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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063164
Ensembl Protein ID ENSMUSP00000022531.7
UniProt Accession Q7TSJ6; Q8CDJ4; Q9JMI3; LATS2_MOUSE
Genbank Protein ID BAA92380.1; BAC26704.1; AAH53028.1
Protein Name Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm
Genbank Nucleotide ID AB023958; AK029966; BC053028
Gene Name Lats2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021959.15 ENSMUST00000174694.7 ENSMUSP00000133680.1
ENSMUSG00000021959.15 ENSMUST00000022531.13 ENSMUSP00000022531.7
ENSMUSG00000021959.15 ENSMUST00000174213.7 ENSMUSP00000134321.1
ENSMUSG00000021959.15 ENSMUST00000173990.7 ENSMUSP00000133976.1
ENSMUSG00000021959.15 ENSMUST00000173964.1 ENSMUSP00000134142.1
ENSMUSG00000021959.15 ENSMUST00000038381.13 ENSMUSP00000038982.7
ENSMUSG00000021959.15 ENSMUST00000077981.6 ENSMUSP00000077130.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRecordsRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDHINTMentha
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 81.70 0.00e+00 1655.00 IUUC-Hsa-046254
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity).
 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity).
Protein Sequence
(Fasta)
MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KASTQGLLVG PNSDTSLDAK VLGSKDASRQ 60
QQMRATPKFG PYQKALREIR YSLLPFANES GTSAAAEVNR QMLQELVNAG CDQEMAGRAL 120
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Protein Fasta Sequence


>IUUC-Mmu-063164|UBD,UBA|Mus musculus
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Nucleotide Sequence
(Fasta)
ATTTGTCCAT TCCCTTTGTT CAGTCTGCTG GCTTGGCCCA TGGCCCTAGA GAAGCTGCAC 60
CACCCACTTT TGCTCCTAAA CTAGGCAGTT CTTCTAAGAA GTCATCTCCA GTCCCTCTGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063164|UBD,UBA|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor
Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF00069--Pkinase
SMART

SM00133--S_TK_X
SM00220--S_TKc
Gene Ontology

GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051301--P:cell division
GO:0034613--P:cellular protein localization
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0030216--P:keratinocyte differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0006468--P:protein phosphorylation
GO:0046620--P:regulation of organ growth
KEGG mmu:50523
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001960 Ailuropoda melanoleuca 78.23 0.00e+00 1694.00
IUUC-Apl-003521 Anas platyrhynchos 69.16 0.00e+00 1157.00
IUUC-Aca-004995 Anolis carolinensis 68.87 0.00e+00 1410.00
IUUC-Ame-011481 Astyanax mexicanus 60.93 0.00e+00 1210.00
IUUC-Bta-012618 Bos taurus 76.69 0.00e+00 1013.00
IUUC-Cja-019430 Callithrix jacchus 81.82 0.00e+00 1644.00
IUUC-Cfa-020687 Canis familiaris 77.10 0.00e+00 1643.00
IUUC-Cpo-021985 Cavia porcellus 73.12 0.00e+00 1389.00
IUUC-Csa-023534 Chlorocebus sabaeus 91.93 0.00e+00 949.00
IUUC-Dre-027538 Danio rerio 60.64 0.00e+00 1230.00
IUUC-Dno-029126 Dasypus novemcinctus 75.44 0.00e+00 1632.00
IUUC-Dor-030172 Dipodomys ordii 78.97 0.00e+00 1442.00
IUUC-Eca-033868 Equus caballus 78.38 0.00e+00 1634.00
IUUC-Eeu-034881 Erinaceus europaeus 66.01 0.00e+00 1268.00
IUUC-Fca-036203 Felis catus 75.02 0.00e+00 1555.00
IUUC-Fal-036668 Ficedula albicollis 70.13 0.00e+00 1495.00
IUUC-Gmo-039195 Gadus morhua 83.88 0.00e+00 773.00
IUUC-Gac-041789 Gasterosteus aculeatus 59.29 0.00e+00 1147.00
IUUC-Ggo-044904 Gorilla gorilla 78.61 0.00e+00 1573.00
IUUC-Hsa-046254 Homo sapiens 80.88 0.00e+00 1594.00
IUUC-Itr-047948 Ictidomys tridecemlineatus 82.01 0.00e+00 1477.00
IUUC-Lch-050079 Latimeria chalumnae 64.77 0.00e+00 1386.00
IUUC-Loc-052265 Lepisosteus oculatus 68.00 0.00e+00 922.00
IUUC-Laf-053806 Loxodonta africana 78.92 0.00e+00 1679.00
IUUC-Mcc-055253 Macaca mulatta 80.73 0.00e+00 1604.00
IUUC-Meu-056509 Macropus eugenii 80.00 0.00e+00 774.00
IUUC-Mga-059600 Meleagris gallopavo 70.19 0.00e+00 1516.00
IUUC-Mmr-061586 Microcebus murinus 79.94 0.00e+00 1599.00
IUUC-Mdo-062126 Monodelphis domestica 69.64 0.00e+00 1464.00
IUUC-Mpu-065992 Mustela putorius furo 77.87 0.00e+00 1683.00
IUUC-Mlu-067728 Myotis lucifugus 72.88 0.00e+00 1483.00
IUUC-Nle-069546 Nomascus leucogenys 80.17 0.00e+00 1587.00
IUUC-Opr-070872 Ochotona princeps 79.80 0.00e+00 1588.00
IUUC-Ont-072296 Oreochromis niloticus 84.14 0.00e+00 905.00
IUUC-Ocu-074068 Oryctolagus cuniculus 79.91 0.00e+00 1616.00
IUUC-Ola-086756 Oryzias latipes 57.19 0.00e+00 1174.00
IUUC-Oga-089066 Otolemur garnettii 81.37 0.00e+00 1662.00
IUUC-Oar-090416 Ovis aries 83.16 0.00e+00 986.00
IUUC-Ptr-091247 Pan troglodytes 80.51 0.00e+00 1604.00
IUUC-Pan-092438 Papio anubis 80.73 0.00e+00 1603.00
IUUC-Psi-093920 Pelodiscus sinensis 69.52 0.00e+00 1505.00
IUUC-Pfo-096334 Poecilia formosa 83.43 0.00e+00 881.00
IUUC-Pab-098452 Pongo abelii 80.94 0.00e+00 1611.00
IUUC-Pca-101081 Procavia capensis 72.49 0.00e+00 1529.00
IUUC-Rno-105102 Rattus norvegicus 94.35 0.00e+00 1937.00
IUUC-Sha-106917 Sarcophilus harrisii 70.68 0.00e+00 1501.00
IUUC-Sar-113711 Sorex araneus 74.95 0.00e+00 1430.00
IUUC-Tgu-116553 Taeniopygia guttata 72.87 0.00e+00 1538.00
IUUC-Tru-118069 Takifugu rubripes 82.90 0.00e+00 887.00
IUUC-Tni-120617 Tetraodon nigroviridis 80.31 0.00e+00 876.00
IUUC-Ttr-129256 Tursiops truncatus 69.29 0.00e+00 1358.00
IUUC-Xtr-132593 Xenopus tropicalis 68.16 0.00e+00 1415.00
Created Date 25-Jun-2017

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