iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069260

Ensembl Protein ID

ENSNLEP00000011854.1

UniProt Accession

G1RF54; G1RF54_NOMLE

Genbank Protein ID

ENSNLEP00000011854

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01183008

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000009731.1	ENSNLET00000012436.1	ENSNLEP00000011854.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	6.00e-37	127.1	184	365
UBD/ZnF/ZnF_A20	9.20e-17	60.7	796	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A + +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 184  LPLATTGDGNCLLHAWATGMWGFHDRDLmLRKALYALMEKGVEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 272
           6899********************************************************************************98887 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 273  lgtN-GancggvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHFS 360
           7650.255579****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 361  ALVSM 365
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 796  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 830
           59********************************9 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLPPSFSEGS 60
GGSRTPEKGF SDREPTRPPR PILQRQDDIV QEKRLSRGIS HASSSIVSLA RSHVSSNGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAAAAGCC ACTGGGGGAG GCCAGTCCCG ATCAGTCCCT TCTGGCTCCA GCTGCAGATC 60
CCGTGCGGAG CAACAGCTGC GGTCGCAGTC TCCACCACCG CCTCCACCAC CATCGCCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	93.07	0.00e+00	1425.00
IUUC-Apl-003567	Anas platyrhynchos	67.59	0.00e+00	966.00
IUUC-Bta-013398	Bos taurus	93.48	0.00e+00	1397.00
IUUC-Cel-018468	Caenorhabditis elegans	49.67	1.00e-83	303.00
IUUC-Cja-019965	Callithrix jacchus	95.98	0.00e+00	1424.00
IUUC-Cfa-020191	Canis familiaris	93.12	0.00e+00	1428.00
IUUC-Cpo-022232	Cavia porcellus	90.22	0.00e+00	1342.00
IUUC-Csa-023593	Chlorocebus sabaeus	98.22	0.00e+00	1538.00
IUUC-Cho-024729	Choloepus hoffmanni	84.49	2.00e-175	609.00
IUUC-Csv-026177	Ciona savignyi	30.56	3.00e-03	35.00
IUUC-Dno-029900	Dasypus novemcinctus	92.47	0.00e+00	1373.00
IUUC-Dor-031121	Dipodomys ordii	84.92	0.00e+00	687.00
IUUC-Ete-032473	Echinops telfairi	88.33	0.00e+00	1040.00
IUUC-Eca-033946	Equus caballus	94.85	0.00e+00	1042.00
IUUC-Eeu-034670	Erinaceus europaeus	90.87	0.00e+00	1366.00
IUUC-Fca-035871	Felis catus	93.48	0.00e+00	1342.00
IUUC-Fso-038203	Fusarium solani	29.59	4.70e-02	33.50
IUUC-Gmo-039373	Gadus morhua	76.39	0.00e+00	673.00
IUUC-Gga-041105	Gallus gallus	67.95	0.00e+00	993.00
IUUC-Ggo-045472	Gorilla gorilla	99.05	0.00e+00	1506.00
IUUC-Hsa-046473	Homo sapiens	99.05	0.00e+00	1516.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	94.42	0.00e+00	1432.00
IUUC-Lch-050432	Latimeria chalumnae	63.25	0.00e+00	946.00
IUUC-Mcc-055261	Macaca mulatta	97.86	0.00e+00	1537.00
IUUC-Meu-056477	Macropus eugenii	79.18	0.00e+00	933.00
IUUC-Mga-059533	Meleagris gallopavo	69.54	0.00e+00	993.00
IUUC-Mdo-062847	Monodelphis domestica	82.47	0.00e+00	1162.00
IUUC-Mmu-064260	Mus musculus	88.74	0.00e+00	1330.00
IUUC-Mpu-066876	Mustela putorius furo	88.05	0.00e+00	1311.00
IUUC-Mlu-068039	Myotis lucifugus	93.48	0.00e+00	1407.00
IUUC-Opr-070564	Ochotona princeps	90.93	0.00e+00	777.00
IUUC-Ocu-073824	Oryctolagus cuniculus	94.85	0.00e+00	944.00
IUUC-Opu-083273	Oryza punctata	24.36	5.80e-02	32.30
IUUC-Oga-088124	Otolemur garnettii	93.72	0.00e+00	1400.00
IUUC-Oar-090086	Ovis aries	93.95	0.00e+00	1399.00
IUUC-Ptr-091622	Pan troglodytes	98.90	0.00e+00	1136.00
IUUC-Pan-092724	Papio anubis	97.75	0.00e+00	1528.00
IUUC-Psi-093333	Pelodiscus sinensis	64.46	0.00e+00	953.00
IUUC-Pab-098667	Pongo abelii	98.70	0.00e+00	1490.00
IUUC-Pca-100701	Procavia capensis	92.12	0.00e+00	751.00
IUUC-Pva-102136	Pteropus vampyrus	92.05	0.00e+00	1377.00
IUUC-Rno-105546	Rattus norvegicus	89.57	0.00e+00	1349.00
IUUC-Sha-106732	Sarcophilus harrisii	82.24	0.00e+00	1070.00
IUUC-Sar-113562	Sorex araneus	81.16	0.00e+00	1112.00
IUUC-Ssc-116191	Sus scrofa	93.95	0.00e+00	1417.00
IUUC-Tgu-116942	Taeniopygia guttata	75.72	0.00e+00	782.00
IUUC-Tsy-119343	Tarsius syrichta	83.94	0.00e+00	1232.00
IUUC-Tur-126860	Triticum urartu	24.39	3.40e-02	33.10
IUUC-Tbe-127283	Tupaia belangeri	95.45	0.00e+00	744.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence