iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053651

UUCD1 version

UUC-LoA-00554

Ensembl Protein ID

ENSLAFP00000013336.4

UniProt Accession

G3TFY1; G3TFY1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

SH3RF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000015901.4	ENSLAFT00000015901.4	ENSLAFP00000013336.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.40e-08	33.2	12	53
UBD/SH3	1.80e-47	159.5	442	497

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle+++   +vlpC+H+f++ Cl  +      s++e rCP Cr
   Q: 12   CPVCLERLDASAKVLPCQHTFCKRCLLGI----VGSRNELRCPECR 53
           **********9**************9777....899*********8 PP

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +  ++y+y++ ++deL+l+kG++ lv  + +   gW kg++  + k G+fP n+v+ +
   Q: 442  VYVAIYPYTPRKEDELELRKGEMFLVF-ERC-QDGWFKGTSMHTSKIGVFPGNYVAPV 497
           5679**********************9.555.569********************988 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP ECRTLVGSGV 60
EELPSNILLV RLLDGIKQRP WKPGPGGGGG TNCTNALRAQ SSTVCSTKDL QNSQGGQQPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGAAT CTGCCTTGTT GGATCTTCTG GAGTGTCCGG TGTGTCTAGA GCGGCTTGAT 60
GCTTCTGCAA AAGTCTTGCC TTGTCAGCAC ACGTTTTGCA AACGATGTTT GTTGGGGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001452--SH3_domain
IPR028502--SH3RF1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00018--SH3_1
PF14604--SH3_9
PF00097--zf-C3HC4

PRINTS

PR00452--SH3DOMAIN

SMART

SM00184--RING
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0046328--P:regulation of JNK cascade

KEGG

lav:100676529

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001528	Ailuropoda melanoleuca	90.32	0.00e+00	1323.00
IUUC-Apl-003961	Anas platyrhynchos	79.23	0.00e+00	1202.00
IUUC-Aca-004386	Anolis carolinensis	76.24	0.00e+00	1186.00
IUUC-Ame-010659	Astyanax mexicanus	59.61	0.00e+00	879.00
IUUC-Bta-012563	Bos taurus	65.36	2.00e-125	443.00
IUUC-Cja-019730	Callithrix jacchus	88.68	0.00e+00	1308.00
IUUC-Cfa-020992	Canis familiaris	88.40	0.00e+00	1367.00
IUUC-Cpo-021304	Cavia porcellus	89.79	0.00e+00	1397.00
IUUC-Csa-023925	Chlorocebus sabaeus	90.00	0.00e+00	1323.00
IUUC-Cho-024630	Choloepus hoffmanni	84.16	0.00e+00	905.00
IUUC-Cin-025274	Ciona intestinalis	45.69	2.00e-71	262.00
IUUC-Csv-026136	Ciona savignyi	41.69	2.00e-72	266.00
IUUC-Dre-028290	Danio rerio	61.54	0.00e+00	912.00
IUUC-Dno-029083	Dasypus novemcinctus	87.92	0.00e+00	1276.00
IUUC-Dor-030388	Dipodomys ordii	94.08	0.00e+00	664.00
IUUC-Dme-032207	Drosophila melanogaster	46.24	5.00e-65	242.00
IUUC-Ete-032809	Echinops telfairi	82.27	0.00e+00	876.00
IUUC-Eca-034185	Equus caballus	89.59	0.00e+00	1131.00
IUUC-Eeu-034816	Erinaceus europaeus	77.09	0.00e+00	1140.00
IUUC-Fca-036439	Felis catus	88.42	0.00e+00	1397.00
IUUC-Fal-037074	Ficedula albicollis	78.67	0.00e+00	1164.00
IUUC-Gmo-039443	Gadus morhua	60.75	8.00e-121	427.00
IUUC-Gga-040749	Gallus gallus	79.26	0.00e+00	1137.00
IUUC-Gac-041420	Gasterosteus aculeatus	74.25	5.00e-147	514.00
IUUC-Ggo-045215	Gorilla gorilla	90.33	0.00e+00	1349.00
IUUC-Hsa-046315	Homo sapiens	89.89	0.00e+00	1341.00
IUUC-Itr-048265	Ictidomys tridecemlineatus	87.10	7.00e-151	526.00
IUUC-Lch-049453	Latimeria chalumnae	70.30	0.00e+00	899.00
IUUC-Loc-052248	Lepisosteus oculatus	36.36	8.00e-77	281.00
IUUC-Mcc-054688	Macaca mulatta	89.46	0.00e+00	1341.00
IUUC-Meu-056291	Macropus eugenii	74.78	0.00e+00	793.00
IUUC-Mor-056932	Magnaporthe oryzae	39.34	8.00e-12	66.60
IUUC-Mga-059944	Meleagris gallopavo	78.71	0.00e+00	1174.00
IUUC-Mmr-061553	Microcebus murinus	88.18	0.00e+00	1255.00
IUUC-Mdo-062313	Monodelphis domestica	77.72	0.00e+00	1176.00
IUUC-Mmu-063516	Mus musculus	89.06	0.00e+00	1390.00
IUUC-Mpu-066064	Mustela putorius furo	88.74	0.00e+00	1327.00
IUUC-Mlu-067312	Myotis lucifugus	86.51	0.00e+00	1257.00
IUUC-Nle-069035	Nomascus leucogenys	89.65	0.00e+00	1345.00
IUUC-Opr-070690	Ochotona princeps	82.65	0.00e+00	636.00
IUUC-Ont-071484	Oreochromis niloticus	63.17	0.00e+00	722.00
IUUC-Oan-073305	Ornithorhynchus anatinus	81.76	0.00e+00	1215.00
IUUC-Ocu-074936	Oryctolagus cuniculus	89.42	0.00e+00	1353.00
IUUC-Ola-086675	Oryzias latipes	62.07	1.00e-177	617.00
IUUC-Oga-087933	Otolemur garnettii	80.76	0.00e+00	1019.00
IUUC-Oar-090408	Ovis aries	63.91	6.00e-113	401.00
IUUC-Ptr-090865	Pan troglodytes	90.11	0.00e+00	1346.00
IUUC-Pan-092362	Papio anubis	90.11	0.00e+00	1322.00
IUUC-Psi-093876	Pelodiscus sinensis	78.47	0.00e+00	1179.00
IUUC-Pfo-097116	Poecilia formosa	60.67	0.00e+00	865.00
IUUC-Pab-098127	Pongo abelii	90.00	0.00e+00	1346.00
IUUC-Pca-100485	Procavia capensis	89.03	0.00e+00	1003.00
IUUC-Pva-102661	Pteropus vampyrus	87.06	0.00e+00	1249.00
IUUC-Rno-105728	Rattus norvegicus	87.76	0.00e+00	1338.00
IUUC-Sha-106515	Sarcophilus harrisii	84.35	0.00e+00	848.00
IUUC-Sar-113161	Sorex araneus	94.66	0.00e+00	642.00
IUUC-Ssc-115314	Sus scrofa	77.40	0.00e+00	1069.00
IUUC-Tgu-117012	Taeniopygia guttata	76.30	0.00e+00	1178.00
IUUC-Tru-118467	Takifugu rubripes	62.19	3.00e-164	572.00
IUUC-Tsy-119566	Tarsius syrichta	82.67	2.00e-175	609.00
IUUC-Tni-120830	Tetraodon nigroviridis	56.35	3.00e-170	592.00
IUUC-Tbe-128070	Tupaia belangeri	96.69	0.00e+00	712.00
IUUC-Ttr-128161	Tursiops truncatus	92.94	1.00e-134	474.00
IUUC-Xtr-132628	Xenopus tropicalis	75.77	0.00e+00	892.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence