iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132186

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PRP19/PSO4 homolog (S. cerevisiae); Pre-mRNA-processing factor 19

Genbank Nucleotide ID

AAMC01122134

Gene Name

prpf19; prp19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000011938.3	ENSXETT00000026115.3	ENSXETP00000026115.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.50e-14	53.3	3	64
E3 adaptor/Cullin RING/DCX/DWD	6.40e-27	92.7	390	423
UBD/Beta-Prp	1.40e-42	146.1	232	429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           + C Is+e+   P+++p sG+ +dr+ Iek+la++g+ +Pvt+qpl+e++l++ ++ + +  +
   Q: 3    LTCYISNEVTDRPCISPvSGHIFDRRLIEKYLAENGT-DPVTNQPLSEDQLIDIKVAHPIRPK 64
           67**********************************9.***************9998877665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH+++v+c+af  ++ +l++++dD ++k+WDlr+
   Q: 390  GHSGPVSCIAFseNGYYLATAADDSSVKLWDLRK 423
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
            d++  +tg++d+++ v+d+ +++ l++l+gh+++vt+v f+p++++  ++s D ti+vw++ + +c ++l++he  v+ ls++++gd+
   Q: 232  TDTNKTLTGGADKSVVVFDALSQQILATLKGHTKKVTSVVFHPSQELVFSASPDSTIRVWSVPDASCAQVLRAHEGAVTGLSLHATGDY 320
           5778889********************************************************************************** PP
   S: 109  lvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           l+s s+d++    d++ g +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++v +++f++ng +l+
   Q: 321  LLSCSDDQYWAFSDIHVGRVLTKvTDESSGCALTCAQFHPDGLIFGTGTVDSQIKIWDLKERSNVANFPG-HSGPVSCIAFSENGYYLA 408
           *********************997777777789************************************9.****************** PP
   S: 197  sgsldgtvklwdlqtgecvrt 217
           ++++d++vklwdl++ +  +t
   Q: 409  TAADDSSVKLWDLRKLKNFKT 429
           *************97665555 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MSLTCYISNE VTDRPCISPV SGHIFDRRLI EKYLAENGTD PVTNQPLSED QLIDIKVAHP 60
IRPKPPSATS IPAILKSLQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGATAGCC CGCCAAAGGG CCTGCCCAAT TTAAGTCTGA AAACAGGGAG TCCTAGCTGA 60
ACAGCATCAC TAAAAAGAAA ACAACGCTAT TTCTCGCCTA ACCATATTGC TCAAAGAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0000974--C:Prp19 complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator

KEGG

xtr:448017

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	42.49	1.00e-86	315.00
IUUC-Aml-001230	Ailuropoda melanoleuca	82.77	0.00e+00	735.00
IUUC-Atr-002594	Amborella trichopoda	46.76	3.00e-107	382.00
IUUC-Apl-003686	Anas platyrhynchos	77.47	2.00e-171	595.00
IUUC-Aca-005272	Anolis carolinensis	85.88	0.00e+00	770.00
IUUC-Aly-005586	Arabidopsis lyrata	44.44	1.00e-105	376.00
IUUC-Ath-007696	Arabidopsis thaliana	46.24	5.00e-104	371.00
IUUC-Ago-007879	Ashbya gossypii	28.38	2.00e-25	110.00
IUUC-Acl-008335	Aspergillus clavatus	38.37	1.00e-65	243.00
IUUC-Afl-008527	Aspergillus flavus	39.13	4.00e-69	255.00
IUUC-Afu-008957	Aspergillus fumigatus	39.73	1.00e-76	280.00
IUUC-Ani-009280	Aspergillus nidulans	39.00	4.00e-60	225.00
IUUC-Ang-009746	Aspergillus niger	37.30	9.00e-64	237.00
IUUC-Aor-009905	Aspergillus oryzae	38.90	8.00e-73	267.00
IUUC-Ate-010412	Aspergillus terreus	38.13	2.00e-62	232.00
IUUC-Ame-011561	Astyanax mexicanus	79.58	5.00e-102	363.00
IUUC-Bgr-012283	Blumeria graminis	32.86	1.00e-49	190.00
IUUC-Bta-013242	Bos taurus	85.65	0.00e+00	772.00
IUUC-Bci-013901	Botrytis cinerea	36.64	6.00e-64	238.00
IUUC-Bdi-014277	Brachypodium distachyon	46.58	3.00e-108	385.00
IUUC-Bol-016207	Brassica oleracea	46.91	4.00e-106	378.00
IUUC-Bra-017650	Brassica rapa	45.96	5.00e-105	374.00
IUUC-Cel-018271	Caenorhabditis elegans	55.05	2.00e-136	478.00
IUUC-Cja-019879	Callithrix jacchus	85.23	0.00e+00	766.00
IUUC-Cfa-020175	Canis familiaris	85.88	0.00e+00	773.00
IUUC-Cpo-022379	Cavia porcellus	85.42	0.00e+00	770.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	41.61	5.00e-88	318.00
IUUC-Csa-023500	Chlorocebus sabaeus	85.42	0.00e+00	771.00
IUUC-Cho-025065	Choloepus hoffmanni	73.95	2.00e-127	447.00
IUUC-Cin-025699	Ciona intestinalis	67.59	2.00e-170	591.00
IUUC-Csv-026128	Ciona savignyi	64.62	1.00e-164	572.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	35.60	2.00e-62	233.00
IUUC-Cne-026860	Cryptococcus neoformans	38.60	3.00e-80	292.00
IUUC-Dre-028187	Danio rerio	79.77	0.00e+00	694.00
IUUC-Dno-029453	Dasypus novemcinctus	85.42	0.00e+00	770.00
IUUC-Dor-030150	Dipodomys ordii	86.13	3.00e-111	395.00
IUUC-Dse-031220	Dothistroma septosporum	32.95	2.00e-56	213.00
IUUC-Dme-031906	Drosophila melanogaster	65.91	1.00e-163	569.00
IUUC-Ete-033035	Echinops telfairi	72.67	0.00e+00	632.00
IUUC-Eca-033478	Equus caballus	85.65	0.00e+00	771.00
IUUC-Eeu-034974	Erinaceus europaeus	87.88	3.00e-141	494.00
IUUC-Fca-036194	Felis catus	85.35	0.00e+00	764.00
IUUC-Fal-037417	Ficedula albicollis	86.33	0.00e+00	777.00
IUUC-Fox-037922	Fusarium oxysporum	34.55	4.00e-58	218.00
IUUC-Fso-038256	Fusarium solani	33.71	2.00e-58	219.00
IUUC-Gmo-038713	Gadus morhua	81.14	0.00e+00	708.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.17	1.00e-46	180.00
IUUC-Gga-041143	Gallus gallus	85.65	0.00e+00	773.00
IUUC-Gac-042129	Gasterosteus aculeatus	81.36	0.00e+00	725.00
IUUC-Gma-043635	Glycine max	45.91	7.00e-105	374.00
IUUC-Ggo-045262	Gorilla gorilla	85.42	0.00e+00	771.00
IUUC-Hsa-046036	Homo sapiens	85.42	0.00e+00	771.00
IUUC-Hvu-047442	Hordeum vulgare	44.65	6.00e-67	247.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	85.19	0.00e+00	749.00
IUUC-Lch-050105	Latimeria chalumnae	83.14	0.00e+00	754.00
IUUC-Lpe-050976	Leersia perrieri	46.10	2.00e-103	369.00
IUUC-Loc-052042	Lepisosteus oculatus	69.31	5.00e-145	507.00
IUUC-Lma-053143	Leptosphaeria maculans	33.93	7.00e-55	209.00
IUUC-Laf-053451	Loxodonta africana	82.46	0.00e+00	760.00
IUUC-Mcc-055786	Macaca mulatta	85.42	0.00e+00	771.00
IUUC-Meu-056161	Macropus eugenii	86.72	2.00e-126	445.00
IUUC-Mor-057215	Magnaporthe oryzae	32.06	7.00e-51	194.00
IUUC-Mpo-057419	Magnaporthe poae	31.02	2.00e-42	166.00
IUUC-Mtr-057756	Medicago truncatula	46.88	1.00e-103	370.00
IUUC-Mla-059085	Melampsora laricipopulina	39.51	6.00e-74	271.00
IUUC-Mga-060158	Meleagris gallopavo	85.05	0.00e+00	727.00
IUUC-Mvi-060441	Microbotryum violaceum	39.39	4.00e-68	251.00
IUUC-Mmr-061085	Microcebus murinus	85.42	0.00e+00	771.00
IUUC-Mdo-061804	Monodelphis domestica	85.42	0.00e+00	770.00
IUUC-Mmu-063608	Mus musculus	81.66	0.00e+00	756.00
IUUC-Mac-064972	Musa acuminata	46.70	2.00e-100	359.00
IUUC-Mpu-065700	Mustela putorius furo	85.88	0.00e+00	773.00
IUUC-Mlu-068223	Myotis lucifugus	83.04	0.00e+00	761.00
IUUC-Nfi-068504	Neosartorya fischeri	38.67	6.00e-75	274.00
IUUC-Ncr-068729	Neurospora crassa	35.31	1.00e-56	214.00
IUUC-Nle-069754	Nomascus leucogenys	85.42	0.00e+00	771.00
IUUC-Opr-070621	Ochotona princeps	85.65	0.00e+00	760.00
IUUC-Ont-071377	Oreochromis niloticus	80.68	0.00e+00	706.00
IUUC-Oan-073498	Ornithorhynchus anatinus	62.46	1.00e-106	379.00
IUUC-Ocu-074182	Oryctolagus cuniculus	81.52	0.00e+00	758.00
IUUC-Oba-075509	Oryza barthii	45.87	7.00e-106	377.00
IUUC-Obr-076480	Oryza brachyantha	46.33	4.00e-107	381.00
IUUC-Ogl-077052	Oryza glaberrima	45.87	6.00e-106	377.00
IUUC-Ogu-078919	Oryza glumaepatula	45.87	9.00e-106	377.00
IUUC-Oin-079357	Oryza indica	45.03	3.00e-99	355.00
IUUC-Olo-080376	Oryza longistaminata	46.15	8.00e-96	343.00
IUUC-Ome-081973	Oryza meridionalis	45.66	9.00e-95	340.00
IUUC-Oni-082849	Oryza nivara	45.87	5.00e-106	377.00
IUUC-Opu-083243	Oryza punctata	45.87	5.00e-106	377.00
IUUC-Oru-084613	Oryza rufipogon	46.12	3.00e-105	375.00
IUUC-Osa-085407	Oryza sativa	45.87	9.00e-106	377.00
IUUC-Ola-086566	Oryzias latipes	80.14	0.00e+00	700.00
IUUC-Olu-087757	Ostreococcus lucimarinus	41.13	4.00e-85	308.00
IUUC-Oga-089010	Otolemur garnettii	81.45	0.00e+00	725.00
IUUC-Oar-089638	Ovis aries	85.65	0.00e+00	772.00
IUUC-Ptr-091141	Pan troglodytes	85.42	0.00e+00	771.00
IUUC-Pan-092662	Papio anubis	85.42	0.00e+00	771.00
IUUC-Psi-093777	Pelodiscus sinensis	85.59	8.00e-177	612.00
IUUC-Pno-095115	Phaeosphaeria nodorum	35.43	2.00e-60	226.00
IUUC-Ppa-095841	Physcomitrella patens	45.35	1.00e-104	373.00
IUUC-Pfo-096390	Poecilia formosa	80.23	0.00e+00	703.00
IUUC-Pab-098250	Pongo abelii	85.42	0.00e+00	768.00
IUUC-Pop-099854	Populus trichocarpa	46.49	1.00e-106	380.00
IUUC-Pca-100553	Procavia capensis	85.42	0.00e+00	764.00
IUUC-Ppe-101383	Prunus persica	44.52	1.00e-97	350.00
IUUC-Pva-102189	Pteropus vampyrus	85.42	0.00e+00	771.00
IUUC-Pgr-103304	Puccinia graminis	36.58	5.00e-70	258.00
IUUC-Ptt-103984	Puccinia triticina	37.15	9.00e-75	274.00
IUUC-Pte-104385	Pyrenophora teres	33.02	1.00e-62	233.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.02	5.00e-63	234.00
IUUC-Rno-105581	Rattus norvegicus	85.19	0.00e+00	769.00
IUUC-Sha-107071	Sarcophilus harrisii	81.34	0.00e+00	757.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	31.44	5.00e-37	148.00
IUUC-Spo-108315	Schizosaccharomyces pombe	31.15	6.00e-41	161.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	36.88	1.00e-63	236.00
IUUC-Smo-109648	Selaginella moellendorffii	47.49	2.00e-108	386.00
IUUC-Sit-109873	Setaria italica	46.22	1.00e-104	374.00
IUUC-Sly-111673	Solanum lycopersicum	46.26	9.00e-96	343.00
IUUC-Stu-112125	Solanum tuberosum	45.54	4.00e-95	341.00
IUUC-Sbi-114696	Sorghum bicolor	43.39	3.00e-93	335.00
IUUC-Sre-115134	Sporisorium reilianum	33.89	4.00e-65	242.00
IUUC-Ssc-116260	Sus scrofa	85.65	0.00e+00	772.00
IUUC-Tgu-116533	Taeniopygia guttata	86.10	0.00e+00	775.00
IUUC-Tru-117800	Takifugu rubripes	80.68	0.00e+00	722.00
IUUC-Tsy-118980	Tarsius syrichta	79.86	0.00e+00	695.00
IUUC-Tni-120334	Tetraodon nigroviridis	78.78	7.00e-134	470.00
IUUC-Tca-121807	Theobroma cacao	44.77	2.00e-104	372.00
IUUC-Tre-121920	Trichoderma reesei	32.35	2.00e-56	213.00
IUUC-Tvi-122294	Trichoderma virens	32.35	2.00e-48	186.00
IUUC-Tae-125713	Triticum aestivum	47.26	5.00e-109	388.00
IUUC-Tur-126664	Triticum urartu	42.18	4.00e-100	358.00
IUUC-Tme-127026	Tuber melanosporum	36.64	1.00e-65	243.00
IUUC-Tbe-127582	Tupaia belangeri	87.50	2.00e-140	492.00
IUUC-Ttr-128313	Tursiops truncatus	85.42	0.00e+00	766.00
IUUC-Uma-129626	Ustilago maydis	35.90	6.00e-66	244.00
IUUC-Vda-129699	Verticillium dahliae	36.18	2.00e-63	236.00
IUUC-Vpa-130593	Vicugna pacos	85.19	0.00e+00	757.00
IUUC-Vvi-131668	Vitis vinifera	45.33	3.00e-105	375.00
IUUC-Xma-133212	Xiphophorus maculatus	80.23	0.00e+00	701.00
IUUC-Yli-134607	Yarrowia lipolytica	54.55	2.00e-39	154.00
IUUC-Zma-135662	Zea mays	46.58	1.00e-105	376.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence