iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072122

Ensembl Protein ID

ENSONIP00000015134.1

UniProt Accession

I3K1Y9; I3K1Y9_ORENI

Genbank Protein ID

ENSONIP00000015134

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01018626

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000012024.1	ENSONIT00000015147.1	ENSONIP00000015134.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-101	340.0	484	821

Active Site

Position(s)	Description	Evidence
789	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k l++++++lf ++s+n++  ++pnp++   ++ +lk++ef+Gr++gk+l+++     
   Q: 484  SDWSKNFEVVFQDEEALDWGGPRREWFELICKTLFDTSNQLFtRFSDNNQGLVHPNPERP--PHLRLKMYEFAGRVVGKCLYESalgga 570
           7999**************************************7789999*********98..459******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ d+e+yk+ + +i++n   d++e++l ++ ++ +++ +  k++eL++gG++i VtneNk 
   Q: 571  ykQLVRARFTRSFLAQIIGLRMNYKYFETDDQEFYKTkVCFILNN---DVSEMDLVFAEEKYSKSGQLEKVVELISGGAQIAVTNENKM 656
           99***********************************99****99...9**************************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++ +ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v+++f++e
   Q: 657  HYLNLLAQYRLASQVRDEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVQDFKAHAvIVGGSWHFREKVMKWFWAVVSSFTQE 745
           **************************************************************445778999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGf++l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+l+++L +Ai+e+ +gF++
   Q: 746  ELARLLQFTTGSSQLPHGGFNTLCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEELHKMLKLAISEGsEGFGM 821
           ************************99555555.******************************************97 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MFYVIGGITV SIIAFVFTIK FLCELAARVV SFLQNEDPGR RGDRSIYDYV RGNYLDPRSC 60
KVSWDWKEPQ EVGQTMSFRV QLFYKNGQPF PAHRPVGLRV NITHIELALD IPATQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACG TGATTGGTGA GTACAACATT ATCTAGTAGT ATAAAAGGCT GGGCTGATAC 60
GGTTGGTGTT TACTTATGTG ACTGATTTTT ATTCCTGCTC ACACTTTGGC TTTAGTTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	81.87	0.00e+00	1368.00
IUUC-Apl-004071	Anas platyrhynchos	78.86	0.00e+00	1297.00
IUUC-Aca-005218	Anolis carolinensis	80.58	0.00e+00	1348.00
IUUC-Ame-011871	Astyanax mexicanus	94.16	0.00e+00	1583.00
IUUC-Bta-012978	Bos taurus	81.77	0.00e+00	1367.00
IUUC-Cja-019081	Callithrix jacchus	81.77	0.00e+00	1363.00
IUUC-Cfa-020736	Canis familiaris	79.47	0.00e+00	1290.00
IUUC-Cpo-021581	Cavia porcellus	81.65	0.00e+00	1365.00
IUUC-Csa-024189	Chlorocebus sabaeus	76.16	0.00e+00	700.00
IUUC-Cho-024751	Choloepus hoffmanni	81.41	0.00e+00	1322.00
IUUC-Cin-025773	Ciona intestinalis	42.47	5.00e-149	521.00
IUUC-Csv-026090	Ciona savignyi	40.47	3.00e-174	605.00
IUUC-Dre-027788	Danio rerio	92.21	0.00e+00	1554.00
IUUC-Dno-030022	Dasypus novemcinctus	81.53	0.00e+00	1363.00
IUUC-Dme-031577	Drosophila melanogaster	48.68	0.00e+00	718.00
IUUC-Ete-032402	Echinops telfairi	80.22	0.00e+00	1305.00
IUUC-Eca-033908	Equus caballus	82.26	0.00e+00	1374.00
IUUC-Eeu-034869	Erinaceus europaeus	87.69	0.00e+00	839.00
IUUC-Fca-036023	Felis catus	81.77	0.00e+00	1366.00
IUUC-Fal-037477	Ficedula albicollis	81.29	0.00e+00	1349.00
IUUC-Gmo-039197	Gadus morhua	94.53	0.00e+00	1558.00
IUUC-Gga-040704	Gallus gallus	79.10	0.00e+00	1340.00
IUUC-Gac-041511	Gasterosteus aculeatus	95.38	0.00e+00	1601.00
IUUC-Ggo-044527	Gorilla gorilla	78.76	0.00e+00	1291.00
IUUC-Hsa-046082	Homo sapiens	81.77	0.00e+00	1364.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	82.14	0.00e+00	1373.00
IUUC-Lch-049772	Latimeria chalumnae	75.46	0.00e+00	1204.00
IUUC-Loc-052541	Lepisosteus oculatus	89.93	0.00e+00	1507.00
IUUC-Laf-053852	Loxodonta africana	81.65	0.00e+00	1357.00
IUUC-Mcc-054759	Macaca mulatta	75.98	0.00e+00	630.00
IUUC-Meu-056247	Macropus eugenii	67.11	0.00e+00	721.00
IUUC-Mga-060161	Meleagris gallopavo	78.64	0.00e+00	1324.00
IUUC-Mmr-061447	Microcebus murinus	81.90	0.00e+00	1368.00
IUUC-Mdo-062110	Monodelphis domestica	79.47	0.00e+00	1329.00
IUUC-Mmu-064349	Mus musculus	81.77	0.00e+00	1368.00
IUUC-Mpu-065824	Mustela putorius furo	82.26	0.00e+00	1365.00
IUUC-Mlu-067729	Myotis lucifugus	82.14	0.00e+00	1349.00
IUUC-Nle-069721	Nomascus leucogenys	81.90	0.00e+00	1353.00
IUUC-Opr-070189	Ochotona princeps	81.64	0.00e+00	1356.00
IUUC-Oan-072700	Ornithorhynchus anatinus	72.21	0.00e+00	1072.00
IUUC-Ocu-074057	Oryctolagus cuniculus	81.90	0.00e+00	1369.00
IUUC-Ola-087492	Oryzias latipes	94.65	0.00e+00	1579.00
IUUC-Oga-088084	Otolemur garnettii	82.02	0.00e+00	1363.00
IUUC-Oar-090354	Ovis aries	81.57	0.00e+00	1348.00
IUUC-Ptr-091456	Pan troglodytes	81.65	0.00e+00	1360.00
IUUC-Pan-092596	Papio anubis	80.70	0.00e+00	1336.00
IUUC-Psi-092942	Pelodiscus sinensis	81.17	0.00e+00	1346.00
IUUC-Pma-094662	Petromyzon marinus	63.11	0.00e+00	775.00
IUUC-Pfo-096838	Poecilia formosa	95.86	0.00e+00	1550.00
IUUC-Pab-097849	Pongo abelii	81.53	0.00e+00	1361.00
IUUC-Pca-100498	Procavia capensis	76.35	0.00e+00	731.00
IUUC-Pva-102599	Pteropus vampyrus	81.53	0.00e+00	1350.00
IUUC-Rno-105776	Rattus norvegicus	81.90	0.00e+00	1359.00
IUUC-Sha-106699	Sarcophilus harrisii	80.07	0.00e+00	1338.00
IUUC-Sar-113621	Sorex araneus	80.69	0.00e+00	1324.00
IUUC-Ssc-115742	Sus scrofa	81.77	0.00e+00	1368.00
IUUC-Tgu-116490	Taeniopygia guttata	80.92	0.00e+00	1347.00
IUUC-Tru-117679	Takifugu rubripes	95.86	0.00e+00	1580.00
IUUC-Tsy-119607	Tarsius syrichta	77.39	0.00e+00	928.00
IUUC-Tni-120376	Tetraodon nigroviridis	91.61	0.00e+00	1480.00
IUUC-Tbe-127348	Tupaia belangeri	56.88	2.00e-148	519.00
IUUC-Ttr-128786	Tursiops truncatus	78.61	0.00e+00	1301.00
IUUC-Vpa-130180	Vicugna pacos	80.15	0.00e+00	1059.00
IUUC-Xtr-132631	Xenopus tropicalis	67.11	0.00e+00	1112.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence