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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046669
Ensembl Protein ID ENSP00000365576.4
UniProt Accession Q9UMX0; A0A024R284; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; UBQL1_HUMAN
Genbank Protein ID AAD49751.3; AAG02473.1; BAB20436.1; AEE61129.1; CAB66578.1; CAI15100.1; CAI15101.1; EAW62659.1; EAW62661.1; EAW62664.1; AAH10066.1; AAH39294.1; ENSP00000257468
Protein Name Ubiquilin-1; Protein linking IAP with cytoskeleton 1
Genbank Nucleotide ID AF176069; AF293384; AB035275; HM005532; AL136643; AL354920; AL354920; CH471089; CH471089; CH471089; BC010066; BC039294; AK074535
Gene Name UBQLN1; DA41; PLIC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135018.13 ENST00000376395.8 ENSP00000365576.4
ENSG00000135018.13 ENST00000257468.11 ENSP00000257468.7
ENSG00000135018.13 ENST00000526134.1 ENSP00000436912.1
ENSG00000135018.13 ENST00000529923.1 ENSP00000434194.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 17614368; 23649778
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 10807547; 11853878; 12634373; 14662753; 15082787; 15147878; 16159959
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 1.40e-09 39.4 547 584
ULD/UDP/UBQ/UBQ_PIM 1.50e-24 87.4 37 110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 547  FQQQLEQLSAMGFlNREANLQALIATGGDINAAIERLL 584
           799**********************************9 PP
   

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           mk+tvkt+k+ke e+ v e+++v+++Ke+i+k+++ + +q+ LI+aGkiLkD++tLs++gi+dg +vhlv+k+++
   Q: 37   MKVTVKTPKEKE-EFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQN 110
           99**********.***********************************************************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).
 Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).
Protein Sequence
(Fasta)
MAESGESGGP PGSQDSAAGA EGAGAPAAAA SAEPKIMKVT VKTPKEKEEF AVPENSSVQQ 60
FKEEISKRFK SHTDQLVLIF AGKILKDQDT LSQHGIHDGL TVHLVIKTQN RPQDHSAQQT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046669|UBD,UBA;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAACTGCG ATTTAGTTTT TGGTGAAAGG AGTGGAAAAA AACCATGAAC TGACCTACCC 60
CGCCCCATTT TGCTTTTAGT CCTTCACACT GGCTTCGCCT GCACTTTGGG CAATGGAGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046669|UBD,UBA;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2
Pfam

PF00627--UBA
PF00240--ubiquitin
SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ
Gene Ontology

GO:0016235--C:aggresome
GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0043234--C:protein complex
GO:0042802--F:identical protein binding
GO:0019900--F:kinase binding
GO:0031593--F:polyubiquitin binding
GO:0035973--P:aggrephagy
GO:0000045--P:autophagosome assembly
GO:0097352--P:autophagosome maturation
GO:0071456--P:cellular response to hypoxia
GO:0016236--P:macroautophagy
GO:1901340--P:negative regulation of store-operated calcium channel activity
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:1902175--P:regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0031396--P:regulation of protein ubiquitination
GO:0034976--P:response to endoplasmic reticulum stress
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:29979
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000864 Aegilops tauschii 49.65 8.00e-38 151.00
IUUC-Aml-001461 Ailuropoda melanoleuca 96.05 0.00e+00 811.00
IUUC-Atr-002470 Amborella trichopoda 39.78 3.00e-44 172.00
IUUC-Apl-003241 Anas platyrhynchos 83.58 0.00e+00 718.00
IUUC-Aca-004511 Anolis carolinensis 80.29 0.00e+00 726.00
IUUC-Aly-005419 Arabidopsis lyrata 34.28 9.00e-52 197.00
IUUC-Ath-007350 Arabidopsis thaliana 34.46 7.00e-52 198.00
IUUC-Bta-013048 Bos taurus 94.72 0.00e+00 828.00
IUUC-Bdi-014506 Brachypodium distachyon 35.68 3.00e-52 199.00
IUUC-Bol-015326 Brassica oleracea 33.57 1.00e-52 201.00
IUUC-Bra-018014 Brassica rapa 38.06 1.00e-41 164.00
IUUC-Cel-018631 Caenorhabditis elegans 38.48 2.00e-67 249.00
IUUC-Cja-019976 Callithrix jacchus 98.20 0.00e+00 843.00
IUUC-Cfa-020092 Canis familiaris 96.22 0.00e+00 836.00
IUUC-Cpo-022388 Cavia porcellus 96.22 0.00e+00 831.00
IUUC-Csa-024087 Chlorocebus sabaeus 99.45 0.00e+00 845.00
IUUC-Cho-024834 Choloepus hoffmanni 96.71 0.00e+00 845.00
IUUC-Cin-025136 Ciona intestinalis 51.10 3.00e-113 402.00
IUUC-Cme-027155 Cyanidioschyzon merolae 58.10 2.00e-34 140.00
IUUC-Dno-028970 Dasypus novemcinctus 78.09 0.00e+00 667.00
IUUC-Dor-030519 Dipodomys ordii 92.63 0.00e+00 804.00
IUUC-Dme-032013 Drosophila melanogaster 46.75 2.00e-115 409.00
IUUC-Ete-032273 Echinops telfairi 95.09 0.00e+00 810.00
IUUC-Eca-033667 Equus caballus 94.91 0.00e+00 833.00
IUUC-Fca-036179 Felis catus 92.99 0.00e+00 791.00
IUUC-Fal-037642 Ficedula albicollis 82.65 0.00e+00 773.00
IUUC-Gga-041264 Gallus gallus 83.51 0.00e+00 806.00
IUUC-Gma-043430 Glycine max 35.03 3.00e-44 173.00
IUUC-Ggo-044969 Gorilla gorilla 99.82 0.00e+00 826.00
IUUC-Itr-048337 Ictidomys tridecemlineatus 96.95 0.00e+00 688.00
IUUC-Lch-050192 Latimeria chalumnae 77.45 0.00e+00 676.00
IUUC-Lpe-051401 Leersia perrieri 37.70 1.00e-36 147.00
IUUC-Loc-052846 Lepisosteus oculatus 77.61 0.00e+00 670.00
IUUC-Lma-053152 Leptosphaeria maculans 28.94 2.00e-11 64.30
IUUC-Laf-054278 Loxodonta africana 94.74 0.00e+00 796.00
IUUC-Mcc-055680 Macaca mulatta 99.46 0.00e+00 858.00
IUUC-Meu-056414 Macropus eugenii 79.64 2.00e-156 545.00
IUUC-Mtr-058674 Medicago truncatula 35.20 3.00e-47 182.00
IUUC-Mga-059894 Meleagris gallopavo 82.64 0.00e+00 649.00
IUUC-Mmr-061094 Microcebus murinus 97.30 0.00e+00 832.00
IUUC-Mdo-062728 Monodelphis domestica 86.20 0.00e+00 773.00
IUUC-Mmu-064088 Mus musculus 85.98 0.00e+00 835.00
IUUC-Mac-065458 Musa acuminata 35.78 1.00e-43 171.00
IUUC-Mpu-066282 Mustela putorius furo 92.45 0.00e+00 804.00
IUUC-Mlu-068158 Myotis lucifugus 94.41 0.00e+00 795.00
IUUC-Nle-069321 Nomascus leucogenys 99.82 0.00e+00 858.00
IUUC-Opr-071098 Ochotona princeps 89.70 0.00e+00 629.00
IUUC-Oan-072808 Ornithorhynchus anatinus 86.83 0.00e+00 739.00
IUUC-Ocu-074301 Oryctolagus cuniculus 88.14 0.00e+00 787.00
IUUC-Oba-074973 Oryza barthii 39.02 1.00e-43 170.00
IUUC-Obr-076444 Oryza brachyantha 50.34 2.00e-32 134.00
IUUC-Ogl-077319 Oryza glaberrima 39.02 4.00e-44 172.00
IUUC-Ogu-078074 Oryza glumaepatula 35.07 4.00e-51 196.00
IUUC-Oin-079142 Oryza indica 38.36 4.00e-44 172.00
IUUC-Olo-080565 Oryza longistaminata 35.29 2.00e-49 189.00
IUUC-Ome-081155 Oryza meridionalis 46.15 1.00e-34 141.00
IUUC-Oni-082272 Oryza nivara 38.36 4.00e-44 172.00
IUUC-Opu-083241 Oryza punctata 36.75 1.00e-51 197.00
IUUC-Oru-085257 Oryza rufipogon 38.36 4.00e-44 172.00
IUUC-Osa-086257 Oryza sativa 39.02 4.00e-44 172.00
IUUC-Olu-087597 Ostreococcus lucimarinus 32.12 1.00e-25 110.00
IUUC-Oga-088495 Otolemur garnettii 96.76 0.00e+00 807.00
IUUC-Oar-089711 Ovis aries 94.23 0.00e+00 805.00
IUUC-Ptr-091439 Pan troglodytes 99.64 0.00e+00 852.00
IUUC-Pan-092641 Papio anubis 99.46 0.00e+00 858.00
IUUC-Psi-093518 Pelodiscus sinensis 83.15 0.00e+00 718.00
IUUC-Pma-094727 Petromyzon marinus 43.58 3.00e-52 199.00
IUUC-Ppa-095193 Physcomitrella patens 52.80 2.00e-35 144.00
IUUC-Pfo-096638 Poecilia formosa 67.86 5.00e-174 604.00
IUUC-Pab-098699 Pongo abelii 97.48 0.00e+00 850.00
IUUC-Pop-099549 Populus trichocarpa 37.10 2.00e-55 209.00
IUUC-Pca-100497 Procavia capensis 84.09 2.00e-135 475.00
IUUC-Ppe-101901 Prunus persica 35.00 4.00e-57 216.00
IUUC-Pva-102513 Pteropus vampyrus 83.70 2.00e-147 515.00
IUUC-Rno-104908 Rattus norvegicus 86.49 0.00e+00 870.00
IUUC-Sha-106881 Sarcophilus harrisii 84.33 0.00e+00 700.00
IUUC-Smo-108910 Selaginella moellendorffii 35.81 3.00e-38 153.00
IUUC-Sit-110766 Setaria italica 39.67 7.00e-37 148.00
IUUC-Sar-113648 Sorex araneus 87.68 0.00e+00 634.00
IUUC-Sbi-114307 Sorghum bicolor 37.79 3.00e-45 176.00
IUUC-Ssc-115820 Sus scrofa 96.76 0.00e+00 838.00
IUUC-Tgu-116845 Taeniopygia guttata 78.38 0.00e+00 687.00
IUUC-Tni-119780 Tetraodon nigroviridis 65.78 7.00e-171 593.00
IUUC-Tca-121558 Theobroma cacao 35.31 2.00e-54 207.00
IUUC-Tae-125518 Triticum aestivum 49.65 2.00e-38 153.00
IUUC-Tur-126783 Triticum urartu 54.41 1.00e-38 154.00
IUUC-Tbe-127379 Tupaia belangeri 83.40 0.00e+00 675.00
IUUC-Ttr-128630 Tursiops truncatus 93.75 0.00e+00 839.00
IUUC-Vpa-130413 Vicugna pacos 70.92 1.00e-159 556.00
IUUC-Vvi-131599 Vitis vinifera 39.80 6.00e-43 169.00
IUUC-Xtr-132595 Xenopus tropicalis 79.34 0.00e+00 710.00
IUUC-Xma-134155 Xiphophorus maculatus 64.84 5.00e-169 587.00
Created Date 25-Jun-2017

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