iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069968

Ensembl Protein ID

ENSNLEP00000013029.1

UniProt Accession

G1RIH3; G1RIH3_NOMLE

Genbank Protein ID

ENSNLEP00000013029

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

ADFV01066086

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000010727.2	ENSNLET00000013666.2	ENSNLEP00000013029.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.00e-09	36.9	173	219

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 173  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 219
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MDQDGDQHLG PSRILAPQTL KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK 60
IQIVTQMLEL VENRARQMEL HSQCFQDPAE SERAPDKAKM DSSQPERSSR RPRRQRTSES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGCGTTC CCGCGGGCCT GGAAAATGGC TGGTCGCGAG AGGGGCGGCG GCGAGCCGGA 60
TGCTGGGGAG AGAGTCGGGG CTGTGCGGGG GCGTTGGTTC GGCCCCAGCG GAATCCGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0008285--P:negative regulation of cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042981--P:regulation of apoptotic process
GO:2000772--P:regulation of cellular senescence

KEGG

nle:100583744

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	97.06	4.00e-88	317.00
IUUC-Apl-003705	Anas platyrhynchos	88.34	7.00e-90	322.00
IUUC-Aca-004990	Anolis carolinensis	83.41	4.00e-83	301.00
IUUC-Bta-012721	Bos taurus	98.04	3.00e-89	321.00
IUUC-Cja-018960	Callithrix jacchus	98.42	8.00e-82	296.00
IUUC-Cfa-020869	Canis familiaris	96.57	1.00e-87	315.00
IUUC-Cpo-021414	Cavia porcellus	95.10	1.00e-86	312.00
IUUC-Csa-023304	Chlorocebus sabaeus	99.47	4.00e-83	300.00
IUUC-Dno-029945	Dasypus novemcinctus	97.06	1.00e-88	319.00
IUUC-Dor-030141	Dipodomys ordii	96.08	2.00e-86	312.00
IUUC-Ete-032709	Echinops telfairi	95.52	2.00e-97	348.00
IUUC-Eca-033432	Equus caballus	98.04	1.00e-88	319.00
IUUC-Eeu-035285	Erinaceus europaeus	97.55	2.00e-88	318.00
IUUC-Fca-036467	Felis catus	97.55	3.00e-88	318.00
IUUC-Fal-036700	Ficedula albicollis	87.89	5.00e-89	320.00
IUUC-Gga-040175	Gallus gallus	87.56	7.00e-90	323.00
IUUC-Hsa-045837	Homo sapiens	99.47	4.00e-83	300.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	97.06	4.00e-88	317.00
IUUC-Lch-049965	Latimeria chalumnae	83.41	9.00e-84	303.00
IUUC-Laf-053353	Loxodonta africana	96.86	1.00e-98	352.00
IUUC-Mcc-055155	Macaca mulatta	99.43	4.00e-73	266.00
IUUC-Meu-056470	Macropus eugenii	93.72	4.00e-93	333.00
IUUC-Mga-059570	Meleagris gallopavo	87.89	4.00e-89	320.00
IUUC-Mmr-061385	Microcebus murinus	98.95	1.00e-82	298.00
IUUC-Mdo-062144	Monodelphis domestica	94.17	2.00e-93	335.00
IUUC-Mmu-063215	Mus musculus	96.08	4.00e-88	317.00
IUUC-Mpu-065749	Mustela putorius furo	96.57	1.00e-87	315.00
IUUC-Mlu-067245	Myotis lucifugus	75.00	3.00e-80	290.00
IUUC-Ocu-074870	Oryctolagus cuniculus	98.04	3.00e-89	321.00
IUUC-Ola-087400	Oryzias latipes	89.02	4.00e-44	170.00
IUUC-Oga-088336	Otolemur garnettii	98.42	4.00e-82	297.00
IUUC-Oar-090136	Ovis aries	97.55	8.00e-89	319.00
IUUC-Ptr-091348	Pan troglodytes	99.17	3.00e-92	330.00
IUUC-Pan-092819	Papio anubis	99.47	4.00e-83	300.00
IUUC-Psi-093854	Pelodiscus sinensis	86.21	3.00e-62	230.00
IUUC-Pab-098346	Pongo abelii	98.95	1.00e-82	299.00
IUUC-Pca-100278	Procavia capensis	94.62	1.00e-96	345.00
IUUC-Pva-103190	Pteropus vampyrus	98.53	2.00e-89	321.00
IUUC-Rno-104940	Rattus norvegicus	95.59	5.00e-87	313.00
IUUC-Sha-107533	Sarcophilus harrisii	93.72	2.00e-94	338.00
IUUC-Sar-113630	Sorex araneus	96.08	7.00e-88	316.00
IUUC-Ssc-115734	Sus scrofa	98.53	2.00e-89	321.00
IUUC-Tgu-117034	Taeniopygia guttata	88.34	2.00e-89	321.00
IUUC-Tsy-119494	Tarsius syrichta	99.02	4.00e-82	296.00
IUUC-Ttr-128442	Tursiops truncatus	98.04	8.00e-89	319.00
IUUC-Vpa-130063	Vicugna pacos	96.57	1.00e-87	316.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence