iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006915

UUCD1 version

UUC-ArT-01597

Ensembl Protein ID

AT1G23260.1

UniProt Accession

Q93YP0; Q9LR36; UEV1A_ARATH

Genbank Protein ID

AAF87019.1; AEE30365.1; AAL24378.1; AAM13339.1

Protein Name

Ubiquitin-conjugating enzyme E2 variant 1A; Protein MMS ZWEI HOMOLOG 1

Genbank Nucleotide ID

AC005292; CP002684; AY059896; AY093340

Gene Name

UEV1A; MMZ1; At1g23260; F26F24.10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G23260	AT1G23260.1	AT1G23260.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UEV	E2_UEV	18178771

Classification

Family	E-value	Score	Start	End
E2/UBC	4.70e-20	72.7	32	137
E2/UEV	7.10e-71	237.6	1	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 17   isakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvllsiqsll.a 110
           +s++++d +d  ++ w  +ilGp++t Yeg++F+l++ + ++YP +PP+v+f t+i   +v+++ G v  s++   ++W+  +++e++l+++++ + +
   Q: 32   VSYGMDDADDiyMQSWTGTILGPPNTAYEGKIFQLKLFCGKEYPESPPTVRFQTRINMACVNPEtGVVEPSLFPMLTNWRREYTMEDILVKLKKEMmT 129
           45556666557799************************************************999*******9889****************987735 PP
   S: 111  epnpespl 118
           + n + ++
   Q: 130  SHNRKLAQ 137
           55554444 PP

E2/UEV

   S: 2    vseselkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevndsnGv 99
           +s++e+kvvvprnfrlleele+gekg+gdgtvsyg+dD+ddi+++s+tgtI+gp++tayeg+I+qlklf+gk+YPe+PPtvrf+++inma+vn+++Gv
   Q: 1    MSSEEAKVVVPRNFRLLEELERGEKGIGDGTVSYGMDDADDIYMQSWTGTILGPPNTAYEGKIFQLKLFCGKEYPESPPTVRFQTRINMACVNPETGV 98
           6899********************************************************************************************** PP
   S: 100  vdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGn 143
           v+p+ +p+L+nW+rey++e++lv+lkke+++++nrkl+qPpeGn
   Q: 99   VEPSLFPMLTNWRREYTMEDILVKLKKEMMTSHNRKLAQPPEGN 142
           *******************************************8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. Probably not involved in the error-free DNA repair.

Protein Sequence
(Fasta)

MSSEEAKVVV PRNFRLLEEL ERGEKGIGDG TVSYGMDDAD DIYMQSWTGT ILGPPNTAYE 60
GKIFQLKLFC GKEYPESPPT VRFQTRINMA CVNPETGVVE PSLFPMLTNW RREYTMEDIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTATAGA AAGGCTTCTT CTTCTTCTGC TCTCAAACAG TACTTTGAAC ATTCTCTCTC 60
TCTCTTTTAT CTCTGAGATT GCTTCTTCGC TATTGCTCAA TTCTCTCTCT CACCTAACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

KEGG

ath:AT1G23260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000636	Aegilops tauschii	72.19	2.00e-61	228.00
IUUC-Aml-001242	Ailuropoda melanoleuca	54.07	1.00e-37	150.00
IUUC-Apl-003600	Anas platyrhynchos	54.07	2.00e-38	150.00
IUUC-Aca-004448	Anolis carolinensis	53.73	3.00e-37	146.00
IUUC-Aly-006115	Arabidopsis lyrata	97.47	6.00e-87	311.00
IUUC-Ago-007810	Ashbya gossypii	55.64	4.00e-36	142.00
IUUC-Ani-009325	Aspergillus nidulans	50.36	4.00e-35	139.00
IUUC-Bol-015658	Brassica oleracea	96.84	5.00e-86	309.00
IUUC-Bra-017054	Brassica rapa	97.47	1.00e-86	310.00
IUUC-Cfa-021118	Canis familiaris	54.07	3.00e-38	150.00
IUUC-Cpo-021317	Cavia porcellus	52.99	1.00e-41	160.00
IUUC-Csa-024275	Chlorocebus sabaeus	54.07	1.00e-37	149.00
IUUC-Cne-026817	Cryptococcus neoformans	53.79	2.00e-42	164.00
IUUC-Cme-027257	Cyanidioschyzon merolae	54.55	7.00e-31	125.00
IUUC-Dno-029762	Dasypus novemcinctus	54.07	2.00e-38	150.00
IUUC-Dor-030185	Dipodomys ordii	66.67	2.00e-15	74.30
IUUC-Dme-031635	Drosophila melanogaster	47.52	6.00e-41	159.00
IUUC-Ete-033017	Echinops telfairi	52.24	1.00e-35	143.00
IUUC-Eca-034422	Equus caballus	53.68	9.00e-39	151.00
IUUC-Eeu-035327	Erinaceus europaeus	54.07	6.00e-38	150.00
IUUC-Fca-035746	Felis catus	52.99	1.00e-41	160.00
IUUC-Fal-037350	Ficedula albicollis	54.07	2.00e-38	150.00
IUUC-Fso-038147	Fusarium solani	55.64	1.00e-38	150.00
IUUC-Gma-043467	Glycine max	79.87	2.00e-70	257.00
IUUC-Ggo-044696	Gorilla gorilla	52.99	7.00e-42	162.00
IUUC-Itr-048139	Ictidomys tridecemlineatus	54.07	3.00e-38	149.00
IUUC-Lch-050494	Latimeria chalumnae	52.99	2.00e-41	160.00
IUUC-Lpe-050978	Leersia perrieri	76.92	2.00e-60	224.00
IUUC-Mcc-055788	Macaca mulatta	54.07	1.00e-37	150.00
IUUC-Mtr-058655	Medicago truncatula	79.29	1.00e-62	231.00
IUUC-Mla-058919	Melampsora laricipopulina	60.61	1.00e-36	144.00
IUUC-Mga-059210	Meleagris gallopavo	53.73	2.00e-37	147.00
IUUC-Mmr-061751	Microcebus murinus	51.49	2.00e-40	157.00
IUUC-Mdo-062503	Monodelphis domestica	53.33	1.00e-37	147.00
IUUC-Mmu-063294	Mus musculus	53.73	2.00e-42	163.00
IUUC-Mac-065408	Musa acuminata	74.68	1.00e-65	241.00
IUUC-Mlu-067702	Myotis lucifugus	52.99	1.00e-41	160.00
IUUC-Nfi-068400	Neosartorya fischeri	44.79	4.00e-28	115.00
IUUC-Opr-070859	Ochotona princeps	50.77	8.00e-33	133.00
IUUC-Ocu-073859	Oryctolagus cuniculus	52.99	7.00e-42	162.00
IUUC-Oba-075192	Oryza barthii	72.50	7.00e-64	234.00
IUUC-Obr-076537	Oryza brachyantha	74.17	2.00e-63	233.00
IUUC-Ogl-077199	Oryza glaberrima	72.50	7.00e-64	234.00
IUUC-Ogu-078862	Oryza glumaepatula	72.50	7.00e-64	234.00
IUUC-Oin-079321	Oryza indica	72.50	7.00e-64	234.00
IUUC-Ome-081774	Oryza meridionalis	72.50	7.00e-64	234.00
IUUC-Oni-083086	Oryza nivara	72.50	7.00e-64	234.00
IUUC-Opu-083978	Oryza punctata	72.50	8.00e-64	234.00
IUUC-Osa-086254	Oryza sativa	72.50	7.00e-64	234.00
IUUC-Oga-087972	Otolemur garnettii	54.07	3.00e-38	149.00
IUUC-Oar-090166	Ovis aries	54.07	7.00e-38	150.00
IUUC-Pan-091955	Papio anubis	52.99	7.00e-42	162.00
IUUC-Pab-098753	Pongo abelii	52.99	7.00e-42	162.00
IUUC-Pca-100723	Procavia capensis	54.07	9.00e-38	150.00
IUUC-Ppe-101725	Prunus persica	81.13	7.00e-72	261.00
IUUC-Pva-102989	Pteropus vampyrus	52.99	7.00e-42	162.00
IUUC-Sce-106349	Saccharomyces cerevisiae	56.82	2.00e-34	137.00
IUUC-Sha-106779	Sarcophilus harrisii	54.07	2.00e-38	150.00
IUUC-Sja-107722	Schizosaccharomyces japonicus	56.39	4.00e-33	132.00
IUUC-Sit-109746	Setaria italica	73.29	6.00e-64	235.00
IUUC-Sar-113197	Sorex araneus	61.54	4.00e-30	124.00
IUUC-Sbi-114473	Sorghum bicolor	73.75	4.00e-64	236.00
IUUC-Tgu-117289	Taeniopygia guttata	54.07	5.00e-38	149.00
IUUC-Tru-118526	Takifugu rubripes	52.59	3.00e-28	116.00
IUUC-Tni-120169	Tetraodon nigroviridis	48.55	1.00e-27	114.00
IUUC-Tca-121025	Theobroma cacao	81.13	1.00e-72	265.00
IUUC-Tae-124991	Triticum aestivum	72.50	3.00e-63	233.00
IUUC-Tur-126426	Triticum urartu	73.15	2.00e-61	227.00
IUUC-Tbe-128105	Tupaia belangeri	52.99	4.00e-40	157.00
IUUC-Ttr-128790	Tursiops truncatus	54.07	8.00e-38	150.00
IUUC-Vpa-130575	Vicugna pacos	54.07	6.00e-38	150.00
IUUC-Vvi-130831	Vitis vinifera	79.87	2.00e-71	259.00
IUUC-Xtr-132359	Xenopus tropicalis	53.33	1.00e-36	144.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence