iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020262

Ensembl Protein ID

ENSCAFP00000017015.3

UniProt Accession

E2R7N4; E2R7N4_CANLF

Genbank Protein ID

ENSCAFP00000017015

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03017021

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000011559.3	ENSCAFT00000018370.3	ENSCAFP00000017015.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-11	43.5	435	486

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++lydy+++ +de ++   d+++ i  e  degW++g    +g  GlfP+n+v+ l
   Q: 435  IALYDYQGEGSDEISFDPDDIITDI--EMVDEGWWRG--RCHGHFGLFPANYVKLL 486
           79**********************9..9*********..8*************977 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDILKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAARGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGGAACTG ACTCAAACTT CAGGAAGTAG CTATGAGGAC AGGGTGTCAG GAAATGACAG 60
AAAACCTGAA TACGGAACTG AAGCAGCAGC TCAGAGCTTC TTGCTCTGAA GTGGCAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

KEGG

cfa:100684969

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	88.87	0.00e+00	771.00
IUUC-Bta-012591	Bos taurus	92.37	1.00e-167	582.00
IUUC-Cja-019982	Callithrix jacchus	82.52	0.00e+00	676.00
IUUC-Cpo-021362	Cavia porcellus	80.33	0.00e+00	636.00
IUUC-Csa-023911	Chlorocebus sabaeus	91.50	1.00e-170	592.00
IUUC-Dor-030437	Dipodomys ordii	72.45	8.00e-169	586.00
IUUC-Ete-033160	Echinops telfairi	72.67	2.00e-148	518.00
IUUC-Eca-033269	Equus caballus	88.19	0.00e+00	724.00
IUUC-Eeu-035032	Erinaceus europaeus	71.10	6.00e-123	434.00
IUUC-Fca-035999	Felis catus	89.58	0.00e+00	777.00
IUUC-Gga-040335	Gallus gallus	67.14	5.00e-106	377.00
IUUC-Ggo-044505	Gorilla gorilla	80.89	0.00e+00	675.00
IUUC-Hsa-046728	Homo sapiens	90.11	1.00e-168	585.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	65.71	2.00e-163	568.00
IUUC-Laf-054202	Loxodonta africana	82.93	0.00e+00	661.00
IUUC-Mcc-055824	Macaca mulatta	91.24	1.00e-171	595.00
IUUC-Mmr-061281	Microcebus murinus	72.86	3.00e-164	571.00
IUUC-Mdo-062515	Monodelphis domestica	68.27	2.00e-149	521.00
IUUC-Mmu-064341	Mus musculus	82.72	0.00e+00	671.00
IUUC-Mpu-066565	Mustela putorius furo	90.16	0.00e+00	742.00
IUUC-Mlu-066942	Myotis lucifugus	84.29	0.00e+00	670.00
IUUC-Nle-069436	Nomascus leucogenys	90.96	8.00e-171	593.00
IUUC-Opr-070288	Ochotona princeps	74.59	8.00e-165	573.00
IUUC-Ocu-074686	Oryctolagus cuniculus	81.84	2.00e-177	615.00
IUUC-Ola-086894	Oryzias latipes	59.44	9.00e-94	337.00
IUUC-Oga-088585	Otolemur garnettii	74.80	0.00e+00	647.00
IUUC-Oar-089686	Ovis aries	85.63	0.00e+00	708.00
IUUC-Ptr-090461	Pan troglodytes	90.96	3.00e-170	591.00
IUUC-Pan-091887	Papio anubis	91.24	3.00e-171	594.00
IUUC-Psi-093785	Pelodiscus sinensis	68.90	6.00e-113	401.00
IUUC-Pab-098222	Pongo abelii	90.40	5.00e-169	587.00
IUUC-Pca-100668	Procavia capensis	83.51	0.00e+00	671.00
IUUC-Pva-102767	Pteropus vampyrus	73.62	5.00e-166	577.00
IUUC-Rno-106001	Rattus norvegicus	81.50	0.00e+00	670.00
IUUC-Sar-113338	Sorex araneus	76.96	2.00e-170	592.00
IUUC-Ssc-116027	Sus scrofa	86.79	0.00e+00	721.00
IUUC-Tgu-117472	Taeniopygia guttata	56.39	4.00e-145	508.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence