iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053452

UUCD1 version

UUC-LoA-00597

Ensembl Protein ID

ENSLAFP00000014508.3

UniProt Accession

G3TIM2; G3TIM2_LOXAF

Protein Name

Uncharacterized protein

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000017297.3	ENSLAFT00000017300.3	ENSLAFP00000014508.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.00e-09	36.6	258	296
UBD/Alpha-Helix/CUE	2.50e-11	43.6	373	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 258  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 296
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 373  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 414
           5889*********************.***************95 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

VQVLVNTACC ILMLVAKLIQ CIVFGPLRVS ERQHLKDKFW NFIFYKFIFI FGVLNVQTVE 60
EVVMWCLWFA GLVFLHLMVQ LCKDRFEYLS FSPTTPMSSH GRVLSLLIAM LLSCCGLAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCAGGTCC TGGTAAATAC TGCTTGCTGT ATTTTGATGT TGGTGGCAAA GCTAATCCAG 60
TGTATTGTGT TCGGTCCCCT TCGAGTGAGC GAAAGACAGG TAAGTCAAGC ACAGGTGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	93.90	0.00e+00	1012.00
IUUC-Apl-003404	Anas platyrhynchos	88.71	0.00e+00	937.00
IUUC-Aca-004559	Anolis carolinensis	85.85	0.00e+00	880.00
IUUC-Ame-011640	Astyanax mexicanus	76.60	0.00e+00	764.00
IUUC-Bta-012980	Bos taurus	95.89	0.00e+00	1045.00
IUUC-Cel-018598	Caenorhabditis elegans	24.53	2.00e-30	127.00
IUUC-Cja-019577	Callithrix jacchus	96.25	0.00e+00	1053.00
IUUC-Cfa-020793	Canis familiaris	95.54	0.00e+00	1040.00
IUUC-Cpo-022387	Cavia porcellus	96.61	0.00e+00	1019.00
IUUC-Csa-023168	Chlorocebus sabaeus	97.32	0.00e+00	1065.00
IUUC-Cho-024433	Choloepus hoffmanni	97.87	0.00e+00	869.00
IUUC-Cin-025215	Ciona intestinalis	48.95	2.00e-143	502.00
IUUC-Csv-026133	Ciona savignyi	49.71	8.00e-132	464.00
IUUC-Dre-027594	Danio rerio	75.49	0.00e+00	721.00
IUUC-Dno-029407	Dasypus novemcinctus	97.67	0.00e+00	1031.00
IUUC-Dor-030961	Dipodomys ordii	96.95	0.00e+00	1046.00
IUUC-Ete-032962	Echinops telfairi	88.35	0.00e+00	870.00
IUUC-Eca-033683	Equus caballus	94.63	0.00e+00	1003.00
IUUC-Eeu-034515	Erinaceus europaeus	100.00	2.00e-80	293.00
IUUC-Fca-035398	Felis catus	96.88	0.00e+00	1008.00
IUUC-Fal-036758	Ficedula albicollis	82.06	0.00e+00	885.00
IUUC-Gmo-039014	Gadus morhua	73.60	0.00e+00	708.00
IUUC-Gga-040575	Gallus gallus	88.75	0.00e+00	975.00
IUUC-Gac-041414	Gasterosteus aculeatus	73.08	0.00e+00	694.00
IUUC-Hsa-046272	Homo sapiens	96.79	0.00e+00	1059.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	97.32	0.00e+00	1026.00
IUUC-Lch-050491	Latimeria chalumnae	81.00	0.00e+00	820.00
IUUC-Loc-052758	Lepisosteus oculatus	79.89	0.00e+00	780.00
IUUC-Mcc-055820	Macaca mulatta	97.08	0.00e+00	1038.00
IUUC-Meu-056726	Macropus eugenii	87.78	0.00e+00	771.00
IUUC-Mga-059937	Meleagris gallopavo	88.93	0.00e+00	948.00
IUUC-Mmr-060730	Microcebus murinus	96.61	0.00e+00	1021.00
IUUC-Mdo-062771	Monodelphis domestica	93.33	0.00e+00	1000.00
IUUC-Mmu-064219	Mus musculus	96.11	0.00e+00	1043.00
IUUC-Mpu-066796	Mustela putorius furo	96.72	0.00e+00	1030.00
IUUC-Mlu-068189	Myotis lucifugus	94.46	0.00e+00	989.00
IUUC-Nle-069239	Nomascus leucogenys	96.96	0.00e+00	1061.00
IUUC-Opr-070702	Ochotona princeps	90.94	4.00e-142	498.00
IUUC-Ont-072033	Oreochromis niloticus	75.14	0.00e+00	752.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.69	0.00e+00	872.00
IUUC-Ocu-074145	Oryctolagus cuniculus	94.29	0.00e+00	1035.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	7.00e-12	63.20
IUUC-Ola-087152	Oryzias latipes	72.68	0.00e+00	725.00
IUUC-Oga-088486	Otolemur garnettii	97.32	0.00e+00	1026.00
IUUC-Oar-089310	Ovis aries	96.43	0.00e+00	1050.00
IUUC-Ptr-090649	Pan troglodytes	96.95	0.00e+00	1058.00
IUUC-Pan-091692	Papio anubis	92.32	0.00e+00	996.00
IUUC-Psi-093064	Pelodiscus sinensis	95.48	0.00e+00	780.00
IUUC-Pma-094763	Petromyzon marinus	77.87	3.00e-97	347.00
IUUC-Ppa-095969	Physcomitrella patens	29.94	8.00e-36	145.00
IUUC-Pfo-096810	Poecilia formosa	73.99	0.00e+00	731.00
IUUC-Pab-097859	Pongo abelii	97.08	0.00e+00	1040.00
IUUC-Pop-099576	Populus trichocarpa	27.35	2.00e-28	120.00
IUUC-Pca-100344	Procavia capensis	95.91	0.00e+00	997.00
IUUC-Pva-103114	Pteropus vampyrus	67.86	0.00e+00	640.00
IUUC-Rno-105880	Rattus norvegicus	94.43	0.00e+00	1019.00
IUUC-Sha-107015	Sarcophilus harrisii	93.95	0.00e+00	983.00
IUUC-Smo-109599	Selaginella moellendorffii	31.15	5.00e-33	135.00
IUUC-Sar-113397	Sorex araneus	98.65	0.00e+00	768.00
IUUC-Ssc-115988	Sus scrofa	92.71	7.00e-144	502.00
IUUC-Tgu-116717	Taeniopygia guttata	90.19	0.00e+00	921.00
IUUC-Tru-117805	Takifugu rubripes	71.89	0.00e+00	756.00
IUUC-Tsy-119442	Tarsius syrichta	91.04	0.00e+00	953.00
IUUC-Tni-119777	Tetraodon nigroviridis	73.00	8.00e-172	596.00
IUUC-Tbe-127322	Tupaia belangeri	68.98	2.00e-116	412.00
IUUC-Ttr-128181	Tursiops truncatus	95.88	0.00e+00	1046.00
IUUC-Vpa-130483	Vicugna pacos	86.19	0.00e+00	669.00
IUUC-Xtr-132614	Xenopus tropicalis	81.82	0.00e+00	775.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence