iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037597

Ensembl Protein ID

ENSFALP00000003056.1

UniProt Accession

U3JJV2; U3JJV2_FICAL

Genbank Protein ID

ENSFALP00000003056

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AGTO01010641

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000002923.1	ENSFALT00000003069.1	ENSFALP00000003056.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.80e-89	300.1	1	297

Active Site

Position(s)	Description	Evidence
63	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
139	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 26   gvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedk 114
           g+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat+A++svllnc ++
   Q: 1    GCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCAHQ 78
           78899.****************.********************.........899********************************** PP
   S: 115  lldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldl 203
            ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + + +++    +++afhfvsyv++ngrlyeldgl++ P+dl
   Q: 79   DIHLGETLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSSAK----EEDAFHFVSYVPVNGRLYELDGLREGPIDL 163
           *************************************************888776....89**************************** PP
   S: 204  gkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqldde 283
           g+ + ++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++r+  l+ +          +  ++l+ i+se++k+++ +++e
   Q: 164  GA-CHQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQRIAELQQQlaeeepmdtDQSSNMLSSIQSEVAKYQMLIEEE 249
           *9.67889*********..******************************987766677888888755678******************* PP
   S: 284  kekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgv 334
           ++k k++ki++irR++ny  fi++++k+la++++l  lve+    + ++++
   Q: 250  NQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQNA 297
           ****************************************93...333554 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

GCRGAQVEEI WSLEPENFEK LKPVHGLIFL FKWQPGEEPA GSVVQDSRLD TIFFAKQVIN 60
NACATQAIVS VLLNCAHQDI HLGETLSEFK EFSQSFDAAM KGLALSNSEV IRQVHNSFAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTGTAGAG GAGCACAAGT TGAAGAAATA TGGAGTTTGG AGCCAGAGAA CTTTGAAAAG 60
TTGAAGTAAG GCACATTTTT TTATTCACAT TTGTCTGAAG TCCCTGAAAG AATGTGTACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.69	2.00e-75	275.00
IUUC-Aml-001866	Ailuropoda melanoleuca	95.83	4.00e-166	576.00
IUUC-Atr-002966	Amborella trichopoda	48.29	3.00e-78	285.00
IUUC-Apl-003306	Anas platyrhynchos	90.36	2.00e-172	598.00
IUUC-Aca-004763	Anolis carolinensis	96.53	7.00e-168	582.00
IUUC-Aly-005581	Arabidopsis lyrata	47.25	7.00e-71	260.00
IUUC-Ath-007283	Arabidopsis thaliana	46.93	7.00e-73	266.00
IUUC-Ago-007999	Ashbya gossypii	36.70	1.00e-26	113.00
IUUC-Acl-008231	Aspergillus clavatus	42.66	7.00e-46	177.00
IUUC-Afl-008557	Aspergillus flavus	36.97	2.00e-47	182.00
IUUC-Afu-008988	Aspergillus fumigatus	43.58	1.00e-46	179.00
IUUC-Ani-009420	Aspergillus nidulans	37.58	1.00e-47	182.00
IUUC-Ang-009859	Aspergillus niger	40.81	1.00e-42	166.00
IUUC-Aor-010145	Aspergillus oryzae	36.97	2.00e-47	182.00
IUUC-Ate-010347	Aspergillus terreus	41.81	1.00e-46	179.00
IUUC-Ame-010791	Astyanax mexicanus	90.79	2.00e-168	584.00
IUUC-Bgr-012298	Blumeria graminis	38.49	7.00e-44	170.00
IUUC-Bta-013251	Bos taurus	95.49	2.00e-164	570.00
IUUC-Bci-013786	Botrytis cinerea	37.11	5.00e-51	194.00
IUUC-Bdi-014132	Brachypodium distachyon	47.87	6.00e-72	263.00
IUUC-Bol-015611	Brassica oleracea	48.21	2.00e-75	275.00
IUUC-Bra-017769	Brassica rapa	48.21	2.00e-75	275.00
IUUC-Cel-018604	Caenorhabditis elegans	44.86	7.00e-71	260.00
IUUC-Cja-019768	Callithrix jacchus	86.08	3.00e-159	553.00
IUUC-Cfa-020207	Canis familiaris	95.83	4.00e-166	576.00
IUUC-Cpo-021925	Cavia porcellus	91.67	2.00e-157	547.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	44.67	1.00e-65	242.00
IUUC-Csa-023958	Chlorocebus sabaeus	94.79	5.00e-163	566.00
IUUC-Cho-024928	Choloepus hoffmanni	97.40	4.00e-42	164.00
IUUC-Cin-025771	Ciona intestinalis	52.00	2.00e-88	318.00
IUUC-Csv-026149	Ciona savignyi	55.89	2.00e-92	331.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.59	5.00e-51	194.00
IUUC-Cne-026955	Cryptococcus neoformans	35.14	6.00e-46	177.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.35	4.00e-41	161.00
IUUC-Dre-027409	Danio rerio	90.46	2.00e-166	578.00
IUUC-Dno-028921	Dasypus novemcinctus	95.83	2.00e-166	577.00
IUUC-Dse-031170	Dothistroma septosporum	37.29	2.00e-50	192.00
IUUC-Dme-031677	Drosophila melanogaster	60.34	2.00e-102	365.00
IUUC-Ete-032707	Echinops telfairi	69.49	2.00e-103	369.00
IUUC-Eca-033776	Equus caballus	95.49	4.00e-166	576.00
IUUC-Eeu-035305	Erinaceus europaeus	74.23	4.00e-66	244.00
IUUC-Fca-035846	Felis catus	87.62	3.00e-161	560.00
IUUC-Fox-037670	Fusarium oxysporum	49.74	2.00e-47	182.00
IUUC-Fso-038243	Fusarium solani	49.74	6.00e-47	181.00
IUUC-Gmo-038499	Gadus morhua	85.07	9.00e-150	522.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.54	1.00e-42	166.00
IUUC-Gga-040904	Gallus gallus	98.03	1.00e-177	615.00
IUUC-Gac-042058	Gasterosteus aculeatus	90.28	5.00e-159	553.00
IUUC-Gma-043763	Glycine max	49.06	5.00e-77	280.00
IUUC-Ggo-044699	Gorilla gorilla	88.65	3.00e-148	517.00
IUUC-Hsa-046227	Homo sapiens	95.14	4.00e-165	573.00
IUUC-Hvu-047359	Hordeum vulgare	46.13	2.00e-74	271.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.52	9.00e-161	559.00
IUUC-Lch-049829	Latimeria chalumnae	93.40	2.00e-162	564.00
IUUC-Lpe-050899	Leersia perrieri	46.64	3.00e-69	254.00
IUUC-Loc-052264	Lepisosteus oculatus	92.04	5.00e-161	559.00
IUUC-Lma-053110	Leptosphaeria maculans	36.82	2.00e-42	166.00
IUUC-Laf-053639	Loxodonta africana	95.83	4.00e-166	576.00
IUUC-Mcc-055506	Macaca mulatta	94.79	5.00e-163	566.00
IUUC-Mor-057001	Magnaporthe oryzae	43.81	8.00e-48	183.00
IUUC-Mpo-057608	Magnaporthe poae	39.76	4.00e-27	114.00
IUUC-Mtr-057731	Medicago truncatula	47.78	2.00e-76	278.00
IUUC-Mla-059016	Melampsora laricipopulina	42.62	9.00e-38	149.00
IUUC-Mga-060178	Meleagris gallopavo	98.36	7.00e-179	619.00
IUUC-Mvi-060353	Microbotryum violaceum	37.74	4.00e-48	184.00
IUUC-Mmr-060738	Microcebus murinus	95.49	1.00e-165	575.00
IUUC-Mdo-062266	Monodelphis domestica	96.22	4.00e-107	379.00
IUUC-Mmu-063619	Mus musculus	93.40	1.00e-162	565.00
IUUC-Mac-065301	Musa acuminata	50.17	3.00e-80	291.00
IUUC-Mpu-066058	Mustela putorius furo	96.18	1.00e-166	578.00
IUUC-Mlu-067292	Myotis lucifugus	94.79	5.00e-163	566.00
IUUC-Nfi-068275	Neosartorya fischeri	37.33	3.00e-48	185.00
IUUC-Ncr-068713	Neurospora crassa	38.51	9.00e-52	196.00
IUUC-Nle-069013	Nomascus leucogenys	94.44	1.00e-162	565.00
IUUC-Opr-070628	Ochotona princeps	86.31	1.00e-158	552.00
IUUC-Ont-072688	Oreochromis niloticus	91.03	5.00e-159	553.00
IUUC-Oan-073004	Ornithorhynchus anatinus	96.30	5.00e-141	493.00
IUUC-Ocu-074303	Oryctolagus cuniculus	96.18	7.00e-167	580.00
IUUC-Oba-075002	Oryza barthii	47.12	2.00e-73	269.00
IUUC-Obr-076392	Oryza brachyantha	47.99	6.00e-71	260.00
IUUC-Ogl-077271	Oryza glaberrima	47.12	2.00e-73	269.00
IUUC-Ogu-078493	Oryza glumaepatula	46.96	3.00e-74	271.00
IUUC-Oin-080084	Oryza indica	46.96	3.00e-74	271.00
IUUC-Olo-080803	Oryza longistaminata	46.65	8.00e-74	270.00
IUUC-Ome-081146	Oryza meridionalis	46.01	8.00e-73	266.00
IUUC-Oni-082146	Oryza nivara	46.96	3.00e-74	271.00
IUUC-Opu-083633	Oryza punctata	47.32	1.00e-69	256.00
IUUC-Oru-084789	Oryza rufipogon	46.96	3.00e-74	271.00
IUUC-Osa-086196	Oryza sativa	46.96	3.00e-74	271.00
IUUC-Ola-087126	Oryzias latipes	91.32	7.00e-155	539.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.89	7.00e-61	226.00
IUUC-Oga-089140	Otolemur garnettii	86.67	5.00e-160	556.00
IUUC-Oar-090296	Ovis aries	95.83	2.00e-166	577.00
IUUC-Ptr-090566	Pan troglodytes	95.14	4.00e-165	573.00
IUUC-Pan-092052	Papio anubis	94.79	4.00e-163	566.00
IUUC-Psi-093723	Pelodiscus sinensis	97.92	6.00e-170	589.00
IUUC-Pma-094568	Petromyzon marinus	60.76	6.00e-108	383.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.93	1.00e-43	169.00
IUUC-Ppa-095761	Physcomitrella patens	46.75	1.00e-76	279.00
IUUC-Pfo-096210	Poecilia formosa	89.93	1.00e-158	551.00
IUUC-Pab-098463	Pongo abelii	95.14	3.00e-165	574.00
IUUC-Pop-099423	Populus trichocarpa	49.53	3.00e-77	281.00
IUUC-Pca-100108	Procavia capensis	94.57	2.00e-124	437.00
IUUC-Ppe-101176	Prunus persica	49.83	6.00e-76	276.00
IUUC-Pva-102629	Pteropus vampyrus	92.83	6.00e-130	456.00
IUUC-Pgr-103419	Puccinia graminis	40.32	3.00e-50	191.00
IUUC-Pte-104207	Pyrenophora teres	42.57	9.00e-26	108.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.03	5.00e-50	191.00
IUUC-Rno-105579	Rattus norvegicus	83.59	1.00e-157	548.00
IUUC-Sha-106894	Sarcophilus harrisii	93.12	3.00e-154	536.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	37.81	3.00e-52	198.00
IUUC-Spo-108371	Schizosaccharomyces pombe	40.00	1.00e-53	202.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.13	3.00e-48	184.00
IUUC-Smo-109396	Selaginella moellendorffii	50.33	3.00e-80	291.00
IUUC-Sit-110630	Setaria italica	48.70	2.00e-77	281.00
IUUC-Sly-110972	Solanum lycopersicum	49.84	1.00e-81	296.00
IUUC-Stu-112185	Solanum tuberosum	49.52	4.00e-81	294.00
IUUC-Sar-113294	Sorex araneus	78.72	5.00e-147	513.00
IUUC-Sbi-113951	Sorghum bicolor	49.03	1.00e-77	282.00
IUUC-Ssc-115501	Sus scrofa	96.18	7.00e-167	579.00
IUUC-Tgu-117152	Taeniopygia guttata	99.65	7.00e-166	575.00
IUUC-Tru-118388	Takifugu rubripes	89.93	4.00e-159	553.00
IUUC-Tsy-119109	Tarsius syrichta	95.49	2.00e-165	574.00
IUUC-Tni-120048	Tetraodon nigroviridis	89.93	1.00e-159	555.00
IUUC-Tca-121750	Theobroma cacao	49.22	1.00e-80	292.00
IUUC-Tre-122130	Trichoderma reesei	37.63	2.00e-48	186.00
IUUC-Tvi-122284	Trichoderma virens	38.61	2.00e-46	179.00
IUUC-Tae-125344	Triticum aestivum	46.25	3.00e-73	268.00
IUUC-Tur-126366	Triticum urartu	43.65	2.00e-65	242.00
IUUC-Tme-127187	Tuber melanosporum	40.07	1.00e-52	199.00
IUUC-Tbe-127619	Tupaia belangeri	86.76	1.00e-139	488.00
IUUC-Ttr-128867	Tursiops truncatus	85.31	1.00e-121	429.00
IUUC-Vda-129912	Verticillium dahliae	37.32	2.00e-46	179.00
IUUC-Vpa-130552	Vicugna pacos	97.28	3.00e-108	384.00
IUUC-Vvi-130881	Vitis vinifera	49.69	2.00e-76	278.00
IUUC-Xtr-131934	Xenopus tropicalis	85.86	2.00e-160	557.00
IUUC-Xma-133312	Xiphophorus maculatus	89.58	2.00e-157	548.00
IUUC-Yli-134487	Yarrowia lipolytica	37.44	2.00e-42	165.00
IUUC-Zma-135639	Zea mays	49.15	3.00e-70	258.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence