iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000008087.1	ENSLACT00000009232.1	ENSLACP00000009162.1
ENSLACG00000008087.1	ENSLACT00000009233.1	ENSLACP00000009163.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-119	397.9	582	912

Active Site

Position(s)	Description	Evidence
883	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al++++l+++
   Q: 582  YEKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIINPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALYHRQLVNI 667
           678999**************.**********************6666.67788*******9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt+eNk eYv+lv+e
   Q: 668  YFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGTSIIVTQENKAEYVQLVTE 753
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy +d+p+iqwFw+v++++++eer  +LqFv
   Q: 754  LRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWYKNTEYTSGYDRDEPVIQWFWDVVHNLTQEERVLLLQFV 842
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           Tgssr+P+gGfa+++     ++f+i     +++ lP+s+TC+n+LkLPeY+ske+lk++Ll+A + +  g
   Q: 843  TGSSRVPHGGFAYIMggsgLQKFTIAAvPYTTNLLPTSSTCINMLKLPEYPSKEVLKDRLLVALHCGsYG 912
           *******************8889998867788********************************986555 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MMERAMEQLN RLTRSLRRAR TVELPEDNET AVYTLMPMVM ADQHRSVAEL LSNSKFDVNY 60
AFGRVKRSLL HIAANCGSVE CLVLLLKKGA NPNYQDISGC TPLHLAARNG QKKCMGKLLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGAATTGC AGGAAAGTGG GCCGAGGGAA CAGCAACCAG GAAATCCACA CACAAAGCCA 60
TTCCTGCGAG TGGGGAAGTG GCCGGAGAGC ATGGCCGATC CGAAGGAGAC GCGCGGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	89.22	0.00e+00	1681.00
IUUC-Apl-003400	Anas platyrhynchos	83.78	0.00e+00	1096.00
IUUC-Aca-005375	Anolis carolinensis	88.96	0.00e+00	1692.00
IUUC-Ame-011847	Astyanax mexicanus	86.79	0.00e+00	1680.00
IUUC-Bta-012831	Bos taurus	88.94	0.00e+00	1645.00
IUUC-Cja-019160	Callithrix jacchus	89.29	0.00e+00	1697.00
IUUC-Cfa-020346	Canis familiaris	89.40	0.00e+00	1686.00
IUUC-Cpo-021766	Cavia porcellus	89.18	0.00e+00	1692.00
IUUC-Csa-023768	Chlorocebus sabaeus	89.17	0.00e+00	1698.00
IUUC-Cho-024688	Choloepus hoffmanni	83.69	0.00e+00	1042.00
IUUC-Cin-025417	Ciona intestinalis	51.18	2.00e-140	493.00
IUUC-Csv-025993	Ciona savignyi	44.21	0.00e+00	775.00
IUUC-Dre-027819	Danio rerio	87.42	0.00e+00	1669.00
IUUC-Dno-029027	Dasypus novemcinctus	89.13	0.00e+00	1685.00
IUUC-Dor-030327	Dipodomys ordii	82.45	0.00e+00	1477.00
IUUC-Ete-032966	Echinops telfairi	82.84	0.00e+00	1555.00
IUUC-Eca-034339	Equus caballus	89.73	0.00e+00	1691.00
IUUC-Eeu-034544	Erinaceus europaeus	61.50	7.00e-169	587.00
IUUC-Fca-035617	Felis catus	87.00	0.00e+00	1167.00
IUUC-Fal-036687	Ficedula albicollis	87.13	0.00e+00	1699.00
IUUC-Gmo-039508	Gadus morhua	90.66	0.00e+00	856.00
IUUC-Gga-040845	Gallus gallus	87.12	0.00e+00	1701.00
IUUC-Gac-041894	Gasterosteus aculeatus	86.80	0.00e+00	1613.00
IUUC-Ggo-044465	Gorilla gorilla	86.17	0.00e+00	1620.00
IUUC-Hsa-045731	Homo sapiens	89.27	0.00e+00	1699.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	89.47	0.00e+00	1699.00
IUUC-Loc-052287	Lepisosteus oculatus	86.67	0.00e+00	1698.00
IUUC-Laf-053846	Loxodonta africana	90.05	0.00e+00	1706.00
IUUC-Mcc-055845	Macaca mulatta	89.27	0.00e+00	1701.00
IUUC-Meu-056060	Macropus eugenii	93.24	0.00e+00	662.00
IUUC-Mga-059935	Meleagris gallopavo	89.61	0.00e+00	1688.00
IUUC-Mmr-060960	Microcebus murinus	89.84	0.00e+00	1697.00
IUUC-Mdo-061851	Monodelphis domestica	86.39	0.00e+00	1696.00
IUUC-Mmu-063657	Mus musculus	88.77	0.00e+00	1689.00
IUUC-Mpu-066161	Mustela putorius furo	93.22	0.00e+00	784.00
IUUC-Mlu-067354	Myotis lucifugus	86.88	0.00e+00	1613.00
IUUC-Nle-069112	Nomascus leucogenys	89.27	0.00e+00	1702.00
IUUC-Opr-070686	Ochotona princeps	83.83	0.00e+00	766.00
IUUC-Ont-072398	Oreochromis niloticus	86.74	0.00e+00	1627.00
IUUC-Oan-073194	Ornithorhynchus anatinus	89.10	0.00e+00	1628.00
IUUC-Ocu-074397	Oryctolagus cuniculus	81.24	0.00e+00	1496.00
IUUC-Ola-086777	Oryzias latipes	82.18	0.00e+00	1599.00
IUUC-Oga-088684	Otolemur garnettii	89.74	0.00e+00	1692.00
IUUC-Oar-089428	Ovis aries	89.02	0.00e+00	1658.00
IUUC-Ptr-090529	Pan troglodytes	89.17	0.00e+00	1698.00
IUUC-Pan-091702	Papio anubis	89.17	0.00e+00	1699.00
IUUC-Psi-093969	Pelodiscus sinensis	86.76	0.00e+00	1635.00
IUUC-Pfo-097364	Poecilia formosa	87.53	0.00e+00	1647.00
IUUC-Pab-098574	Pongo abelii	89.27	0.00e+00	1699.00
IUUC-Pca-100525	Procavia capensis	82.12	2.00e-169	589.00
IUUC-Pva-102365	Pteropus vampyrus	78.31	0.00e+00	1439.00
IUUC-Rno-105153	Rattus norvegicus	88.99	0.00e+00	1693.00
IUUC-Sha-107319	Sarcophilus harrisii	86.83	0.00e+00	1691.00
IUUC-Stu-112894	Solanum tuberosum	35.33	4.00e-56	213.00
IUUC-Sar-113449	Sorex araneus	69.92	2.00e-145	509.00
IUUC-Ssc-115865	Sus scrofa	88.74	0.00e+00	1689.00
IUUC-Tgu-117225	Taeniopygia guttata	87.13	0.00e+00	1702.00
IUUC-Tru-118026	Takifugu rubripes	84.11	0.00e+00	1599.00
IUUC-Tsy-119407	Tarsius syrichta	77.16	0.00e+00	1402.00
IUUC-Tni-120234	Tetraodon nigroviridis	85.20	0.00e+00	1283.00
IUUC-Tbe-127708	Tupaia belangeri	77.60	0.00e+00	759.00
IUUC-Ttr-128667	Tursiops truncatus	88.64	0.00e+00	1689.00
IUUC-Vpa-130200	Vicugna pacos	88.98	0.00e+00	1627.00
IUUC-Xtr-132176	Xenopus tropicalis	85.92	0.00e+00	1680.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence