• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063421
UUCD1 version UUC-MuM-00150
Ensembl Protein ID ENSMUSP00000052856.4
UniProt Accession Q9WTZ1; Q3UKF8; RBX2_MOUSE
Genbank Protein ID AAD25961.1; BAB22666.1; BAE26843.1; AAH11127.1
Protein Name RING-box protein 2; RING finger protein 7; Sensitive to apoptosis gene protein
Genbank Nucleotide ID AF092877; AK003248; AK146030; BC011127
Gene Name Rnf7; Rbx2; Sag
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000051234.6 ENSMUST00000057500.5 ENSMUSP00000052856.4
ENSMUSG00000051234.6 ENSMUST00000071301.4 ENSMUSP00000108581.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 81.52 2.00e-39 156.00 IUUC-Dme-031722
E3 activity/RING/RING 96.46 3.00e-50 194.00 IUUC-Hsa-045901
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents (By similarity).
 Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents (By similarity).
Protein Sequence
(Fasta)
MADVEDGEEP CVLSSHSGSA GSKSGGDKMF SLKKWNAVAM WSWDVECDTC AICRVQVMDA 60
CLRCQAENKQ EDCVVVWGEC NHSFHNCCMS LWVKQNNRCP LCQQDWVVQR IGK 113
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063421|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGGCTCC GTGGCGTGTG TTGTGGCCCC GCTGAGCCAC CGTACCTCCC GCCTCCGCGC 60
CCAACGTCCG CGTCGCCGTT CTGCGCCGCC GCCATGGCCG ACGTGGAGGA CGGCGAGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063421|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0097602--F:cullin family protein binding
GO:0019788--F:NEDD8 transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008637--P:apoptotic mitochondrial changes
GO:0021799--P:cerebral cortex radially oriented cell migration
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0043066--P:negative regulation of apoptotic process
GO:0045116--P:protein neddylation
GO:0016567--P:protein ubiquitination
GO:0021942--P:radial glia guided migration of Purkinje cell
KEGG mmu:19823
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001959 Ailuropoda melanoleuca 99.08 5.00e-50 188.00
IUUC-Apl-003554 Anas platyrhynchos 96.49 2.00e-28 116.00
IUUC-Aca-004651 Anolis carolinensis 82.76 6.00e-49 185.00
IUUC-Ame-010935 Astyanax mexicanus 84.87 1.00e-47 181.00
IUUC-Bta-013315 Bos taurus 99.12 3.00e-52 196.00
IUUC-Cel-018286 Caenorhabditis elegans 68.97 2.00e-33 134.00
IUUC-Cja-019230 Callithrix jacchus 98.23 3.00e-51 193.00
IUUC-Cfa-020188 Canis familiaris 98.23 7.00e-52 194.00
IUUC-Cpo-021681 Cavia porcellus 97.35 3.00e-52 196.00
IUUC-Csa-023305 Chlorocebus sabaeus 96.46 1.00e-51 194.00
IUUC-Cho-024539 Choloepus hoffmanni 96.46 2.00e-49 187.00
IUUC-Cin-025216 Ciona intestinalis 82.56 4.00e-40 155.00
IUUC-Csv-026356 Ciona savignyi 85.53 3.00e-36 142.00
IUUC-Dre-027952 Danio rerio 92.04 6.00e-49 185.00
IUUC-Dno-029920 Dasypus novemcinctus 97.35 2.00e-50 190.00
IUUC-Dme-031722 Drosophila melanogaster 81.52 2.00e-40 156.00
IUUC-Ete-033111 Echinops telfairi 76.11 1.00e-37 147.00
IUUC-Eca-034329 Equus caballus 96.51 2.00e-44 169.00
IUUC-Fal-037052 Ficedula albicollis 97.75 2.00e-47 179.00
IUUC-Gmo-038573 Gadus morhua 90.18 3.00e-49 186.00
IUUC-Gga-040409 Gallus gallus 87.72 3.00e-50 189.00
IUUC-Gac-041808 Gasterosteus aculeatus 89.29 3.00e-49 186.00
IUUC-Ggo-045314 Gorilla gorilla 96.46 1.00e-51 194.00
IUUC-Hsa-045901 Homo sapiens 96.46 1.00e-51 194.00
IUUC-Itr-048540 Ictidomys tridecemlineatus 97.35 1.00e-51 194.00
IUUC-Lch-049958 Latimeria chalumnae 89.38 5.00e-48 182.00
IUUC-Loc-052481 Lepisosteus oculatus 90.27 3.00e-49 186.00
IUUC-Laf-054260 Loxodonta africana 97.35 4.00e-49 186.00
IUUC-Mcc-055092 Macaca mulatta 82.30 1.00e-39 153.00
IUUC-Meu-056081 Macropus eugenii 89.19 3.00e-28 115.00
IUUC-Mga-059532 Meleagris gallopavo 91.80 1.00e-28 117.00
IUUC-Mmr-061775 Microcebus murinus 84.07 2.00e-39 152.00
IUUC-Mdo-062083 Monodelphis domestica 92.92 2.00e-50 190.00
IUUC-Mpu-066010 Mustela putorius furo 99.12 3.00e-52 196.00
IUUC-Mlu-067975 Myotis lucifugus 96.49 2.00e-28 116.00
IUUC-Nle-069723 Nomascus leucogenys 96.46 1.00e-51 194.00
IUUC-Opr-070339 Ochotona princeps 97.35 2.00e-52 196.00
IUUC-Ont-072072 Oreochromis niloticus 90.18 2.00e-50 190.00
IUUC-Oan-073574 Ornithorhynchus anatinus 85.96 1.00e-46 177.00
IUUC-Ola-087260 Oryzias latipes 87.50 2.00e-49 186.00
IUUC-Oga-089038 Otolemur garnettii 96.46 3.00e-51 193.00
IUUC-Oar-089945 Ovis aries 99.12 3.00e-52 196.00
IUUC-Ptr-091040 Pan troglodytes 96.46 1.00e-51 194.00
IUUC-Pan-092693 Papio anubis 96.46 1.00e-51 194.00
IUUC-Psi-093633 Pelodiscus sinensis 100.00 4.00e-47 179.00
IUUC-Pfo-096440 Poecilia formosa 91.07 5.00e-49 185.00
IUUC-Pab-098277 Pongo abelii 96.46 1.00e-51 194.00
IUUC-Pva-102548 Pteropus vampyrus 99.12 3.00e-52 196.00
IUUC-Rno-105855 Rattus norvegicus 100.00 1.00e-52 197.00
IUUC-Sha-107430 Sarcophilus harrisii 94.69 2.00e-50 190.00
IUUC-Sar-112957 Sorex araneus 84.96 3.00e-46 176.00
IUUC-Ssc-115606 Sus scrofa 86.15 1.00e-18 84.30
IUUC-Tgu-116519 Taeniopygia guttata 90.32 6.00e-29 118.00
IUUC-Tru-117658 Takifugu rubripes 85.96 3.00e-48 183.00
IUUC-Tsy-119251 Tarsius syrichta 97.35 3.00e-51 193.00
IUUC-Tni-120364 Tetraodon nigroviridis 88.50 2.00e-48 183.00
IUUC-Tbe-127256 Tupaia belangeri 85.84 3.00e-39 152.00
IUUC-Ttr-129140 Tursiops truncatus 99.12 3.00e-52 196.00
IUUC-Vpa-130670 Vicugna pacos 96.55 8.00e-44 167.00
IUUC-Xtr-132382 Xenopus tropicalis 100.00 3.00e-46 175.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved