iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020886

Ensembl Protein ID

ENSCAFP00000013009.3

UniProt Accession

E2R0M6; E2R0M6_CANLF

Genbank Protein ID

ENSCAFP00000013009

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03010117

Gene Name

KLHL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000008844.3	ENSCAFT00000014062.3	ENSCAFP00000013009.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.20e-21	75.8	50	117
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.90e-11	41.3	150	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv++v ++ e++ah++vLaa+S++F+a+f++e++es+  ++v ik+v+   +r l++++Yt +++ +e
   Q: 50   CDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESR-AKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 117
           8*************************************.*************************99765 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
            Nclgi++fAd++ c+dL  +a++++++hF
   Q: 150  VNCLGIRAFADMHACTDLLNKANTYAEQHF 179
           6****************************9 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MYRCTKQGHQ KPLDSKDDNT EKHCPVTVNP WHMKKAFKVM NELRSQNLLC DVTIVAEDME 60
ISAHRVVLAA CSPYFHAMFT GEMSESRAKR VRIKEVDGWT LRMLIDYVYT AEIQVTEENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGATTA AGCAACTAAT GCAAGTAAAT GACTTAGCAC TGTTGCCACT GTATAGCAAA 60
TACTCAATAA ACTCTACCTA ACGTGATTAA TTGTTGCAAA AGCAGGTCTG AAATATGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0003779--F:actin binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002378	Ailuropoda melanoleuca	99.66	0.00e+00	1168.00
IUUC-Apl-003260	Anas platyrhynchos	93.32	0.00e+00	1104.00
IUUC-Aca-005143	Anolis carolinensis	89.21	0.00e+00	1096.00
IUUC-Cja-018942	Callithrix jacchus	99.32	0.00e+00	1172.00
IUUC-Cpo-022543	Cavia porcellus	99.83	0.00e+00	1172.00
IUUC-Csa-023088	Chlorocebus sabaeus	99.49	0.00e+00	1169.00
IUUC-Dre-028082	Danio rerio	82.02	0.00e+00	979.00
IUUC-Dno-029873	Dasypus novemcinctus	97.12	0.00e+00	1152.00
IUUC-Dor-030460	Dipodomys ordii	79.28	0.00e+00	859.00
IUUC-Dse-031229	Dothistroma septosporum	33.72	4.00e-08	51.20
IUUC-Dme-032172	Drosophila melanogaster	62.08	0.00e+00	674.00
IUUC-Eca-033798	Equus caballus	98.97	0.00e+00	1165.00
IUUC-Eeu-034824	Erinaceus europaeus	91.71	0.00e+00	973.00
IUUC-Fca-036455	Felis catus	100.00	0.00e+00	1180.00
IUUC-Fal-037293	Ficedula albicollis	92.79	0.00e+00	1043.00
IUUC-Gmo-038811	Gadus morhua	78.85	0.00e+00	876.00
IUUC-Gga-040805	Gallus gallus	92.82	0.00e+00	1103.00
IUUC-Gac-041979	Gasterosteus aculeatus	81.29	0.00e+00	880.00
IUUC-Ggo-044620	Gorilla gorilla	94.70	0.00e+00	1110.00
IUUC-Hsa-046265	Homo sapiens	99.83	0.00e+00	1172.00
IUUC-Lch-049939	Latimeria chalumnae	83.99	0.00e+00	981.00
IUUC-Loc-052780	Lepisosteus oculatus	86.99	0.00e+00	1033.00
IUUC-Laf-053800	Loxodonta africana	98.81	0.00e+00	1167.00
IUUC-Mcc-055732	Macaca mulatta	98.46	0.00e+00	1162.00
IUUC-Meu-056011	Macropus eugenii	96.31	0.00e+00	1053.00
IUUC-Mmr-061067	Microcebus murinus	98.12	0.00e+00	1152.00
IUUC-Mdo-062977	Monodelphis domestica	95.38	0.00e+00	1132.00
IUUC-Mmu-064035	Mus musculus	98.61	0.00e+00	1145.00
IUUC-Mpu-066726	Mustela putorius furo	99.83	0.00e+00	1179.00
IUUC-Mlu-067020	Myotis lucifugus	99.32	0.00e+00	1168.00
IUUC-Nle-069456	Nomascus leucogenys	99.32	0.00e+00	1176.00
IUUC-Opr-071130	Ochotona princeps	89.55	0.00e+00	1026.00
IUUC-Ont-072219	Oreochromis niloticus	81.88	0.00e+00	931.00
IUUC-Oan-073699	Ornithorhynchus anatinus	94.69	0.00e+00	962.00
IUUC-Ocu-074045	Oryctolagus cuniculus	99.49	0.00e+00	1169.00
IUUC-Oga-088494	Otolemur garnettii	99.32	0.00e+00	1175.00
IUUC-Oar-089645	Ovis aries	99.32	0.00e+00	1167.00
IUUC-Ptr-091063	Pan troglodytes	99.83	0.00e+00	1170.00
IUUC-Pan-092273	Papio anubis	99.58	0.00e+00	956.00
IUUC-Psi-093946	Pelodiscus sinensis	92.19	0.00e+00	1115.00
IUUC-Pma-094177	Petromyzon marinus	74.70	0.00e+00	797.00
IUUC-Pfo-096817	Poecilia formosa	80.85	0.00e+00	944.00
IUUC-Pab-097768	Pongo abelii	99.66	0.00e+00	1170.00
IUUC-Pca-100607	Procavia capensis	82.73	0.00e+00	832.00
IUUC-Pva-102218	Pteropus vampyrus	93.84	0.00e+00	1086.00
IUUC-Rno-105250	Rattus norvegicus	98.80	0.00e+00	1159.00
IUUC-Sar-113249	Sorex araneus	98.96	0.00e+00	1145.00
IUUC-Ssc-115423	Sus scrofa	99.49	0.00e+00	1174.00
IUUC-Tgu-117050	Taeniopygia guttata	91.62	0.00e+00	1087.00
IUUC-Tru-118239	Takifugu rubripes	82.02	0.00e+00	973.00
IUUC-Tsy-119377	Tarsius syrichta	85.45	0.00e+00	1007.00
IUUC-Tni-120122	Tetraodon nigroviridis	80.83	0.00e+00	878.00
IUUC-Ttr-128574	Tursiops truncatus	99.70	0.00e+00	701.00
IUUC-Vpa-130707	Vicugna pacos	95.28	0.00e+00	879.00
IUUC-Xtr-132035	Xenopus tropicalis	86.88	0.00e+00	1055.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence