iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062902

UUCD1 version

UUC-MoD-00897

Ensembl Protein ID

ENSMODP00000023684.2

UniProt Accession

F7FP95; F7FP95_MONDO

Protein Name

Uncharacterized protein

Gene Name

CUL9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018980.3	ENSMODT00000024104.3	ENSMODP00000023684.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.30e-118	397.5	1288	1806

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 67   ktynreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvvesl 153
               ++W+ freql++ +++f      y+++           +++w+++i++d +krll+l+ +l+ a+R+++ +++r+l++++++ 
   Q: 1288 GPKPTFWPLFREQLCRRTHLF------YTVR-----------AQAWSQDIARD-RKRLLQLCPRLNGALRHEQSFADRFLPDDEAA- 1355
           555689***************......****...........***********.********************************. PP
   S: 154  veLslnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesl 239
                  la++++++Ea++++ +q +++++ + ++   + + +Yl+++e++  ++ ++ +++++++++++Ll++ve+   +      
   Q: 1356 -------LALGRTCWEALVSPLVQSITAPDGSGVSPLaWLLGQYLEHREKARCPQGRADSFASRVRRLSHLLVHVEPPPGP------ 1429
           .......89************************************************************************...... PP
   S: 240  laelvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndak 324
            ++ + +  + k+++++++ + +  +++  +l+ ++++++ +++eq++++lta++++ d    V+r+++ +++lq++  e+F+++a+
   Q: 1430 -PPEPPTRPNGKNSKIRELNSGAGLGPPggSLRGITQCWRGVVQEQVSRFLTAAWQAPD---LVPRYCDTYERLQSAGAELFGPRAA 1512
           .**************************9989****************************...************************* PP
   S: 325  FlkaldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsg 407
           F+ al+++f+ ++++ s+l+aa+++E++Ar+iDq+++ks ++g+++ee++ ql++ l+ ++++s++++   Fe++Y+ +La+RLls 
   Q: 1513 FTLALRQGFSGALLQLSFLTAAHVSEQFARHIDQQIQKSrVGGPRGEEVLGQLQRSLEPMMVLSGLELattFEHFYQYYLADRLLS- 1598
           **************************************************************************************. PP
   S: 408  ksasseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk.................................eekentee 460
               s++E++v+e++    g++f+++L ++M+ +l++S++l++qF+                                  e+e  +e
   Q: 1599 -LGPSWLERAVLEQI----GLCFPNRLpQQMLSSLSTSQELQHQFHlfqleqidqqlleqeedeehslearpqeeeegrGERELPRE 1680
           .**************....********************************************************99998899999* PP
   S: 461  sesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtlgraelkaelkkgkyelqV 535
           ++++e+svlvLs+++Wp++  +    ++  LP+ l+  + +f++fY        le ++ R+LqW + lgrael +    g+++l+V
   Q: 1681 EPAPEVSVLVLSPRCWPVSplCYLyePNKYLPPALSTNLSRFSNFYsqsqnrpvLELGPRRRLQWSW-LGRAELLF----GTQTLHV 1762
           *******************986656699***************************************.********....******* PP
   S: 536  stfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk 579
           st+Qm++LL+fn+ e+v +++l ++++++ e+L+++lq+L+s+ 
   Q: 1763 STLQMWLLLHFNEMEEVALDTLLQSSDISSELLNQALQPLTSGL 1806
           *****************************************975 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MVGERRSRDL LVPLGPRLQA YPEELLRQRQ GHDGHPEYLI RWTVLQRGKE GGVGSGSSLE 60
GKAEHILMWL SAPEVYANCP MLLGERAPAK GPQHEPAGSV GAFPRDAGGL DETSLGEMAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAAAAGCA CCGCGCGACG GCCGCCAGTG ACGTCATCGC CTCCCAAGCC AAGAGTCATA 60
CCTCCATCCC TGAAGAAATC GGGCAAGGCT AGATCCCGCC CTATCCGGAG GAGGATGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR016150--Casein_kin_II_reg-sub_b-sht
IPR021097--CPH_domain
IPR031222--CUL9
IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR002867--IBR_dom
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
PS51284--DOC
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8
PF01485--IBR

SMART

SM01337--APC10
SM00884--Cullin_Nedd8
SM00647--IBR

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0008270--F:zinc ion binding
GO:0000226--P:microtubule cytoskeleton organization
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001405	Ailuropoda melanoleuca	74.61	0.00e+00	3432.00
IUUC-Apl-003458	Anas platyrhynchos	69.19	0.00e+00	785.00
IUUC-Aca-004815	Anolis carolinensis	59.89	0.00e+00	2729.00
IUUC-Ame-010611	Astyanax mexicanus	51.93	0.00e+00	2340.00
IUUC-Bta-012877	Bos taurus	72.70	0.00e+00	3318.00
IUUC-Cja-019255	Callithrix jacchus	74.16	0.00e+00	3349.00
IUUC-Cfa-020119	Canis familiaris	74.75	0.00e+00	3409.00
IUUC-Cpo-022473	Cavia porcellus	69.84	0.00e+00	3097.00
IUUC-Csa-024157	Chlorocebus sabaeus	74.31	0.00e+00	3355.00
IUUC-Cho-024879	Choloepus hoffmanni	70.11	0.00e+00	720.00
IUUC-Cin-025402	Ciona intestinalis	33.29	0.00e+00	749.00
IUUC-Dno-028904	Dasypus novemcinctus	72.67	0.00e+00	3309.00
IUUC-Dor-030112	Dipodomys ordii	74.46	0.00e+00	1133.00
IUUC-Ete-032516	Echinops telfairi	63.06	0.00e+00	1036.00
IUUC-Eca-034394	Equus caballus	73.29	0.00e+00	3306.00
IUUC-Eeu-035166	Erinaceus europaeus	78.42	0.00e+00	1888.00
IUUC-Fca-035740	Felis catus	74.28	0.00e+00	3389.00
IUUC-Fal-036672	Ficedula albicollis	53.42	0.00e+00	1581.00
IUUC-Gga-040154	Gallus gallus	63.86	0.00e+00	942.00
IUUC-Gac-041628	Gasterosteus aculeatus	56.59	0.00e+00	1016.00
IUUC-Ggo-045570	Gorilla gorilla	73.89	0.00e+00	3325.00
IUUC-Hsa-046690	Homo sapiens	74.12	0.00e+00	3326.00
IUUC-Itr-048680	Ictidomys tridecemlineatus	73.32	0.00e+00	3382.00
IUUC-Loc-052706	Lepisosteus oculatus	54.02	0.00e+00	2423.00
IUUC-Mcc-055727	Macaca mulatta	74.10	0.00e+00	3374.00
IUUC-Meu-056074	Macropus eugenii	92.90	0.00e+00	1836.00
IUUC-Mga-059683	Meleagris gallopavo	51.64	4.00e-98	351.00
IUUC-Mmr-060869	Microcebus murinus	73.26	0.00e+00	3346.00
IUUC-Mmu-063991	Mus musculus	71.38	0.00e+00	3231.00
IUUC-Mpu-065974	Mustela putorius furo	73.79	0.00e+00	3364.00
IUUC-Nle-069292	Nomascus leucogenys	77.76	0.00e+00	2244.00
IUUC-Opr-071020	Ochotona princeps	71.19	0.00e+00	1723.00
IUUC-Ont-071953	Oreochromis niloticus	52.30	0.00e+00	2257.00
IUUC-Oan-073534	Ornithorhynchus anatinus	63.71	0.00e+00	2262.00
IUUC-Ocu-074244	Oryctolagus cuniculus	73.30	0.00e+00	3330.00
IUUC-Ola-087072	Oryzias latipes	53.35	0.00e+00	1793.00
IUUC-Oga-088310	Otolemur garnettii	71.74	0.00e+00	3274.00
IUUC-Oar-090174	Ovis aries	72.57	0.00e+00	3269.00
IUUC-Ptr-091410	Pan troglodytes	74.16	0.00e+00	3310.00
IUUC-Pan-091856	Papio anubis	71.81	0.00e+00	2070.00
IUUC-Pma-094192	Petromyzon marinus	45.70	0.00e+00	1425.00
IUUC-Pfo-096773	Poecilia formosa	58.13	0.00e+00	999.00
IUUC-Pab-098635	Pongo abelii	76.09	0.00e+00	2336.00
IUUC-Pca-100539	Procavia capensis	78.33	0.00e+00	1166.00
IUUC-Pva-102813	Pteropus vampyrus	73.27	0.00e+00	1355.00
IUUC-Rno-106105	Rattus norvegicus	71.66	0.00e+00	3250.00
IUUC-Sha-106896	Sarcophilus harrisii	95.39	0.00e+00	1592.00
IUUC-Sar-113132	Sorex araneus	65.89	0.00e+00	989.00
IUUC-Ssc-116000	Sus scrofa	73.91	0.00e+00	3353.00
IUUC-Tgu-116915	Taeniopygia guttata	65.23	2.00e-147	515.00
IUUC-Tru-118013	Takifugu rubripes	56.28	0.00e+00	1604.00
IUUC-Tsy-118860	Tarsius syrichta	64.16	0.00e+00	836.00
IUUC-Tni-120062	Tetraodon nigroviridis	53.09	0.00e+00	2334.00
IUUC-Ttr-128780	Tursiops truncatus	69.50	0.00e+00	2058.00
IUUC-Vpa-130086	Vicugna pacos	70.64	4.00e-156	546.00
IUUC-Xtr-132882	Xenopus tropicalis	52.23	0.00e+00	1909.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence