iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011678

Ensembl Protein ID

ENSAMXP00000007235.1

UniProt Accession

W5KI23; W5KI23_ASTMX

Genbank Protein ID

ENSAMXP00000007235

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

APWO01075047

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000007046.1	ENSAMXT00000007235.1	ENSAMXP00000007235.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.09	5.00e-140	494.00	IUUC-Hsa-046179
E3 activity/RING/RING	92.09	2.00e-140	495.00	IUUC-Mmu-063206
E3 activity/RING/RING	92.09	1.00e-140	495.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Astyanax mexicanus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

AMSRPSSAGG AGGGLGAGKA GGGSKHGGSG AAGGGGAAAA AAAAAAAAAA AAAAAGVSGS 60
VSGSGSVTAA TAVALPTAAA AAAALPGQSA ELTALFECPV CFDYVLPPIL QCQAGHLVCN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCATGAGCC GTCCGTCCTC AGCGGGAGGA GCGGGCGGAG GACTGGGAGC CGGTAAGGCG 60
GGAGGAGGGA GTAAACACGG CGGCTCCGGA GCAGCAGGAG GAGGAGGAGC GGCGGCAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	92.09	1.00e-141	495.00
IUUC-Bta-012750	Bos taurus	91.70	2.00e-141	494.00
IUUC-Cja-019800	Callithrix jacchus	92.09	1.00e-141	495.00
IUUC-Cfa-020505	Canis familiaris	91.70	3.00e-141	494.00
IUUC-Cpo-021394	Cavia porcellus	92.09	5.00e-142	496.00
IUUC-Csa-023374	Chlorocebus sabaeus	92.09	1.00e-141	495.00
IUUC-Cho-024933	Choloepus hoffmanni	92.09	1.00e-141	495.00
IUUC-Dre-027711	Danio rerio	98.43	5.00e-154	536.00
IUUC-Dno-029260	Dasypus novemcinctus	93.00	5.00e-138	483.00
IUUC-Dor-030489	Dipodomys ordii	91.80	2.00e-101	361.00
IUUC-Ete-032946	Echinops telfairi	92.09	1.00e-141	495.00
IUUC-Eca-033546	Equus caballus	92.09	2.00e-142	498.00
IUUC-Eeu-034861	Erinaceus europaeus	89.33	4.00e-137	480.00
IUUC-Gmo-039091	Gadus morhua	95.28	9.00e-147	512.00
IUUC-Gga-040252	Gallus gallus	90.12	1.00e-138	485.00
IUUC-Gac-041673	Gasterosteus aculeatus	95.65	1.00e-146	512.00
IUUC-Ggo-044618	Gorilla gorilla	92.09	1.00e-141	495.00
IUUC-Hsa-046179	Homo sapiens	92.09	1.00e-141	495.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	91.30	1.00e-140	491.00
IUUC-Lch-049496	Latimeria chalumnae	91.70	6.00e-142	496.00
IUUC-Loc-052107	Lepisosteus oculatus	99.20	8.00e-153	532.00
IUUC-Laf-054257	Loxodonta africana	91.70	8.00e-140	489.00
IUUC-Mcc-055023	Macaca mulatta	92.09	1.00e-141	495.00
IUUC-Meu-055922	Macropus eugenii	90.12	5.00e-138	483.00
IUUC-Mga-060070	Meleagris gallopavo	88.58	2.00e-135	474.00
IUUC-Mmr-061494	Microcebus murinus	92.09	1.00e-141	495.00
IUUC-Mdo-061971	Monodelphis domestica	92.09	1.00e-141	495.00
IUUC-Mmu-063206	Mus musculus	92.09	7.00e-142	496.00
IUUC-Mpu-066597	Mustela putorius furo	92.09	1.00e-141	495.00
IUUC-Mlu-067199	Myotis lucifugus	91.70	5.00e-141	493.00
IUUC-Nle-069342	Nomascus leucogenys	92.09	1.00e-141	495.00
IUUC-Opr-070341	Ochotona princeps	58.17	4.00e-51	194.00
IUUC-Ont-071906	Oreochromis niloticus	96.85	8.00e-150	522.00
IUUC-Oan-073701	Ornithorhynchus anatinus	55.13	5.00e-51	194.00
IUUC-Ocu-073950	Oryctolagus cuniculus	91.70	2.00e-141	494.00
IUUC-Oga-089154	Otolemur garnettii	92.09	1.00e-141	495.00
IUUC-Oar-089446	Ovis aries	91.70	2.00e-141	494.00
IUUC-Ptr-091088	Pan troglodytes	92.09	1.00e-141	495.00
IUUC-Psi-093079	Pelodiscus sinensis	92.09	2.00e-141	494.00
IUUC-Pfo-097007	Poecilia formosa	90.51	4.00e-140	490.00
IUUC-Pab-098092	Pongo abelii	92.09	1.00e-141	495.00
IUUC-Pca-100328	Procavia capensis	89.72	1.00e-137	482.00
IUUC-Pva-102368	Pteropus vampyrus	97.27	6.00e-61	227.00
IUUC-Rno-105477	Rattus norvegicus	92.09	7.00e-142	496.00
IUUC-Sha-107630	Sarcophilus harrisii	91.70	5.00e-141	493.00
IUUC-Ssc-116441	Sus scrofa	91.70	3.00e-141	494.00
IUUC-Tru-118004	Takifugu rubripes	92.91	3.00e-143	501.00
IUUC-Tsy-119548	Tarsius syrichta	86.36	4.00e-64	237.00
IUUC-Tni-120846	Tetraodon nigroviridis	94.47	2.00e-145	508.00
IUUC-Vpa-130799	Vicugna pacos	94.15	1.00e-97	348.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence