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Tag Content
UUCD2 ID IUUC-Eca-033569
UUCD1 version UUC-EqC-00098
Ensembl Protein ID ENSECAP00000022364.1
UniProt Accession F6R504; F6R504_HORSE
Protein Name Apoptotic protease-activating factor 1
Gene Name APAF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSECAG00000024703.1 ENSECAT00000026768.1 ENSECAP00000022364.1
ENSECAG00000024703.1 ENSECAT00000026769.1 ENSECAP00000022365.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.40e-63 208.1 742 777
UBD/Beta-Prp 1.70e-91 306.6 613 784
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
    gHt+sv+ ++f +d +ll+s+s Dg++k+WD+++ +
   Q: 742 GHTNSVNHCRFsPDdKLLASCSADGSLKLWDVKSAN 777
    8***********777****************98765 PP
   


   UBD/Beta-Prp

   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltggh 179
    + h+d v+ fs +g++++s ++d+t++v++ etg++l e+++ +d+v +c +++ d++ ++++s D++v++W++ tg+l++t + h
   Q: 613 RPHTDAVYHACFSGDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-H 699
    4466666666666666666666666666666666666666444444433333.3334455666666666666666666666666655.6 PP
   S: 180 tdsvyslsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
    ++v++ f+ n+ l++gs d+ +klwdl +++c +t+ ght+ v+ rfsp+d++l+s+s+Dgs+++Wd++s + k+++
   Q: 700 SEQVNCCHFTNNShhLLLATGSSDSFLKLWDLNEKDCRNTMFGHTNSVNHCRFSPDDKLLASCSADGSLKLWDVKSANERKSINV 784
    6666666666666222334566666666666666666666666666666666666666666666666666666666666555555 PP
   

Organism Equus caballus
Functional Description
(View)

Functional Description



     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Protein Sequence
(Fasta)
RMDAKARNCL LQHREALEKD IKTSYIMDYM ISDGVLTVSE EEKVKNEPTR QQKAAMLIKM 60
ILKKDNYCYI SFYKALLQEG YKDLAALLHG GIPVLSSSNG KDSLVGVTSY VKTVLCEGGV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Eca-033569|E3,WD_repeat;UBD,Beta-Prp|Equus caballus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTTGTAGTT CATGGTTGAC AGTTCAGAAA GAGAAAAATT TGAAGGAGGA TGGATGCAAA 60
AGCTCGAAAT TGTTTACTTC AACATAGAGA AGCCCTGGAA AAGGACATCA AAACCTCCTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Eca-033569|E3,WD_repeat;UBD,Beta-Prp|Equus caballus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001432 Ailuropoda melanoleuca 92.02 0.00e+00 2376.00
IUUC-Apl-004201 Anas platyrhynchos 71.06 0.00e+00 1840.00
IUUC-Aca-004638 Anolis carolinensis 69.11 0.00e+00 1835.00
IUUC-Ani-009285 Aspergillus nidulans 26.07 6.00e-70 259.00
IUUC-Ame-011062 Astyanax mexicanus 55.07 0.00e+00 1380.00
IUUC-Bta-012865 Bos taurus 90.32 0.00e+00 2383.00
IUUC-Cja-018815 Callithrix jacchus 80.93 0.00e+00 2059.00
IUUC-Cfa-020222 Canis familiaris 87.16 0.00e+00 2226.00
IUUC-Cpo-021524 Cavia porcellus 88.15 0.00e+00 2295.00
IUUC-Csa-023861 Chlorocebus sabaeus 90.79 0.00e+00 2347.00
IUUC-Cho-024484 Choloepus hoffmanni 80.37 0.00e+00 1229.00
IUUC-Dre-028006 Danio rerio 53.96 0.00e+00 1274.00
IUUC-Dno-029591 Dasypus novemcinctus 91.59 0.00e+00 2401.00
IUUC-Dor-030237 Dipodomys ordii 76.24 0.00e+00 1096.00
IUUC-Ete-032620 Echinops telfairi 85.32 0.00e+00 1106.00
IUUC-Eeu-035354 Erinaceus europaeus 67.15 0.00e+00 642.00
IUUC-Fca-036337 Felis catus 91.84 0.00e+00 2403.00
IUUC-Fal-037077 Ficedula albicollis 70.70 0.00e+00 1838.00
IUUC-Gmo-039687 Gadus morhua 50.92 0.00e+00 936.00
IUUC-Ggr-039828 Gaeumannomyces graminis 23.68 4.00e-43 171.00
IUUC-Gga-040299 Gallus gallus 69.70 0.00e+00 1847.00
IUUC-Gac-041762 Gasterosteus aculeatus 52.32 0.00e+00 1290.00
IUUC-Ggo-045563 Gorilla gorilla 90.72 0.00e+00 2349.00
IUUC-Hsa-046771 Homo sapiens 90.39 0.00e+00 2340.00
IUUC-Lch-050200 Latimeria chalumnae 65.78 0.00e+00 1658.00
IUUC-Loc-052090 Lepisosteus oculatus 59.57 0.00e+00 1530.00
IUUC-Laf-053861 Loxodonta africana 90.00 0.00e+00 2350.00
IUUC-Mcc-055543 Macaca mulatta 91.11 0.00e+00 2352.00
IUUC-Meu-056688 Macropus eugenii 81.39 0.00e+00 2083.00
IUUC-Mga-059243 Meleagris gallopavo 70.79 0.00e+00 1877.00
IUUC-Mmr-061134 Microcebus murinus 85.59 0.00e+00 2008.00
IUUC-Mdo-062913 Monodelphis domestica 79.71 0.00e+00 2078.00
IUUC-Mmu-063811 Mus musculus 87.03 0.00e+00 2297.00
IUUC-Mpu-066780 Mustela putorius furo 91.84 0.00e+00 2350.00
IUUC-Mlu-067276 Myotis lucifugus 90.41 0.00e+00 2371.00
IUUC-Nfi-068459 Neosartorya fischeri 26.95 2.00e-60 228.00
IUUC-Nle-069129 Nomascus leucogenys 90.15 0.00e+00 2333.00
IUUC-Opr-071007 Ochotona princeps 67.10 0.00e+00 1127.00
IUUC-Ont-071348 Oreochromis niloticus 55.25 0.00e+00 1413.00
IUUC-Oan-072717 Ornithorhynchus anatinus 81.39 0.00e+00 2143.00
IUUC-Ocu-074286 Oryctolagus cuniculus 90.79 0.00e+00 2011.00
IUUC-Ola-086895 Oryzias latipes 49.92 0.00e+00 1187.00
IUUC-Oga-088678 Otolemur garnettii 90.31 0.00e+00 2349.00
IUUC-Oar-089359 Ovis aries 89.76 0.00e+00 2356.00
IUUC-Ptr-091062 Pan troglodytes 90.39 0.00e+00 2342.00
IUUC-Pan-092528 Papio anubis 93.54 0.00e+00 1390.00
IUUC-Psi-093430 Pelodiscus sinensis 74.42 0.00e+00 1952.00
IUUC-Pma-094690 Petromyzon marinus 38.69 1.00e-153 536.00
IUUC-Pfo-097204 Poecilia formosa 54.65 0.00e+00 1388.00
IUUC-Pab-097690 Pongo abelii 90.79 0.00e+00 2350.00
IUUC-Pca-100778 Procavia capensis 72.25 0.00e+00 1207.00
IUUC-Pva-102870 Pteropus vampyrus 89.11 0.00e+00 2140.00
IUUC-Pyt-104620 Pyrenophora triticirepentis 27.86 5.00e-63 236.00
IUUC-Rno-104889 Rattus norvegicus 87.51 0.00e+00 2270.00
IUUC-Sha-107465 Sarcophilus harrisii 80.25 0.00e+00 2131.00
IUUC-Sar-113268 Sorex araneus 89.17 0.00e+00 671.00
IUUC-Ssc-115654 Sus scrofa 90.63 0.00e+00 2385.00
IUUC-Tgu-117302 Taeniopygia guttata 70.94 0.00e+00 1853.00
IUUC-Tru-118363 Takifugu rubripes 54.53 0.00e+00 1387.00
IUUC-Tsy-119007 Tarsius syrichta 86.71 0.00e+00 2247.00
IUUC-Tni-120910 Tetraodon nigroviridis 53.08 0.00e+00 1336.00
IUUC-Tbe-127413 Tupaia belangeri 77.78 0.00e+00 1435.00
IUUC-Ttr-129213 Tursiops truncatus 84.63 0.00e+00 2179.00
IUUC-Vpa-130146 Vicugna pacos 86.99 0.00e+00 1671.00
IUUC-Xtr-132559 Xenopus tropicalis 60.89 0.00e+00 1564.00
Created Date 25-Jun-2017

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