iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000012993.3	ENSMMUT00000018229.3	ENSMMUP00000017066.2
ENSMMUG00000012993.3	ENSMMUT00000061103.1	ENSMMUP00000042251.1
ENSMMUG00000012993.3	ENSMMUT00000066100.1	ENSMMUP00000053126.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-76	257.5	527	853

Active Site

Position(s)	Description	Evidence
823	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l
   Q: 527  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFL 615
           355*****************************9999*99**********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeY 173
            l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      +++++++++f ++ +    l++++++eL+pgG+ i V + +++++
   Q: 616  VLALPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVMEG-----MDKETFEFKFGKELTFttvLSDQQVVELIPGGAGIIVGYGDRSRF 699
           **************************************5.....56666777777443334449************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  keqv+a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ ++++++ +q+Fwe+l++f++e+r+
   Q: 700  IQLVQKARLEE-SKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDSRVQYFWEALNNFTNEDRS 786
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 787  RFLRFVTGRSRLPA--------RIYIYPDklgYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAID 853
           *************5........6667777799999**********************************998776 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAGPGPGAVL ESPRQLLGRV RFLAEAARSL RAGRPLPAAL AFVPQEVLYK LYKDPAGPSR 60
VLLPVWEAEG LGLRVGAAGP APGTGSGPLR AARDSIELRR GACVRTTGEE LCNGHGLWVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGTGGGAA GCTCCGTCCG CGGTCGCGCC AGCTGTTCAC CGGGTAGGAT CGCCCTTAGG 60
CGCTCACCTC CGCCACTTAG CCATGGCGGG TCCTGGCCCG GGCGCGGTGC TGGAGTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

mcc:705051

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	97.68	0.00e+00	1671.00
IUUC-Apl-003715	Anas platyrhynchos	85.12	0.00e+00	1316.00
IUUC-Aca-004377	Anolis carolinensis	78.78	0.00e+00	1384.00
IUUC-Ame-011918	Astyanax mexicanus	64.17	0.00e+00	1117.00
IUUC-Bta-012736	Bos taurus	98.37	0.00e+00	1691.00
IUUC-Cja-019926	Callithrix jacchus	98.49	0.00e+00	1682.00
IUUC-Cfa-020753	Canis familiaris	98.44	0.00e+00	1175.00
IUUC-Cpo-021415	Cavia porcellus	97.33	0.00e+00	1664.00
IUUC-Csa-023096	Chlorocebus sabaeus	99.77	0.00e+00	1696.00
IUUC-Dre-028746	Danio rerio	69.17	0.00e+00	1196.00
IUUC-Dno-029293	Dasypus novemcinctus	97.93	0.00e+00	1073.00
IUUC-Dor-031113	Dipodomys ordii	98.36	0.00e+00	1238.00
IUUC-Ete-032601	Echinops telfairi	89.41	0.00e+00	1422.00
IUUC-Eca-034198	Equus caballus	95.70	0.00e+00	1639.00
IUUC-Eeu-034708	Erinaceus europaeus	97.32	0.00e+00	900.00
IUUC-Fca-035478	Felis catus	98.55	0.00e+00	1654.00
IUUC-Fal-037366	Ficedula albicollis	76.87	0.00e+00	1341.00
IUUC-Gmo-039020	Gadus morhua	75.46	0.00e+00	1045.00
IUUC-Gga-040332	Gallus gallus	79.48	0.00e+00	1402.00
IUUC-Gac-042336	Gasterosteus aculeatus	69.86	0.00e+00	1239.00
IUUC-Ggo-045382	Gorilla gorilla	99.77	0.00e+00	1699.00
IUUC-Hsa-046562	Homo sapiens	99.77	0.00e+00	1699.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	98.26	0.00e+00	1679.00
IUUC-Lch-049606	Latimeria chalumnae	65.21	0.00e+00	838.00
IUUC-Loc-052448	Lepisosteus oculatus	62.63	0.00e+00	1069.00
IUUC-Laf-054507	Loxodonta africana	97.10	0.00e+00	1694.00
IUUC-Meu-055970	Macropus eugenii	85.02	0.00e+00	1437.00
IUUC-Mga-059654	Meleagris gallopavo	85.32	0.00e+00	1302.00
IUUC-Mmr-061069	Microcebus murinus	98.49	0.00e+00	1681.00
IUUC-Mdo-062547	Monodelphis domestica	92.20	0.00e+00	791.00
IUUC-Mmu-063096	Mus musculus	97.56	0.00e+00	1671.00
IUUC-Mpu-065846	Mustela putorius furo	97.79	0.00e+00	1684.00
IUUC-Mlu-067992	Myotis lucifugus	97.04	0.00e+00	1568.00
IUUC-Nle-069565	Nomascus leucogenys	99.75	0.00e+00	1591.00
IUUC-Opr-070853	Ochotona princeps	84.30	0.00e+00	1016.00
IUUC-Ont-071628	Oreochromis niloticus	69.36	0.00e+00	1208.00
IUUC-Ocu-074094	Oryctolagus cuniculus	98.37	0.00e+00	1680.00
IUUC-Ola-087384	Oryzias latipes	69.49	0.00e+00	1254.00
IUUC-Oga-088224	Otolemur garnettii	98.02	0.00e+00	1678.00
IUUC-Oar-090043	Ovis aries	92.22	0.00e+00	1570.00
IUUC-Ptr-090852	Pan troglodytes	99.54	0.00e+00	1691.00
IUUC-Pan-092787	Papio anubis	100.00	0.00e+00	1701.00
IUUC-Psi-092986	Pelodiscus sinensis	72.57	0.00e+00	976.00
IUUC-Pma-094416	Petromyzon marinus	40.45	2.00e-175	609.00
IUUC-Pfo-096720	Poecilia formosa	69.54	0.00e+00	1250.00
IUUC-Pab-098325	Pongo abelii	99.26	0.00e+00	1307.00
IUUC-Pca-100885	Procavia capensis	83.01	0.00e+00	1196.00
IUUC-Pva-102829	Pteropus vampyrus	86.20	0.00e+00	1054.00
IUUC-Rno-104882	Rattus norvegicus	97.79	0.00e+00	1671.00
IUUC-Sha-106811	Sarcophilus harrisii	91.04	6.00e-116	410.00
IUUC-Sar-113020	Sorex araneus	83.14	0.00e+00	707.00
IUUC-Ssc-115436	Sus scrofa	98.52	1.00e-158	552.00
IUUC-Tgu-117042	Taeniopygia guttata	79.30	0.00e+00	1391.00
IUUC-Tru-118419	Takifugu rubripes	67.21	0.00e+00	1170.00
IUUC-Tsy-118829	Tarsius syrichta	97.73	0.00e+00	989.00
IUUC-Tni-120410	Tetraodon nigroviridis	56.43	0.00e+00	925.00
IUUC-Tbe-128113	Tupaia belangeri	98.43	0.00e+00	779.00
IUUC-Ttr-128167	Tursiops truncatus	93.84	0.00e+00	1611.00
IUUC-Xtr-132910	Xenopus tropicalis	64.46	0.00e+00	1078.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence