iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/Autophagy_C	Autophagy_C	17986448

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E2/Autophagy_C	32.05	1.00e-30	130.00	IUUC-Ath-006802
E2/Autophagy_C	34.26	6.00e-37	152.00	IUUC-Hsa-046449

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.

Protein Sequence
(Fasta)

MIRSTLSSWR EYLTPITHKS TFLTTGQITP EEFVQAGDYL CHMFPTWKWN EESSDISYRD 60
FLPKNKQFLI IRKVPCDKRA EQCVEVEGPD VIMKGFAEDG DEDDVLEYIG SETEHVQSTP 120

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Nucleotide Sequence
(Fasta)

ATGATTAGAT CTACACTAAG TAGTTGGAGA GAATATCTTA CCCCCATAAC GCACAAATCT 60
ACCTTTTTAA CCACAGGTCA AATAACTCCT GAGGAGTTTG TACAAGCAGG TGATTATTTA 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007135--Autophagy-rel_prot_3
IPR019461--Autophagy-rel_prot_3_C
IPR007134--Autophagy-rel_prot_3_N

Pfam

PF03987--Autophagy_act_C
PF10381--Autophagy_C
PF03986--Autophagy_N

Gene Ontology

GO:0000153--C:cytoplasmic ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006612--P:protein targeting to membrane

KEGG

sce:YNR007C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001111	Aegilops tauschii	33.07	1.00e-24	105.00
IUUC-Aml-002081	Ailuropoda melanoleuca	33.95	2.00e-38	150.00
IUUC-Atr-002712	Amborella trichopoda	30.50	3.00e-23	100.00
IUUC-Apl-003956	Anas platyrhynchos	28.08	9.00e-21	92.00
IUUC-Aca-004578	Anolis carolinensis	36.00	4.00e-22	96.30
IUUC-Aly-005823	Arabidopsis lyrata	32.37	5.00e-34	135.00
IUUC-Ath-006802	Arabidopsis thaliana	32.37	5.00e-34	135.00
IUUC-Ago-007855	Ashbya gossypii	56.13	1.00e-98	350.00
IUUC-Acl-008147	Aspergillus clavatus	37.01	3.00e-52	196.00
IUUC-Afl-008483	Aspergillus flavus	36.71	7.00e-52	195.00
IUUC-Afu-008818	Aspergillus fumigatus	37.12	3.00e-57	213.00
IUUC-Ani-009481	Aspergillus nidulans	34.85	1.00e-53	201.00
IUUC-Ang-009800	Aspergillus niger	39.57	7.00e-57	211.00
IUUC-Aor-010150	Aspergillus oryzae	36.71	7.00e-52	195.00
IUUC-Ate-010545	Aspergillus terreus	38.76	4.00e-30	122.00
IUUC-Ame-011793	Astyanax mexicanus	30.99	4.00e-40	156.00
IUUC-Bgr-012167	Blumeria graminis	33.15	4.00e-47	179.00
IUUC-Bta-012695	Bos taurus	34.26	2.00e-39	154.00
IUUC-Bci-013972	Botrytis cinerea	36.97	3.00e-24	103.00
IUUC-Bdi-014756	Brachypodium distachyon	31.25	2.00e-30	124.00
IUUC-Bol-015091	Brassica oleracea	31.25	3.00e-28	116.00
IUUC-Bra-016662	Brassica rapa	31.29	5.00e-18	82.80
IUUC-Cel-018143	Caenorhabditis elegans	34.29	1.00e-20	91.30
IUUC-Cja-018991	Callithrix jacchus	33.54	3.00e-40	156.00
IUUC-Cfa-020070	Canis familiaris	33.54	1.00e-38	151.00
IUUC-Cpo-021860	Cavia porcellus	35.28	7.00e-39	152.00
IUUC-Cre-022948	Chlamydomonas reinhardtii	33.12	1.00e-39	154.00
IUUC-Csa-023881	Chlorocebus sabaeus	34.26	2.00e-39	154.00
IUUC-Cho-024852	Choloepus hoffmanni	36.11	1.00e-21	94.70
IUUC-Cin-025787	Ciona intestinalis	37.91	3.00e-22	97.10
IUUC-Csv-026369	Ciona savignyi	37.91	3.00e-22	96.70
IUUC-Cgl-026680	Colletotrichum gloeosporioides	42.11	1.00e-32	131.00
IUUC-Cne-026905	Cryptococcus neoformans	49.37	2.00e-18	84.70
IUUC-Dre-028811	Danio rerio	30.99	2.00e-39	154.00
IUUC-Dno-030081	Dasypus novemcinctus	33.03	8.00e-36	142.00
IUUC-Dor-030183	Dipodomys ordii	51.39	4.00e-18	83.20
IUUC-Dse-031539	Dothistroma septosporum	37.09	5.00e-21	93.20
IUUC-Dme-031805	Drosophila melanogaster	35.71	2.00e-21	94.40
IUUC-Ete-033171	Echinops telfairi	34.53	5.00e-38	149.00
IUUC-Eca-034083	Equus caballus	34.26	2.00e-39	154.00
IUUC-Eeu-034804	Erinaceus europaeus	33.02	2.00e-36	143.00
IUUC-Fca-036289	Felis catus	33.95	4.00e-39	152.00
IUUC-Fal-037060	Ficedula albicollis	33.54	8.00e-39	151.00
IUUC-Fox-038051	Fusarium oxysporum	37.64	1.00e-52	198.00
IUUC-Fso-038124	Fusarium solani	38.75	4.00e-45	172.00
IUUC-Gmo-039538	Gadus morhua	33.13	3.00e-42	163.00
IUUC-Ggr-039880	Gaeumannomyces graminis	46.11	1.00e-36	144.00
IUUC-Gga-041108	Gallus gallus	33.64	2.00e-38	150.00
IUUC-Gac-041558	Gasterosteus aculeatus	33.75	2.00e-41	160.00
IUUC-Gma-043969	Glycine max	29.71	7.00e-28	115.00
IUUC-Ggo-045071	Gorilla gorilla	34.26	2.00e-39	154.00
IUUC-Hsa-046449	Homo sapiens	34.26	2.00e-39	154.00
IUUC-Hvu-047451	Hordeum vulgare	30.72	1.00e-29	121.00
IUUC-Itr-048360	Ictidomys tridecemlineatus	34.26	3.00e-39	153.00
IUUC-Kpa-049096	Komagataella pastoris	47.37	1.00e-74	271.00
IUUC-Lch-049726	Latimeria chalumnae	33.93	8.00e-41	158.00
IUUC-Lpe-050734	Leersia perrieri	33.86	2.00e-29	120.00
IUUC-Loc-051983	Lepisosteus oculatus	31.45	5.00e-40	155.00
IUUC-Lma-053038	Leptosphaeria maculans	36.13	2.00e-52	197.00
IUUC-Laf-054510	Loxodonta africana	32.29	9.00e-35	138.00
IUUC-Mcc-054792	Macaca mulatta	34.26	2.00e-39	154.00
IUUC-Meu-055965	Macropus eugenii	30.36	2.00e-20	90.50
IUUC-Mor-057292	Magnaporthe oryzae	37.36	8.00e-55	205.00
IUUC-Mtr-058282	Medicago truncatula	32.37	9.00e-32	128.00
IUUC-Mla-059144	Melampsora laricipopulina	33.90	2.00e-22	98.20
IUUC-Mga-059509	Meleagris gallopavo	33.54	4.00e-38	149.00
IUUC-Mvi-060281	Microbotryum violaceum	31.84	4.00e-21	93.60
IUUC-Mmr-061788	Microcebus murinus	34.26	3.00e-39	153.00
IUUC-Mdo-062922	Monodelphis domestica	34.57	1.00e-39	154.00
IUUC-Mmu-064249	Mus musculus	33.95	3.00e-39	153.00
IUUC-Mac-064474	Musa acuminata	30.61	2.00e-31	127.00
IUUC-Mpu-065717	Mustela putorius furo	34.46	1.00e-37	147.00
IUUC-Mlu-067151	Myotis lucifugus	32.72	1.00e-33	134.00
IUUC-Nfi-068551	Neosartorya fischeri	38.31	7.00e-57	212.00
IUUC-Ncr-068846	Neurospora crassa	38.40	7.00e-55	205.00
IUUC-Nle-069790	Nomascus leucogenys	34.26	2.00e-39	154.00
IUUC-Opr-070828	Ochotona princeps	28.40	8.00e-05	38.10
IUUC-Ont-072517	Oreochromis niloticus	31.52	5.00e-41	159.00
IUUC-Oan-073285	Ornithorhynchus anatinus	36.11	1.00e-21	94.40
IUUC-Ocu-074695	Oryctolagus cuniculus	34.26	3.00e-39	153.00
IUUC-Oba-074991	Oryza barthii	32.79	6.00e-36	142.00
IUUC-Obr-076787	Oryza brachyantha	31.86	1.00e-33	134.00
IUUC-Ogl-077440	Oryza glaberrima	32.49	8.00e-36	141.00
IUUC-Ogu-078037	Oryza glumaepatula	32.49	6.00e-34	135.00
IUUC-Oin-079452	Oryza indica	32.59	1.00e-34	138.00
IUUC-Olo-080450	Oryza longistaminata	33.11	1.00e-36	144.00
IUUC-Ome-081514	Oryza meridionalis	32.49	9.00e-36	141.00
IUUC-Oni-082677	Oryza nivara	32.59	1.00e-34	138.00
IUUC-Opu-083925	Oryza punctata	32.49	1.00e-34	137.00
IUUC-Oru-084828	Oryza rufipogon	33.22	1.00e-35	141.00
IUUC-Osa-085937	Oryza sativa	32.91	2.00e-34	137.00
IUUC-Ola-086559	Oryzias latipes	30.56	4.00e-22	95.90
IUUC-Olu-087766	Ostreococcus lucimarinus	31.03	4.00e-36	142.00
IUUC-Oga-087983	Otolemur garnettii	34.15	3.00e-38	150.00
IUUC-Oar-089281	Ovis aries	34.57	2.00e-39	154.00
IUUC-Ptr-090983	Pan troglodytes	34.26	2.00e-39	154.00
IUUC-Pan-092457	Papio anubis	34.26	2.00e-39	154.00
IUUC-Psi-094046	Pelodiscus sinensis	30.67	4.00e-35	139.00
IUUC-Pma-094174	Petromyzon marinus	28.57	3.00e-02	30.80
IUUC-Pno-094925	Phaeosphaeria nodorum	36.81	2.00e-54	204.00
IUUC-Ppa-095487	Physcomitrella patens	30.53	2.00e-29	120.00
IUUC-Pfo-096968	Poecilia formosa	32.04	2.00e-41	160.00
IUUC-Pab-098621	Pongo abelii	34.26	4.00e-38	149.00
IUUC-Pop-100007	Populus trichocarpa	31.21	5.00e-30	122.00
IUUC-Pca-100590	Procavia capensis	36.11	2.00e-21	94.40
IUUC-Ppe-101657	Prunus persica	30.23	5.00e-29	119.00
IUUC-Pva-102446	Pteropus vampyrus	34.26	2.00e-39	154.00
IUUC-Pgr-103604	Puccinia graminis	56.00	5.00e-21	93.20
IUUC-Ptt-103941	Puccinia triticina	56.00	6.00e-21	93.20
IUUC-Pte-104252	Pyrenophora teres	35.13	8.00e-54	201.00
IUUC-Pyt-104556	Pyrenophora triticirepentis	34.84	5.00e-54	202.00
IUUC-Rno-106025	Rattus norvegicus	34.57	6.00e-39	152.00
IUUC-Sha-106858	Sarcophilus harrisii	35.19	3.00e-39	153.00
IUUC-Sja-107905	Schizosaccharomyces japonicus	32.70	4.00e-38	149.00
IUUC-Spo-108185	Schizosaccharomyces pombe	30.77	6.00e-18	82.40
IUUC-Smo-108883	Selaginella moellendorffii	32.43	6.00e-19	85.90
IUUC-Sit-110512	Setaria italica	31.65	8.00e-32	128.00
IUUC-Sly-111238	Solanum lycopersicum	32.30	2.00e-33	133.00
IUUC-Stu-112441	Solanum tuberosum	32.61	1.00e-33	134.00
IUUC-Sar-113039	Sorex araneus	34.64	1.00e-21	94.70
IUUC-Sbi-113776	Sorghum bicolor	31.43	3.00e-31	127.00
IUUC-Sre-115074	Sporisorium reilianum	52.05	1.00e-17	82.40
IUUC-Ssc-115262	Sus scrofa	34.26	2.00e-39	153.00
IUUC-Tgu-116790	Taeniopygia guttata	33.54	3.00e-38	149.00
IUUC-Tru-118160	Takifugu rubripes	32.24	4.00e-42	162.00
IUUC-Tsy-119145	Tarsius syrichta	26.85	5.00e-16	76.30
IUUC-Tni-119937	Tetraodon nigroviridis	29.94	5.00e-34	135.00
IUUC-Tca-121323	Theobroma cacao	30.13	2.00e-30	124.00
IUUC-Tre-121993	Trichoderma reesei	37.79	2.00e-29	120.00
IUUC-Tvi-122332	Trichoderma virens	35.38	5.00e-50	189.00
IUUC-Tae-124391	Triticum aestivum	31.75	2.00e-31	127.00
IUUC-Tur-126679	Triticum urartu	31.23	5.00e-30	122.00
IUUC-Tme-127159	Tuber melanosporum	46.36	8.00e-19	85.10
IUUC-Tbe-127590	Tupaia belangeri	27.71	6.00e-05	38.50
IUUC-Ttr-128261	Tursiops truncatus	33.54	2.00e-36	143.00
IUUC-Uma-129572	Ustilago maydis	46.46	5.00e-19	86.70
IUUC-Vda-129966	Verticillium dahliae	35.94	2.00e-54	203.00
IUUC-Vpa-130698	Vicugna pacos	30.15	5.00e-29	119.00
IUUC-Vvi-131240	Vitis vinifera	29.21	4.00e-07	46.20
IUUC-Xtr-132878	Xenopus tropicalis	32.41	2.00e-38	150.00
IUUC-Xma-134017	Xiphophorus maculatus	31.44	2.00e-40	157.00
IUUC-Yli-134373	Yarrowia lipolytica	42.19	5.00e-62	229.00
IUUC-Zma-135222	Zea mays	29.79	4.00e-31	126.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence