iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000112357.12	ENST00000367756.8	ENSP00000356730.4
ENSG00000112357.12	ENST00000318471.4	ENSP00000315680.3
ENSG00000112357.12	ENST00000541292.5	ENSP00000441004.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.70e-38	128.2	110	149
UBD/Beta-Prp	1.70e-41	144.0	72	187

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllk 37
           H+ +v+++++    +  l+vsGs+D t+k+WD++ g++l+
   Q: 110  HAQEVYSVDWsqtRGeQLVVSGSWDQTVKLWDPTVGKSLC 149
           999********8855689****************999887 PP

UBD/Beta-Prp

   S: 57   avkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp.sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvv 144
           +v++s++ + +l+t+s D+ +++wd   +  +++++k+h ++v+s+++s+  g + +vsGs+d+t+++wd   g+ l  t++gh++++ ++ 
   Q: 72   DVTWSENNEhVLITCSGDGSLQLWDTAkAAGPLQVYKEHAQEVYSVDWSQtRGeQLVVSGSWDQTVKLWDPTVGKSLC-TFRGHESIIYSTI 162
           5566555545**************76648889******************644799*********************9.************* PP
   S: 145  vhpdg.nllvsGslDrtvrlWdlkt 168
           ++p    +++s+s D+t+r+Wd+k 
   Q: 163  WSPHIpGCFASASGDQTLRIWDVKA 187
           **********************986 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the WD repeat peroxin-7 family.

Protein Sequence
(Fasta)

MSAVCGGAAR MLRTPGRHGY AAEFSPYLPG RLACATAQHY GIAGCGTLLI LDPDEAGLRL 60
FRSFDWNDGL FDVTWSENNE HVLITCSGDG SLQLWDTAKA AGPLQVYKEH AQEVYSVDWS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCCGTCC GGTCTGCCTG GTCTCTCTAA CCGCGCCAGT GTGCCTCCGA CTCGGAACGG 60
CTTCCGCGGC CGGGGCAGCG AGGGCCGGGG GCGGCGGGCG GGATGAGTGC GGTGTGCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0898--Cataract
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0209--Deafness
KW-0225--Disease mutation
KW-0977--Ichthyosis
KW-0576--Peroxisome
KW-0958--Peroxisome biogenesis disorder
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0682--Retinitis pigmentosa
KW-0685--Rhizomelic chondrodysplasia punctata
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005782--C:peroxisomal matrix
GO:0005777--C:peroxisome
GO:0019899--F:enzyme binding
GO:0005053--F:peroxisome matrix targeting signal-2 binding
GO:0042803--F:protein homodimerization activity
GO:0001958--P:endochondral ossification
GO:0008611--P:ether lipid biosynthetic process
GO:0006635--P:fatty acid beta-oxidation
GO:0001764--P:neuron migration
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix

KEGG

hsa:5191

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001966	Ailuropoda melanoleuca	94.14	2.00e-177	614.00
IUUC-Atr-003127	Amborella trichopoda	45.45	8.00e-79	286.00
IUUC-Apl-004050	Anas platyrhynchos	81.05	5.00e-142	496.00
IUUC-Aca-004489	Anolis carolinensis	80.00	1.00e-157	548.00
IUUC-Aly-006031	Arabidopsis lyrata	43.85	1.00e-72	266.00
IUUC-Ath-007361	Arabidopsis thaliana	44.85	1.00e-73	270.00
IUUC-Ago-007708	Ashbya gossypii	33.43	1.00e-46	180.00
IUUC-Acl-008039	Aspergillus clavatus	32.38	2.00e-44	172.00
IUUC-Afl-008394	Aspergillus flavus	33.33	3.00e-48	186.00
IUUC-Afu-008754	Aspergillus fumigatus	33.52	4.00e-45	175.00
IUUC-Ani-009421	Aspergillus nidulans	33.62	6.00e-49	187.00
IUUC-Ang-009727	Aspergillus niger	38.56	2.00e-53	202.00
IUUC-Aor-010236	Aspergillus oryzae	33.33	3.00e-48	186.00
IUUC-Ate-010324	Aspergillus terreus	33.62	9.00e-49	187.00
IUUC-Ame-011226	Astyanax mexicanus	70.97	1.00e-137	482.00
IUUC-Bgr-012081	Blumeria graminis	36.86	2.00e-48	186.00
IUUC-Bta-013366	Bos taurus	90.71	2.00e-179	621.00
IUUC-Bci-013909	Botrytis cinerea	33.93	6.00e-43	167.00
IUUC-Bdi-014172	Brachypodium distachyon	44.55	1.00e-73	269.00
IUUC-Bol-015677	Brassica oleracea	44.19	6.00e-74	270.00
IUUC-Bra-017874	Brassica rapa	43.85	9.00e-74	270.00
IUUC-Cja-019975	Callithrix jacchus	95.36	0.00e+00	649.00
IUUC-Cfa-020059	Canis familiaris	92.57	0.00e+00	633.00
IUUC-Cpo-021881	Cavia porcellus	93.95	6.00e-180	623.00
IUUC-Cre-022741	Chlamydomonas reinhardtii	42.31	3.00e-71	261.00
IUUC-Csa-024220	Chlorocebus sabaeus	98.19	3.00e-162	563.00
IUUC-Cho-024382	Choloepus hoffmanni	83.15	6.00e-140	489.00
IUUC-Cin-025606	Ciona intestinalis	45.56	6.00e-44	170.00
IUUC-Csv-026072	Ciona savignyi	45.51	2.00e-86	312.00
IUUC-Cne-027080	Cryptococcus neoformans	35.26	6.00e-50	191.00
IUUC-Dre-028830	Danio rerio	68.71	1.00e-135	476.00
IUUC-Dno-029570	Dasypus novemcinctus	91.80	4.00e-178	617.00
IUUC-Dor-030458	Dipodomys ordii	67.09	7.00e-116	410.00
IUUC-Dse-031399	Dothistroma septosporum	34.52	2.00e-51	196.00
IUUC-Dme-031641	Drosophila melanogaster	43.12	5.00e-70	258.00
IUUC-Ete-032339	Echinops telfairi	92.63	4.00e-176	610.00
IUUC-Eca-034154	Equus caballus	92.50	7.00e-159	552.00
IUUC-Eeu-034764	Erinaceus europaeus	88.92	9.00e-171	592.00
IUUC-Fca-036310	Felis catus	91.01	8.00e-153	532.00
IUUC-Fal-036714	Ficedula albicollis	82.44	1.00e-142	498.00
IUUC-Fox-037723	Fusarium oxysporum	36.09	8.00e-52	197.00
IUUC-Fso-038438	Fusarium solani	33.82	5.00e-45	174.00
IUUC-Gmo-038852	Gadus morhua	57.82	6.00e-92	330.00
IUUC-Ggr-040004	Gaeumannomyces graminis	35.55	8.00e-46	177.00
IUUC-Gga-040465	Gallus gallus	82.75	1.00e-158	552.00
IUUC-Gac-042212	Gasterosteus aculeatus	65.50	1.00e-121	429.00
IUUC-Gma-042686	Glycine max	43.04	2.00e-72	265.00
IUUC-Ggo-045510	Gorilla gorilla	95.67	0.00e+00	641.00
IUUC-Hvu-047261	Hordeum vulgare	45.87	1.00e-73	270.00
IUUC-Itr-048170	Ictidomys tridecemlineatus	95.45	2.00e-99	354.00
IUUC-Kpa-049116	Komagataella pastoris	31.44	3.00e-42	166.00
IUUC-Lch-050018	Latimeria chalumnae	75.56	2.00e-60	223.00
IUUC-Lpe-051285	Leersia perrieri	44.22	2.00e-73	268.00
IUUC-Loc-051817	Lepisosteus oculatus	75.12	3.00e-99	354.00
IUUC-Lma-053274	Leptosphaeria maculans	34.29	1.00e-44	173.00
IUUC-Laf-053781	Loxodonta africana	91.93	0.00e+00	625.00
IUUC-Mcc-054938	Macaca mulatta	98.70	0.00e+00	630.00
IUUC-Meu-056863	Macropus eugenii	80.73	5.00e-135	473.00
IUUC-Mor-057017	Magnaporthe oryzae	36.83	2.00e-51	196.00
IUUC-Mpo-057357	Magnaporthe poae	33.96	5.00e-38	151.00
IUUC-Mtr-058152	Medicago truncatula	42.72	1.00e-72	266.00
IUUC-Mga-059292	Meleagris gallopavo	84.15	7.00e-146	509.00
IUUC-Mvi-060494	Microbotryum violaceum	34.99	1.00e-58	220.00
IUUC-Mmr-060856	Microcebus murinus	93.50	0.00e+00	630.00
IUUC-Mdo-062810	Monodelphis domestica	87.58	2.00e-174	604.00
IUUC-Mmu-063693	Mus musculus	92.41	1.00e-179	622.00
IUUC-Mac-065170	Musa acuminata	44.52	9.00e-76	276.00
IUUC-Mpu-066229	Mustela putorius furo	93.19	0.00e+00	635.00
IUUC-Mlu-067861	Myotis lucifugus	91.08	3.00e-149	520.00
IUUC-Nfi-068268	Neosartorya fischeri	33.24	9.00e-45	174.00
IUUC-Ncr-068756	Neurospora crassa	34.73	1.00e-47	184.00
IUUC-Nle-070047	Nomascus leucogenys	97.21	0.00e+00	650.00
IUUC-Opr-070256	Ochotona princeps	76.64	3.00e-134	471.00
IUUC-Ont-071850	Oreochromis niloticus	69.43	7.00e-136	476.00
IUUC-Oan-073642	Ornithorhynchus anatinus	88.21	2.00e-122	431.00
IUUC-Ocu-074437	Oryctolagus cuniculus	92.26	0.00e+00	633.00
IUUC-Oba-075964	Oryza barthii	44.26	2.00e-72	266.00
IUUC-Obr-076872	Oryza brachyantha	44.08	3.00e-72	265.00
IUUC-Ogl-077459	Oryza glaberrima	44.26	2.00e-72	266.00
IUUC-Ogu-078461	Oryza glumaepatula	44.48	5.00e-73	267.00
IUUC-Oin-079865	Oryza indica	44.59	7.00e-73	267.00
IUUC-Olo-081022	Oryza longistaminata	49.04	9.00e-43	166.00
IUUC-Ome-081607	Oryza meridionalis	44.59	7.00e-73	267.00
IUUC-Oni-082386	Oryza nivara	44.59	7.00e-73	267.00
IUUC-Opu-083636	Oryza punctata	44.01	4.00e-72	265.00
IUUC-Oru-084504	Oryza rufipogon	44.30	1.00e-72	266.00
IUUC-Osa-086268	Oryza sativa	44.59	7.00e-73	267.00
IUUC-Ola-086475	Oryzias latipes	70.32	2.00e-136	478.00
IUUC-Olu-087686	Ostreococcus lucimarinus	42.35	3.00e-71	262.00
IUUC-Oga-088529	Otolemur garnettii	94.62	4.00e-148	516.00
IUUC-Oar-089862	Ovis aries	92.14	3.00e-157	547.00
IUUC-Ptr-090607	Pan troglodytes	99.07	0.00e+00	664.00
IUUC-Pan-092393	Papio anubis	96.25	0.00e+00	629.00
IUUC-Psi-093958	Pelodiscus sinensis	83.27	3.00e-146	510.00
IUUC-Pma-094611	Petromyzon marinus	67.22	3.00e-126	444.00
IUUC-Pno-094866	Phaeosphaeria nodorum	33.14	5.00e-44	171.00
IUUC-Ppa-095768	Physcomitrella patens	48.00	6.00e-81	293.00
IUUC-Pab-097924	Pongo abelii	99.38	0.00e+00	667.00
IUUC-Pop-100046	Populus trichocarpa	42.72	2.00e-70	259.00
IUUC-Pca-100754	Procavia capensis	79.05	6.00e-144	503.00
IUUC-Ppe-102047	Prunus persica	42.26	9.00e-71	260.00
IUUC-Pva-102614	Pteropus vampyrus	92.88	0.00e+00	634.00
IUUC-Pgr-103662	Puccinia graminis	38.39	5.00e-60	224.00
IUUC-Ptt-103891	Puccinia triticina	36.42	5.00e-51	194.00
IUUC-Pte-104317	Pyrenophora teres	33.91	4.00e-42	165.00
IUUC-Pyt-104463	Pyrenophora triticirepentis	34.01	2.00e-42	166.00
IUUC-Rno-105921	Rattus norvegicus	91.14	1.00e-177	615.00
IUUC-Sce-106373	Saccharomyces cerevisiae	30.03	6.00e-42	164.00
IUUC-Sha-106887	Sarcophilus harrisii	85.45	2.00e-170	591.00
IUUC-Sja-107795	Schizosaccharomyces japonicus	30.00	2.00e-41	162.00
IUUC-Spo-108216	Schizosaccharomyces pombe	32.79	8.00e-44	170.00
IUUC-Ssl-108661	Sclerotinia sclerotiorum	34.90	5.00e-43	168.00
IUUC-Smo-109680	Selaginella moellendorffii	48.01	6.00e-79	287.00
IUUC-Sit-110327	Setaria italica	42.38	2.00e-69	255.00
IUUC-Sly-111794	Solanum lycopersicum	43.32	3.00e-73	268.00
IUUC-Stu-112137	Solanum tuberosum	43.32	1.00e-73	269.00
IUUC-Sar-113164	Sorex araneus	85.45	9.00e-168	582.00
IUUC-Sbi-114484	Sorghum bicolor	43.93	5.00e-73	268.00
IUUC-Sre-114949	Sporisorium reilianum	36.26	2.00e-54	206.00
IUUC-Ssc-116090	Sus scrofa	91.06	3.00e-167	580.00
IUUC-Tgu-116617	Taeniopygia guttata	81.58	2.00e-155	541.00
IUUC-Tru-118094	Takifugu rubripes	58.15	2.00e-107	382.00
IUUC-Tsy-118792	Tarsius syrichta	93.19	0.00e+00	630.00
IUUC-Tca-121170	Theobroma cacao	44.16	2.00e-71	262.00
IUUC-Tre-122029	Trichoderma reesei	34.99	3.00e-52	198.00
IUUC-Tvi-122286	Trichoderma virens	34.40	2.00e-53	202.00
IUUC-Tae-124120	Triticum aestivum	44.88	4.00e-72	264.00
IUUC-Tme-127139	Tuber melanosporum	37.89	8.00e-51	194.00
IUUC-Tbe-127809	Tupaia belangeri	73.12	6.00e-109	386.00
IUUC-Ttr-128258	Tursiops truncatus	87.71	4.00e-157	546.00
IUUC-Uma-129560	Ustilago maydis	34.01	3.00e-51	195.00
IUUC-Vda-129997	Verticillium dahliae	35.78	1.00e-51	196.00
IUUC-Vpa-130088	Vicugna pacos	88.51	1.00e-172	598.00
IUUC-Vvi-131333	Vitis vinifera	45.28	3.00e-76	278.00
IUUC-Xtr-132344	Xenopus tropicalis	70.86	7.00e-74	269.00
IUUC-Xma-133170	Xiphophorus maculatus	66.83	8.00e-84	302.00
IUUC-Yli-134347	Yarrowia lipolytica	33.24	9.00e-50	190.00
IUUC-Zma-135332	Zea mays	44.04	1.00e-73	270.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence