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Tag Content
iUUCD ID IUUC-Mcc-054859
Ensembl Protein ID ENSMMUP00000004072.3
UniProt Accession H9EP74; F6VET7; H9EP74_MACMU
Genbank Protein ID AFE64183.1; AFH27923.1; AFI35526.1
Protein Name Coatomer subunit beta'
Genbank Nucleotide ID JSUE03024736; JU471119; JV045455
Gene Name COPB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000003051.3 ENSMMUT00000004320.3 ENSMMUP00000004072.3
ENSMMUG00000003051.3 ENSMMUT00000058926.1 ENSMMUP00000052275.1
ENSMMUG00000003051.3 ENSMMUT00000078454.1 ENSMMUP00000056372.1
ENSMMUG00000003051.3 ENSMMUT00000060154.1 ENSMMUP00000060384.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.70e-33 112.6 183 224
UBD/Beta-Prp 1.40e-71 242.2 13 292
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ +v+c+++    d ++l+sG+dD  +k+WD+   +++++
   Q: 183  GHEKGVNCIDYysgGDkPYLISGADDRLVKIWDYQNKTCVQT 224
           8*********9999778****************999988875 PP
   

   UBD/Beta-Prp
   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           ++++++++v+ +p +++++++ ++g++ vw+ +t++l+++++ ++ +v+a kf  ++++ vtg++D+ i+v++++t + vh +++h+d+
   Q: 13   ARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDY 101
           67899************************************************************************************ PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
           +++++++p++ ++++ s+d  i++wd+++++  +++++gh++ v+ +v++p++ n ++s+slDrt+++W+l + +   tl+g h++ v+
   Q: 102  IRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDnNQFASASLDRTIKVWQLGSSSPNFTLEG-HEKGVN 189
           *******************************9999**********************************************9.****** PP
   S: 185  slsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisva 271
           ++++ s g  ++l+sg++d+ vk+wd+q+++cv+tl+gh +nv++  f+p+  ++++gs+Dg++riW + +  l +tl++  ++v++va
   Q: 190  CIDYYSGGdkPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVA 278
           ***8887777******************************************************************************* PP
   S: 272  vlsfgdnvlvlgse 285
            l+ ++nv +  +e
   Q: 279  SLRGSNNVALGYDE 292
           *9999998755544 PP
   
Organism Macaca mulatta
Functional Description
(View)

Functional Description


     The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Protein Sequence
(Fasta)
MPLRLDIKRK LTARSDRVKS VDLHPTEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV 60
RAAKFVARKN WVVTGADDMQ IRVFNYNTLE RVHMFEAHSD YIRCIAVHPT QPFILTSSDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-054859|E3,WD_repeat;UBD,Beta-Prp|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGATGGGTCT GCGCGCCGTT TGCGCAGGCG CTTCGGCCCT GGCGTCTGAC TATCGCGAGA 60
ATCGGCTCCC GGAAGTTCCA CGTCAGTCAG TCTGACGGTC AGAGGTTCGG TGGCTTTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-054859|E3,WD_repeat;UBD,Beta-Prp|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04053--Coatomer_WDAD
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:1901998--P:toxin transport
KEGG mcc:717632
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000654 Aegilops tauschii 52.81 0.00e+00 942.00
IUUC-Aml-002154 Ailuropoda melanoleuca 98.90 0.00e+00 1832.00
IUUC-Atr-003090 Amborella trichopoda 58.66 0.00e+00 1076.00
IUUC-Apl-003976 Anas platyrhynchos 94.73 0.00e+00 1731.00
IUUC-Aca-004301 Anolis carolinensis 94.81 0.00e+00 1720.00
IUUC-Aly-006508 Arabidopsis lyrata 60.12 0.00e+00 1093.00
IUUC-Ath-007630 Arabidopsis thaliana 61.82 0.00e+00 1103.00
IUUC-Ago-007914 Ashbya gossypii 46.07 0.00e+00 756.00
IUUC-Acl-008237 Aspergillus clavatus 56.63 0.00e+00 969.00
IUUC-Afl-008535 Aspergillus flavus 56.09 0.00e+00 917.00
IUUC-Afu-008845 Aspergillus fumigatus 54.92 0.00e+00 946.00
IUUC-Ani-009135 Aspergillus nidulans 56.08 0.00e+00 921.00
IUUC-Ang-009654 Aspergillus niger 56.32 0.00e+00 863.00
IUUC-Aor-009939 Aspergillus oryzae 54.89 0.00e+00 973.00
IUUC-Ate-010355 Aspergillus terreus 54.33 0.00e+00 924.00
IUUC-Ame-010922 Astyanax mexicanus 84.69 0.00e+00 1494.00
IUUC-Bgr-012249 Blumeria graminis 53.49 0.00e+00 934.00
IUUC-Bta-013579 Bos taurus 99.02 0.00e+00 1483.00
IUUC-Bci-013866 Botrytis cinerea 56.03 0.00e+00 934.00
IUUC-Bdi-015046 Brachypodium distachyon 60.97 0.00e+00 1107.00
IUUC-Bol-015731 Brassica oleracea 61.14 0.00e+00 1108.00
IUUC-Bra-017758 Brassica rapa 60.43 0.00e+00 1108.00
IUUC-Cel-018387 Caenorhabditis elegans 65.33 0.00e+00 1181.00
IUUC-Cja-019145 Callithrix jacchus 99.89 0.00e+00 1848.00
IUUC-Cfa-020564 Canis familiaris 99.45 0.00e+00 1837.00
IUUC-Cpo-022201 Cavia porcellus 97.57 0.00e+00 1814.00
IUUC-Cre-022938 Chlamydomonas reinhardtii 58.55 0.00e+00 987.00
IUUC-Csa-023383 Chlorocebus sabaeus 98.59 0.00e+00 1182.00
IUUC-Cho-024454 Choloepus hoffmanni 92.52 0.00e+00 1409.00
IUUC-Cin-025681 Ciona intestinalis 76.04 0.00e+00 1367.00
IUUC-Csv-026012 Ciona savignyi 76.90 0.00e+00 1337.00
IUUC-Cgl-026649 Colletotrichum gloeosporioides 52.34 0.00e+00 850.00
IUUC-Cne-026986 Cryptococcus neoformans 51.81 0.00e+00 919.00
IUUC-Cme-027219 Cyanidioschyzon merolae 48.45 0.00e+00 850.00
IUUC-Dre-027846 Danio rerio 93.61 0.00e+00 1675.00
IUUC-Dor-030462 Dipodomys ordii 93.08 0.00e+00 1274.00
IUUC-Dse-031268 Dothistroma septosporum 54.91 0.00e+00 958.00
IUUC-Dme-031791 Drosophila melanogaster 70.16 0.00e+00 1273.00
IUUC-Ete-033166 Echinops telfairi 88.89 0.00e+00 1019.00
IUUC-Eca-034180 Equus caballus 96.58 0.00e+00 1761.00
IUUC-Eeu-035086 Erinaceus europaeus 88.54 0.00e+00 898.00
IUUC-Fca-036265 Felis catus 99.12 0.00e+00 1826.00
IUUC-Fal-037202 Ficedula albicollis 95.56 0.00e+00 1670.00
IUUC-Fox-037711 Fusarium oxysporum 56.83 0.00e+00 894.00
IUUC-Fso-038268 Fusarium solani 56.29 0.00e+00 892.00
IUUC-Gmo-039046 Gadus morhua 92.65 0.00e+00 1654.00
IUUC-Ggr-039863 Gaeumannomyces graminis 55.54 0.00e+00 911.00
IUUC-Gga-041112 Gallus gallus 94.74 0.00e+00 1732.00
IUUC-Gac-041733 Gasterosteus aculeatus 92.78 0.00e+00 1616.00
IUUC-Gma-042910 Glycine max 62.35 0.00e+00 1117.00
IUUC-Ggo-044984 Gorilla gorilla 99.45 0.00e+00 1843.00
IUUC-Hsa-046698 Homo sapiens 99.56 0.00e+00 1845.00
IUUC-Hvu-047669 Hordeum vulgare 70.90 8.00e-169 586.00
IUUC-Itr-048212 Ictidomys tridecemlineatus 96.80 0.00e+00 1779.00
IUUC-Kpa-049265 Komagataella pastoris 49.32 0.00e+00 863.00
IUUC-Lch-050473 Latimeria chalumnae 91.08 0.00e+00 1715.00
IUUC-Lpe-051579 Leersia perrieri 60.93 0.00e+00 1097.00
IUUC-Loc-052675 Lepisosteus oculatus 94.26 0.00e+00 1698.00
IUUC-Lma-053218 Leptosphaeria maculans 54.78 0.00e+00 932.00
IUUC-Laf-053757 Loxodonta africana 98.90 0.00e+00 1825.00
IUUC-Meu-056174 Macropus eugenii 96.08 0.00e+00 755.00
IUUC-Mor-057264 Magnaporthe oryzae 56.06 0.00e+00 896.00
IUUC-Mpo-057538 Magnaporthe poae 55.79 0.00e+00 924.00
IUUC-Mtr-058310 Medicago truncatula 62.59 0.00e+00 1127.00
IUUC-Mla-058937 Melampsora laricipopulina 53.44 0.00e+00 917.00
IUUC-Mga-059875 Meleagris gallopavo 94.52 0.00e+00 1727.00
IUUC-Mvi-060240 Microbotryum violaceum 49.13 0.00e+00 918.00
IUUC-Mmr-061261 Microcebus murinus 99.34 0.00e+00 1840.00
IUUC-Mdo-062076 Monodelphis domestica 95.81 0.00e+00 1759.00
IUUC-Mmu-063324 Mus musculus 98.45 0.00e+00 1820.00
IUUC-Mac-064636 Musa acuminata 59.95 0.00e+00 1084.00
IUUC-Mpu-065961 Mustela putorius furo 99.23 0.00e+00 1829.00
IUUC-Mlu-067059 Myotis lucifugus 98.51 0.00e+00 1754.00
IUUC-Nfi-068277 Neosartorya fischeri 54.63 0.00e+00 937.00
IUUC-Ncr-068659 Neurospora crassa 52.83 0.00e+00 914.00
IUUC-Nle-069034 Nomascus leucogenys 99.78 0.00e+00 1847.00
IUUC-Opr-070334 Ochotona princeps 98.78 0.00e+00 1524.00
IUUC-Ont-071563 Oreochromis niloticus 87.90 0.00e+00 1675.00
IUUC-Oan-073416 Ornithorhynchus anatinus 97.93 0.00e+00 1659.00
IUUC-Ocu-074522 Oryctolagus cuniculus 98.90 0.00e+00 1830.00
IUUC-Oba-075760 Oryza barthii 59.05 0.00e+00 1077.00
IUUC-Obr-076163 Oryza brachyantha 62.00 0.00e+00 1098.00
IUUC-Ogl-077450 Oryza glaberrima 60.24 0.00e+00 1105.00
IUUC-Ogu-078994 Oryza glumaepatula 60.05 0.00e+00 1075.00
IUUC-Oin-079856 Oryza indica 57.68 0.00e+00 1080.00
IUUC-Olo-080731 Oryza longistaminata 58.37 0.00e+00 1060.00
IUUC-Ome-081554 Oryza meridionalis 57.49 0.00e+00 1000.00
IUUC-Oni-082324 Oryza nivara 59.05 0.00e+00 1077.00
IUUC-Opu-083400 Oryza punctata 56.17 0.00e+00 1067.00
IUUC-Oru-084829 Oryza rufipogon 59.05 0.00e+00 1077.00
IUUC-Osa-086026 Oryza sativa 60.24 0.00e+00 1107.00
IUUC-Ola-087245 Oryzias latipes 88.25 0.00e+00 1677.00
IUUC-Olu-087655 Ostreococcus lucimarinus 59.98 0.00e+00 1058.00
IUUC-Oga-088163 Otolemur garnettii 95.92 0.00e+00 1756.00
IUUC-Oar-089842 Ovis aries 98.97 0.00e+00 1816.00
IUUC-Ptr-090501 Pan troglodytes 99.67 0.00e+00 1844.00
IUUC-Pan-092011 Papio anubis 99.89 0.00e+00 1847.00
IUUC-Psi-093308 Pelodiscus sinensis 97.87 0.00e+00 1736.00
IUUC-Pma-094695 Petromyzon marinus 81.12 0.00e+00 1442.00
IUUC-Pno-094785 Phaeosphaeria nodorum 62.41 1.00e-112 400.00
IUUC-Ppa-095911 Physcomitrella patens 61.97 0.00e+00 1130.00
IUUC-Pfo-096587 Poecilia formosa 86.25 0.00e+00 1676.00
IUUC-Pab-097926 Pongo abelii 97.15 0.00e+00 1749.00
IUUC-Pop-099634 Populus trichocarpa 62.11 0.00e+00 1103.00
IUUC-Pca-100965 Procavia capensis 97.24 0.00e+00 1777.00
IUUC-Ppe-101470 Prunus persica 62.59 0.00e+00 1117.00
IUUC-Pva-102451 Pteropus vampyrus 92.48 0.00e+00 1271.00
IUUC-Pgr-103453 Puccinia graminis 54.31 0.00e+00 927.00
IUUC-Ptt-103868 Puccinia triticina 54.55 0.00e+00 925.00
IUUC-Pte-104274 Pyrenophora teres 55.57 0.00e+00 963.00
IUUC-Pyt-104794 Pyrenophora triticirepentis 55.04 0.00e+00 912.00
IUUC-Rno-105979 Rattus norvegicus 84.40 0.00e+00 1263.00
IUUC-Sce-106269 Saccharomyces cerevisiae 47.30 0.00e+00 790.00
IUUC-Sha-106905 Sarcophilus harrisii 96.88 0.00e+00 1756.00
IUUC-Sja-107838 Schizosaccharomyces japonicus 47.34 0.00e+00 834.00
IUUC-Spo-108299 Schizosaccharomyces pombe 47.66 0.00e+00 837.00
IUUC-Smo-108695 Selaginella moellendorffii 61.60 0.00e+00 1072.00
IUUC-Sit-110692 Setaria italica 62.95 0.00e+00 1102.00
IUUC-Sly-111775 Solanum lycopersicum 62.38 0.00e+00 1094.00
IUUC-Stu-112906 Solanum tuberosum 62.10 0.00e+00 989.00
IUUC-Sar-113472 Sorex araneus 91.42 0.00e+00 1162.00
IUUC-Sbi-114052 Sorghum bicolor 63.16 0.00e+00 1115.00
IUUC-Sre-115040 Sporisorium reilianum 52.62 0.00e+00 917.00
IUUC-Ssc-115593 Sus scrofa 99.12 0.00e+00 1837.00
IUUC-Tgu-117239 Taeniopygia guttata 94.50 0.00e+00 1727.00
IUUC-Tru-118025 Takifugu rubripes 92.82 0.00e+00 1665.00
IUUC-Tsy-118824 Tarsius syrichta 90.76 0.00e+00 1170.00
IUUC-Tni-120142 Tetraodon nigroviridis 90.56 0.00e+00 1657.00
IUUC-Tca-121613 Theobroma cacao 59.03 0.00e+00 1113.00
IUUC-Tre-122072 Trichoderma reesei 55.12 0.00e+00 936.00
IUUC-Tvi-122546 Trichoderma virens 54.62 0.00e+00 922.00
IUUC-Tae-125321 Triticum aestivum 61.32 0.00e+00 1093.00
IUUC-Tur-126283 Triticum urartu 53.89 0.00e+00 942.00
IUUC-Tme-127041 Tuber melanosporum 56.54 0.00e+00 976.00
IUUC-Tbe-127770 Tupaia belangeri 92.17 0.00e+00 1270.00
IUUC-Ttr-129294 Tursiops truncatus 99.12 0.00e+00 1836.00
IUUC-Uma-129351 Ustilago maydis 51.16 0.00e+00 908.00
IUUC-Vda-129716 Verticillium dahliae 55.61 0.00e+00 958.00
IUUC-Vpa-130037 Vicugna pacos 90.07 0.00e+00 946.00
IUUC-Vvi-131689 Vitis vinifera 59.91 0.00e+00 1112.00
IUUC-Xtr-132633 Xenopus tropicalis 94.21 0.00e+00 1684.00
IUUC-Xma-133347 Xiphophorus maculatus 87.99 0.00e+00 1682.00
IUUC-Yli-134455 Yarrowia lipolytica 50.38 0.00e+00 838.00
IUUC-Zma-135706 Zea mays 61.78 0.00e+00 1120.00
Created Date 25-Jun-2017

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