iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000000078.3	ENSXETT00000053945.2	ENSXETP00000053945.2
ENSXETG00000000078.3	ENSXETT00000000143.3	ENSXETP00000000143.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	54.58	2.00e-66	249.00	IUUC-Hsa-046678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MILCVRGTQS LLAEQRVSRP CSCVGAPGFS ADQVMHPLNS PACTRPAPNP VEVPTSTEDS 60
VTNPQPQSRS RDPEADLLCI ARTFCYLRES GWYWGSITAT EAKQQLQKMP EGFFLVRDST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGACACATA ACCGGGAATC AGCTGGAGCA GACACAAAGG GAATTTTGCA CAGATTTAGC 60
CCACACTGAC CACTGAGTAA CTGCTGACAT TGTTGGGGCT CTGTCTCTAG GGGAGACCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	55.79	1.00e-65	243.00
IUUC-Aca-004372	Anolis carolinensis	60.23	1.00e-77	282.00
IUUC-Ame-010787	Astyanax mexicanus	55.08	2.00e-47	181.00
IUUC-Bta-012826	Bos taurus	56.88	2.00e-69	255.00
IUUC-Cja-020004	Callithrix jacchus	56.30	6.00e-63	233.00
IUUC-Cfa-020150	Canis familiaris	62.31	6.00e-65	240.00
IUUC-Csa-023173	Chlorocebus sabaeus	57.46	6.00e-63	233.00
IUUC-Dre-028606	Danio rerio	48.12	8.00e-31	126.00
IUUC-Dno-028956	Dasypus novemcinctus	58.15	2.00e-66	245.00
IUUC-Dor-030148	Dipodomys ordii	50.56	1.00e-62	232.00
IUUC-Ete-032313	Echinops telfairi	53.05	9.00e-64	236.00
IUUC-Eca-033422	Equus caballus	50.72	3.00e-68	251.00
IUUC-Eeu-034806	Erinaceus europaeus	52.09	3.00e-65	241.00
IUUC-Fca-036374	Felis catus	50.72	1.00e-68	252.00
IUUC-Fal-036801	Ficedula albicollis	57.84	3.00e-75	274.00
IUUC-Gmo-038483	Gadus morhua	46.56	6.00e-35	140.00
IUUC-Gga-040891	Gallus gallus	57.31	2.00e-73	268.00
IUUC-Gac-042147	Gasterosteus aculeatus	38.89	1.00e-33	135.00
IUUC-Ggo-045511	Gorilla gorilla	55.60	9.00e-63	233.00
IUUC-Hsa-046678	Homo sapiens	53.48	3.00e-66	244.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	52.22	1.00e-68	252.00
IUUC-Lch-050555	Latimeria chalumnae	53.28	3.00e-65	241.00
IUUC-Laf-054141	Loxodonta africana	53.48	2.00e-69	255.00
IUUC-Mcc-055401	Macaca mulatta	56.39	3.00e-62	231.00
IUUC-Meu-056592	Macropus eugenii	65.64	3.00e-67	248.00
IUUC-Mga-059515	Meleagris gallopavo	55.81	5.00e-69	253.00
IUUC-Mmr-060848	Microcebus murinus	57.52	5.00e-66	243.00
IUUC-Mdo-062720	Monodelphis domestica	55.09	3.00e-69	254.00
IUUC-Mmu-063348	Mus musculus	51.45	2.00e-69	254.00
IUUC-Mpu-065834	Mustela putorius furo	51.99	5.00e-67	247.00
IUUC-Mlu-067687	Myotis lucifugus	53.16	2.00e-64	238.00
IUUC-Nle-069277	Nomascus leucogenys	54.21	7.00e-66	243.00
IUUC-Ont-071890	Oreochromis niloticus	50.00	4.00e-35	140.00
IUUC-Oan-073672	Ornithorhynchus anatinus	54.34	3.00e-72	264.00
IUUC-Ocu-073875	Oryctolagus cuniculus	52.31	2.00e-66	245.00
IUUC-Oga-087943	Otolemur garnettii	50.55	2.00e-66	245.00
IUUC-Oar-090194	Ovis aries	57.85	6.00e-67	246.00
IUUC-Ptr-090934	Pan troglodytes	56.72	4.00e-63	234.00
IUUC-Pan-092121	Papio anubis	52.94	1.00e-64	239.00
IUUC-Psi-093733	Pelodiscus sinensis	58.82	3.00e-71	261.00
IUUC-Pfo-096313	Poecilia formosa	47.18	2.00e-40	158.00
IUUC-Pab-098439	Pongo abelii	53.48	4.00e-66	244.00
IUUC-Pca-101010	Procavia capensis	51.97	7.00e-67	246.00
IUUC-Pva-103112	Pteropus vampyrus	53.33	5.00e-67	246.00
IUUC-Rno-105917	Rattus norvegicus	50.00	1.00e-65	242.00
IUUC-Sha-106954	Sarcophilus harrisii	66.15	3.00e-69	254.00
IUUC-Sar-113001	Sorex araneus	56.65	3.00e-66	244.00
IUUC-Ssc-115922	Sus scrofa	56.86	1.00e-38	151.00
IUUC-Tgu-117338	Taeniopygia guttata	57.36	8.00e-72	263.00
IUUC-Tru-118511	Takifugu rubripes	46.58	4.00e-32	130.00
IUUC-Tsy-119434	Tarsius syrichta	56.64	2.00e-66	245.00
IUUC-Tni-119837	Tetraodon nigroviridis	46.81	3.00e-29	121.00
IUUC-Ttr-128340	Tursiops truncatus	51.55	2.00e-43	168.00
IUUC-Vpa-130443	Vicugna pacos	54.07	3.00e-68	251.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence