iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000029195.5	ENSRNOT00000068295.2	ENSRNOP00000062984.1
ENSRNOG00000029195.5	ENSRNOT00000084429.1	ENSRNOP00000074046.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.40e-191	636.2	402	865

Active Site

Position(s)	Description	Evidence
583	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G   qekl+  ++llvGag++GcE+lK ++l+G+     g +t+ Dmd+ve snl+rqFLfr++d g++KAevaaea+++l
   Q: 402  YDGQIAVFGTGFQEKLSYKHYLLVGAGAIGCEMLKGFALVGLgvrdnGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRL 490
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           npd +v++h++++++++e+i+   Ff+++d+Vv+ald+++ar +v+ +c+++ +pl+e+gt G+ G ++v+++++te y+ ++  ++  
   Q: 491  NPDLQVTSHTCPLDPTTEDIYdddFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAP 579
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa........vlfnklleeeage.eevlekldseekeegkdkvkselksedeenfeeaieiavkafaktti 250
           +P+ctl+++p+++eh+++wa        +l +++++++++  ++ l  +d + +++ +++v   l+ ++++++++++ +a+ +++ ++ 
   Q: 580  YPVCTLRHFPSTVEHSLQWAqdefeglfRLSAETINDYQQTcTSSLLGTDGTGILALLQQVMGVLR-TRPQTWQDCVVWALGHWQLCFR 667
           ****************************88888877777761556778999999999999966555.57******************** PP
   S: 251  nsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekvek 291
            +i +ll+ f+ d+v ++++ fw+                                                ++  ++e  ++p++  +
   Q: 668  DNIVELLRKFPSDKVLEDGTLFWSgskkcphplqfdpnqdthflyvlaaanlyarmhglpgsqsqtalrellTLTLLQEPDSMPQNLFS 756
           *********************************99999999999999999999988888888777777655444444444445555555 PP
   S: 292  deevvkasaplylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgG 378
            e  +   ++l+ l ++l+ ++k + +kp  + f kdd s  + d+v aa  lr++++gi p +++ +ik+ +g+iipaiat +avv+G
   Q: 757  AEFGQ---EQLKELQETLDDWNKGPPLKP--VLFGKDDSSnfHEDFVVAATDLRCQNYGILP-VNRARIKQTIGRIIPAIATSTAVVAG 839
           55533...34899***************9..88889888889********************.************************** PP
   S: 379  laaqEviKvvsg..kfeplknfflfd 402
           l+ +E++Kvvsg  +   +++ +l++
   Q: 840  LLGLELYKVVSGprPLGTFRHSYLHL 865
           ************55555566666665 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDEELYSRQL YVLGLPAMQR IREAKVLLCG LQGLGAEVAK NLVLMGVGSL TLHDPHPTCW 60
ADLAAQFFLS EESLGRSRAE ASQPQLAQLN EAVQISVHRG DITEDLVRGF QVVVLTDSKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCATTGGA AGGACCAGGA ACCAACTCTG TCTAGTTTCA CTTTTGGTTT CCTGAAATTA 60
CAGAGGAGCC AGAAAGAGAG CTGTAACCAG CAGCACCCAG CAGCTCCAAG CCCTGTTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	71.63	0.00e+00	1344.00
IUUC-Bta-012665	Bos taurus	67.90	0.00e+00	1214.00
IUUC-Cja-019047	Callithrix jacchus	70.72	0.00e+00	1350.00
IUUC-Cfa-021225	Canis familiaris	72.90	0.00e+00	1409.00
IUUC-Cpo-022336	Cavia porcellus	68.33	0.00e+00	1283.00
IUUC-Csa-023462	Chlorocebus sabaeus	73.80	0.00e+00	1358.00
IUUC-Cho-024436	Choloepus hoffmanni	65.40	5.00e-84	305.00
IUUC-Dno-029347	Dasypus novemcinctus	71.31	0.00e+00	1321.00
IUUC-Dor-030997	Dipodomys ordii	70.56	0.00e+00	1332.00
IUUC-Ete-033124	Echinops telfairi	70.00	0.00e+00	902.00
IUUC-Eca-033929	Equus caballus	72.71	0.00e+00	1449.00
IUUC-Eeu-034717	Erinaceus europaeus	66.26	0.00e+00	925.00
IUUC-Fca-036564	Felis catus	71.88	0.00e+00	1355.00
IUUC-Ggo-044480	Gorilla gorilla	73.14	0.00e+00	1351.00
IUUC-Hsa-046498	Homo sapiens	72.41	0.00e+00	1331.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	71.91	0.00e+00	1332.00
IUUC-Laf-054119	Loxodonta africana	69.93	0.00e+00	1365.00
IUUC-Mcc-055597	Macaca mulatta	71.37	0.00e+00	1290.00
IUUC-Mdo-063058	Monodelphis domestica	54.70	0.00e+00	1003.00
IUUC-Mmu-063578	Mus musculus	86.29	0.00e+00	1706.00
IUUC-Mpu-066255	Mustela putorius furo	70.97	0.00e+00	1338.00
IUUC-Mlu-067814	Myotis lucifugus	68.22	0.00e+00	1211.00
IUUC-Nle-069193	Nomascus leucogenys	72.90	0.00e+00	1352.00
IUUC-Opr-070715	Ochotona princeps	67.13	0.00e+00	1280.00
IUUC-Ocu-074162	Oryctolagus cuniculus	71.56	0.00e+00	1323.00
IUUC-Oga-088895	Otolemur garnettii	69.65	0.00e+00	1278.00
IUUC-Oar-089579	Ovis aries	67.13	0.00e+00	1201.00
IUUC-Ptr-090581	Pan troglodytes	72.13	0.00e+00	1305.00
IUUC-Pan-092458	Papio anubis	73.61	0.00e+00	1342.00
IUUC-Pab-098653	Pongo abelii	67.83	0.00e+00	1236.00
IUUC-Pca-100578	Procavia capensis	67.14	0.00e+00	804.00
IUUC-Pva-102914	Pteropus vampyrus	68.63	0.00e+00	1060.00
IUUC-Sha-107368	Sarcophilus harrisii	56.90	0.00e+00	1077.00
IUUC-Ssc-115743	Sus scrofa	71.12	0.00e+00	1339.00
IUUC-Tbe-127587	Tupaia belangeri	73.77	0.00e+00	1005.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence