iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054115

UUCD1 version

UUC-LoA-00735

Ensembl Protein ID

ENSLAFP00000019862.1

UniProt Accession

G3TWA4; G3TWA4_LOXAF

Protein Name

Uncharacterized protein

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000016463.4	ENSLAFT00000035532.1	ENSLAFP00000019862.1
ENSLAFG00000016463.4	ENSLAFT00000016463.4	ENSLAFP00000013827.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.90e-08	33.3	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999****************9999876 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSLLNCENSC GSSQPDGDCC AAMASSCSAT TKDDSVSGTA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACITKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGC TAAACTGTGA AAACAGCTGT GGATCCAGCC AGCCTGACGG TGACTGTTGT 60
GCTGCCATGG CCAGCTCCTG TAGTGCCACA ACCAAAGATG ACAGTGTGAG TGGGACAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	88.91	0.00e+00	942.00
IUUC-Apl-004062	Anas platyrhynchos	73.14	0.00e+00	830.00
IUUC-Aca-004636	Anolis carolinensis	69.16	0.00e+00	751.00
IUUC-Acl-008349	Aspergillus clavatus	28.51	2.00e-12	67.00
IUUC-Ame-011682	Astyanax mexicanus	53.36	1.00e-160	560.00
IUUC-Bta-012692	Bos taurus	86.35	0.00e+00	952.00
IUUC-Cja-019426	Callithrix jacchus	84.47	0.00e+00	917.00
IUUC-Cfa-020948	Canis familiaris	88.14	0.00e+00	829.00
IUUC-Cpo-021378	Cavia porcellus	85.82	0.00e+00	932.00
IUUC-Csa-024045	Chlorocebus sabaeus	85.03	0.00e+00	927.00
IUUC-Cho-024973	Choloepus hoffmanni	71.19	1.00e-97	350.00
IUUC-Csv-026300	Ciona savignyi	37.55	7.00e-41	160.00
IUUC-Dre-027557	Danio rerio	55.80	3.00e-171	594.00
IUUC-Dno-030032	Dasypus novemcinctus	87.12	3.00e-146	511.00
IUUC-Dor-030790	Dipodomys ordii	83.92	0.00e+00	911.00
IUUC-Dme-031921	Drosophila melanogaster	28.17	8.00e-42	164.00
IUUC-Ete-032952	Echinops telfairi	79.35	1.00e-158	552.00
IUUC-Eca-033924	Equus caballus	83.61	0.00e+00	858.00
IUUC-Eeu-034734	Erinaceus europaeus	77.68	0.00e+00	814.00
IUUC-Fca-036222	Felis catus	81.00	0.00e+00	831.00
IUUC-Fal-036834	Ficedula albicollis	73.89	0.00e+00	729.00
IUUC-Fox-037935	Fusarium oxysporum	28.37	1.00e-18	87.80
IUUC-Gmo-039061	Gadus morhua	55.88	2.00e-82	300.00
IUUC-Gga-040599	Gallus gallus	73.58	0.00e+00	837.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.66	4.00e-164	571.00
IUUC-Ggo-044508	Gorilla gorilla	79.56	0.00e+00	841.00
IUUC-Hsa-046349	Homo sapiens	85.77	0.00e+00	961.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	84.29	0.00e+00	932.00
IUUC-Lch-049821	Latimeria chalumnae	64.94	0.00e+00	723.00
IUUC-Loc-051995	Lepisosteus oculatus	57.55	2.00e-178	618.00
IUUC-Mcc-055298	Macaca mulatta	85.03	0.00e+00	926.00
IUUC-Mga-059340	Meleagris gallopavo	74.13	0.00e+00	818.00
IUUC-Mmr-061063	Microcebus murinus	86.69	0.00e+00	934.00
IUUC-Mdo-062075	Monodelphis domestica	78.45	0.00e+00	883.00
IUUC-Mmu-063780	Mus musculus	82.26	0.00e+00	865.00
IUUC-Mpu-065748	Mustela putorius furo	88.17	0.00e+00	941.00
IUUC-Mlu-067888	Myotis lucifugus	84.47	0.00e+00	918.00
IUUC-Ncr-068632	Neurospora crassa	27.50	5.00e-14	72.80
IUUC-Nle-069234	Nomascus leucogenys	85.95	0.00e+00	938.00
IUUC-Opr-070393	Ochotona princeps	91.08	7.00e-119	420.00
IUUC-Ont-072459	Oreochromis niloticus	53.18	2.00e-173	602.00
IUUC-Oan-073578	Ornithorhynchus anatinus	80.88	0.00e+00	895.00
IUUC-Ocu-074201	Oryctolagus cuniculus	85.77	0.00e+00	931.00
IUUC-Ola-087319	Oryzias latipes	56.81	2.00e-85	310.00
IUUC-Olu-087748	Ostreococcus lucimarinus	24.30	5.00e-06	45.40
IUUC-Oga-087936	Otolemur garnettii	84.84	0.00e+00	922.00
IUUC-Oar-089379	Ovis aries	86.16	0.00e+00	956.00
IUUC-Ptr-090758	Pan troglodytes	85.95	0.00e+00	933.00
IUUC-Pan-092590	Papio anubis	85.21	0.00e+00	927.00
IUUC-Psi-093948	Pelodiscus sinensis	70.75	0.00e+00	788.00
IUUC-Pma-094434	Petromyzon marinus	43.44	1.00e-120	426.00
IUUC-Pfo-096912	Poecilia formosa	51.84	1.00e-164	572.00
IUUC-Pab-097651	Pongo abelii	85.95	0.00e+00	936.00
IUUC-Pca-100958	Procavia capensis	83.93	0.00e+00	689.00
IUUC-Pva-103247	Pteropus vampyrus	86.51	4.00e-121	428.00
IUUC-Rno-104994	Rattus norvegicus	80.78	0.00e+00	878.00
IUUC-Sha-106494	Sarcophilus harrisii	78.74	0.00e+00	893.00
IUUC-Sar-113375	Sorex araneus	83.39	0.00e+00	893.00
IUUC-Sre-115218	Sporisorium reilianum	25.54	3.00e-13	70.50
IUUC-Ssc-115417	Sus scrofa	86.35	0.00e+00	957.00
IUUC-Tgu-117232	Taeniopygia guttata	72.29	0.00e+00	784.00
IUUC-Tru-118321	Takifugu rubripes	54.44	4.00e-165	574.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.27	2.00e-161	562.00
IUUC-Tbe-127719	Tupaia belangeri	74.95	0.00e+00	783.00
IUUC-Ttr-129264	Tursiops truncatus	83.00	5.00e-115	407.00
IUUC-Uma-129620	Ustilago maydis	25.97	1.00e-16	81.60
IUUC-Vpa-130244	Vicugna pacos	83.00	3.00e-117	415.00
IUUC-Xtr-131948	Xenopus tropicalis	64.70	0.00e+00	733.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence