iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068063

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02030599

Gene Name

WSB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000001791.2	ENSMLUT00000001792.2	ENSMLUP00000001636.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-33	112.8	169	203
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.30e-15	55.7	375	420
UBD/Beta-Prp	3.90e-48	164.2	134	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++++ +SLqhLCR++Irr +++q++   +kLP+P++  ++L+y+
   Q: 375  VYFWATPRQIPSLQHLCRMSIRRVMPTQEV---QKLPIPSKVLEFLSYR 420
           689************************999...**************97 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
            kf +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l++h++ v+s++f
   Q: 134  FKFGQDQLLLATGLSNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRAHQNWVYSCAF 222
           68899999***********************************************************9799****************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tggh 179
           sp+++ l s ++ + + +wd+++++ ++  l+gh++ v    ++pdg ll+++s+D+ v +Wd  tg++l ++             g++
   Q: 223  SPDSSMLCSVGASKAVFLWDMDKYTMIR-KLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHTGDILMEFghlfppptpifaGGAN 310
           ****************************.9******************************************************9888* PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           ++ v+s+sf+++g +++s ++d+ v++w + +      + +  +n ++ +fs ++  l+ g++Dgs+++W
   Q: 311  DRWVRSVSFSHDGLHIASLADDKMVRFWRIDED--YPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           ******************************888..68899****************************** PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MASFPPRVNE KEIVRSRTIG ELLALAAPFD KKCGRENWTV AFAPDGSYFA WSQGYCTVKL 60
VPWSQCLTNF LLHGTKNITN SNSLRLSRQN SDGAQKNKPR EHIIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCGCCGCT CCCTTCTCTG TCGTTGCGCC CGCCTCGCAC CCCCGGAATC AGACGGTGCC 60
CCATAGATGG CCAGCTTTCC TCCGAGGGTT AACGAGAAAG AGATCGGTGA GGAACGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR023294--Tachylectin2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	96.67	0.00e+00	826.00
IUUC-Apl-003903	Anas platyrhynchos	89.68	0.00e+00	768.00
IUUC-Aca-005214	Anolis carolinensis	77.70	0.00e+00	695.00
IUUC-Ame-011740	Astyanax mexicanus	75.30	0.00e+00	670.00
IUUC-Bta-013475	Bos taurus	95.96	0.00e+00	823.00
IUUC-Cja-019053	Callithrix jacchus	95.94	0.00e+00	842.00
IUUC-Cfa-020103	Canis familiaris	96.44	0.00e+00	825.00
IUUC-Cpo-022438	Cavia porcellus	94.77	0.00e+00	836.00
IUUC-Csa-024062	Chlorocebus sabaeus	95.72	0.00e+00	846.00
IUUC-Cho-024334	Choloepus hoffmanni	84.09	0.00e+00	699.00
IUUC-Cin-025590	Ciona intestinalis	38.81	2.00e-77	282.00
IUUC-Csv-026023	Ciona savignyi	40.19	5.00e-79	288.00
IUUC-Dre-028089	Danio rerio	75.53	0.00e+00	677.00
IUUC-Dno-029436	Dasypus novemcinctus	92.01	0.00e+00	678.00
IUUC-Dor-031107	Dipodomys ordii	88.36	0.00e+00	740.00
IUUC-Ete-032326	Echinops telfairi	93.12	0.00e+00	777.00
IUUC-Eca-033401	Equus caballus	95.49	0.00e+00	816.00
IUUC-Eeu-034520	Erinaceus europaeus	93.59	0.00e+00	830.00
IUUC-Fca-036386	Felis catus	96.44	0.00e+00	827.00
IUUC-Fal-036616	Ficedula albicollis	86.00	0.00e+00	741.00
IUUC-Gmo-039335	Gadus morhua	71.25	1.00e-175	609.00
IUUC-Gga-040856	Gallus gallus	88.60	0.00e+00	785.00
IUUC-Gac-042140	Gasterosteus aculeatus	73.00	0.00e+00	653.00
IUUC-Ggo-044619	Gorilla gorilla	95.49	0.00e+00	846.00
IUUC-Hsa-046300	Homo sapiens	95.49	0.00e+00	844.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	94.77	0.00e+00	837.00
IUUC-Lch-049550	Latimeria chalumnae	80.06	5.00e-170	590.00
IUUC-Loc-051769	Lepisosteus oculatus	77.20	0.00e+00	680.00
IUUC-Laf-054576	Loxodonta africana	96.20	0.00e+00	822.00
IUUC-Mcc-054666	Macaca mulatta	96.95	8.00e-154	535.00
IUUC-Meu-055989	Macropus eugenii	89.14	0.00e+00	649.00
IUUC-Mga-059722	Meleagris gallopavo	88.19	0.00e+00	778.00
IUUC-Mmr-060970	Microcebus murinus	95.49	0.00e+00	818.00
IUUC-Mdo-062249	Monodelphis domestica	78.62	0.00e+00	645.00
IUUC-Mmu-063742	Mus musculus	91.43	0.00e+00	811.00
IUUC-Mpu-066518	Mustela putorius furo	95.72	0.00e+00	847.00
IUUC-Nle-069561	Nomascus leucogenys	95.25	0.00e+00	843.00
IUUC-Opr-071158	Ochotona princeps	90.71	0.00e+00	798.00
IUUC-Ont-072542	Oreochromis niloticus	72.77	0.00e+00	647.00
IUUC-Oan-073217	Ornithorhynchus anatinus	91.21	0.00e+00	799.00
IUUC-Ocu-074251	Oryctolagus cuniculus	94.62	0.00e+00	794.00
IUUC-Ola-086549	Oryzias latipes	71.83	0.00e+00	650.00
IUUC-Oga-088382	Otolemur garnettii	95.49	0.00e+00	821.00
IUUC-Oar-090263	Ovis aries	94.06	0.00e+00	824.00
IUUC-Ptr-090922	Pan troglodytes	95.25	0.00e+00	844.00
IUUC-Pan-092518	Papio anubis	95.72	0.00e+00	846.00
IUUC-Psi-093512	Pelodiscus sinensis	89.07	0.00e+00	788.00
IUUC-Pma-094324	Petromyzon marinus	57.64	5.00e-135	474.00
IUUC-Pfo-096264	Poecilia formosa	72.30	0.00e+00	651.00
IUUC-Pab-098018	Pongo abelii	93.82	0.00e+00	828.00
IUUC-Pca-101034	Procavia capensis	94.59	0.00e+00	764.00
IUUC-Pva-102862	Pteropus vampyrus	92.40	0.00e+00	761.00
IUUC-Rno-106116	Rattus norvegicus	91.69	0.00e+00	815.00
IUUC-Sha-106952	Sarcophilus harrisii	89.98	0.00e+00	751.00
IUUC-Sar-113211	Sorex araneus	82.70	9.00e-146	509.00
IUUC-Ssc-116440	Sus scrofa	96.91	0.00e+00	828.00
IUUC-Tgu-116675	Taeniopygia guttata	86.24	0.00e+00	740.00
IUUC-Tru-118295	Takifugu rubripes	71.36	0.00e+00	629.00
IUUC-Tsy-118916	Tarsius syrichta	83.61	0.00e+00	697.00
IUUC-Tni-120302	Tetraodon nigroviridis	71.13	6.00e-180	623.00
IUUC-Tbe-127416	Tupaia belangeri	82.06	0.00e+00	662.00
IUUC-Ttr-128185	Tursiops truncatus	96.20	0.00e+00	825.00
IUUC-Xtr-132465	Xenopus tropicalis	83.33	0.00e+00	738.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence