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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045973
UUCD1 version UUC-HoS-00475
Ensembl Protein ID ENSP00000376765.2
UniProt Accession Q9Y6X2; Q9UFI3; PIAS3_HUMAN
Genbank Protein ID BAA78533.1; AAH01154.2; AAH30556.2
Protein Name E3 SUMO-protein ligase PIAS3; Protein inhibitor of activated STAT protein 3
Genbank Nucleotide ID AB021868; BC001154; BC030556
Gene Name PIAS3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000131788.15 ENST00000369298.5 ENSP00000358304.1
ENSG00000131788.15 ENST00000393045.6 ENSP00000376765.2
ENSG00000131788.15 ENST00000463514.2 ENSP00000476245.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
iRefIndexPINAHINTMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17066076; 15961505; 20935639; 20637912; 18212042
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.086 15.0 327 370
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++ + ++  + + l C H+  +d    +++++n+++++++CP+C+
   Q: 327  CPLGKMRLTVPCRALTCAHLQSFDAA--LYLQMNEKKPTWTCPVCD 370
           44444455555667889998877774..34789************5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Protein Sequence
(Fasta)
MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 60
YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL LAPGTLLGPK REVDMHPPLP 120
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Protein Fasta Sequence


>IUUC-Hsa-045973|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCTAGGCCGG GCGGAGCTCC GGCCCGGGCG GAGCCGCGGC CGCCGCGTCC GGCTGCTGGA 60
CCGAACTTCT GCCGTGCGGA CAGCAGGAGC AGCGCCGAGC CCCATTCCCC CACCTCTCCA 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045973|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027226--PIAS3
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ
PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING
Pfam

PF14324--PINIT
PF02891--zf-MIZ
SMART

SM00513--SAP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0045202--C:synapse
GO:0019899--F:enzyme binding
GO:0016874--F:ligase activity
GO:0015459--F:potassium channel regulator activity
GO:0008022--F:protein C-terminus binding
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0010628--P:positive regulation of gene expression
GO:0045838--P:positive regulation of membrane potential
GO:0033235--P:positive regulation of protein sumoylation
GO:0016925--P:protein sumoylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009725--P:response to hormone
GO:0006351--P:transcription, DNA-templated
KEGG hsa:10401
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002142 Ailuropoda melanoleuca 96.86 0.00e+00 1104.00
IUUC-Aca-004903 Anolis carolinensis 73.71 0.00e+00 737.00
IUUC-Ago-007762 Ashbya gossypii 27.44 1.00e-18 88.60
IUUC-Bta-013566 Bos taurus 98.09 0.00e+00 1110.00
IUUC-Bol-015575 Brassica oleracea 24.84 3.00e-18 87.40
IUUC-Cja-019111 Callithrix jacchus 98.10 0.00e+00 1107.00
IUUC-Cfa-020209 Canis familiaris 97.29 0.00e+00 1120.00
IUUC-Cpo-022188 Cavia porcellus 96.02 0.00e+00 1123.00
IUUC-Csa-024163 Chlorocebus sabaeus 98.71 0.00e+00 967.00
IUUC-Cin-025791 Ciona intestinalis 44.40 3.00e-91 329.00
IUUC-Dno-029139 Dasypus novemcinctus 97.90 0.00e+00 1055.00
IUUC-Dor-030842 Dipodomys ordii 93.06 0.00e+00 1056.00
IUUC-Eca-034115 Equus caballus 97.93 0.00e+00 1102.00
IUUC-Eeu-034486 Erinaceus europaeus 92.84 0.00e+00 738.00
IUUC-Fca-035527 Felis catus 93.45 0.00e+00 1114.00
IUUC-Ggo-045185 Gorilla gorilla 99.36 0.00e+00 1119.00
IUUC-Itr-049072 Ictidomys tridecemlineatus 96.21 0.00e+00 1083.00
IUUC-Kpa-049203 Komagataella pastoris 31.14 3.00e-22 100.00
IUUC-Lch-050349 Latimeria chalumnae 69.23 0.00e+00 821.00
IUUC-Laf-054406 Loxodonta africana 96.34 0.00e+00 1112.00
IUUC-Mcc-054886 Macaca mulatta 99.04 0.00e+00 1114.00
IUUC-Meu-055949 Macropus eugenii 85.85 0.00e+00 939.00
IUUC-Mor-057185 Magnaporthe oryzae 31.35 9.00e-26 111.00
IUUC-Mmr-060659 Microcebus murinus 98.41 0.00e+00 1110.00
IUUC-Mdo-062925 Monodelphis domestica 85.94 0.00e+00 951.00
IUUC-Mmu-064247 Mus musculus 96.97 0.00e+00 1092.00
IUUC-Mpu-066833 Mustela putorius furo 96.98 0.00e+00 1089.00
IUUC-Mlu-067384 Myotis lucifugus 94.69 0.00e+00 1021.00
IUUC-Ocu-074264 Oryctolagus cuniculus 96.90 0.00e+00 841.00
IUUC-Oga-088281 Otolemur garnettii 97.91 0.00e+00 1100.00
IUUC-Oar-090090 Ovis aries 97.60 0.00e+00 1102.00
IUUC-Ptr-090687 Pan troglodytes 92.99 0.00e+00 1014.00
IUUC-Pan-091813 Papio anubis 99.20 0.00e+00 1117.00
IUUC-Psi-092943 Pelodiscus sinensis 76.60 0.00e+00 871.00
IUUC-Pab-097650 Pongo abelii 99.52 0.00e+00 1102.00
IUUC-Pop-099241 Populus trichocarpa 26.49 4.00e-12 67.00
IUUC-Pca-100372 Procavia capensis 94.57 0.00e+00 944.00
IUUC-Pva-103134 Pteropus vampyrus 97.51 0.00e+00 1000.00
IUUC-Rno-105009 Rattus norvegicus 96.66 0.00e+00 1100.00
IUUC-Sha-107250 Sarcophilus harrisii 85.96 0.00e+00 984.00
IUUC-Sre-115069 Sporisorium reilianum 26.63 3.00e-21 97.40
IUUC-Ssc-115626 Sus scrofa 97.93 0.00e+00 1108.00
IUUC-Tvi-122408 Trichoderma virens 31.66 1.00e-29 124.00
IUUC-Tbe-127583 Tupaia belangeri 97.78 0.00e+00 778.00
Created Date 25-Jun-2017

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