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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045831
Ensembl Protein ID ENSP00000266269.5
UniProt Accession Q9HBE1; Q9HBE2; Q9HBE3; Q9P1A9; Q9UDU0; Q9Y529; PATZ1_HUMAN
Genbank Protein ID AAF32518.1; AAG09031.1; AAG09032.1; AAG09033.1; AAG09034.1; AAK19024.1; CAB51404.1; CAG30499.1; AAF01349.1; AAH21091.1
Protein Name POZ-, AT hook-, and zinc finger-containing protein 1; BTB/POZ domain zinc finger transcription factor; Protein kinase A RI subunit alpha-associated protein; Zinc finger and BTB domain-containing protein 19; Zinc finger protein 278; Zinc finger sarcoma gene protein
Genbank Nucleotide ID AF119256; AF254082; AF254083; AF254084; AF254085; AY028384; AL096880; CR456613; AC005003; BC021091
Gene Name PATZ1; PATZ; RIAZ; ZBTB19; ZNF278; ZSG
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100105.17 ENST00000266269.9 ENSP00000266269.5
ENSG00000100105.17 ENST00000405309.7 ENSP00000384173.3
ENSG00000100105.17 ENST00000351933.8 ENSP00000337520.4
ENSG00000100105.17 ENST00000215919.3 ENSP00000215919.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDA
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.90e-13 51.6 41 126
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees......................ksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+l vg+e f+ah++vLaa+S++F++ f+ +l ++                        + + e++ ++ +vf ++l+F Yt+++
   Q: 41   CDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGgaadggpadvggataapgggagG-SRELEMHTISSKVFGDILDFAYTSRI 126
           8**********************************999********************54.8899999****************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional repressor.
 Transcriptional repressor.
Protein Sequence
(Fasta)
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE SFPAHRAVLA 60
ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG SRELEMHTIS SKVFGDILDF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045831|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCCAGCCG CCGCCGCCGC CGCCACCGCC CTCCAGGCTC CGGGACCCGG CCCGCGCCAC 60
CGCCCCCGTG CGCGCCCCGC CGCCGCCGCC TTCGCCTTCG CCTTTTGTTT CCTCCGCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045831|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR000637--HMGI/Y_DNA-bd_CS
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00354--HMGI_Y
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008584--P:male gonad development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007283--P:spermatogenesis
GO:0030217--P:T cell differentiation
KEGG hsa:23598
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001393 Ailuropoda melanoleuca 99.13 0.00e+00 1273.00
IUUC-Ame-010861 Astyanax mexicanus 58.56 0.00e+00 710.00
IUUC-Bta-012647 Bos taurus 99.13 0.00e+00 1271.00
IUUC-Cja-019987 Callithrix jacchus 99.42 0.00e+00 1248.00
IUUC-Cfa-020091 Canis familiaris 99.27 0.00e+00 1273.00
IUUC-Cpo-021731 Cavia porcellus 98.40 0.00e+00 1260.00
IUUC-Csa-023323 Chlorocebus sabaeus 96.56 0.00e+00 944.00
IUUC-Cho-024339 Choloepus hoffmanni 96.64 7.00e-104 371.00
IUUC-Dre-028776 Danio rerio 54.30 0.00e+00 651.00
IUUC-Dno-028988 Dasypus novemcinctus 98.55 0.00e+00 1169.00
IUUC-Eca-034224 Equus caballus 92.58 0.00e+00 1164.00
IUUC-Fca-035834 Felis catus 92.72 0.00e+00 1159.00
IUUC-Gmo-038564 Gadus morhua 54.67 0.00e+00 671.00
IUUC-Gga-040923 Gallus gallus 88.20 0.00e+00 1145.00
IUUC-Gac-042115 Gasterosteus aculeatus 56.35 0.00e+00 732.00
IUUC-Ggo-045483 Gorilla gorilla 99.85 0.00e+00 1285.00
IUUC-Itr-048966 Ictidomys tridecemlineatus 99.13 0.00e+00 1274.00
IUUC-Lch-050298 Latimeria chalumnae 70.69 0.00e+00 904.00
IUUC-Laf-053714 Loxodonta africana 98.54 0.00e+00 1276.00
IUUC-Mcc-055844 Macaca mulatta 82.53 0.00e+00 753.00
IUUC-Mmr-061004 Microcebus murinus 96.24 0.00e+00 1224.00
IUUC-Mdo-061816 Monodelphis domestica 83.71 0.00e+00 972.00
IUUC-Mmu-063774 Mus musculus 98.98 0.00e+00 1271.00
IUUC-Mpu-066238 Mustela putorius furo 96.37 0.00e+00 937.00
IUUC-Mlu-068149 Myotis lucifugus 98.98 0.00e+00 1270.00
IUUC-Opr-071017 Ochotona princeps 88.33 0.00e+00 752.00
IUUC-Ont-072352 Oreochromis niloticus 55.17 0.00e+00 704.00
IUUC-Oan-073423 Ornithorhynchus anatinus 93.18 0.00e+00 1208.00
IUUC-Ocu-074291 Oryctolagus cuniculus 95.99 0.00e+00 939.00
IUUC-Oga-088646 Otolemur garnettii 99.27 0.00e+00 1268.00
IUUC-Oar-089847 Ovis aries 88.65 0.00e+00 1093.00
IUUC-Ptr-091669 Pan troglodytes 99.85 0.00e+00 1285.00
IUUC-Pfo-097307 Poecilia formosa 53.18 0.00e+00 657.00
IUUC-Pab-097693 Pongo abelii 99.56 0.00e+00 1282.00
IUUC-Pca-100274 Procavia capensis 83.50 2.00e-143 503.00
IUUC-Pva-102261 Pteropus vampyrus 99.42 0.00e+00 1273.00
IUUC-Ptt-103895 Puccinia triticina 38.10 8.00e-06 44.70
IUUC-Rno-105339 Rattus norvegicus 92.43 0.00e+00 1155.00
IUUC-Ssc-116429 Sus scrofa 91.99 0.00e+00 1148.00
IUUC-Tgu-116916 Taeniopygia guttata 82.43 0.00e+00 972.00
IUUC-Tru-117811 Takifugu rubripes 57.68 0.00e+00 751.00
IUUC-Tni-120697 Tetraodon nigroviridis 52.78 0.00e+00 642.00
IUUC-Ttr-128276 Tursiops truncatus 99.13 0.00e+00 1271.00
IUUC-Xtr-131778 Xenopus tropicalis 71.45 0.00e+00 892.00
Created Date 25-Jun-2017

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