iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054640

Ensembl Protein ID

ENSMMUP00000014922.3

UniProt Accession

F6WEY4; F6WEY4_MACMU

Genbank Protein ID

AFI33579.1; EHH31645.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

JSUE03026154; CM001272

Gene Name

SIAH1; EGK_12755

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000007400.3	ENSMMUT00000015923.3	ENSMMUP00000014922.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	2.00e-125	446.00	IUUC-Dme-031700
E3 activity/RING/RING	100.00	0.00e+00	655.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.65	8.00e-169	590.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTGKATPPSL YSWRGVLFTC LPAARTRKRK EMSRQTATAL PTGTSKCPPS QRVPALTGTT 60
ASNNDLASLF ECPVCFDYVL PPILQCQSGH LVCSNCRPKL TCCPTCRGPL GSIRNLAMEK 120

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Nucleotide Sequence
(Fasta)

AGTGTGGATG GTGTGGAGTG GGATGGTGAA GGATGGGGTC AGAGGAAGGA AGGGCATGCC 60
CGCCCAGCTG TATGTGGATT GCTGCCTCCC TGGAGAGGGG TCATGAAGCC TAGCAGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:716629

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.09	2.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	97.76	0.00e+00	638.00
IUUC-Atr-002857	Amborella trichopoda	36.19	2.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	99.65	6.00e-170	589.00
IUUC-Aca-005014	Anolis carolinensis	99.65	1.00e-170	591.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	32.87	4.00e-42	164.00
IUUC-Ame-011196	Astyanax mexicanus	88.34	5.00e-171	593.00
IUUC-Bta-012887	Bos taurus	97.44	0.00e+00	637.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	4.00e-45	174.00
IUUC-Bol-016263	Brassica oleracea	33.57	2.00e-42	166.00
IUUC-Bra-016910	Brassica rapa	36.82	3.00e-41	162.00
IUUC-Cel-018320	Caenorhabditis elegans	61.98	2.00e-114	405.00
IUUC-Cja-019796	Callithrix jacchus	99.04	0.00e+00	649.00
IUUC-Cfa-020642	Canis familiaris	96.30	4.00e-172	596.00
IUUC-Cpo-022348	Cavia porcellus	100.00	1.00e-170	591.00
IUUC-Csa-023974	Chlorocebus sabaeus	100.00	0.00e+00	655.00
IUUC-Cin-025674	Ciona intestinalis	78.01	1.00e-134	472.00
IUUC-Csv-026233	Ciona savignyi	84.25	4.00e-132	463.00
IUUC-Dre-028041	Danio rerio	88.34	1.00e-171	595.00
IUUC-Dno-029764	Dasypus novemcinctus	99.65	3.00e-170	591.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	8.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	99.25	1.00e-159	555.00
IUUC-Eca-033536	Equus caballus	99.65	6.00e-170	589.00
IUUC-Eeu-035314	Erinaceus europaeus	95.70	7.00e-160	556.00
IUUC-Fca-035362	Felis catus	97.76	0.00e+00	641.00
IUUC-Fal-037487	Ficedula albicollis	94.89	2.00e-179	620.00
IUUC-Gga-040269	Gallus gallus	99.65	6.00e-170	589.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.52	1.00e-167	582.00
IUUC-Gma-042926	Glycine max	34.44	1.00e-40	159.00
IUUC-Ggo-045444	Gorilla gorilla	100.00	0.00e+00	655.00
IUUC-Hsa-046357	Homo sapiens	100.00	0.00e+00	655.00
IUUC-Hvu-047574	Hordeum vulgare	36.73	2.00e-44	172.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	100.00	1.00e-170	591.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	5.00e-169	586.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	166.00
IUUC-Loc-052191	Lepisosteus oculatus	98.94	8.00e-170	589.00
IUUC-Laf-053668	Loxodonta africana	99.65	6.00e-170	589.00
IUUC-Mtr-058747	Medicago truncatula	34.81	4.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	95.62	1.00e-170	591.00
IUUC-Mmr-060794	Microcebus murinus	100.00	1.00e-170	591.00
IUUC-Mmu-064129	Mus musculus	99.65	4.00e-170	590.00
IUUC-Mac-065670	Musa acuminata	35.44	2.00e-42	166.00
IUUC-Mpu-066488	Mustela putorius furo	97.76	0.00e+00	638.00
IUUC-Mlu-067207	Myotis lucifugus	99.65	6.00e-171	592.00
IUUC-Nle-069706	Nomascus leucogenys	99.36	0.00e+00	653.00
IUUC-Ont-071849	Oreochromis niloticus	97.53	2.00e-168	584.00
IUUC-Ocu-074876	Oryctolagus cuniculus	98.08	0.00e+00	642.00
IUUC-Oba-075454	Oryza barthii	40.66	1.00e-42	166.00
IUUC-Obr-076037	Oryza brachyantha	35.43	3.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	1.00e-42	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.66	1.00e-42	167.00
IUUC-Oin-079749	Oryza indica	40.66	1.00e-42	166.00
IUUC-Olo-080244	Oryza longistaminata	35.43	3.00e-40	159.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	1.00e-42	166.00
IUUC-Opu-084065	Oryza punctata	41.08	6.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	1.00e-42	166.00
IUUC-Osa-085610	Oryza sativa	40.66	1.00e-42	166.00
IUUC-Ola-086814	Oryzias latipes	97.52	1.00e-167	582.00
IUUC-Oga-088399	Otolemur garnettii	100.00	1.00e-170	591.00
IUUC-Oar-089323	Ovis aries	96.81	0.00e+00	632.00
IUUC-Ptr-090692	Pan troglodytes	100.00	3.00e-171	593.00
IUUC-Pan-092012	Papio anubis	100.00	0.00e+00	655.00
IUUC-Psi-093687	Pelodiscus sinensis	95.24	2.00e-180	624.00
IUUC-Pma-094387	Petromyzon marinus	93.66	2.00e-160	557.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	7.00e-41	160.00
IUUC-Pfo-097134	Poecilia formosa	97.52	1.00e-167	582.00
IUUC-Pab-097555	Pongo abelii	100.00	0.00e+00	655.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	171.00
IUUC-Ppe-101760	Prunus persica	36.10	7.00e-44	170.00
IUUC-Rno-104866	Rattus norvegicus	99.65	4.00e-170	590.00
IUUC-Sha-106547	Sarcophilus harrisii	97.12	0.00e+00	634.00
IUUC-Smo-109412	Selaginella moellendorffii	33.91	6.00e-40	157.00
IUUC-Sit-110595	Setaria italica	37.45	1.00e-41	163.00
IUUC-Sly-111259	Solanum lycopersicum	38.04	3.00e-41	162.00
IUUC-Stu-112571	Solanum tuberosum	38.04	3.00e-41	162.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	3.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	99.65	6.00e-170	589.00
IUUC-Tru-118250	Takifugu rubripes	92.91	2.00e-158	551.00
IUUC-Tni-120488	Tetraodon nigroviridis	97.16	3.00e-164	570.00
IUUC-Tca-121228	Theobroma cacao	35.50	4.00e-41	161.00
IUUC-Tae-123647	Triticum aestivum	37.09	2.00e-44	172.00
IUUC-Tur-126259	Triticum urartu	34.88	8.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	4.00e-143	500.00
IUUC-Vvi-131233	Vitis vinifera	34.60	1.00e-42	166.00
IUUC-Xtr-132553	Xenopus tropicalis	99.29	3.00e-170	590.00
IUUC-Xma-133670	Xiphophorus maculatus	97.52	1.00e-167	582.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence