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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108034
UUCD1 version UUC-ScP-00271
Ensembl Protein ID SPBC1604.21c.1:pep
UniProt Accession O94609; Q9P7R2; Q9USY9; UBA1_SCHPO
Genbank Protein ID BAA75198.1; CAA22354.1
Protein Name Ubiquitin-activating enzyme E1 1; Poly(A)+ RNA transport protein 3
Genbank Nucleotide ID D87259; CU329671
Gene Name ptr3; SPBC1604.21c; SPBC211.09
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC1604.21c SPBC1604.21c.1 SPBC1604.21c.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E1 1.30e-180 599.1 410 891
Active Site
Position(s) Description Evidence
593 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnp 86
           YD+Qi+++G+e qek+ s + +lvGag++GcE+lKn +++Gv     g+i v+Dmd +e+snlnrqFLfr++dvgk K+e+a  a+  +np
   Q: 410  YDGQIAVFGSEFQEKIASLSTFLVGAGAIGCEMLKNWAMMGVatgesGHISVTDMDSIEKSNLNRQFLFRPRDVGKLKSECASTAVSIMNP 500
           ******************************************************************************************* PP
   S: 87   dv..nveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiP 172
           +   ++++++e++ ++ e i+   Ff+k+++V +aldn+ear++v+r+c+  ++pl+esgtlG++G+++v++++lte+y +s+dpp+k++P
   Q: 501  SLtgKITSYQERVGPESEGIFgdeFFEKLSLVTNALDNVEARMYVDRRCVFFEKPLLESGTLGTKGNTQVVVPHLTESYGSSQDPPEKSFP 591
           *955678999*********99********************************************************************** PP
   S: 173  fctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttin 251
           +ctlk++pn +ehti wa              +n++l+  ++ e+ l+  +s++++e+++ +++ l++e++ +fee+i +a+ +f+k+++n
   Q: 592  ICTLKNFPNRIEHTIAWArdlfeglfkqpiDNVNMYLSSPNFLETSLK--TSSNPREVLENIRDYLVTEKPLSFEECIMWARLQFDKFFNN 680
           *****************************9999****99999999998..789************************************** PP
   S: 252  sikqllksfecdivtkskspfwv.......................................................sfcsnaealqvpe 287
           +i+qll +f++d vt+ ++pfw+                                                         ++   ++qv+e
   Q: 681  NIQQLLFNFPKDSVTSTGQPFWSgpkraptplsfdihnrehfdfivaaaslyafnyglksetdpaiyervlagynpppFAPKSGIKIQVNE 771
           **************************************************************************99987777777888888 PP
   S: 288  kvekdeevvkasap.lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnav 375
           + e +e++  ++++ l+    +l   ++  g   +  +fekddds  ++d++taa+nlra +++i p +d++++k +ag+i+pa+ t +av
   Q: 772  NEEAPETAANKDKQeLKSIADSLPPPSSLVGFRLTPAEFEKDDDSnhHIDFITAASNLRAMNYDITP-ADRFKTKFVAGKIVPAMCTSTAV 861
           8877777666666678899999999******************************************.*********************** PP
   S: 376  vgGlaaqEviKvvsg..kfeplknfflfda 403
           v+Gl+++E++K+v+g  k e +kn f+++a
   Q: 862  VSGLVCLELVKLVDGkkKIEEYKNGFFNLA 891
           ***************777888*****9976 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
 Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
Protein Sequence
(Fasta)
MSNNMNIDQT DQNTIDEGLY SRQLYVLGHE AMKQMSQSNV LIIGCKGLGV EIAKNVCLAG 60
VKSVTLYDPQ PTRIEDLSSQ YFLTEDDIGV PRAKVTVSKL AELNQYVPVS VVDELSTEYL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108034|E1,E1_ThiF|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACTATATTA TAGCCTACGT ATGACTCTCC TCTGCCAACA CCACGTTTCG TAATGAGTGT 60
ATGTAATTTG TTTAAATGAT TCAAGTATTT TTCGCTTCTT ACTAACATTG CAAAAGAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108034|E1,E1_ThiF|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like
PROSITE

PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0016567--P:protein ubiquitination
KEGG spo:SPBC1604.21c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000456 Aegilops tauschii 44.68 0.00e+00 837.00
IUUC-Aml-001311 Ailuropoda melanoleuca 54.10 0.00e+00 1093.00
IUUC-Atr-002684 Amborella trichopoda 43.06 0.00e+00 827.00
IUUC-Apl-004158 Anas platyrhynchos 41.59 0.00e+00 689.00
IUUC-Aca-004620 Anolis carolinensis 53.07 0.00e+00 1068.00
IUUC-Aly-005515 Arabidopsis lyrata 44.05 0.00e+00 850.00
IUUC-Ath-006891 Arabidopsis thaliana 44.37 0.00e+00 848.00
IUUC-Ago-007873 Ashbya gossypii 57.33 0.00e+00 1136.00
IUUC-Acl-008181 Aspergillus clavatus 60.88 0.00e+00 1239.00
IUUC-Afl-008455 Aspergillus flavus 61.12 0.00e+00 1198.00
IUUC-Afu-009065 Aspergillus fumigatus 61.76 0.00e+00 1276.00
IUUC-Ani-009371 Aspergillus nidulans 60.90 0.00e+00 1208.00
IUUC-Ang-009737 Aspergillus niger 61.24 0.00e+00 1243.00
IUUC-Aor-010007 Aspergillus oryzae 61.12 0.00e+00 1199.00
IUUC-Ate-010466 Aspergillus terreus 60.17 0.00e+00 1258.00
IUUC-Ame-010933 Astyanax mexicanus 54.60 0.00e+00 1027.00
IUUC-Bgr-012281 Blumeria graminis 58.37 0.00e+00 1176.00
IUUC-Bta-012767 Bos taurus 53.52 0.00e+00 1086.00
IUUC-Bci-013721 Botrytis cinerea 59.16 0.00e+00 1165.00
IUUC-Bdi-014009 Brachypodium distachyon 42.89 0.00e+00 804.00
IUUC-Bol-015665 Brassica oleracea 44.40 0.00e+00 848.00
IUUC-Bra-017252 Brassica rapa 44.10 0.00e+00 859.00
IUUC-Cel-018260 Caenorhabditis elegans 46.71 0.00e+00 825.00
IUUC-Cja-019152 Callithrix jacchus 53.82 0.00e+00 1083.00
IUUC-Cfa-020622 Canis familiaris 52.92 0.00e+00 1035.00
IUUC-Cpo-022526 Cavia porcellus 54.36 0.00e+00 1072.00
IUUC-Cre-022702 Chlamydomonas reinhardtii 42.29 0.00e+00 746.00
IUUC-Csa-023780 Chlorocebus sabaeus 53.91 0.00e+00 1080.00
IUUC-Cho-024682 Choloepus hoffmanni 37.83 2.00e-88 318.00
IUUC-Cin-025790 Ciona intestinalis 53.22 0.00e+00 1092.00
IUUC-Csv-026084 Ciona savignyi 52.02 0.00e+00 1073.00
IUUC-Cgl-026512 Colletotrichum gloeosporioides 58.46 0.00e+00 1204.00
IUUC-Cne-026960 Cryptococcus neoformans 58.59 0.00e+00 1177.00
IUUC-Cme-027290 Cyanidioschyzon merolae 42.04 0.00e+00 796.00
IUUC-Dre-028149 Danio rerio 55.77 0.00e+00 1061.00
IUUC-Dno-028884 Dasypus novemcinctus 53.96 0.00e+00 1078.00
IUUC-Dor-030229 Dipodomys ordii 51.93 0.00e+00 1022.00
IUUC-Dse-031524 Dothistroma septosporum 59.80 0.00e+00 1212.00
IUUC-Dme-032045 Drosophila melanogaster 51.84 0.00e+00 1013.00
IUUC-Ete-033124 Echinops telfairi 40.92 2.00e-143 501.00
IUUC-Eca-033330 Equus caballus 54.16 0.00e+00 1085.00
IUUC-Eeu-035323 Erinaceus europaeus 39.29 7.00e-151 526.00
IUUC-Fca-036255 Felis catus 54.31 0.00e+00 1086.00
IUUC-Fal-037445 Ficedula albicollis 38.66 0.00e+00 660.00
IUUC-Fox-038007 Fusarium oxysporum 59.66 0.00e+00 644.00
IUUC-Fso-038339 Fusarium solani 58.52 0.00e+00 1145.00
IUUC-Gmo-039338 Gadus morhua 53.42 0.00e+00 1023.00
IUUC-Ggr-039823 Gaeumannomyces graminis 58.58 0.00e+00 1212.00
IUUC-Gga-040747 Gallus gallus 41.79 0.00e+00 701.00
IUUC-Gac-041773 Gasterosteus aculeatus 52.48 0.00e+00 1013.00
IUUC-Gma-043165 Glycine max 44.08 0.00e+00 855.00
IUUC-Ggo-045336 Gorilla gorilla 54.11 0.00e+00 1072.00
IUUC-Hsa-045982 Homo sapiens 54.01 0.00e+00 1068.00
IUUC-Hvu-047418 Hordeum vulgare 44.62 0.00e+00 821.00
IUUC-Itr-048460 Ictidomys tridecemlineatus 53.91 0.00e+00 1082.00
IUUC-Kpa-049112 Komagataella pastoris 60.16 0.00e+00 1184.00
IUUC-Lch-050371 Latimeria chalumnae 54.75 0.00e+00 1084.00
IUUC-Lpe-051299 Leersia perrieri 43.65 0.00e+00 838.00
IUUC-Loc-052936 Lepisosteus oculatus 55.41 0.00e+00 1077.00
IUUC-Lma-053315 Leptosphaeria maculans 58.61 0.00e+00 1223.00
IUUC-Laf-053948 Loxodonta africana 53.42 0.00e+00 1050.00
IUUC-Mcc-055843 Macaca mulatta 53.82 0.00e+00 1082.00
IUUC-Meu-056258 Macropus eugenii 53.42 0.00e+00 1069.00
IUUC-Mor-057269 Magnaporthe oryzae 58.13 0.00e+00 1184.00
IUUC-Mpo-057435 Magnaporthe poae 58.19 0.00e+00 1185.00
IUUC-Mtr-058572 Medicago truncatula 44.51 0.00e+00 832.00
IUUC-Mla-059176 Melampsora laricipopulina 57.78 0.00e+00 1123.00
IUUC-Mga-059721 Meleagris gallopavo 41.73 0.00e+00 682.00
IUUC-Mvi-060437 Microbotryum violaceum 57.16 0.00e+00 1132.00
IUUC-Mmr-061405 Microcebus murinus 52.77 0.00e+00 1036.00
IUUC-Mdo-062032 Monodelphis domestica 52.45 0.00e+00 1044.00
IUUC-Mmu-063280 Mus musculus 53.72 0.00e+00 1068.00
IUUC-Mac-065505 Musa acuminata 44.18 0.00e+00 835.00
IUUC-Mpu-066409 Mustela putorius furo 54.31 0.00e+00 1093.00
IUUC-Mlu-067217 Myotis lucifugus 53.22 0.00e+00 1060.00
IUUC-Nfi-068407 Neosartorya fischeri 61.37 0.00e+00 1248.00
IUUC-Ncr-068698 Neurospora crassa 59.47 0.00e+00 1220.00
IUUC-Nle-070072 Nomascus leucogenys 51.53 0.00e+00 993.00
IUUC-Opr-070715 Ochotona princeps 37.17 0.00e+00 627.00
IUUC-Ont-071671 Oreochromis niloticus 55.09 0.00e+00 1059.00
IUUC-Oan-073268 Ornithorhynchus anatinus 41.00 0.00e+00 654.00
IUUC-Ocu-074544 Oryctolagus cuniculus 54.26 0.00e+00 1088.00
IUUC-Oba-075120 Oryza barthii 43.63 0.00e+00 821.00
IUUC-Obr-076557 Oryza brachyantha 44.56 0.00e+00 823.00
IUUC-Ogl-077887 Oryza glaberrima 43.54 0.00e+00 819.00
IUUC-Ogu-078305 Oryza glumaepatula 43.66 0.00e+00 837.00
IUUC-Oin-080154 Oryza indica 43.76 0.00e+00 838.00
IUUC-Olo-081089 Oryza longistaminata 43.86 0.00e+00 843.00
IUUC-Ome-081942 Oryza meridionalis 43.54 0.00e+00 823.00
IUUC-Oni-082365 Oryza nivara 43.73 0.00e+00 825.00
IUUC-Opu-083977 Oryza punctata 44.19 0.00e+00 828.00
IUUC-Oru-084469 Oryza rufipogon 43.76 0.00e+00 838.00
IUUC-Osa-085949 Oryza sativa 43.83 0.00e+00 831.00
IUUC-Ola-087002 Oryzias latipes 54.26 0.00e+00 1051.00
IUUC-Olu-087687 Ostreococcus lucimarinus 44.00 0.00e+00 776.00
IUUC-Oga-088594 Otolemur garnettii 54.06 0.00e+00 1068.00
IUUC-Oar-090068 Ovis aries 53.42 0.00e+00 1085.00
IUUC-Ptr-090609 Pan troglodytes 40.89 0.00e+00 686.00
IUUC-Pan-092114 Papio anubis 53.91 0.00e+00 1082.00
IUUC-Psi-093489 Pelodiscus sinensis 41.85 0.00e+00 713.00
IUUC-Pma-094214 Petromyzon marinus 48.78 7.00e-38 147.00
IUUC-Pno-095154 Phaeosphaeria nodorum 57.51 0.00e+00 1197.00
IUUC-Ppa-095227 Physcomitrella patens 45.73 0.00e+00 851.00
IUUC-Pfo-097184 Poecilia formosa 54.30 0.00e+00 1048.00
IUUC-Pab-097861 Pongo abelii 53.91 0.00e+00 1057.00
IUUC-Pop-098934 Populus trichocarpa 44.02 0.00e+00 858.00
IUUC-Pca-100347 Procavia capensis 52.46 0.00e+00 912.00
IUUC-Ppe-102012 Prunus persica 43.85 0.00e+00 847.00
IUUC-Pva-102584 Pteropus vampyrus 54.55 0.00e+00 1114.00
IUUC-Pgr-103336 Puccinia graminis 55.44 0.00e+00 1071.00
IUUC-Ptt-103939 Puccinia triticina 55.54 0.00e+00 1071.00
IUUC-Pte-104200 Pyrenophora teres 58.91 0.00e+00 1224.00
IUUC-Pyt-104441 Pyrenophora triticirepentis 57.70 0.00e+00 1214.00
IUUC-Rno-105462 Rattus norvegicus 53.56 0.00e+00 1064.00
IUUC-Sce-106245 Saccharomyces cerevisiae 58.54 0.00e+00 1199.00
IUUC-Sha-107142 Sarcophilus harrisii 52.91 0.00e+00 1067.00
IUUC-Sja-107841 Schizosaccharomyces japonicus 73.74 0.00e+00 1559.00
IUUC-Ssl-108497 Sclerotinia sclerotiorum 59.26 0.00e+00 1190.00
IUUC-Smo-109211 Selaginella moellendorffii 46.36 0.00e+00 843.00
IUUC-Sit-110281 Setaria italica 43.96 0.00e+00 832.00
IUUC-Sly-110914 Solanum lycopersicum 43.65 0.00e+00 867.00
IUUC-Stu-112109 Solanum tuberosum 43.26 0.00e+00 864.00
IUUC-Sar-113737 Sorex araneus 53.52 0.00e+00 1075.00
IUUC-Sbi-114089 Sorghum bicolor 43.87 0.00e+00 837.00
IUUC-Sre-115148 Sporisorium reilianum 56.05 0.00e+00 1128.00
IUUC-Ssc-115777 Sus scrofa 53.91 0.00e+00 1086.00
IUUC-Tgu-116565 Taeniopygia guttata 40.73 0.00e+00 683.00
IUUC-Tru-118742 Takifugu rubripes 54.36 0.00e+00 1008.00
IUUC-Tsy-119436 Tarsius syrichta 36.64 2.00e-163 568.00
IUUC-Tni-120401 Tetraodon nigroviridis 54.39 0.00e+00 1021.00
IUUC-Tca-121672 Theobroma cacao 44.63 0.00e+00 857.00
IUUC-Tre-122009 Trichoderma reesei 57.81 0.00e+00 1135.00
IUUC-Tvi-122259 Trichoderma virens 58.03 0.00e+00 1130.00
IUUC-Tae-125676 Triticum aestivum 43.47 0.00e+00 838.00
IUUC-Tur-126330 Triticum urartu 44.58 0.00e+00 836.00
IUUC-Tme-127055 Tuber melanosporum 58.93 0.00e+00 1164.00
IUUC-Tbe-127487 Tupaia belangeri 54.10 4.00e-146 510.00
IUUC-Ttr-128331 Tursiops truncatus 54.10 0.00e+00 1073.00
IUUC-Uma-129387 Ustilago maydis 56.72 0.00e+00 1135.00
IUUC-Vda-129977 Verticillium dahliae 59.15 0.00e+00 1115.00
IUUC-Vpa-130716 Vicugna pacos 39.98 0.00e+00 659.00
IUUC-Vvi-130857 Vitis vinifera 44.36 0.00e+00 850.00
IUUC-Xtr-132947 Xenopus tropicalis 38.98 0.00e+00 636.00
IUUC-Xma-133805 Xiphophorus maculatus 54.30 0.00e+00 1032.00
IUUC-Yli-134547 Yarrowia lipolytica 57.25 0.00e+00 1212.00
IUUC-Zma-135052 Zea mays 43.86 0.00e+00 836.00
Created Date 25-Jun-2017

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