iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-041258

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine-signaling 3

Genbank Nucleotide ID

AADN04000355

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000027786.3	ENSGALT00000043264.3	ENSGALP00000042295.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	83.11	1.00e-95	346.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gallus gallus

Protein Sequence
(Fasta)

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNTVRK LQESGFYWST VTGGEANVLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTESGT KNLRIQCEGG SFSLQSDPRS SQPVPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTCCGCCG CCGTCCGCCG CCGCACACTG AGCCCCGCGC CCCGGCCGCC ACCGAGACCA 60
GCACTGCGCC CCAGGTACCG GCACGGGACG GGACGGGGGA GGCGGGGAGG GTCCCCCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	80.89	7.00e-100	355.00
IUUC-Apl-003607	Anas platyrhynchos	94.74	2.00e-104	370.00
IUUC-Aca-005063	Anolis carolinensis	87.20	1.00e-103	368.00
IUUC-Ath-006990	Arabidopsis thaliana	31.76	3.20e-02	33.90
IUUC-Ame-010859	Astyanax mexicanus	57.27	3.00e-69	254.00
IUUC-Bta-012817	Bos taurus	79.74	3.00e-103	367.00
IUUC-Cja-019605	Callithrix jacchus	81.33	2.00e-102	364.00
IUUC-Cfa-021231	Canis familiaris	81.78	1.00e-101	361.00
IUUC-Cpo-022003	Cavia porcellus	80.70	3.00e-101	360.00
IUUC-Csa-023511	Chlorocebus sabaeus	81.50	2.00e-102	364.00
IUUC-Dre-028536	Danio rerio	62.62	4.00e-75	273.00
IUUC-Dno-029003	Dasypus novemcinctus	81.25	2.00e-101	361.00
IUUC-Eca-034205	Equus caballus	70.39	3.00e-63	233.00
IUUC-Fca-036317	Felis catus	80.27	1.00e-98	351.00
IUUC-Gmo-038777	Gadus morhua	62.04	6.00e-35	139.00
IUUC-Gac-041837	Gasterosteus aculeatus	60.56	1.00e-67	248.00
IUUC-Ggo-045620	Gorilla gorilla	81.50	2.00e-102	364.00
IUUC-Hsa-046909	Homo sapiens	81.50	2.00e-102	364.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	79.49	5.00e-102	363.00
IUUC-Lch-049510	Latimeria chalumnae	72.43	3.00e-83	300.00
IUUC-Loc-052863	Lepisosteus oculatus	69.16	7.00e-82	295.00
IUUC-Laf-054136	Loxodonta africana	80.26	1.00e-101	361.00
IUUC-Mcc-055383	Macaca mulatta	81.50	2.00e-102	364.00
IUUC-Meu-056153	Macropus eugenii	81.86	7.00e-103	365.00
IUUC-Mmr-061185	Microcebus murinus	81.42	5.00e-101	359.00
IUUC-Mdo-061819	Monodelphis domestica	81.78	3.00e-104	370.00
IUUC-Mmu-064231	Mus musculus	84.44	2.00e-104	371.00
IUUC-Mpu-066691	Mustela putorius furo	82.22	1.00e-101	361.00
IUUC-Mlu-067673	Myotis lucifugus	81.86	1.00e-104	371.00
IUUC-Ont-072406	Oreochromis niloticus	61.03	1.00e-72	265.00
IUUC-Oan-073249	Ornithorhynchus anatinus	79.90	3.00e-92	330.00
IUUC-Ocu-074935	Oryctolagus cuniculus	80.00	7.00e-28	114.00
IUUC-Ola-087373	Oryzias latipes	51.06	1.00e-49	189.00
IUUC-Oga-088041	Otolemur garnettii	82.14	3.00e-102	363.00
IUUC-Oar-089646	Ovis aries	79.04	4.00e-98	350.00
IUUC-Ptr-091502	Pan troglodytes	81.50	2.00e-102	364.00
IUUC-Pan-091934	Papio anubis	81.50	2.00e-102	364.00
IUUC-Pfo-096412	Poecilia formosa	45.54	3.00e-49	187.00
IUUC-Pab-098554	Pongo abelii	81.50	2.00e-102	364.00
IUUC-Rno-105874	Rattus norvegicus	82.67	1.00e-104	371.00
IUUC-Sha-107151	Sarcophilus harrisii	80.70	1.00e-102	365.00
IUUC-Ssc-115722	Sus scrofa	73.10	4.00e-61	226.00
IUUC-Tgu-117151	Taeniopygia guttata	97.61	3.00e-110	390.00
IUUC-Tru-118428	Takifugu rubripes	61.03	4.00e-71	259.00
IUUC-Tni-120590	Tetraodon nigroviridis	61.03	3.00e-70	257.00
IUUC-Ttr-129065	Tursiops truncatus	80.09	7.00e-102	362.00
IUUC-Xtr-132167	Xenopus tropicalis	71.77	2.00e-83	301.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence