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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104972
UUCD1 version UUC-RaN-00374
Ensembl Protein ID ENSRNOP00000004508.5
UniProt Accession D4A2K4; KLH21_RAT
Genbank Protein ID EDL81211.1
Protein Name Kelch-like protein 21
Genbank Nucleotide ID CH473968
Gene Name Klhl21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000003334.5 ENSRNOT00000004508.5 ENSRNOP00000004508.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.50e-19 69.8 36 100
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.70e-09 35.0 136 164
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 2    Dvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           Dv+l+ + g+ f+ah++vLaa+S++F+a+f ++l+es+  ++v +++v p+ ++ ll+F+Ytg++ 
   Q: 36   DVTLEAAgGRDFPAHRAVLAAASPYFRAMFAGQLRESR-AERVRLHGVPPDMLQLLLDFSYTGRVA 100
           9*****99******************************.************************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkh 30
            Ncl++ +fA++++c+ L++aa++fil+h
   Q: 136  ANCLDMQDFAEAFSCSGLASAAQRFILRH 164
           6***************************9 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
 Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
Protein Sequence
(Fasta)
MERPAPLAVL PFSDPAHALS LLRGLSQLRA ERKFLDVTLE AAGGRDFPAH RAVLAAASPY 60
FRAMFAGQLR ESRAERVRLH GVPPDMLQLL LDFSYTGRVA VSGDNAEPLL RAADLLQFPA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104972|E3,BTB_3-box|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGCGGC CGGCGCCTTT GGCCGTGCTG CCCTTCTCCG ATCCCGCGCA CGCCCTGAGC 60
CTGCTGCGCG GCCTGAGCCA GCTGCGCGCC GAGCGCAAGT TCCTGGACGT GACCCTGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104972|E3,BTB_3-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005827--C:polar microtubule
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0035853--P:chromosome passenger complex localization to spindle midzone
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
GO:0032465--P:regulation of cytokinesis
KEGG rno:313743
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001782 Ailuropoda melanoleuca 87.06 0.00e+00 924.00
IUUC-Apl-003189 Anas platyrhynchos 87.80 8.00e-141 492.00
IUUC-Ani-009467 Aspergillus nidulans 35.29 8.00e-08 51.20
IUUC-Ame-011774 Astyanax mexicanus 66.11 3.00e-137 481.00
IUUC-Bta-012367 Bos taurus 96.31 0.00e+00 1150.00
IUUC-Cja-019501 Callithrix jacchus 88.55 0.00e+00 1028.00
IUUC-Cfa-020550 Canis familiaris 96.15 0.00e+00 1150.00
IUUC-Cpo-022072 Cavia porcellus 95.14 0.00e+00 1118.00
IUUC-Csa-023364 Chlorocebus sabaeus 97.68 0.00e+00 1014.00
IUUC-Cin-025253 Ciona intestinalis 43.45 2.00e-146 513.00
IUUC-Csv-025871 Ciona savignyi 45.01 7.00e-153 533.00
IUUC-Dre-028694 Danio rerio 72.89 0.00e+00 863.00
IUUC-Dno-029082 Dasypus novemcinctus 92.40 0.00e+00 942.00
IUUC-Dor-030680 Dipodomys ordii 95.81 0.00e+00 1145.00
IUUC-Ete-032315 Echinops telfairi 93.87 0.00e+00 955.00
IUUC-Eca-033570 Equus caballus 93.75 0.00e+00 692.00
IUUC-Eeu-035067 Erinaceus europaeus 91.80 6.00e-144 504.00
IUUC-Fca-035663 Felis catus 88.51 6.00e-124 436.00
IUUC-Fal-037103 Ficedula albicollis 84.66 0.00e+00 894.00
IUUC-Gmo-039420 Gadus morhua 68.47 0.00e+00 842.00
IUUC-Ggr-039811 Gaeumannomyces graminis 38.36 3.00e-08 52.80
IUUC-Gga-040161 Gallus gallus 84.15 0.00e+00 861.00
IUUC-Gac-041755 Gasterosteus aculeatus 72.19 0.00e+00 871.00
IUUC-Ggo-044899 Gorilla gorilla 97.25 0.00e+00 1132.00
IUUC-Hsa-045834 Homo sapiens 97.75 0.00e+00 1131.00
IUUC-Itr-048413 Ictidomys tridecemlineatus 96.15 0.00e+00 1145.00
IUUC-Lch-050338 Latimeria chalumnae 71.06 0.00e+00 878.00
IUUC-Loc-051780 Lepisosteus oculatus 75.22 0.00e+00 886.00
IUUC-Laf-053725 Loxodonta africana 93.75 0.00e+00 791.00
IUUC-Mcc-055032 Macaca mulatta 98.60 0.00e+00 980.00
IUUC-Meu-056661 Macropus eugenii 94.06 0.00e+00 768.00
IUUC-Mpo-057626 Magnaporthe poae 31.67 4.00e-07 49.70
IUUC-Mga-059821 Meleagris gallopavo 87.61 2.00e-124 438.00
IUUC-Mdo-062095 Monodelphis domestica 95.06 0.00e+00 961.00
IUUC-Mmu-063138 Mus musculus 98.83 0.00e+00 1178.00
IUUC-Mpu-066386 Mustela putorius furo 94.10 0.00e+00 639.00
IUUC-Mlu-067807 Myotis lucifugus 93.26 0.00e+00 696.00
IUUC-Nle-069181 Nomascus leucogenys 95.14 0.00e+00 1126.00
IUUC-Opr-070658 Ochotona princeps 96.15 0.00e+00 1174.00
IUUC-Ont-072209 Oreochromis niloticus 72.71 0.00e+00 861.00
IUUC-Oan-072861 Ornithorhynchus anatinus 88.84 2.00e-117 414.00
IUUC-Ocu-074631 Oryctolagus cuniculus 86.54 0.00e+00 996.00
IUUC-Ola-087553 Oryzias latipes 71.30 0.00e+00 846.00
IUUC-Oga-088782 Otolemur garnettii 96.48 0.00e+00 1155.00
IUUC-Oar-089634 Ovis aries 95.98 0.00e+00 1146.00
IUUC-Ptr-091259 Pan troglodytes 96.52 0.00e+00 837.00
IUUC-Pan-091734 Papio anubis 97.59 0.00e+00 1136.00
IUUC-Psi-092979 Pelodiscus sinensis 84.30 0.00e+00 922.00
IUUC-Pma-094459 Petromyzon marinus 53.47 1.00e-125 442.00
IUUC-Pfo-097446 Poecilia formosa 72.01 0.00e+00 856.00
IUUC-Pab-098765 Pongo abelii 96.15 0.00e+00 1146.00
IUUC-Pca-101018 Procavia capensis 99.42 5.00e-94 338.00
IUUC-Pva-102730 Pteropus vampyrus 92.63 0.00e+00 1094.00
IUUC-Ssc-115869 Sus scrofa 97.22 0.00e+00 974.00
IUUC-Tgu-116562 Taeniopygia guttata 84.52 0.00e+00 927.00
IUUC-Tru-118490 Takifugu rubripes 71.65 0.00e+00 853.00
IUUC-Tni-119898 Tetraodon nigroviridis 69.54 0.00e+00 817.00
IUUC-Ttr-128976 Tursiops truncatus 92.19 6.00e-144 504.00
IUUC-Xtr-132876 Xenopus tropicalis 74.91 0.00e+00 910.00
IUUC-Xma-133540 Xiphophorus maculatus 72.54 0.00e+00 860.00
Created Date 25-Jun-2017

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