iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
DNA & RNA Element
TRANSFAC	TargetScan	miRcode
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-06	30.4	51	102

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkw.....pglknssskefrCPlCr 46
           C+iC++ +   ++ p+ l+C Hvf+++Cl ++     +g++     +  CP Cr
   Q: 51   CSICFSGYdniFKTPKELSCTHVFCLECLARLaaaqpVGRP--GGEAVPCPFCR 102
           ****999944433366677**********888888777777..999999****8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSSGQQVWHT AVPPPRRSSS IASMPRSPSS AGSPRSPGTP GSERVASPLE CSICFSGYDN 60
IFKTPKELSC THVFCLECLA RLAAAQPVGR PGGEAVPCPF CRQPTAVPPA GAPALCTSRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAACTCAC ACCTGCCTCA GACCAGAGCT CTGTGCGGGT GACGGCGCAC GCATTCCTTG 60
TGTCCCCGCC TGTCTTGGAC AGAGCAGAAG CCACACCTGC CAGACCAGTG CCACCGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0008270--F:zinc ion binding

KEGG

hsa:401934

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003890	Anas platyrhynchos	52.57	4.00e-46	177.00
IUUC-Aca-005120	Anolis carolinensis	47.53	1.00e-28	119.00
IUUC-Ame-010644	Astyanax mexicanus	40.62	3.00e-34	137.00
IUUC-Bta-013148	Bos taurus	77.43	6.00e-63	233.00
IUUC-Cfa-020556	Canis familiaris	77.25	4.00e-59	221.00
IUUC-Cpo-022176	Cavia porcellus	78.07	3.00e-63	234.00
IUUC-Csa-023157	Chlorocebus sabaeus	94.17	2.00e-74	272.00
IUUC-Dre-028766	Danio rerio	44.75	1.00e-36	146.00
IUUC-Eca-034096	Equus caballus	77.10	1.00e-50	192.00
IUUC-Fca-036424	Felis catus	90.00	1.00e-28	117.00
IUUC-Gmo-038633	Gadus morhua	38.71	2.00e-15	73.60
IUUC-Gga-040232	Gallus gallus	50.49	8.00e-50	190.00
IUUC-Ggo-045542	Gorilla gorilla	80.27	3.00e-52	197.00
IUUC-Itr-048513	Ictidomys tridecemlineatus	36.97	2.00e-09	55.50
IUUC-Lch-049896	Latimeria chalumnae	45.05	2.00e-40	158.00
IUUC-Laf-054336	Loxodonta africana	75.47	3.00e-58	218.00
IUUC-Mcc-055051	Macaca mulatta	93.98	6.00e-83	300.00
IUUC-Mga-060186	Meleagris gallopavo	46.88	5.00e-42	164.00
IUUC-Mmu-063376	Mus musculus	79.65	8.00e-72	263.00
IUUC-Mpu-066249	Mustela putorius furo	79.64	1.00e-65	242.00
IUUC-Ont-071891	Oreochromis niloticus	39.56	2.00e-35	142.00
IUUC-Oga-088065	Otolemur garnettii	76.89	1.00e-64	239.00
IUUC-Pan-091816	Papio anubis	93.52	2.00e-81	295.00
IUUC-Psi-093845	Pelodiscus sinensis	52.57	4.00e-38	151.00
IUUC-Pfo-097099	Poecilia formosa	46.03	4.00e-36	144.00
IUUC-Sha-106674	Sarcophilus harrisii	48.72	8.00e-06	43.50
IUUC-Sar-113158	Sorex araneus	37.07	1.00e-11	62.80
IUUC-Ssc-115834	Sus scrofa	35.04	4.00e-08	51.20
IUUC-Tgu-117099	Taeniopygia guttata	54.01	4.00e-49	187.00
IUUC-Tni-119763	Tetraodon nigroviridis	50.00	8.00e-22	94.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence