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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105903
Ensembl Protein ID ENSRNOP00000008585.3
UniProt Accession D3Z9Z9; SMRCD_RAT
Genbank Protein ID ENSRNOP00000008585
Protein Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Genbank Nucleotide ID AABR03032021
Gene Name Smarcad1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000006391.3 ENSRNOT00000008585.3 ENSRNOP00000008585.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/CUE 44.84 3.00e-117 418.00 IUUC-Sce-106399
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).
 DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).
Protein Sequence
(Fasta)
MNLFNLDRFR FEKRSKIEEA PEAAPQPSQP GPSSPISLSA EEENAEGEVS RANTPDSDVT 60
EKTEDSSVPE PPDNESKASL SCFQNQRTIQ EYIDLSSDSE DVSPNCSSTV QEKKFSKDTV 120
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Protein Fasta Sequence


>IUUC-Rno-105903|UBD,CUE|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CTAGTTCATT GAAAGCTGTC AGCCTCCTCA GGGAGGTGCT TCCTATCAAT ATGAATCTTT 60
TCAACTTGGA CCGTTTTCGC TTTGAGAAAA GGAGTAAGAT TGAGGAAGCT CCTGAAGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105903|UBD,CUE|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR003892--CUE
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
PROSITE

PS51140--CUE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00271--Helicase_C
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00490--HELICc
Gene Ontology

GO:0000792--C:heterochromatin
GO:0043596--C:nuclear replication fork
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0051304--P:chromosome separation
GO:0000729--P:DNA double-strand break processing
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0000018--P:regulation of DNA recombination
KEGG rno:312398
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000567 Aegilops tauschii 37.39 8.00e-101 361.00
IUUC-Aml-002063 Ailuropoda melanoleuca 91.35 0.00e+00 1802.00
IUUC-Atr-003078 Amborella trichopoda 35.49 1.00e-102 367.00
IUUC-Apl-003860 Anas platyrhynchos 71.49 0.00e+00 1358.00
IUUC-Aca-004485 Anolis carolinensis 69.54 0.00e+00 1384.00
IUUC-Aly-006561 Arabidopsis lyrata 38.55 4.00e-103 369.00
IUUC-Ath-006832 Arabidopsis thaliana 38.91 2.00e-104 373.00
IUUC-Ago-007758 Ashbya gossypii 45.68 7.00e-133 468.00
IUUC-Acl-008226 Aspergillus clavatus 45.40 5.00e-134 472.00
IUUC-Afl-008556 Aspergillus flavus 45.59 6.00e-131 462.00
IUUC-Afu-008799 Aspergillus fumigatus 44.16 2.00e-133 470.00
IUUC-Ani-009127 Aspergillus nidulans 45.57 9.00e-131 461.00
IUUC-Ang-009676 Aspergillus niger 44.63 5.00e-134 472.00
IUUC-Aor-010184 Aspergillus oryzae 44.03 2.00e-131 463.00
IUUC-Ate-010559 Aspergillus terreus 36.93 4.00e-131 462.00
IUUC-Ame-011933 Astyanax mexicanus 58.77 0.00e+00 892.00
IUUC-Bta-012963 Bos taurus 89.90 0.00e+00 1781.00
IUUC-Bci-013670 Botrytis cinerea 41.44 3.00e-118 420.00
IUUC-Bdi-014286 Brachypodium distachyon 37.84 2.00e-102 367.00
IUUC-Bol-016519 Brassica oleracea 39.19 6.00e-105 375.00
IUUC-Bra-017239 Brassica rapa 39.01 5.00e-104 372.00
IUUC-Cel-018253 Caenorhabditis elegans 42.98 3.00e-140 492.00
IUUC-Cja-019465 Callithrix jacchus 90.35 0.00e+00 1801.00
IUUC-Cfa-020637 Canis familiaris 90.09 0.00e+00 1805.00
IUUC-Cpo-021822 Cavia porcellus 91.39 0.00e+00 1726.00
IUUC-Csa-023315 Chlorocebus sabaeus 94.40 0.00e+00 1590.00
IUUC-Cin-025444 Ciona intestinalis 49.46 5.00e-174 604.00
IUUC-Cgl-026383 Colletotrichum gloeosporioides 40.33 5.00e-106 379.00
IUUC-Cne-027090 Cryptococcus neoformans 36.42 2.00e-115 410.00
IUUC-Dre-028385 Danio rerio 56.53 0.00e+00 870.00
IUUC-Dno-028932 Dasypus novemcinctus 92.11 0.00e+00 1848.00
IUUC-Dse-031394 Dothistroma septosporum 36.60 1.00e-104 374.00
IUUC-Dme-031640 Drosophila melanogaster 46.00 6.00e-158 551.00
IUUC-Eca-033276 Equus caballus 92.52 0.00e+00 1864.00
IUUC-Fca-035936 Felis catus 89.70 0.00e+00 1782.00
IUUC-Fal-037636 Ficedula albicollis 66.31 0.00e+00 1303.00
IUUC-Fso-038229 Fusarium solani 35.25 3.00e-111 396.00
IUUC-Gmo-039654 Gadus morhua 56.88 0.00e+00 890.00
IUUC-Ggr-039922 Gaeumannomyces graminis 33.38 1.00e-91 331.00
IUUC-Gga-040646 Gallus gallus 66.51 0.00e+00 1369.00
IUUC-Gac-042320 Gasterosteus aculeatus 66.20 0.00e+00 805.00
IUUC-Gma-042832 Glycine max 39.06 2.00e-105 376.00
IUUC-Ggo-044875 Gorilla gorilla 83.88 0.00e+00 1669.00
IUUC-Hsa-046992 Homo sapiens 91.64 0.00e+00 1831.00
IUUC-Hvu-047408 Hordeum vulgare 38.87 2.00e-103 370.00
IUUC-Itr-047881 Ictidomys tridecemlineatus 97.28 0.00e+00 1102.00
IUUC-Kpa-049212 Komagataella pastoris 43.21 4.00e-127 449.00
IUUC-Lpe-050987 Leersia perrieri 35.17 3.00e-101 363.00
IUUC-Loc-052272 Lepisosteus oculatus 53.35 0.00e+00 1016.00
IUUC-Lma-053118 Leptosphaeria maculans 42.04 3.00e-122 433.00
IUUC-Laf-053436 Loxodonta africana 90.75 0.00e+00 1783.00
IUUC-Mcc-055209 Macaca mulatta 94.36 0.00e+00 1642.00
IUUC-Mor-056994 Magnaporthe oryzae 34.21 3.00e-93 337.00
IUUC-Mpo-057305 Magnaporthe poae 33.85 7.00e-98 352.00
IUUC-Mtr-058432 Medicago truncatula 39.42 1.00e-103 370.00
IUUC-Mla-058972 Melampsora laricipopulina 38.95 1.00e-122 433.00
IUUC-Mga-059572 Meleagris gallopavo 63.89 0.00e+00 1216.00
IUUC-Mvi-060209 Microbotryum violaceum 40.53 1.00e-141 497.00
IUUC-Mmr-061416 Microcebus murinus 91.78 0.00e+00 1115.00
IUUC-Mdo-062869 Monodelphis domestica 79.25 0.00e+00 1592.00
IUUC-Mmu-064272 Mus musculus 96.58 0.00e+00 1794.00
IUUC-Mac-064963 Musa acuminata 34.88 1.00e-94 341.00
IUUC-Mpu-065755 Mustela putorius furo 91.35 0.00e+00 1840.00
IUUC-Mlu-067604 Myotis lucifugus 89.41 0.00e+00 1777.00
IUUC-Nfi-068310 Neosartorya fischeri 43.97 7.00e-133 468.00
IUUC-Ncr-068841 Neurospora crassa 34.03 2.00e-110 394.00
IUUC-Nle-069227 Nomascus leucogenys 91.74 0.00e+00 1833.00
IUUC-Opr-071088 Ochotona princeps 85.09 0.00e+00 1311.00
IUUC-Ont-072291 Oreochromis niloticus 66.15 0.00e+00 828.00
IUUC-Oan-073460 Ornithorhynchus anatinus 82.85 0.00e+00 1356.00
IUUC-Ocu-074811 Oryctolagus cuniculus 93.37 0.00e+00 1792.00
IUUC-Oba-075463 Oryza barthii 37.28 4.00e-101 362.00
IUUC-Obr-076342 Oryza brachyantha 37.28 8.00e-104 371.00
IUUC-Ogu-078837 Oryza glumaepatula 37.28 3.00e-101 363.00
IUUC-Oin-079623 Oryza indica 38.11 1.00e-101 364.00
IUUC-Ome-081105 Oryza meridionalis 37.28 7.00e-102 365.00
IUUC-Oni-082598 Oryza nivara 37.28 2.00e-101 363.00
IUUC-Opu-084040 Oryza punctata 37.28 2.00e-101 363.00
IUUC-Oru-084219 Oryza rufipogon 38.11 1.00e-101 364.00
IUUC-Osa-085461 Oryza sativa 37.28 2.00e-101 363.00
IUUC-Ola-087307 Oryzias latipes 66.93 0.00e+00 803.00
IUUC-Olu-087812 Ostreococcus lucimarinus 38.79 7.00e-99 354.00
IUUC-Oga-089064 Otolemur garnettii 91.07 0.00e+00 1814.00
IUUC-Oar-090054 Ovis aries 92.23 0.00e+00 1805.00
IUUC-Ptr-091228 Pan troglodytes 91.92 0.00e+00 1838.00
IUUC-Pan-092769 Papio anubis 91.75 0.00e+00 1716.00
IUUC-Psi-093202 Pelodiscus sinensis 71.07 0.00e+00 1375.00
IUUC-Pma-094725 Petromyzon marinus 52.48 0.00e+00 892.00
IUUC-Pno-095130 Phaeosphaeria nodorum 41.15 4.00e-109 389.00
IUUC-Ppa-095559 Physcomitrella patens 40.26 3.00e-107 383.00
IUUC-Pfo-096546 Poecilia formosa 66.46 0.00e+00 837.00
IUUC-Pab-097698 Pongo abelii 92.61 0.00e+00 1827.00
IUUC-Pop-099986 Populus trichocarpa 38.83 6.00e-104 371.00
IUUC-Ppe-101649 Prunus persica 39.17 5.00e-102 365.00
IUUC-Pva-102138 Pteropus vampyrus 89.32 0.00e+00 1764.00
IUUC-Pgr-103272 Puccinia graminis 35.70 6.00e-122 432.00
IUUC-Ptt-103880 Puccinia triticina 35.91 9.00e-128 451.00
IUUC-Pte-104260 Pyrenophora teres 42.45 5.00e-117 416.00
IUUC-Pyt-104532 Pyrenophora triticirepentis 32.45 3.00e-71 263.00
IUUC-Sce-106399 Saccharomyces cerevisiae 44.84 2.00e-125 443.00
IUUC-Sha-106783 Sarcophilus harrisii 77.48 0.00e+00 1511.00
IUUC-Sja-107887 Schizosaccharomyces japonicus 40.71 1.00e-142 501.00
IUUC-Spo-108154 Schizosaccharomyces pombe 42.21 1.00e-146 514.00
IUUC-Smo-108759 Selaginella moellendorffii 40.30 5.00e-104 371.00
IUUC-Sit-110023 Setaria italica 37.74 2.00e-100 360.00
IUUC-Sly-111423 Solanum lycopersicum 38.74 8.00e-104 371.00
IUUC-Sbi-114688 Sorghum bicolor 37.74 2.00e-103 370.00
IUUC-Sre-114983 Sporisorium reilianum 36.18 1.00e-112 401.00
IUUC-Ssc-116030 Sus scrofa 89.41 0.00e+00 1818.00
IUUC-Tgu-117451 Taeniopygia guttata 76.49 0.00e+00 1188.00
IUUC-Tru-118600 Takifugu rubripes 50.91 0.00e+00 852.00
IUUC-Tsy-119130 Tarsius syrichta 82.98 0.00e+00 1517.00
IUUC-Tni-119758 Tetraodon nigroviridis 56.96 0.00e+00 884.00
IUUC-Tca-121797 Theobroma cacao 39.32 1.00e-104 374.00
IUUC-Tre-121883 Trichoderma reesei 40.56 6.00e-102 365.00
IUUC-Tvi-122333 Trichoderma virens 40.15 9.00e-110 391.00
IUUC-Tae-122848 Triticum aestivum 37.39 4.00e-101 362.00
IUUC-Tur-126594 Triticum urartu 38.30 2.00e-100 360.00
IUUC-Tme-127106 Tuber melanosporum 42.34 2.00e-123 437.00
IUUC-Tbe-127911 Tupaia belangeri 96.63 0.00e+00 988.00
IUUC-Ttr-128597 Tursiops truncatus 91.07 0.00e+00 1753.00
IUUC-Uma-129321 Ustilago maydis 36.18 9.00e-112 398.00
IUUC-Vpa-130686 Vicugna pacos 84.85 0.00e+00 1595.00
IUUC-Vvi-131046 Vitis vinifera 38.64 6.00e-105 375.00
IUUC-Xtr-132740 Xenopus tropicalis 64.54 0.00e+00 1132.00
IUUC-Xma-134260 Xiphophorus maculatus 66.15 0.00e+00 829.00
IUUC-Yli-134634 Yarrowia lipolytica 40.39 7.00e-138 484.00
IUUC-Zma-135493 Zea mays 37.55 6.00e-102 365.00
Created Date 25-Jun-2017

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