iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.80e-60	203.2	52	359

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q+ ++  ++r  l++    ++++ + +e+k ++  +l  l+e++++s++kav p+el+++l+k+++    + q
   Q: 52   VGLHNIGQTCCLNSLIQVFMMNVDFRMVLKR---ITVPRGA-EEQKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYNVP--LFVQ 134
           6******************************...5555544.57889**********************************99..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  ++  + +  ++++                          ++    + ++dlF + ++++++c  c+ +ssr+ + l+lslp+ +
   Q: 135  HDAAHLFLTIWNLTKDQI--------------------------TDIDLAERLQDLFTIWTEESLMCVGCGAESSRRGKLLTLSLPLFD 197
           ******************..........................556778899***********************************9 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +++ +++l+d+L+ f++++el +++k++ce+c kk+ +++  kl+ +P++L++hL+Rfs++  +++  ki  +v+fp++Ld s+ + +
   Q: 198  MDSKPLKTLEDALRCFFQPKELASSDKCFCETCGKKTPCKQAQKLTGFPQTLTIHLMRFSVR--NSQTVKICHSVYFPQSLDFSQILPT 284
           99999******************************************************665..56888***************99887 PP
   S: 268  peekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
           ++++   +  YeL+av+ H G ++ GHY+ay++n  +g+W++f+Ds+V  v++++v+ + g       +taY+l+Y++
   Q: 285  TDQS---EIHYELFAVIAHVGMADFGHYCAYIRNpVDGEWFCFNDSHVCWVTWKDVQCTYGdhiyrwrETAYLLVYMK 359
           5544...89*************************55666*******************888***************98 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGKGFGLLRK TCQSVVANPQ QHSALEEEKN MKRKRVLSRE LCSAWDRPHG FVGLHNIGQT 60
CCLNSLIQVF MMNVDFRMVL KRITVPRGAE EQKRSVPFQL LLLLEKMQDS RQKAVLPTEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGCGAGGC TGGGAGGTGA CTTGGCTGCT CTGCTCCGCG GTGCCACGTT CTCCTCTGGA 60
GCCCTTTGCA GATACCGCTC GGTCTTCGCT TCGGTGCTTG AGGCAAGTTT GTGGCTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:312688

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	69.38	1.00e-139	489.00
IUUC-Apl-004006	Anas platyrhynchos	54.83	2.00e-100	358.00
IUUC-Aca-005088	Anolis carolinensis	52.58	1.00e-84	306.00
IUUC-Ame-010606	Astyanax mexicanus	34.62	1.00e-42	167.00
IUUC-Bta-013036	Bos taurus	69.38	4.00e-133	467.00
IUUC-Cja-019052	Callithrix jacchus	67.60	8.00e-123	433.00
IUUC-Cfa-020554	Canis familiaris	72.27	1.00e-147	515.00
IUUC-Cpo-022421	Cavia porcellus	68.17	1.00e-146	512.00
IUUC-Csa-023737	Chlorocebus sabaeus	66.50	6.00e-78	283.00
IUUC-Cho-024807	Choloepus hoffmanni	59.69	1.00e-58	220.00
IUUC-Dre-027408	Danio rerio	35.28	4.00e-49	188.00
IUUC-Dno-029813	Dasypus novemcinctus	59.73	3.00e-108	384.00
IUUC-Dor-030532	Dipodomys ordii	66.94	9.00e-146	509.00
IUUC-Ete-032254	Echinops telfairi	64.44	7.00e-139	486.00
IUUC-Eca-033482	Equus caballus	71.56	2.00e-135	474.00
IUUC-Eeu-034451	Erinaceus europaeus	61.79	1.00e-75	275.00
IUUC-Fca-036313	Felis catus	69.09	3.00e-146	511.00
IUUC-Fal-037216	Ficedula albicollis	48.13	3.00e-94	338.00
IUUC-Gmo-038649	Gadus morhua	34.29	8.00e-43	167.00
IUUC-Gga-041082	Gallus gallus	52.62	3.00e-89	322.00
IUUC-Gac-042439	Gasterosteus aculeatus	36.94	3.00e-49	188.00
IUUC-Ggo-044957	Gorilla gorilla	70.96	8.00e-115	406.00
IUUC-Hsa-046381	Homo sapiens	70.62	9.00e-154	536.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	68.55	2.00e-149	521.00
IUUC-Loc-052688	Lepisosteus oculatus	32.92	1.00e-43	170.00
IUUC-Laf-054109	Loxodonta africana	68.98	1.00e-152	532.00
IUUC-Mcc-054814	Macaca mulatta	68.46	2.00e-150	525.00
IUUC-Meu-056253	Macropus eugenii	63.51	2.00e-101	361.00
IUUC-Mmr-061613	Microcebus murinus	73.73	4.00e-148	517.00
IUUC-Mdo-061890	Monodelphis domestica	61.49	2.00e-114	405.00
IUUC-Mmu-064329	Mus musculus	85.91	0.00e+00	629.00
IUUC-Mpu-066342	Mustela putorius furo	69.73	4.00e-148	517.00
IUUC-Mlu-067010	Myotis lucifugus	67.83	7.00e-147	513.00
IUUC-Nle-069148	Nomascus leucogenys	69.27	9.00e-150	523.00
IUUC-Opr-070988	Ochotona princeps	64.97	2.00e-57	216.00
IUUC-Ont-072039	Oreochromis niloticus	36.19	1.00e-50	193.00
IUUC-Oan-073740	Ornithorhynchus anatinus	54.68	2.00e-69	255.00
IUUC-Ocu-074498	Oryctolagus cuniculus	70.27	2.00e-139	488.00
IUUC-Ola-086753	Oryzias latipes	38.46	8.00e-51	194.00
IUUC-Oga-088497	Otolemur garnettii	68.72	2.00e-143	501.00
IUUC-Oar-089505	Ovis aries	69.69	2.00e-133	468.00
IUUC-Ptr-091656	Pan troglodytes	70.89	1.00e-155	542.00
IUUC-Pan-092498	Papio anubis	68.46	5.00e-150	523.00
IUUC-Psi-093409	Pelodiscus sinensis	51.58	1.00e-100	359.00
IUUC-Pfo-096507	Poecilia formosa	36.54	1.00e-47	183.00
IUUC-Pab-097828	Pongo abelii	72.81	2.00e-138	484.00
IUUC-Pca-100299	Procavia capensis	67.90	2.00e-91	328.00
IUUC-Pva-102972	Pteropus vampyrus	68.01	1.00e-143	502.00
IUUC-Sha-107309	Sarcophilus harrisii	62.86	8.00e-114	403.00
IUUC-Sar-112983	Sorex araneus	67.25	4.00e-107	381.00
IUUC-Ssc-116049	Sus scrofa	68.44	5.00e-134	470.00
IUUC-Tgu-117115	Taeniopygia guttata	52.85	1.00e-92	333.00
IUUC-Tru-118022	Takifugu rubripes	33.54	2.00e-43	169.00
IUUC-Tsy-118986	Tarsius syrichta	52.61	3.00e-52	199.00
IUUC-Tni-120306	Tetraodon nigroviridis	34.94	4.00e-46	178.00
IUUC-Tbe-127768	Tupaia belangeri	63.19	4.00e-97	348.00
IUUC-Ttr-128686	Tursiops truncatus	69.88	4.00e-133	467.00
IUUC-Xtr-132032	Xenopus tropicalis	41.19	2.00e-61	228.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence