iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001376

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

ACTA01139232

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000017217.1	ENSAMET00000018946.1	ENSAMEP00000018207.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.40e-59	201.4	2	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkine...............................kr 64
           ++ ++e +P+++++++ ++gv +++++ ++ +L++e lg+++ p ++llllF+++                                ++
   Q: 2    QLKPMEINPEMLNKVLARLGVAGQWRFADVLGLEEEALGSVPAPACALLLLFPLTAqhclefqreeaaspfqhlnypekefilfmnsQH 90
           5789*********************************************************************************9999 PP
   S: 65   essrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedkl.ld..lGttlsrlkestkaespenkalalgnqqvleci 150
           e++rk+q++    e +++++  +++f+kq+igNsC+t++l+++++n++dkl +d   G+ l++++++t++ spe++a++++++++++++
   Q: 91   ENFRKKQIE----ELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLeFDkeDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAA 175
           99**99998....99***********************************9965227******************************** PP
   S: 151  hnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnll 239
           h+++a++++++ +          +k +fhf+++ n++g+lyeldg++pfP+++g+++e+  l+d++kv+r+f+er    e++e+rf+++
   Q: 176  HDAVAQEGQCRVD----------DKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTER----EQGEVRFSAV 250
           ***********99..........5679************************************************....********** PP
   S: 240  aivad 244
           a++++
   Q: 251  ALCKA 255
           **987 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLARL GVAGQWRFAD VLGLEEEALG SVPAPACALL LLFPLTAQHC 60
LEFQREEAAS PFQHLNYPEK EFILFMNSQH ENFRKKQIEE LKGQEVSPKV YFMKQTIGNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCTCA AACCGATGGA GATTAACCCC GAGGTGAGCG TCAGGTGCAC CGCTGCCCGG 60
GGAGCACGGA GCAGCGGGTC AACCTTCGCC GGGTAGCTGC CTCGATGACC GGTTTTATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003693	Anas platyrhynchos	62.65	3.00e-87	314.00
IUUC-Aca-004716	Anolis carolinensis	66.54	2.00e-95	341.00
IUUC-Ame-011806	Astyanax mexicanus	58.59	4.00e-79	286.00
IUUC-Bta-013521	Bos taurus	91.41	4.00e-124	436.00
IUUC-Cja-018752	Callithrix jacchus	84.38	1.00e-112	398.00
IUUC-Cfa-020442	Canis familiaris	85.99	6.00e-113	399.00
IUUC-Cpo-021723	Cavia porcellus	97.02	1.00e-93	335.00
IUUC-Csa-023626	Chlorocebus sabaeus	84.38	8.00e-112	395.00
IUUC-Cho-024548	Choloepus hoffmanni	68.35	5.00e-37	147.00
IUUC-Dre-027854	Danio rerio	56.81	4.00e-78	283.00
IUUC-Dno-029325	Dasypus novemcinctus	85.16	2.00e-113	400.00
IUUC-Dor-030114	Dipodomys ordii	83.20	7.00e-121	426.00
IUUC-Ete-033092	Echinops telfairi	95.21	3.00e-91	327.00
IUUC-Eca-033854	Equus caballus	97.22	6.00e-79	285.00
IUUC-Eeu-034493	Erinaceus europaeus	82.03	5.00e-108	383.00
IUUC-Fal-036693	Ficedula albicollis	63.79	1.00e-85	308.00
IUUC-Gmo-038848	Gadus morhua	53.06	4.00e-69	253.00
IUUC-Gga-041078	Gallus gallus	65.37	4.00e-95	340.00
IUUC-Gac-042064	Gasterosteus aculeatus	54.15	5.00e-72	263.00
IUUC-Ggo-044827	Gorilla gorilla	84.38	3.00e-112	397.00
IUUC-Hsa-045820	Homo sapiens	84.38	3.00e-112	397.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	85.55	3.00e-113	400.00
IUUC-Lch-050121	Latimeria chalumnae	63.92	2.00e-91	328.00
IUUC-Loc-052342	Lepisosteus oculatus	61.00	4.00e-86	310.00
IUUC-Laf-053916	Loxodonta africana	82.95	4.00e-110	390.00
IUUC-Mcc-054838	Macaca mulatta	84.38	8.00e-112	395.00
IUUC-Meu-056478	Macropus eugenii	77.73	1.00e-114	404.00
IUUC-Mga-059878	Meleagris gallopavo	64.00	5.00e-89	320.00
IUUC-Mdo-062544	Monodelphis domestica	76.95	6.00e-104	369.00
IUUC-Mmu-063300	Mus musculus	85.55	4.00e-123	433.00
IUUC-Mpu-066128	Mustela putorius furo	84.55	1.00e-99	355.00
IUUC-Mlu-067778	Myotis lucifugus	83.98	5.00e-121	426.00
IUUC-Nle-069686	Nomascus leucogenys	84.38	4.00e-112	396.00
IUUC-Opr-070535	Ochotona princeps	96.41	1.00e-93	335.00
IUUC-Ont-071510	Oreochromis niloticus	54.51	1.00e-73	268.00
IUUC-Ocu-074590	Oryctolagus cuniculus	84.38	1.00e-112	398.00
IUUC-Oga-089013	Otolemur garnettii	88.67	5.00e-119	419.00
IUUC-Oar-089861	Ovis aries	92.19	2.00e-125	441.00
IUUC-Ptr-091536	Pan troglodytes	82.81	9.00e-110	389.00
IUUC-Pan-092909	Papio anubis	84.38	8.00e-112	395.00
IUUC-Psi-093818	Pelodiscus sinensis	69.26	6.00e-98	349.00
IUUC-Pfo-097335	Poecilia formosa	51.16	2.00e-71	261.00
IUUC-Pab-098048	Pongo abelii	84.38	3.00e-112	397.00
IUUC-Pca-100818	Procavia capensis	63.16	9.00e-62	229.00
IUUC-Pva-102954	Pteropus vampyrus	84.38	4.00e-108	383.00
IUUC-Rno-105966	Rattus norvegicus	85.55	4.00e-123	433.00
IUUC-Sha-107111	Sarcophilus harrisii	87.43	2.00e-86	310.00
IUUC-Sar-113190	Sorex araneus	76.32	1.00e-38	151.00
IUUC-Ssc-115908	Sus scrofa	70.16	4.00e-95	340.00
IUUC-Tgu-117465	Taeniopygia guttata	60.25	2.00e-79	287.00
IUUC-Tru-118565	Takifugu rubripes	51.90	7.00e-63	233.00
IUUC-Tsy-119561	Tarsius syrichta	95.81	1.00e-91	328.00
IUUC-Tbe-128048	Tupaia belangeri	94.61	2.00e-91	327.00
IUUC-Ttr-128494	Tursiops truncatus	84.31	9.00e-110	389.00
IUUC-Xtr-132286	Xenopus tropicalis	60.16	5.00e-85	306.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence