iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132278

Ensembl Protein ID

ENSXETP00000051195.2

UniProt Accession

F7E182; F7E182_XENTR

Genbank Protein ID

ENSXETP00000051195

Protein Name

Bromodomain and WD repeat domain-containing 1

Genbank Nucleotide ID

AAMC01084193

Gene Name

brwd1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000023728.5	ENSXETT00000051195.2	ENSXETP00000051195.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.20e-29	98.8	169	206
UBD/Beta-Prp	4.90e-55	187.0	311	526

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+af  + +++ +G+dDg +k+W++++g+l+
   Q: 169  GHRSSVYCVAFdRTgHRIFTGADDGLVKIWSTHDGRLI 206
           8**********955599*****************9986 PP

UBD/Beta-Prp

   S: 54   evtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee......... 131
           +  ++++s  g +l+tg++Dr+i+++    +t+k ++ l+gh+d + s++f  sg+++vsGs+d t+r+w l+++ + +          
   Q: 311  QMLCCSCSAGGMYLATGGSDRAIRIYffGCETPKKLIQLEGHNDIIDSVQFANSGERFVSGSNDGTARIWYLHEQNWKSIrldmregdk 399
           567999999999**************9999******************************************999999889******** PP
   S: 132  ....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtge 213
                ++ ++  v +++++ ++  +v++s+ r +++W ++tgkllr l+g h++++y l+   fds  + ++s+++dg++++wd+ +g+
   Q: 400  dseeEEQLTRPKVLMITWDLTDATVVTASNLRSLKVWESRTGKLLRVLSG-HQNDIYVLEphpFDS--RVMISAGYDGKIIIWDVNKGD 485
           *998778888899************************************9.*********877777..99****************766 PP
   S: 214  c...vrtlnght..dnvksvrfspnderlvsgssDgsiriW 249
                   ++h+    +++ ++s ++++++s+ s+g + i+
   Q: 486  QikcYCNTIEHEghGAILDCKLSVDGQHIASTDSHGHLLIF 526
           41114444445555778888999999999999999998886 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

ELHFLIARFL SNGPYHKTAE VRIKPTEQFN LLAFPKRLDW LGNEHGRSFE EMVSANNHVS 60
SDHLLKICQH LGSLLDNITP CNVQTGSLLG AGKQSLLRTE KGCKNVQWNR QMLAALHRGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTTGCACT TCTTAATTGC TCGTTTCCTT TCAAATGGGC CCTACCACAA AACTGCAGAG 60
GTAAGGATTA AGCCAACTGA ACAGTTCAAC TTACTTTTAT GTTGGTGTGG ATGAGTTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csa-023352	Chlorocebus sabaeus	55.91	0.00e+00	1447.00
IUUC-Cin-025553	Ciona intestinalis	38.48	1.00e-106	380.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	59.93	0.00e+00	685.00
IUUC-Lch-049662	Latimeria chalumnae	54.67	0.00e+00	1498.00
IUUC-Loc-052853	Lepisosteus oculatus	53.84	0.00e+00	1422.00
IUUC-Mcc-054638	Macaca mulatta	55.89	0.00e+00	1576.00
IUUC-Nle-069402	Nomascus leucogenys	55.19	0.00e+00	1569.00
IUUC-Ont-072298	Oreochromis niloticus	52.39	0.00e+00	1457.00
IUUC-Pan-092444	Papio anubis	55.86	0.00e+00	1570.00
IUUC-Pfo-097318	Poecilia formosa	51.92	0.00e+00	1389.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence