
IUUC-Mlu-066965	Myotis lucifugus	92.81	0.00e+00	2357.00
IUUC-Nle-069270	Nomascus leucogenys	94.12	0.00e+00	2020.00
IUUC-Opr-070963	Ochotona princeps	78.07	0.00e+00	1642.00
IUUC-Ont-071466	Oreochromis niloticus	70.46	0.00e+00	631.00
IUUC-Oan-073367	Ornithorhynchus anatinus	87.60	0.00e+00	2318.00
IUUC-Ocu-074100	Oryctolagus cuniculus	83.91	0.00e+00	1784.00
IUUC-Ola-087293	Oryzias latipes	67.67	0.00e+00	1197.00
IUUC-Oga-089052	Otolemur garnettii	94.62	0.00e+00	846.00
IUUC-Oar-089692	Ovis aries	85.94	0.00e+00	2157.00
IUUC-Ptr-091107	Pan troglodytes	94.12	0.00e+00	2000.00
IUUC-Pan-092524	Papio anubis	93.97	0.00e+00	2033.00
IUUC-Pfo-096641	Poecilia formosa	70.45	0.00e+00	1181.00
IUUC-Pab-098311	Pongo abelii	93.72	0.00e+00	2028.00
IUUC-Pca-100810	Procavia capensis	91.95	0.00e+00	2221.00
IUUC-Pgr-103522	Puccinia graminis	50.40	8.00e-69	255.00
IUUC-Pyt-104594	Pyrenophora triticirepentis	36.67	5.00e-46	179.00
IUUC-Rno-104990	Rattus norvegicus	86.62	0.00e+00	2318.00
IUUC-Sha-106816	Sarcophilus harrisii	88.60	0.00e+00	2326.00
IUUC-Sre-115066	Sporisorium reilianum	55.56	1.00e-77	285.00
IUUC-Tgu-116639	Taeniopygia guttata	82.77	0.00e+00	1832.00
IUUC-Tru-118571	Takifugu rubripes	73.74	0.00e+00	1217.00
IUUC-Tni-119936	Tetraodon nigroviridis	75.47	0.00e+00	1236.00
IUUC-Tbe-127928	Tupaia belangeri	98.52	0.00e+00	1617.00
IUUC-Uma-129445	Ustilago maydis	56.84	1.00e-79	291.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence