iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044597

Ensembl Protein ID

ENSGGOP00000024442.1

UniProt Accession

G3S8M9; G3S8M9_GORGO

Protein Name

Tyrosine-protein kinase

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000000651.2	ENSGGOT00000033367.1	ENSGGOP00000024442.1
ENSGGOG00000000651.2	ENSGGOT00000000656.2	ENSGGOP00000000640.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-14	54.3	96	151

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 96   FVALYDYEARTTEDLSFKKGERFQII--NNTEGDWWEARSIATGKNGYIPSNYVAPAD 151
           789***********************..8999**********************9875 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEPTTVS PCPSSSAKGT AVNFSSLSMT 60
PFGGSSGVTP FGGASSSFSV VPSSYPAGLT GGVTIFVALY DYEARTTEDL SFKKGERFQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TTAAATACAG ACCTGAAAAT 60
ACTCCAGAGC CTGTCAGTAC AAGTGTGAGC CATTATGGAG CAGAACCCAC TACAGTGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	76.60	0.00e+00	796.00
IUUC-Cfa-020402	Canis familiaris	76.74	0.00e+00	800.00
IUUC-Csa-023713	Chlorocebus sabaeus	78.75	0.00e+00	803.00
IUUC-Cme-027200	Cyanidioschyzon merolae	35.19	4.70e-02	33.50
IUUC-Eca-034157	Equus caballus	77.11	0.00e+00	806.00
IUUC-Eeu-034950	Erinaceus europaeus	83.97	3.00e-153	534.00
IUUC-Fca-036233	Felis catus	76.37	0.00e+00	820.00
IUUC-Hsa-047010	Homo sapiens	79.12	0.00e+00	831.00
IUUC-Mcc-055626	Macaca mulatta	78.75	0.00e+00	802.00
IUUC-Mmr-061652	Microcebus murinus	76.19	0.00e+00	798.00
IUUC-Mmu-064128	Mus musculus	75.46	0.00e+00	808.00
IUUC-Mpu-065906	Mustela putorius furo	76.92	0.00e+00	803.00
IUUC-Nle-069041	Nomascus leucogenys	78.21	0.00e+00	806.00
IUUC-Opr-070299	Ochotona princeps	71.25	0.00e+00	724.00
IUUC-Ocu-074171	Oryctolagus cuniculus	76.19	0.00e+00	800.00
IUUC-Ptr-091352	Pan troglodytes	79.12	0.00e+00	831.00
IUUC-Pan-092202	Papio anubis	78.75	0.00e+00	802.00
IUUC-Pva-102592	Pteropus vampyrus	74.73	0.00e+00	767.00
IUUC-Ttr-128893	Tursiops truncatus	76.56	0.00e+00	801.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence