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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046831
UUCD1 version UUC-HoS-00003
Ensembl Protein ID ENSP00000358815.5
UniProt Accession A8MQ27; C9DQJ5; C9DQJ6; C9DQJ7; NEU1B_HUMAN
Genbank Protein ID ACV53563.1; ACV53564.1; ACV53565.1; ENSP00000358815
Protein Name E3 ubiquitin-protein ligase NEURL1B; Neuralized-2; Neuralized-like protein 1B; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL1B
Genbank Nucleotide ID GQ414757; GQ414758; GQ414759; AC027309
Gene Name NEURL1B; NEURL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000214357.8 ENST00000520919.5 ENSP00000429797.1
ENSG00000214357.8 ENST00000522853.5 ENSP00000430001.1
ENSG00000214357.8 ENST00000369800.5 ENSP00000358815.5
Annotation
Cancer Mutation
ICGCCOSMICCGAPIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanmiRcode
RAID2
Protein-protein Interaction
IIDInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17003037
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.68 12.2 503 543
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgH.vfhadClqkwpglknssskefrCPlCr 46
           C +C++   d +++  CgH + +++C  ++     + + ++ CP+Cr
   Q: 503  CTVCFDGEVD-TVIYTCGHmCLCHSCGLRL-----KRQARACCPICR 543
           99****9999.88899***555****6555.....699999*****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
 E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
Protein Sequence
(Fasta)
MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV RLDGHSRRAT 60
RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG FTAHDPSLMS AQDIPKYACP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046831|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCCCAGCTG CCGCCCGCCG GCTCGCCCGT GCAGCTGCGA TGCCCCGGAG CGTCGACCCC 60
GGTCCTGGTC CCTGGCCCGC CGCGTAATTA GCCTCCGCGC GCCCAGAGCG CGCCGCCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046831|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR006573--NHR_dom
IPR001841--Znf_RING
PROSITE

PS51065--NHR
PS50089--ZF_RING_2
Pfam

PF07177--Neuralized
SMART

SM00588--NEUZ
Gene Ontology

GO:0005769--C:early endosome
GO:0016874--F:ligase activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
GO:0070086--P:ubiquitin-dependent endocytosis
KEGG hsa:54492
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000891 Aegilops tauschii 42.86 2.00e-10 61.20
IUUC-Aml-002324 Ailuropoda melanoleuca 95.58 3.00e-126 445.00
IUUC-Atr-002944 Amborella trichopoda 45.61 4.00e-11 63.90
IUUC-Apl-003920 Anas platyrhynchos 70.00 0.00e+00 636.00
IUUC-Aca-005343 Anolis carolinensis 65.54 5.00e-162 564.00
IUUC-Aly-006153 Arabidopsis lyrata 43.10 2.00e-10 62.00
IUUC-Ath-006731 Arabidopsis thaliana 43.10 1.00e-10 62.00
IUUC-Ate-010322 Aspergillus terreus 42.31 5.00e-09 57.40
IUUC-Ame-010891 Astyanax mexicanus 42.49 5.00e-86 311.00
IUUC-Bta-013255 Bos taurus 94.16 0.00e+00 643.00
IUUC-Bdi-014456 Brachypodium distachyon 45.28 3.00e-11 64.30
IUUC-Bol-016142 Brassica oleracea 48.28 9.00e-13 69.30
IUUC-Bra-016808 Brassica rapa 48.28 7.00e-13 69.70
IUUC-Cja-019314 Callithrix jacchus 98.20 0.00e+00 861.00
IUUC-Cfa-021151 Canis familiaris 98.02 0.00e+00 815.00
IUUC-Cpo-022395 Cavia porcellus 73.48 1.00e-172 599.00
IUUC-Csa-024268 Chlorocebus sabaeus 99.46 0.00e+00 881.00
IUUC-Cho-025082 Choloepus hoffmanni 97.22 5.00e-92 331.00
IUUC-Cin-025529 Ciona intestinalis 38.51 2.00e-32 134.00
IUUC-Csv-026316 Ciona savignyi 27.16 9.00e-55 207.00
IUUC-Dre-028687 Danio rerio 58.33 8.00e-174 603.00
IUUC-Dno-029754 Dasypus novemcinctus 92.25 0.00e+00 763.00
IUUC-Dor-030366 Dipodomys ordii 90.49 0.00e+00 826.00
IUUC-Dme-032154 Drosophila melanogaster 37.29 9.00e-34 138.00
IUUC-Fca-035976 Felis catus 84.29 1.00e-89 323.00
IUUC-Fal-036894 Ficedula albicollis 69.06 5.00e-180 624.00
IUUC-Gmo-038673 Gadus morhua 73.68 1.00e-68 253.00
IUUC-Gga-041040 Gallus gallus 69.29 0.00e+00 647.00
IUUC-Gac-042143 Gasterosteus aculeatus 54.55 1.00e-110 393.00
IUUC-Gma-043468 Glycine max 45.45 7.00e-12 66.60
IUUC-Ggo-045648 Gorilla gorilla 94.79 0.00e+00 832.00
IUUC-Hvu-047768 Hordeum vulgare 42.86 7.00e-11 62.40
IUUC-Itr-048936 Ictidomys tridecemlineatus 97.87 4.00e-135 473.00
IUUC-Lch-049591 Latimeria chalumnae 66.42 1.00e-174 605.00
IUUC-Lpe-051170 Leersia perrieri 45.45 8.00e-12 65.50
IUUC-Loc-052110 Lepisosteus oculatus 60.84 9.00e-163 566.00
IUUC-Laf-054262 Loxodonta africana 94.01 0.00e+00 783.00
IUUC-Mcc-055333 Macaca mulatta 99.62 0.00e+00 845.00
IUUC-Meu-056023 Macropus eugenii 65.69 2.00e-170 592.00
IUUC-Mtr-058048 Medicago truncatula 44.64 5.00e-11 63.50
IUUC-Mga-059732 Meleagris gallopavo 63.24 2.00e-168 585.00
IUUC-Mdo-061835 Monodelphis domestica 69.82 0.00e+00 658.00
IUUC-Mmu-063122 Mus musculus 91.17 0.00e+00 870.00
IUUC-Mac-064976 Musa acuminata 44.64 2.00e-11 64.70
IUUC-Mpu-066450 Mustela putorius furo 98.20 0.00e+00 835.00
IUUC-Mlu-067385 Myotis lucifugus 56.37 8.00e-98 350.00
IUUC-Nle-069149 Nomascus leucogenys 80.17 1.00e-161 562.00
IUUC-Opr-070822 Ochotona princeps 94.40 0.00e+00 880.00
IUUC-Ont-072255 Oreochromis niloticus 63.09 1.00e-159 556.00
IUUC-Oan-073429 Ornithorhynchus anatinus 41.58 4.00e-87 315.00
IUUC-Ocu-074215 Oryctolagus cuniculus 71.33 3.00e-158 551.00
IUUC-Oba-075400 Oryza barthii 45.45 1.00e-11 64.70
IUUC-Obr-076257 Oryza brachyantha 45.45 5.00e-12 65.90
IUUC-Ogl-077249 Oryza glaberrima 45.45 1.00e-11 65.50
IUUC-Ogu-078361 Oryza glumaepatula 42.86 4.00e-11 63.90
IUUC-Oin-080213 Oryza indica 45.45 1.00e-11 65.10
IUUC-Olo-080683 Oryza longistaminata 45.45 1.00e-11 64.70
IUUC-Ome-081101 Oryza meridionalis 45.45 1.00e-11 65.50
IUUC-Oni-082539 Oryza nivara 45.45 1.00e-11 65.50
IUUC-Opu-083826 Oryza punctata 45.45 1.00e-11 65.50
IUUC-Oru-084786 Oryza rufipogon 45.45 1.00e-11 65.10
IUUC-Osa-085344 Oryza sativa 45.45 1.00e-11 65.50
IUUC-Ola-086439 Oryzias latipes 57.82 8.00e-116 410.00
IUUC-Oga-088419 Otolemur garnettii 95.84 0.00e+00 835.00
IUUC-Oar-090002 Ovis aries 70.34 3.00e-128 452.00
IUUC-Ptr-091650 Pan troglodytes 99.64 0.00e+00 880.00
IUUC-Pan-092859 Papio anubis 99.55 0.00e+00 691.00
IUUC-Psi-092984 Pelodiscus sinensis 69.00 0.00e+00 635.00
IUUC-Ppa-095606 Physcomitrella patens 47.46 2.00e-10 61.20
IUUC-Pfo-097341 Poecilia formosa 59.23 1.00e-149 523.00
IUUC-Pab-097779 Pongo abelii 98.92 0.00e+00 894.00
IUUC-Pop-099007 Populus trichocarpa 46.43 3.00e-11 64.30
IUUC-Pca-100160 Procavia capensis 50.32 2.00e-47 184.00
IUUC-Ppe-102105 Prunus persica 44.64 9.00e-11 62.80
IUUC-Pva-102531 Pteropus vampyrus 96.94 0.00e+00 793.00
IUUC-Rno-105206 Rattus norvegicus 91.17 0.00e+00 883.00
IUUC-Sha-107468 Sarcophilus harrisii 69.27 0.00e+00 636.00
IUUC-Smo-108729 Selaginella moellendorffii 38.71 1.00e-08 55.10
IUUC-Sit-110065 Setaria italica 47.17 9.00e-11 62.40
IUUC-Sly-111868 Solanum lycopersicum 45.61 4.00e-11 63.90
IUUC-Stu-112627 Solanum tuberosum 45.61 4.00e-11 63.90
IUUC-Sbi-114634 Sorghum bicolor 41.07 2.00e-10 61.60
IUUC-Tgu-116692 Taeniopygia guttata 71.40 1.00e-179 622.00
IUUC-Tru-118732 Takifugu rubripes 59.43 4.00e-140 491.00
IUUC-Tni-120907 Tetraodon nigroviridis 59.73 5.00e-78 285.00
IUUC-Tca-121136 Theobroma cacao 44.64 1.00e-10 62.40
IUUC-Tae-123897 Triticum aestivum 43.64 2.00e-11 64.70
IUUC-Tur-126117 Triticum urartu 43.64 1.00e-11 64.30
IUUC-Tbe-127614 Tupaia belangeri 52.94 5.00e-33 135.00
IUUC-Ttr-128919 Tursiops truncatus 82.87 0.00e+00 668.00
IUUC-Vpa-130273 Vicugna pacos 99.44 3.00e-94 339.00
IUUC-Vvi-131271 Vitis vinifera 44.64 1.00e-10 62.40
IUUC-Xtr-132312 Xenopus tropicalis 64.34 4.00e-169 587.00
IUUC-Xma-134204 Xiphophorus maculatus 59.34 1.00e-149 523.00
Created Date 25-Jun-2017

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