iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020334

Ensembl Protein ID

ENSCAFP00000022970.3

UniProt Accession

F6XJQ4; F6XJQ4_CANLF

Genbank Protein ID

ENSCAFP00000022970

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03012305

Gene Name

NWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000015626.3	ENSCAFT00000024761.3	ENSCAFP00000022970.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.90e-23	80.1	909	945
UBD/Beta-Prp	8.20e-52	176.5	1094	1461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcla.f.sdtllvsGsdDgtikvWDlrtgvl 35
           gHt++v++++ f  +tl++s+s D+t+++W+l +g +
   Q: 909  GHTGEVRSVKvFgKGTLVLSASKDHTLRLWNLLSGQQ 945
           8********9777669***************988865 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlsls 101
           s+d+slla+g+  ++++++ ++++ +   +++  +he++v    f p+ +++vt+s+D++i+vw+ls +g+ + +l+g  + v +l+
   Q: 1094 SEDESLLAAGF-GRSVRIFLADSQGFhrfMATDLEHEDTVEIAGFGPENNLIVTASRDALIQVWSLSeQGTLLDILEGVGAPVSLLA 1179
           66667666665.777777777777776666666777777777777777777777777777777776656666677777777777777 PP
   S: 102  fspsgdklvsGshd.rtirvwdletgqclee...........................................tlsghdgvvncvv 144
           +      ++s+s+  + ++vwdl   q+ ++                                            l+  +  v+c++
   Q: 1180 WAG--ALVASASQQsSSLKVWDLTYIQKPRActpfldrtgltavshngsyvyfpkigdknkvtiwdsaegeeqdALDTSN-EVRCLE 1263
           776..777777765245777777777777667777777777777777777777777777777777777777766554444.49**** PP
   S: 145  vhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvyslsfdsng..................................... 192
           v +++nll++G   ++v ++ l++ + +      +   ++++++++++                                       
   Q: 1264 VAQQANLLFTGLVSGVVLVFPLNSRQDVMCIppPE-ARKAINCMALSKGEerlaiaydsivlvldispgdpcpvidgptytfytqlp 1349
           **********************7777666666533.688999999777667777777778888888888899999999999999999 PP
   S: 193  ...........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvi 268
                       ++++g ++g++ l+++ +++ v  l++h ++v+++++s ++++ vsgs++  + +Wdl+  +   +++++ns   
   Q: 1350 eaissvavladYRVIYGMTNGDLFLYECANSK-VFPLEAHGSQVTCMQVSHKEQLAVSGSEEALLCLWDLQACKWRFQMSYTNSYCR 1435
           99999999999*****************9887.99************************************************9999 PP
   S: 269  svavlsfg..dnvlvlgsedskvniw 292
            v++++f+  d+++++g +d ++ +w
   Q: 1436 GVQCVCFSkdDKYVYAGLKDRSIIVW 1461
           99998887779999999999999888 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MDAEREALQS TAFPEVQTFC QKNGLMFEVV DLRWGIRNTE ATDHMTTELC LEELDRCRKT 60
SIGPAFVALL GDQYGPCPVP TLIEEKEWEA LRSQLASKPR DLELVARRFR RDENAVPPTY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCCAGTTG CTGGGTGAAT TGGCAGGGAG AGACCTGGGA AGTACCTAAG ACAAAAGTTA 60
CTAGGATTGC CGGGGGCCTG GCTTCCGGGC AGTGCTACGG CCAGAAAACT TTCTTCTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0008380--P:RNA splicing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001525	Ailuropoda melanoleuca	92.75	0.00e+00	2856.00
IUUC-Apl-003467	Anas platyrhynchos	60.94	9.00e-85	306.00
IUUC-Ame-011400	Astyanax mexicanus	36.88	0.00e+00	988.00
IUUC-Bta-013223	Bos taurus	86.77	0.00e+00	2297.00
IUUC-Cel-018404	Caenorhabditis elegans	29.57	2.00e-106	381.00
IUUC-Cja-018773	Callithrix jacchus	82.41	0.00e+00	1520.00
IUUC-Cpo-022316	Cavia porcellus	66.67	0.00e+00	1919.00
IUUC-Csa-023631	Chlorocebus sabaeus	84.03	0.00e+00	2540.00
IUUC-Cin-025646	Ciona intestinalis	31.77	1.00e-127	450.00
IUUC-Csv-026191	Ciona savignyi	24.75	5.00e-24	105.00
IUUC-Dre-028241	Danio rerio	36.43	0.00e+00	956.00
IUUC-Dno-029990	Dasypus novemcinctus	80.47	0.00e+00	682.00
IUUC-Dor-030869	Dipodomys ordii	62.08	4.00e-179	622.00
IUUC-Ete-033059	Echinops telfairi	83.98	0.00e+00	845.00
IUUC-Eca-033718	Equus caballus	82.88	0.00e+00	2531.00
IUUC-Fca-035748	Felis catus	91.15	0.00e+00	2640.00
IUUC-Gac-041507	Gasterosteus aculeatus	35.78	0.00e+00	759.00
IUUC-Ggo-044551	Gorilla gorilla	80.56	0.00e+00	2420.00
IUUC-Hsa-046787	Homo sapiens	83.28	0.00e+00	2533.00
IUUC-Itr-048104	Ictidomys tridecemlineatus	65.09	0.00e+00	1813.00
IUUC-Lch-049578	Latimeria chalumnae	48.71	0.00e+00	1451.00
IUUC-Loc-052039	Lepisosteus oculatus	42.51	0.00e+00	1256.00
IUUC-Laf-054240	Loxodonta africana	84.02	0.00e+00	2658.00
IUUC-Mcc-054657	Macaca mulatta	76.21	0.00e+00	2185.00
IUUC-Meu-056591	Macropus eugenii	64.19	0.00e+00	1169.00
IUUC-Mmr-061577	Microcebus murinus	79.75	0.00e+00	2409.00
IUUC-Mdo-062895	Monodelphis domestica	62.89	0.00e+00	1823.00
IUUC-Mmu-063866	Mus musculus	78.15	0.00e+00	2362.00
IUUC-Mpu-066510	Mustela putorius furo	92.04	0.00e+00	2875.00
IUUC-Mlu-067855	Myotis lucifugus	87.04	0.00e+00	2608.00
IUUC-Nle-069557	Nomascus leucogenys	78.76	0.00e+00	2318.00
IUUC-Opr-071196	Ochotona princeps	63.81	0.00e+00	635.00
IUUC-Ont-072070	Oreochromis niloticus	35.73	0.00e+00	828.00
IUUC-Oan-073437	Ornithorhynchus anatinus	58.21	0.00e+00	1285.00
IUUC-Ocu-074941	Oryctolagus cuniculus	83.64	6.00e-53	200.00
IUUC-Ola-086624	Oryzias latipes	33.38	0.00e+00	702.00
IUUC-Oga-088313	Otolemur garnettii	84.31	0.00e+00	2363.00
IUUC-Oar-090123	Ovis aries	86.34	0.00e+00	2648.00
IUUC-Ptr-090552	Pan troglodytes	82.97	0.00e+00	1048.00
IUUC-Psi-093963	Pelodiscus sinensis	55.26	0.00e+00	1653.00
IUUC-Pfo-096197	Poecilia formosa	34.64	0.00e+00	828.00
IUUC-Pab-097755	Pongo abelii	81.43	0.00e+00	910.00
IUUC-Pca-100809	Procavia capensis	79.38	0.00e+00	1230.00
IUUC-Pva-102554	Pteropus vampyrus	84.78	0.00e+00	2328.00
IUUC-Rno-105174	Rattus norvegicus	71.04	0.00e+00	2082.00
IUUC-Sha-107304	Sarcophilus harrisii	63.61	0.00e+00	2023.00
IUUC-Sar-113168	Sorex araneus	66.91	0.00e+00	1409.00
IUUC-Tru-118251	Takifugu rubripes	35.65	0.00e+00	681.00
IUUC-Tsy-119276	Tarsius syrichta	78.99	6.00e-119	422.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence