iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068223

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02064470

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000017597.2	ENSMLUT00000017603.2	ENSMLUP00000016049.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-32	110.1	405	438
E3 activity/RING/U-box	3.20e-15	56.0	3	64
UBD/Beta-Prp	7.90e-54	182.9	247	476

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 405  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 438
           8**********976699**************986 PP

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s++ y+r+ Iek++a++g+ +P+++qpl+ee+lv+ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHIYERRLIEKYIAENGT-DPINNQPLSEEQLVDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
            d++ ++tg++d+ + v+d ++++ l++l+gh ++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he+sv+ ls++++gd+
   Q: 247  ADTNKILTGGADKNVVVFDKSSEQILATLKGHAKKVTSVVFHPSQELVFSASPDATIRIWSVPSASCVQVVRAHESSVTGLSLHATGDY 335
           58899************************************************************************************ PP
   S: 109  lvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l+
   Q: 336  LLSSSDDQYWAFSDIQTGRVLTKvTDETSGCALTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYLA 423
           *********************997777777799************************************9.****************** PP
   S: 197  sgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           ++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 424  TAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 476
           **************999999999866527*******************99987 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MSLICSISNE VPEHPCVSPV SNHIYERRLI EKYIAENGTD PINNQPLSEE QLVDIKVAHP 60
IRPKPPSATS IPAILKALQD EWGCAHSSLP LTRGCPQDAV MLHSFTLRQQ LQTTRQELSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCTTGA TCTGCTCCAG TGAGTACCTG CTGCGGCCGA TCGAGGGTCG CAGGAGGCCG 60
GGGAGCTGAG CGGGAGGGGC TGCGGCCGCT GGGGCGCCGG GGCCGGGCGG AGGTGACCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0001833--P:inner cell mass cell proliferation
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	38.75	2.00e-95	344.00
IUUC-Aml-001230	Ailuropoda melanoleuca	92.23	0.00e+00	939.00
IUUC-Atr-002594	Amborella trichopoda	43.20	2.00e-116	412.00
IUUC-Apl-003686	Anas platyrhynchos	88.32	0.00e+00	736.00
IUUC-Aca-005272	Anolis carolinensis	93.45	0.00e+00	981.00
IUUC-Aly-005586	Arabidopsis lyrata	42.48	4.00e-115	408.00
IUUC-Ath-007696	Arabidopsis thaliana	42.78	2.00e-111	395.00
IUUC-Acl-008335	Aspergillus clavatus	34.11	4.00e-65	242.00
IUUC-Afl-008527	Aspergillus flavus	35.99	2.00e-69	256.00
IUUC-Afu-008957	Aspergillus fumigatus	36.35	2.00e-76	280.00
IUUC-Ani-009280	Aspergillus nidulans	35.98	5.00e-64	238.00
IUUC-Ang-009746	Aspergillus niger	34.15	2.00e-63	236.00
IUUC-Aor-009905	Aspergillus oryzae	35.79	5.00e-73	268.00
IUUC-Ate-010412	Aspergillus terreus	35.99	8.00e-62	231.00
IUUC-Ame-011561	Astyanax mexicanus	79.22	9.00e-108	382.00
IUUC-Bgr-012283	Blumeria graminis	31.25	1.00e-52	200.00
IUUC-Bta-013242	Bos taurus	95.18	0.00e+00	992.00
IUUC-Bci-013901	Botrytis cinerea	32.43	3.00e-62	232.00
IUUC-Bdi-014277	Brachypodium distachyon	42.72	3.00e-121	428.00
IUUC-Bol-016207	Brassica oleracea	43.88	3.00e-114	405.00
IUUC-Bra-017902	Brassica rapa	42.29	1.00e-113	403.00
IUUC-Cel-018271	Caenorhabditis elegans	50.48	4.00e-149	521.00
IUUC-Cja-019879	Callithrix jacchus	94.62	0.00e+00	985.00
IUUC-Cfa-020175	Canis familiaris	95.18	0.00e+00	991.00
IUUC-Cpo-022379	Cavia porcellus	94.80	0.00e+00	989.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	38.62	3.00e-95	342.00
IUUC-Csa-023500	Chlorocebus sabaeus	94.99	0.00e+00	991.00
IUUC-Cho-025065	Choloepus hoffmanni	81.60	4.00e-143	500.00
IUUC-Cin-025699	Ciona intestinalis	64.75	2.00e-170	592.00
IUUC-Csv-026128	Ciona savignyi	62.43	0.00e+00	668.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	31.68	7.00e-62	231.00
IUUC-Cne-026860	Cryptococcus neoformans	36.69	2.00e-91	329.00
IUUC-Dre-028187	Danio rerio	81.92	0.00e+00	850.00
IUUC-Dno-029453	Dasypus novemcinctus	94.80	0.00e+00	989.00
IUUC-Dor-030150	Dipodomys ordii	97.06	5.00e-126	444.00
IUUC-Dse-031220	Dothistroma septosporum	31.10	2.00e-55	209.00
IUUC-Dme-031906	Drosophila melanogaster	63.08	0.00e+00	654.00
IUUC-Ete-033035	Echinops telfairi	83.04	0.00e+00	840.00
IUUC-Eca-033478	Equus caballus	94.99	0.00e+00	989.00
IUUC-Eeu-034974	Erinaceus europaeus	97.87	0.00e+00	671.00
IUUC-Fca-036194	Felis catus	94.39	0.00e+00	981.00
IUUC-Fal-037417	Ficedula albicollis	93.45	0.00e+00	980.00
IUUC-Fox-037922	Fusarium oxysporum	33.33	6.00e-62	231.00
IUUC-Fso-038256	Fusarium solani	33.07	6.00e-63	234.00
IUUC-Gmo-038713	Gadus morhua	82.88	0.00e+00	864.00
IUUC-Ggr-039854	Gaeumannomyces graminis	31.34	2.00e-51	196.00
IUUC-Gga-041143	Gallus gallus	93.64	0.00e+00	981.00
IUUC-Gac-042129	Gasterosteus aculeatus	82.69	0.00e+00	883.00
IUUC-Gma-044273	Glycine max	44.11	1.00e-118	419.00
IUUC-Ggo-045262	Gorilla gorilla	94.99	0.00e+00	991.00
IUUC-Hsa-046036	Homo sapiens	94.99	0.00e+00	991.00
IUUC-Hvu-047442	Hordeum vulgare	41.19	2.00e-65	242.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	94.41	0.00e+00	946.00
IUUC-Lch-050105	Latimeria chalumnae	87.09	0.00e+00	928.00
IUUC-Lpe-050976	Leersia perrieri	43.42	5.00e-117	414.00
IUUC-Loc-052042	Lepisosteus oculatus	72.31	0.00e+00	657.00
IUUC-Lma-053143	Leptosphaeria maculans	32.72	2.00e-60	227.00
IUUC-Laf-053451	Loxodonta africana	95.01	0.00e+00	992.00
IUUC-Mcc-055786	Macaca mulatta	94.99	0.00e+00	991.00
IUUC-Meu-056161	Macropus eugenii	97.51	4.00e-139	488.00
IUUC-Mor-057215	Magnaporthe oryzae	32.31	8.00e-54	204.00
IUUC-Mpo-057419	Magnaporthe poae	30.80	1.00e-47	184.00
IUUC-Mtr-057756	Medicago truncatula	42.83	3.00e-113	401.00
IUUC-Mla-059085	Melampsora laricipopulina	36.75	4.00e-83	301.00
IUUC-Mga-060158	Meleagris gallopavo	89.46	0.00e+00	882.00
IUUC-Mvi-060441	Microbotryum violaceum	36.57	2.00e-75	276.00
IUUC-Mmr-061085	Microcebus murinus	94.99	0.00e+00	991.00
IUUC-Mdo-061804	Monodelphis domestica	95.38	0.00e+00	994.00
IUUC-Mmu-063608	Mus musculus	95.22	0.00e+00	998.00
IUUC-Mac-064972	Musa acuminata	43.74	7.00e-116	410.00
IUUC-Mpu-065700	Mustela putorius furo	95.18	0.00e+00	993.00
IUUC-Nfi-068504	Neosartorya fischeri	35.95	6.00e-76	278.00
IUUC-Ncr-068729	Neurospora crassa	35.16	4.00e-60	225.00
IUUC-Nle-069754	Nomascus leucogenys	94.99	0.00e+00	991.00
IUUC-Opr-070621	Ochotona princeps	91.02	0.00e+00	928.00
IUUC-Ont-071377	Oreochromis niloticus	82.31	0.00e+00	860.00
IUUC-Oan-073498	Ornithorhynchus anatinus	68.55	2.00e-119	421.00
IUUC-Ocu-074182	Oryctolagus cuniculus	94.10	0.00e+00	991.00
IUUC-Oba-075509	Oryza barthii	42.72	3.00e-119	421.00
IUUC-Obr-076480	Oryza brachyantha	43.10	3.00e-120	425.00
IUUC-Ogl-077052	Oryza glaberrima	42.72	3.00e-119	421.00
IUUC-Ogu-078919	Oryza glumaepatula	42.72	3.00e-119	421.00
IUUC-Oin-079357	Oryza indica	42.21	6.00e-113	400.00
IUUC-Olo-080376	Oryza longistaminata	42.43	4.00e-107	381.00
IUUC-Ome-081973	Oryza meridionalis	41.95	5.00e-107	381.00
IUUC-Oni-082849	Oryza nivara	42.91	6.00e-120	424.00
IUUC-Opu-083243	Oryza punctata	42.54	2.00e-118	419.00
IUUC-Oru-084613	Oryza rufipogon	42.99	3.00e-119	421.00
IUUC-Osa-085407	Oryza sativa	42.70	1.00e-118	420.00
IUUC-Ola-086566	Oryzias latipes	81.52	0.00e+00	851.00
IUUC-Olu-087757	Ostreococcus lucimarinus	37.79	4.00e-91	328.00
IUUC-Oga-089010	Otolemur garnettii	90.61	0.00e+00	938.00
IUUC-Oar-089638	Ovis aries	95.18	0.00e+00	992.00
IUUC-Ptr-091141	Pan troglodytes	94.99	0.00e+00	991.00
IUUC-Pan-092662	Papio anubis	94.99	0.00e+00	991.00
IUUC-Psi-093777	Pelodiscus sinensis	97.14	0.00e+00	820.00
IUUC-Pno-095115	Phaeosphaeria nodorum	33.40	2.00e-61	229.00
IUUC-Ppa-095841	Physcomitrella patens	43.15	5.00e-117	414.00
IUUC-Pfo-096390	Poecilia formosa	81.92	0.00e+00	863.00
IUUC-Pab-098250	Pongo abelii	94.50	0.00e+00	926.00
IUUC-Pop-099854	Populus trichocarpa	43.82	5.00e-117	414.00
IUUC-Pca-100553	Procavia capensis	94.41	0.00e+00	981.00
IUUC-Ppe-101383	Prunus persica	42.78	6.00e-111	394.00
IUUC-Pva-102189	Pteropus vampyrus	95.38	0.00e+00	994.00
IUUC-Pgr-103304	Puccinia graminis	35.96	4.00e-81	295.00
IUUC-Ptt-103984	Puccinia triticina	36.46	5.00e-86	311.00
IUUC-Pte-104385	Pyrenophora teres	31.49	1.00e-65	243.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	31.70	1.00e-66	247.00
IUUC-Rno-105581	Rattus norvegicus	94.80	0.00e+00	990.00
IUUC-Sha-107071	Sarcophilus harrisii	94.15	0.00e+00	997.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	29.84	8.00e-32	131.00
IUUC-Spo-108315	Schizosaccharomyces pombe	32.21	2.00e-44	173.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	33.62	4.00e-61	228.00
IUUC-Smo-109648	Selaginella moellendorffii	43.88	2.00e-119	422.00
IUUC-Sit-109873	Setaria italica	42.96	7.00e-117	414.00
IUUC-Sly-111673	Solanum lycopersicum	43.82	3.00e-110	392.00
IUUC-Stu-112125	Solanum tuberosum	43.69	3.00e-109	388.00
IUUC-Sbi-114696	Sorghum bicolor	41.79	7.00e-107	380.00
IUUC-Sre-115134	Sporisorium reilianum	30.12	2.00e-68	253.00
IUUC-Ssc-116260	Sus scrofa	94.99	0.00e+00	991.00
IUUC-Tgu-116533	Taeniopygia guttata	93.45	0.00e+00	980.00
IUUC-Tru-117800	Takifugu rubripes	81.35	0.00e+00	883.00
IUUC-Tsy-118980	Tarsius syrichta	89.50	0.00e+00	898.00
IUUC-Tni-120334	Tetraodon nigroviridis	79.59	9.00e-173	599.00
IUUC-Tca-121807	Theobroma cacao	42.70	4.00e-117	415.00
IUUC-Tre-121920	Trichoderma reesei	31.76	1.00e-59	224.00
IUUC-Tvi-122294	Trichoderma virens	31.43	9.00e-52	197.00
IUUC-Tae-125713	Triticum aestivum	43.10	6.00e-122	431.00
IUUC-Tur-126664	Triticum urartu	38.87	1.00e-111	397.00
IUUC-Tme-127026	Tuber melanosporum	33.46	7.00e-66	244.00
IUUC-Tbe-127582	Tupaia belangeri	97.57	0.00e+00	668.00
IUUC-Ttr-128313	Tursiops truncatus	94.80	0.00e+00	982.00
IUUC-Uma-129626	Ustilago maydis	32.43	2.00e-71	263.00
IUUC-Vda-129699	Verticillium dahliae	34.08	2.00e-64	239.00
IUUC-Vpa-130593	Vicugna pacos	94.24	0.00e+00	882.00
IUUC-Vvi-131668	Vitis vinifera	42.96	2.00e-116	412.00
IUUC-Xtr-132186	Xenopus tropicalis	83.04	0.00e+00	760.00
IUUC-Xma-133212	Xiphophorus maculatus	81.73	0.00e+00	858.00
IUUC-Yli-134607	Yarrowia lipolytica	52.38	1.00e-38	151.00
IUUC-Zma-135662	Zea mays	44.17	2.00e-119	422.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence