iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117772

Ensembl Protein ID

ENSTRUP00000025681.1

UniProt Accession

H2TLX6; H2TLX6_TAKRU

Protein Name

Coatomer subunit alpha

Gene Name

copa

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000010198.1	ENSTRUT00000025785.1	ENSTRUP00000025681.1
ENSTRUG00000010198.1	ENSTRUT00000025786.1	ENSTRUP00000025682.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-34	116.3	91	129
UBD/Beta-Prp	5.00e-74	250.4	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH d ++   f  ++ + ++s+sdD ti++W++ + ++++
   Q: 91   GHLDYIRTT-FfhHEyPWILSASDDQTIRIWNWQSRTCVC 129
           799999997.55877899**************99888875 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++++  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWVLASLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s+s+d+tir+w++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSASDDQTIRIWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgavet 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                        ++ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   ++t++gh +nv++  f+p++e+++s s
   Q: 180  evrgisgvdlfgVSDAVVKHVLEGHDRGVNWAAFHPSMPLIVSGADDRQVKIWRMNESKAweLDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************666666666556********************************8888789************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++   + +++ n +++g  ds   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLGA-HPNLNLFAAG-HDSGMIVFKLERERP 324
           ***************************9999.5544444433.589999999988765 PP

Organism

Takifugu rubripes

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWVLASLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATGGAAC GCTCGACGTG TCAGCTTCAG TAAGCTAAAT CAGCGAAGTC GATTTAGGTT 60
ATCCGAATTT TCCTGTTTGA ATATTGTTTG TACAGTTGCG TGGGTTAAAC TTATAGCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	53.82	0.00e+00	1293.00
IUUC-Aml-001758	Ailuropoda melanoleuca	86.84	0.00e+00	2224.00
IUUC-Atr-002493	Amborella trichopoda	54.15	0.00e+00	1285.00
IUUC-Apl-003385	Anas platyrhynchos	85.52	0.00e+00	1856.00
IUUC-Aca-005154	Anolis carolinensis	93.24	2.00e-118	417.00
IUUC-Aly-006020	Arabidopsis lyrata	52.83	0.00e+00	1262.00
IUUC-Ath-007058	Arabidopsis thaliana	52.41	0.00e+00	1259.00
IUUC-Ago-007992	Ashbya gossypii	43.90	0.00e+00	1015.00
IUUC-Acl-008027	Aspergillus clavatus	55.40	0.00e+00	976.00
IUUC-Afl-008644	Aspergillus flavus	55.36	0.00e+00	972.00
IUUC-Afu-008964	Aspergillus fumigatus	55.58	0.00e+00	978.00
IUUC-Ani-009379	Aspergillus nidulans	55.62	0.00e+00	986.00
IUUC-Ang-009756	Aspergillus niger	55.63	0.00e+00	984.00
IUUC-Aor-010174	Aspergillus oryzae	55.36	0.00e+00	971.00
IUUC-Ate-010302	Aspergillus terreus	47.71	0.00e+00	1178.00
IUUC-Ame-011229	Astyanax mexicanus	91.36	0.00e+00	2269.00
IUUC-Bgr-012300	Blumeria graminis	46.73	0.00e+00	1092.00
IUUC-Bta-012524	Bos taurus	86.68	0.00e+00	2198.00
IUUC-Bci-013781	Botrytis cinerea	47.68	0.00e+00	1163.00
IUUC-Bdi-014549	Brachypodium distachyon	52.83	0.00e+00	1302.00
IUUC-Bol-015925	Brassica oleracea	51.84	0.00e+00	1247.00
IUUC-Bra-016978	Brassica rapa	51.21	0.00e+00	1240.00
IUUC-Cel-018115	Caenorhabditis elegans	62.43	0.00e+00	1085.00
IUUC-Cja-019107	Callithrix jacchus	84.58	0.00e+00	2154.00
IUUC-Cfa-020675	Canis familiaris	85.99	0.00e+00	2173.00
IUUC-Cpo-021813	Cavia porcellus	86.76	0.00e+00	2213.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	63.34	0.00e+00	1078.00
IUUC-Csa-023523	Chlorocebus sabaeus	86.76	0.00e+00	2219.00
IUUC-Cho-024704	Choloepus hoffmanni	74.72	0.00e+00	1133.00
IUUC-Cin-025572	Ciona intestinalis	70.97	0.00e+00	1811.00
IUUC-Csv-025864	Ciona savignyi	74.14	0.00e+00	1256.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	56.40	0.00e+00	996.00
IUUC-Cne-027053	Cryptococcus neoformans	58.85	0.00e+00	1025.00
IUUC-Cme-027222	Cyanidioschyzon merolae	39.66	2.00e-139	490.00
IUUC-Dre-027421	Danio rerio	91.12	0.00e+00	2264.00
IUUC-Dno-029303	Dasypus novemcinctus	86.69	0.00e+00	2214.00
IUUC-Dor-030290	Dipodomys ordii	80.88	0.00e+00	926.00
IUUC-Dse-031543	Dothistroma septosporum	45.79	0.00e+00	1090.00
IUUC-Dme-031945	Drosophila melanogaster	67.84	0.00e+00	1647.00
IUUC-Ete-032873	Echinops telfairi	82.42	0.00e+00	1925.00
IUUC-Eca-033773	Equus caballus	84.75	0.00e+00	2152.00
IUUC-Eeu-034874	Erinaceus europaeus	74.46	0.00e+00	1320.00
IUUC-Fca-035739	Felis catus	83.43	0.00e+00	2152.00
IUUC-Fal-037263	Ficedula albicollis	81.04	0.00e+00	1970.00
IUUC-Fox-037738	Fusarium oxysporum	47.85	0.00e+00	1183.00
IUUC-Fso-038153	Fusarium solani	48.48	0.00e+00	1166.00
IUUC-Gmo-039602	Gadus morhua	87.91	0.00e+00	2138.00
IUUC-Ggr-039931	Gaeumannomyces graminis	55.41	0.00e+00	989.00
IUUC-Gga-040590	Gallus gallus	87.41	0.00e+00	2213.00
IUUC-Gac-041318	Gasterosteus aculeatus	93.03	0.00e+00	2325.00
IUUC-Gma-043894	Glycine max	53.93	0.00e+00	1316.00
IUUC-Ggo-045029	Gorilla gorilla	86.76	0.00e+00	2223.00
IUUC-Hsa-046078	Homo sapiens	86.68	0.00e+00	2224.00
IUUC-Hvu-047556	Hordeum vulgare	54.20	0.00e+00	1325.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	83.05	0.00e+00	1489.00
IUUC-Kpa-049256	Komagataella pastoris	44.61	0.00e+00	1067.00
IUUC-Lch-049706	Latimeria chalumnae	86.36	0.00e+00	2162.00
IUUC-Lpe-051316	Leersia perrieri	61.70	0.00e+00	1068.00
IUUC-Loc-051867	Lepisosteus oculatus	70.81	0.00e+00	1207.00
IUUC-Lma-053138	Leptosphaeria maculans	55.41	0.00e+00	988.00
IUUC-Laf-053510	Loxodonta africana	87.39	0.00e+00	2240.00
IUUC-Mcc-055836	Macaca mulatta	86.18	0.00e+00	2225.00
IUUC-Meu-056238	Macropus eugenii	81.90	0.00e+00	1112.00
IUUC-Mor-057172	Magnaporthe oryzae	48.00	0.00e+00	1164.00
IUUC-Mpo-057300	Magnaporthe poae	47.84	0.00e+00	1149.00
IUUC-Mtr-058248	Medicago truncatula	54.05	0.00e+00	1322.00
IUUC-Mla-059019	Melampsora laricipopulina	51.68	0.00e+00	1256.00
IUUC-Mga-059499	Meleagris gallopavo	87.27	0.00e+00	2207.00
IUUC-Mvi-060336	Microbotryum violaceum	52.64	0.00e+00	1254.00
IUUC-Mmr-061102	Microcebus murinus	87.01	0.00e+00	2196.00
IUUC-Mdo-062594	Monodelphis domestica	86.92	0.00e+00	2243.00
IUUC-Mmu-063736	Mus musculus	86.60	0.00e+00	2213.00
IUUC-Mac-065272	Musa acuminata	50.52	0.00e+00	1179.00
IUUC-Mpu-066701	Mustela putorius furo	86.77	0.00e+00	2206.00
IUUC-Mlu-067392	Myotis lucifugus	85.73	0.00e+00	2207.00
IUUC-Nfi-068270	Neosartorya fischeri	55.69	0.00e+00	977.00
IUUC-Ncr-068892	Neurospora crassa	47.96	0.00e+00	1153.00
IUUC-Nle-069634	Nomascus leucogenys	91.56	0.00e+00	1288.00
IUUC-Opr-070952	Ochotona princeps	76.41	0.00e+00	1298.00
IUUC-Ont-072488	Oreochromis niloticus	94.58	0.00e+00	2310.00
IUUC-Oan-073184	Ornithorhynchus anatinus	44.22	5.00e-68	250.00
IUUC-Ocu-074211	Oryctolagus cuniculus	86.92	0.00e+00	2221.00
IUUC-Oba-075761	Oryza barthii	61.47	0.00e+00	1065.00
IUUC-Obr-076429	Oryza brachyantha	61.47	0.00e+00	1062.00
IUUC-Ogl-077364	Oryza glaberrima	61.47	0.00e+00	1066.00
IUUC-Ogu-078257	Oryza glumaepatula	53.21	0.00e+00	1263.00
IUUC-Oin-080029	Oryza indica	61.70	0.00e+00	1066.00
IUUC-Olo-080466	Oryza longistaminata	61.84	0.00e+00	1058.00
IUUC-Ome-081668	Oryza meridionalis	60.89	0.00e+00	895.00
IUUC-Oni-082874	Oryza nivara	61.47	0.00e+00	1066.00
IUUC-Opu-083697	Oryza punctata	53.89	0.00e+00	1296.00
IUUC-Oru-084274	Oryza rufipogon	61.47	0.00e+00	1066.00
IUUC-Osa-085565	Oryza sativa	61.47	0.00e+00	1066.00
IUUC-Ola-086921	Oryzias latipes	93.70	0.00e+00	2284.00
IUUC-Olu-087639	Ostreococcus lucimarinus	54.75	0.00e+00	1330.00
IUUC-Oga-087991	Otolemur garnettii	82.10	0.00e+00	2084.00
IUUC-Oar-089590	Ovis aries	86.76	0.00e+00	2217.00
IUUC-Ptr-090808	Pan troglodytes	86.76	0.00e+00	2226.00
IUUC-Pan-092475	Papio anubis	86.29	0.00e+00	2205.00
IUUC-Psi-093044	Pelodiscus sinensis	73.31	0.00e+00	1563.00
IUUC-Pno-094839	Phaeosphaeria nodorum	46.36	0.00e+00	1078.00
IUUC-Ppa-095254	Physcomitrella patens	55.82	0.00e+00	1366.00
IUUC-Pfo-097493	Poecilia formosa	93.69	0.00e+00	2273.00
IUUC-Pab-098497	Pongo abelii	86.84	0.00e+00	2221.00
IUUC-Pop-099992	Populus trichocarpa	54.77	0.00e+00	1299.00
IUUC-Pca-100413	Procavia capensis	82.76	0.00e+00	944.00
IUUC-Ppe-101899	Prunus persica	53.66	0.00e+00	1292.00
IUUC-Pva-102126	Pteropus vampyrus	83.62	0.00e+00	2123.00
IUUC-Pgr-103376	Puccinia graminis	51.84	0.00e+00	1262.00
IUUC-Ptt-103978	Puccinia triticina	46.68	0.00e+00	1048.00
IUUC-Pte-104126	Pyrenophora teres	53.99	0.00e+00	949.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	44.35	6.00e-170	591.00
IUUC-Rno-105428	Rattus norvegicus	86.60	0.00e+00	2205.00
IUUC-Sce-106464	Saccharomyces cerevisiae	43.00	0.00e+00	986.00
IUUC-Sha-107301	Sarcophilus harrisii	86.70	0.00e+00	2194.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	46.10	0.00e+00	1065.00
IUUC-Spo-108217	Schizosaccharomyces pombe	47.11	0.00e+00	1105.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	47.91	0.00e+00	1166.00
IUUC-Smo-109582	Selaginella moellendorffii	62.86	0.00e+00	1117.00
IUUC-Sit-109697	Setaria italica	61.35	0.00e+00	1062.00
IUUC-Sly-111447	Solanum lycopersicum	54.04	0.00e+00	1331.00
IUUC-Stu-112564	Solanum tuberosum	54.07	0.00e+00	1327.00
IUUC-Sar-113313	Sorex araneus	72.39	0.00e+00	1291.00
IUUC-Sbi-114388	Sorghum bicolor	53.57	0.00e+00	1305.00
IUUC-Sre-115209	Sporisorium reilianum	56.39	0.00e+00	1022.00
IUUC-Ssc-115933	Sus scrofa	86.76	0.00e+00	2215.00
IUUC-Tgu-117109	Taeniopygia guttata	74.66	0.00e+00	669.00
IUUC-Tsy-119105	Tarsius syrichta	75.06	0.00e+00	1890.00
IUUC-Tni-120556	Tetraodon nigroviridis	79.62	0.00e+00	1684.00
IUUC-Tca-121046	Theobroma cacao	54.02	0.00e+00	1325.00
IUUC-Tre-121951	Trichoderma reesei	56.01	0.00e+00	990.00
IUUC-Tvi-122359	Trichoderma virens	55.90	0.00e+00	996.00
IUUC-Tae-125527	Triticum aestivum	53.90	0.00e+00	1295.00
IUUC-Tur-126754	Triticum urartu	53.25	0.00e+00	1269.00
IUUC-Tme-127170	Tuber melanosporum	49.32	0.00e+00	1197.00
IUUC-Tbe-127882	Tupaia belangeri	67.25	0.00e+00	764.00
IUUC-Ttr-128217	Tursiops truncatus	84.75	0.00e+00	2152.00
IUUC-Uma-129337	Ustilago maydis	57.08	0.00e+00	1021.00
IUUC-Vda-129828	Verticillium dahliae	47.45	0.00e+00	1147.00
IUUC-Vpa-130537	Vicugna pacos	83.31	0.00e+00	2184.00
IUUC-Vvi-130958	Vitis vinifera	62.10	0.00e+00	1075.00
IUUC-Xtr-132857	Xenopus tropicalis	82.29	0.00e+00	2078.00
IUUC-Xma-133138	Xiphophorus maculatus	93.53	0.00e+00	2271.00
IUUC-Yli-134399	Yarrowia lipolytica	50.06	0.00e+00	843.00
IUUC-Zma-135612	Zea mays	53.77	0.00e+00	1303.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence